France, Brazil and Portugal are the only sides to have already secured World Cup knockout football, with numerous teams facing a nervy final matchday as they bid to reach the round of 16 in Qatar.
Pre-tournament favourites Brazil breezed through Group G with wins over Serbia and Switzerland, while France became the first reigning world champions to escape the group stage since the Selecao in 2006.
Portugal made sure of their round-of-16 spot after Monday's Group H victory over Uruguay, yet the likes of England, Spain, Germany and Argentina all need results on matchday three to progress.
The Netherlands are another big name that have yet to confirm their place in the latter stages of FIFA's top tournament, while Belgium face a tense Group F clash with Croatia to avoid an early exit.
Here, Stats Perform takes a look at the permutations riding on the final selection of group-stage action in the Middle East.
Group A
The Netherlands are largely in control of Group A, needing to just avoid defeat against the already eliminated hosts, Qatar.
Louis van Gaal's side will also reach the round of 16 if Ecuador beat Senegal, who have to win otherwise Aliou Cisse's side will rely on a somewhat unlikely win for Qatar over the Netherlands to remain in contention.
Ecuador, who have impressed in their first two games, must win or draw against Senegal to progress. However, Gustavo Alfaro's men could go through in defeat if Qatar beat the Netherlands.
Group B
A win or a draw is enough for England against fierce rivals Wales. Yet, the Three Lions would still progress as long as they avoid a four-goal defeat against Wales, whose goal difference is six fewer.
Iran are guaranteed to qualify with victory over the United States, who know anything other than a win against Carlos Queiroz's side will see them eliminated from the competition.
Quieroz's men could still escape Group B with a draw, though goal difference would come into play if Wales pick up their first win at the tournament against Gareth Southgate's England.
Group C
All four teams can still make it out of an enticing Group C, with Argentina – who were among the pre-tournament favourites – needing to beat Poland to guarantee a round-of-16 place.
La Albiceleste could progress with a draw, however, and would be through in that instance if Mexico and Saudi Arabia also share the spoils.
Yet, if Lionel Scaloni's men are held and Herve Renard's men beat El Tri, Argentina will be eliminated. If Mexico win and Argentina draw, it goes to goal difference.
Poland would go through by avoiding defeat, but would be knocked out by a loss coupled with a Saudi Arabia victory over Mexico, who must win to have any chance of remaining in the tournament.
If Poland lose and Saudi Arabia draw, the two teams will have to be separated by goal difference, which will also be used if Czeslaw Michniewicz's side are defeated and Mexico win.
Group D
France are already in the round-of-16 draw and will top Group D as long as they do not lose to Tunisia and Australia do not defeat Denmark, otherwise the Socceroos would move level on six points with Les Bleus.
While victory would take Australia through, Graham Arnold's side would still reach the knockout stage with a draw unless Tunisia beat France, which would see Jalel Kadri's men progress on goal difference.
Denmark would grab qualification with a win over Australia unless Tunisia triumph over France, which would leave goal difference or goals scored to separate the Carthage Eagles and Kasper Hjulmand's men.
Group E
Spain are the favourites to progress from Group E, requiring a win or draw against Japan. Defeat would see Luis Enrique's side still go through on goal difference, unless Germany lose to Costa Rica.
Germany must pick up three points to stay in contention and would qualify as long as Spain defeat Japan, though a draw in the latter game or a win for Hajime Moriyasu's men would see goal difference needed.
A win for Japan over Spain would take Moriyasu's side through, while a draw – coupled with a stalemate for Germany – would also see the Samurai Blue make the knockout stage.
Costa Rica would earn a last-16 spot with victory and a point would also take them through if Spain overcome Japan. A draw in both games or a defeat for Fernando Suarez's side sees them eliminated.
Group F
Croatia will pass through Group F if they avoid defeat against Belgium, who require victory against the 2018 runners-up to guarantee a place in the round of 16.
Such a win for Belgium would leave Croatia needing already eliminated Canada to overcome Morocco, with goal difference coming into play to separate Zlatko Dalic's side from the Atlas Lions.
