France will begin their quest to become the first side in six years to retain the Six Nations when they travel to perennial wooden spoon winners Italy on Sunday.
Les Blues ended a 12-year wait to get their hands back on the trophy last year, doing so in style as they claimed a Grand Slam with a perfect five wins from five.
Italy also ended last year's tournament on a high as they broke a 36-game losing run with victory in Wales and are now out to avoid finishing bottom for the first time since 2015.
While France may be reigning champions and in good form, Ireland are top of the world rankings and are many people's favourites to go one better than last year by finishing top.
Up first for Andy Farrell's Ireland side is a trip to Wales, who are in action for the first time since Warren Gatland replaced Wayne Pivac on the back of some alarming results last year.
England also have a new head coach in Steve Borthwick, who replaced Eddie Jones in December, with his first test a mouth-watering Calcutta Cup clash with Scotland.
Ahead of the opening round of action, Stats Perform previews each match with help from Opta.
WALES V IRELAND
FORM
Wales' loss to Italy was their third in a row in the Six Nations – only once since the start of 2008, at the end of their 2020 campaign, have they endured a longer winless run – but Gatland's return has provided fresh hope.
The Dragons won their last seven on the bounce in the championship under Gatland, who landed three Grand Slams in his previous 12-year spell in charge before stepping down in 2019.
Ireland have won seven of their past eight games in the tournament, winning the past three of those by margins of at least 17 points and conceding just one try in total.
However, the away team have not come out on top in any of the past nine Six Nations encounters between these sides, with the nations sharing four wins each over that period and one draw.
ONES TO WATCH
Wales are without the injured Leigh Halfpenny, meaning Liam Williams will start at full-back, but they have plenty of other familiar and experienced faces in their starting line-up – George North among them.
He is one try short of matching Shane Williams' record haul of 23 for Wales in the Six Nations, and behind only Brian O'Driscoll (26) of all players in the tournament's history.
Plenty of eyes will be on Johnny Sexton in what will be his final Six Nations campaign, but Ireland have many other players for Wales to concern themselves with.
James Lowe, returning from a calf injury that ruled him out of the November fixtures, will be looking to push on from last year when he finished level with Damian Penaud and Gabin Villiere as the joint-highest try scorer with three.
ENGLAND V SCOTLAND
FORM
Jones may have bowed out with the best win rate of any England head coach (73 per cent), but the Red Rose won just two of their final five home matches under the now-Australia boss – not since November 2008 have they had a longer winless run at Twickenham.
With former skipper Borthwick now at the helm as head coach, England are aiming to avoid losing their opening fixture in the tournament for a fourth year running, following a streak of five successive round-one wins.
Scotland have a far better recent record on the opening weekend than their opponents, having won four of their past six such matches, including the past two in a row – both against England.
Indeed, Scotland have lost just one of their past five Calcutta Cup clashes, having lost each of the previous seven. A victory on enemy territory this weekend will make it three wins in a row for the first time since 1972.
ONES TO WATCH
Manu Tuilagi's absence will be felt by England, who have handed a debut to wing Ollie Hassell-Collins, but Joe Marchant will add pace alongside exciting Harlequins team-mate Marcus Smith.
Smith was the top points-scorer in last year's Six Nations (71) and also registered over twice as many running metres as any other fly-half in the tournament (412), as well as beating more defenders than anyone other number 10 (10).
Hamish Watson is not ready for a return to the Scotland side this weekend in a blow for coach Gregor Townsend. The 31-year-old was one of just three players to make 50 or more tackles without missing one in the 2022 edition (70), along with team-mate Grant Gilchrist and Ireland's Caelan Doris (both 53).
Gilchrist is available, though, and he resumes a partnership with Richie Gray in the second row that impressed during Scotland's November internationals.
ITALY V FRANCE
FORM
The signs of improvement were clear to see from an Italy perspective in 2022 as they picked up a first win in the tournament since 2015 and then beat Australia for the first time ever in November's Test.
The Azzurri have now won five of their past seven Tests, as many as they had won in their previous 36 combined, but they have not won at home in the Six Nations since 2013 and have won back-to-back games in the championship just twice previously.
France enter the competition boasting a team-record 13-match winning run after winning every game in a calendar year for the first time in 2022. They were not always at their best towards the end of the year, though, with three of their past four wins coming by margins of five points or fewer.
Les Blues have won their opening match in each of their past four campaigns as reigning champions, which does not bode well for an Italy side who have won only two of their 23 Six Nations home matches against this weekend's opponents.
ONES TO WATCH
Italy are without the pace and power of Monty Ioane after he returned to Australia and became unavailable for selection in this championship. No player made more line breaks (seven), beat more defenders (21), completed more offloads (eight) and made more dominant tackles (seven) than Ioane in last year's Six Nations.
