Serie A champions Napoli slipped to a shock defeat on Sunday as Monza claimed a deserved 2-0 win against the Partenopei at Stadio Brianteo.
Goals from Dany Mota and Napoli loanee Andrea Petagna handed Luciano Spalletti's men just their fourth top-flight loss of the season, dampening their ongoing title celebrations.
Spalletti opted for a handful of changes against mid-table opposition, and will have expected more from his men despite the low-stakes nature of this clash.
But for Raffaele Palladino, his Biancorossi will nevertheless delight in taking one of the biggest scalps of their successful first campaign in the top flight.
With Napoli already champions and Monza secure in their Serie A place for next season, a lacklustre dead rubber appeared to be on the cards in the first quarter-hour.
But a shrewd counter-attack from the hosts sparked matters into life shortly afterwards, with Mota taking full advantage of a disjointed defence to tuck home the opener.
The visitors chased a response, with Andre-Frank Zambo Anguissa forcing a cracking save from Michele Di Gregorio just before the break, but Napoli were left trailing at the interval.
Matters worsened following the restart, when Petagna darted into the box to seize on a rebound and curl a shot beyond Pierluigi Gollini, finding the bottom-left corner.
Napoli continued to test Monza, but efforts from Mathias Olivera and Khvicha Kvaratskhelia were ably saved, while Victor Osimhen saw a penalty shout waved away.
Napoli's inability to find a way back in saw them suffer a rare reverse, in what fans will hope was merely a hangover from their Scudetto success.
New England Revolution 1-4 Inter Miami: Messi at the double as Herons run riot
Lionel Messi scored twice and laid on a goal for Luis Suarez as Inter Miami retained their three-point lead at the Eastern Conference summit with a 4-1 win over the New England Revolution.
A franchise-record crowd of 65,612 people witnessed a flying start from the Revs as they took the lead within just 37 seconds at Gillette Stadium. Carles Gil pounced on some sloppy play from Miami to tee up Tomas Chancalay, who lobbed Drake Callender for the opener.
However, Miami roared back with Messi leading from the front. They had a deserved equaliser just after the half-hour mark, Messi slotting home after latching onto Robert Taylor's throughball.
Messi had his second after 67 minutes, producing another composed finish after former Barcelona team-mate Sergio Busquets split the New England backline.
Messi was involved in another two goals as Miami added some gloss to the scoreline late on; his first-time shot was saved by Henrich Ravas but Benjamin Cremaschi was on hand to score on the rebound after 83 minutes, then the Argentine teed up Suarez for a curled finish five minutes later.
Miami stay three points clear of Supporters' Shield holders FC Cincinnati at the top of the East, with the Orange and Blue keeping pace by beating the Colorado Rapids 2-1 on Saturday.
Data Debrief: Messi rolls back the years
Ahead of Saturday's game, some feared Miami boss Gerardo Martino would opt to rest Messi after speaking of the risks of fielding the eight-time Ballon d'Or winner on New England's artificial pitch.
However, Messi came through 90 minutes with another mesmerising performance. He has now recorded a goal involvement in 10 straight club matches for the seventh time in his glittering career, last doing so for Barcelona between September and December in 2018.
Al-Khaleej 0-1 Al-Nassr: Ronaldo misfires on return as Laporte nets winner
Cristiano Ronaldo returned from suspension but failed to find the net as Al-Nassr secured a 1-0 win over Al-Khaleej on Saturday, with Aymeric Laporte coming up with the decisive goal.
Ronaldo was in action for the first time since being sent off for an elbow in a 2-1 Saudi Super Cup loss to Al-Hilal earlier this month, with his initial two-match ban being reduced to one on appeal.
He missed three good chances as Al-Nassr threatened to fall further behind runaway Saudi Pro League leaders Al-Hilal, but former Manchester City defender Laporte spared his blushes by nodding Marcelo Brozovic's deep free-kick into the bottom-left corner with 68 minutes gone.
Al-Nassr remain nine points adrift of Al-Hilal at the summit in spite of their win, with Jorge Jesus' team unbeaten through 28 games this season as they close in on a record-extending 18th title.
Data Debrief: Ronaldo misfires on return
Ronaldo was presented with the Saudi Pro League's Player of the Month award for March ahead of kick-off, having scored four goals in three league appearances last month.
However, his sights were off on Saturday as he failed to net despite three of the visitors' four big chances, as defined by Opta, falling his way. He led all players on the pitch for expected goals (1.27 xG), shots (five), shots on target (three) and touches in the area (nine) without reward.
Juventus 0-0 Milan: Goalless draw ensures Rossoneri retain grip on second
Juventus and Milan played out a 0-0 draw at a sold-out Allianz Stadium in Serie A on Saturday, with both sides still seeking to secure Champions League spots for next season.
Midfielder Filip Kostic and striker Arkadiusz Milik had great chances to give Juventus the lead in the second half but Milan goalkeeper Marco Sportiello showed off his skills to keep their attempts out.
The Rossoneri finished the game without a shot on target as the contest finished goalless, leaving the sides to share the spoils.
Milan remain second in the standings on 70 points while Juventus remain third on 65, after Inter sealed the title on Monday.
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