A draw is likely not enough for Belgium. They would need Morocco to lose to Canada and then rely on goal difference, though Walid Regragui's men (+2) hold the advantage over Roberto Martinez's side (-1) in the decisive metric.
Morocco would progress with victory over Canada, while a defeat would see Regragui's side reliant on Belgium beating Croatia for goal difference to be decisive between Dalic's men and the Atlas Lions for second.
Group G
Brazil have secured knockout football and will finish as Group G winners with anything other than defeat against Cameroon, who need victory against Tite's side and results to go their way to make the last 16.
Rigobert Song's men would be eliminated if they do not win, though victory is not guaranteed to secure progression as Switzerland could play out a high-scoring draw with Serbia to go through on goals scored, which is used if sides cannot be separated on goal difference – Cameroon are currently on -1 and Switzerland level in the latter metric.
The somewhat expected scenario of Cameroon losing to Brazil would see Serbia and Switzerland become a winner-takes-all clash.
Dragan Stojkovic's side need victory to progress in that instance, while a draw would be enough for Switzerland. Goal difference would be required if Serbia (-2) and Cameroon (-1) both win their final encounters.
Group H
Portugal are already through and would top Group H by avoiding defeat against South Korea, who could still make a late charge for the round-of-16 stage should the result between Uruguay and Ghana go their way.
The permutations are straightforward for Uruguay and South Korea, who must win to avoid elimination, though qualification is not assured even with victory.
Both teams would be level on four points with victories, again leading to goal difference to separate. Yet, if Ghana beat Uruguay then South Korea's result against Portugal will prove irrelevant for Paulo Bento's side.
A draw for Ghana and a win for South Korea would also see goal difference required to split the two sides, with Bento's men trailing the Black Stars by one in that metric, which could mean goals scored comes into it.
Messi hopes the 'craziness never ends' after 100th international goal and wild celebrations
Lionel Messi hopes the "craziness never ends" after scoring his 100th goal and ninth hat-trick for his country amid Argentina's homecoming World Cup celebrations on Tuesday.
La Albiceleste routed Curacao 7-0 in Santiago del Estero, with Messi's 20th-minute opener bringing up his 100th international goal, joining only Cristiano Ronaldo (122) and Ali Daei (109) in achieving that feat.
Messi became the first world champion to score 100 international goals, and he showed no signs of stopping there with further first-half strikes for a treble, taking him to 102.
The milestone came as Argentina rounded out their first two games back in their homeland since December's World Cup triumph with wild celebrations, initially in Buenos Aires for Thursday's 2-0 win over Panama.
The players emulated their celebrations from Qatar after the Curacao game, hoisting the World Cup trophy again after it came down from the stadium roof and doing a lap of honour to greet the supporters.
Messi was also presented with a plaque by Argentine Football Association president Claudio Tapia to acknowledge his 100th goal.
"What a nice way to close these dates, impressive today all the people in Santiago del Estero," Messi wrote on Instagram.
"I wish we can continue to share together many moments like these and that this craziness never ends!!!"
Messi's achievement comes after netting 21 goals in his 14 games for Argentina, along with seven assists. That has taken him to 156 goal contributions, which is the most in international football.
Argentina head coach Lionel Scaloni added: "As for Lionel Messi, what I want is for him to be on the pitch and be happy."
He added: "These days were different to the previous friendlies because the players were allowed to be with their people.
"We felt that they had that desire to go out to contact the outside, although that meant that it was difficult to prepare these two games. But in the end we got them through by playing with intensity."
Argentina 7-0 Curacao: Messi caps 100th international goal with first-half hat-trick
Lionel Messi scored his 100th international goal before capping his performance with a first-half hat-trick as Argentina routed Curacao 7-0 during Tuesday's friendly in Santiago del Estero.
Messi came into the game on 99 international goals but did not need to wait long to bring up triple figures, netting a 20th-minute opener, in a lopsided match-up where the world champions raced to a 5-0 half-time lead.
