Matteo Berrettini pulled out of the Australian Open without playing a match as his injury woes continued.
The former Wimbledon finalist had been due to face Stefanos Tsitsipas in the first round on Rod Laver Arena on Monday in one of the plum ties of the first round.
But on Sunday afternoon the tournament announced he had withdrawn with a right foot injury, making it the fourth time in the last eight grand slam tournaments where he has not been able to play a match.
The popular Italian, a semi-finalist in Melbourne in 2022, has been off the tour since suffering an ankle injury during his second-round match against Arthur Rinderknech at the US Open.
He had previously missed the French Open because of an abdominal injury, while in 2022 he also sat out Roland Garros following hand surgery and then tested positive for Covid-19 ahead of Wimbledon.
Once ranked as high as world number six, the 27-year-old, beaten by Djokovic in the Wimbledon final in 2021, is now down at 125.
He has been replaced in the draw by Belgian lucky loser Zizou Bergs, who will take on Tsitsipas on Monday.
Fourth seed Jannik Sinner, one of the favourites for the title following his stellar end to 2023, began his campaign with a straight-sets win over Botic Van De Zandschulp.
Sinner, who beat Djokovic twice in a matter of days at the ATP Finals and Davis Cup in November, was a 6-4 7-5 6-3 winner on Rod Laver Arena.
The Italian did not play a warm-up tournament after his late finish to last season, and he said: “I feel like I started off actually really well for the first match.
“Then after, I had some moments where I made a couple of wrong choices, but this can happen. Even if you made maybe some matches, this can happen. Maybe you are a little bit tired sometimes.
“It was important today for me because I was looking forward to stepping on the court.”
Former finalist Marin Cilic played his first grand slam match since the US Open in 2022 following knee surgery but was beaten in four sets by Hungary’s Fabian Marozsan.
Osaka makes winning return at Italian Open
Naomi Osaka claimed a straight sets victory over Clara Burel in the first round of the Italian Open.
Making her first appearance in Rome since 2021, former world number one Osaka prevailed 7-6 (7-2) 6-1 on Wednesday, marking her first win over a top-50 opponent on clay since she defeated Victoria Azarenka at Roland Garros in 2019.
Osaka, who is now ranked 173rd in the world by the WTA, will face Marta Kostyuk in the second round.
She previously faced Kostyuk in the 2020 US Open, en route to winning her third major title.
Data Debrief: Back with a bang
Osaka reached the quarter-finals of the Italian Open in 2019, but did not win a game in 2021 and has not appeared at any other edition since then.
That means the 26-year-old won her first match at the event since she beat Mihaela Buzarnescu in 2019 (1,819 days ago). She wrapped up the win in one hour and 24 minutes, finishing with 27 winners, including eight aces.
Winning Olympic medal 'equal to Grand Slams', says Gauff
Coco Gauff believes winning a medal at the forthcoming Paris Olympics would be "equal" to winning a Grand Slam.
The world number three was forced to miss the Games in Tokyo three years ago after testing positive for COVID-19, and is eager to sample the "once-in-a-lifetime experience".
The tennis events will be played on the clay of Roland Garros, where Gauff will be bidding for a second major title at the French Open later this month.
And the reigning US Open champion is looking forward to competing, though she admits her preparations will be unprecedented.
"For me, the Olympics is a top priority. I'd say equal to the Grand Slams," Gauff told reporters at the Italian Open, where she will face Magdalena Frech in the last 64.
"I wouldn't put it above or below just because I've never played before. This is my first time. Obviously, I always want to do well, try to get a medal. But the preparation is going to be interesting, because I've never done the grass to clay transition before.
"I'm not putting too much pressure on it because I really want to fully indulge in the experience. Hopefully, I can have it many times in my lifetime. I'll treat it as a once-in-a-lifetime experience."
Before that, Gauff is focused on getting ready for the French Open, where she was runner-up to world number one Iga Swiatek two years ago.
The 20-year-old will step up her preparation at the Italian Open this week, aiming to build on her run to the round of 16 at the Madrid Open last time out, where her run was ended by compatriot Madison Keys.
"For me, it's just about serving better than I did last week," she added. "I feel the other parts of my game are improving. If I can work that through, I think it'll set me up for a very good Roland Garros."
Madrid champion Swiatek keen to maintain level at Italian Open
Iga Swiatek will not rest on her laurels after overcoming Aryna Sabalenka in last week's Madrid Open final, pledging to learn from that gruelling battle ahead of the Italian Open.
Swiatek toppled Sabalenka in an enthralling battle between the world's top two players on Saturday, saving three championship points en route to a 7-5 4-6 7-6 (9-7) win in over three hours on court.
The world number one has now won every European clay court tournament at WTA 500 level or higher, including back-to-back triumphs in Rome in 2021 and 2022.
As she prepares to open her Italian Open campaign against either Caroline Dolehide or a qualifier on Friday, Swiatek is determined to ensure she does not let her level drop.
Speaking during an appearance on the WTA Insider Podcast, Swiatek said: "I feel like after such a match, I deserve a two-month vacation, but I can't have that so I'll trade it for six tiramisus or something!
"I can let it go and rest and just forget about it, or I can really take a big lesson from it, so it depends on what is going to happen in the next few weeks in terms of how I analyse it."
Swiatek's latest win – her seventh in 10 meetings with Sabalenka – saw her put further distance between herself and the world number two in the WTA rankings.
However, the four-time grand slam champion knows she cannot afford to let up, given the fierce competition on the WTA tour.
"I'm not thinking about Aryna when I'm practising, but it's more that I know that the competition is big and if I stop for a while I might be pushed out," Swiatek said.
"But I had this kind of thing in Rome 2022, with the final against Ons [Jabeur]. Physically, I was so tired. The rallies were long, Ons was playing a pretty tricky game.
"So after that game for the next few years, when I was doing the worst practices on court and I was dying, I was thinking about that game."
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