The Azzurri still have Pierre Bruno and Ange Capuozzo at their disposal, with the latter impressing on his tournament bow in 2022 en route to winning World Rugby's men's Breakthrough Player of the Year award.
Even with the likes of regular starters Jonathan Danty and Cameron Woki ruled out, France still boast a number of top-class talents in their squad.
Gregory Alldritt, who will combine with Charles Ollivon and Anthony Jelonch in the back row, made more carries than any other player in last year's tournament (65) and was one of two players, along with team-mate Julien Marchand (50), to hit 50 or more defensive rucks with 59.
Balogun would be 'great addition' for USMNT, 'but his heart needs to be in it'
Folarin Balogun would be a "great addition" to the United States team, but Arsenal's Matt Turner only wants the striker to make the switch if it "comes from the heart".
Arsenal forward Balogun has excelled on loan with Reims this season, scoring 17 goals in 27 Ligue 1 appearances – behind only Jonathan David and Kylian Mbappe (both 19).
The 21-year-old's excellent form has prompted talk of a tussle for his international allegiance, with the New York-born star eligible to represent England, the United States and Nigeria.
Balogun has been a mainstay in the England Under-21 set-up, but he withdrew from the squad for this month's internationals due to injury.
That development has led to fresh hope Balogun will pledge himself to the USMNT, and Turner confirmed he had spoken to his Gunners team-mate on the matter.
"I spoke to Flo. We obviously had most of our preseason together, and I knew going into it he had some roots in the USA," the goalkeeper said on Wednesday.
"So, he and I developed a relationship pretty quickly. That's pretty much the extent of it. We check in on each other here and there.
"He'd be a great addition to our national team. I think he's done really well, obviously, for his club on loan, and we'll see.
"The decision has to come from the heart, because it's not necessarily an easy task to come and play in these CONCACAF games. It's a tough region at times.
"So, for us, we'd be really grateful to have him, but his heart needs to be in it."
Earlier in the week, Balogun told Sky Sports he was yet to decide on his future but has aspirations of playing at the highest level.
"My international future is not decided yet in terms of who I'll play for," he said. "But of course I want to play international football at the highest level, in the World Cups, and I want to compete at the highest level.
"I want to put myself in positions where I'm performing in front of millions of people."
Retegui earns Batistuta comparison from Italy coach Mancini
Argentina-born Italy striker Mateo Retegui reminds Roberto Mancini of the Albiceleste's Serie A great Gabriel Batistuta.
Retegui has been handed a first Italy call-up for this month's Euro 2024 qualifiers, starting at home to England on Thursday.
The Tigre striker, who was born and raised in Argentina, where he has also spent his entire club career, qualifies for the Azzurri through his grandfather.
Strikers travelling between Argentina and Italy is not a new phenomenon, but Retegui is heading for the Italy camp, rather than a Serie A club.
"Coming like this from Argentina to Italy, not in a club team, is not so simple," coach Mancini said on the eve of the England game.
"It takes some time, but the guy is polite and smart. He is a good striker, young, we have great confidence and we have to give him some time."
Retegui has scored 28 goals in 48 Argentine Primera Division games for Tigre.
While Mancini noted comparisons with former Napoli striker German Denis, he preferred to draw parallels with the great Batistuta.
Batistuta joined Fiorentina from Boca Juniors in 1991 and was a great success both with the Viola and with Roma.
"[Retegui] is a classic striker, I see that many compare him to Denis," Mancini said. "I remember when Batistuta arrived in Italy, he reminds me of him.
"Clearly, he is a young guy and needs time and to grow. But I don't think it will take long to settle in."
Zion Williamson cleared for Pelicans return but will miss two more weeks
Zion Williamson has been cleared to return to on-court activities but will need at least two weeks to get up to speed.
The New Orleans Pelicans announced Williamson's return to fitness on Wednesday – a significant boost for a team whose season has gone off the rails.
At the time of Williamson's hamstring strain in January, the Pels were third in the Western Conference, just a game behind the first-placed Denver Nuggets.
Since then, however, New Orleans are 12-23, slipping to 12th place on the outside even of the play-in race.
Williamson has not been the only Pelican to miss time with injury, but Brandon Ingram's return has not improved the team's fortunes.
With the Pels set to re-evaluate Williamson in two weeks' time, he is on course to miss a minimum of seven more games.
New Orleans only have 10 games remaining.
A return in the final week of the regular season could be just the boost the Pels need, but they could also very realistically be out of postseason contention by then.
This has been another season wrecked by injury for Williamson, the former first overall pick.
He played only 24 games in his rookie season and 61 the following year before missing the entire 2021-22 campaign with a foot fracture.
The Pels still handed Williamson a five-year rookie extension worth up to $231million, with $193m guaranteed.
Although he continued to miss games on occasion, the initial signs were encouraging as Williamson averaged 26.0 points through 29 games.
But the hamstring injury derailed his and the Pels' season, with time running out to set it back on track.
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