The Argentinian captain played the entire 90 minutes, scoring three goals within 17 devastating first-half minutes, while he also laid off the assist for Enzo Fernandez's powerful strike among the flurry.
Messi was denied early on by Curacao goalkeeper Eloy Room's sharp save, but soon after Giovani Lo Celso found him in space inside the box, setting him up to jink past two defenders and fire in a low right-foot shot for his 100th Argentina goal.
Nicolas Gonzalez added a second in the 23rd minute when he out-jumped Room to head home from a corner, before he played provider for Messi's second with a neat left-foot finish in the 33rd minute.
Two minutes later, Messi held up the ball and dished out a deft pass for Fernandez to lash home, with the Paris Saint-Germain star wrapping up his hat-trick when he raced on to Lo Celso's lofted pass and coolly converted after taking two touches.
Room brilliantly denied Lautaro Martinez twice early in the second half, while Leandro Bacuna fizzed Curacao's best chance over the bar from a 63rd-minute free-kick on the edge of the box.
Substitute Angel Di Maria added a sixth goal from the penalty spot in the 78th minute after Cuco Martina's handball, with Gonzalo Montiel side-footing home another from Paulo Dybala's cutback in the 88th minute.
Lionel Messi 100: The Argentina great's five best international goals
With his strike against Curacao on Tuesday, Lionel Messi reached another landmark by scoring 100 goals for Argentina.
The 35-year-old brought up the milestone in style, receiving a 20th-minute pass from Giovani Lo Celso before jinking past two Curacao defenders and rifling in a low right-foot finish.
The man considered by many to be the greatest footballer of all time had come in for some criticism over the years for his performances at international level.
That was until he led Argentina to Copa America success in 2021 and followed that up at last year's World Cup, starring as La Albiceleste recovered from a shock opening defeat to Saudi Arabia to beat defending champions France in the final on penalties.
Of course, the sheer volume of his goals has been breathtaking, with only Cristiano Ronaldo and Ali Daei scoring more in international men's football.
But Stats Perform picked out five individual strikes that were particularly memorable.
Argentina v Mexico (July 11, 2007)
Having only just turned 20, Messi was expected to win the Copa America for his country in 2007.
Ultimately, Argentina were beaten in the final by Brazil, but not before Messi had graced the stage with a sumptuous lob in their 3-0 win against Mexico in the semi-finals, being fed on the right of the penalty before an outrageous lob over Oswaldo Sanchez into the far corner.
Argentina v Brazil (June 9, 2012)
The two great rivals faced each other in New Jersey as they prepared for the 2012 Olympic Games in London, and a topsy-turvy contest had already seen Messi score twice.
In the 84th minute and with the score tied at 3-3, Messi went as trademark as possible, picking up the ball on the right just into the Brazil half before dribbling for goal. He cut inside the nearest defender on the edge of the box and curled a shot into the top-left corner of the net.
Argentina v Paraguay (September 7, 2012)
Just a few months later, Messi was at it from distance again, this time even further out as he showed off his supreme free-kick taking ability.
With Argentina leading Paraguay 2-1 in their World Cup qualifier, Messi lined up a set-piece effort a little over 30 yards out, whipping the ball over the wall and in off the goalkeeper's left-hand post.
Argentina v Iran (June 21, 2014)
In their second group game of the 2014 World Cup, Argentina had struggled to break down a resolute Iran side who were on the verge of securing a famous 0-0 draw and valuable point.
That was until Messi picked up the ball on the right in the 91st minute in Belo Horizonte. He darted inside, as he so often does, and curled a sumptuous effort past Alireza Haghighi from some 25 yards, the ball nestling in the bottom-left corner.
Argentina v Mexico (November 26, 2022)
Having already lost to Saudi Arabia in their first game at the 2022 World Cup, Argentina could not find a way past Mexico in the first hour of their second encounter either.
Or, they couldn't until their captain stepped up.
With raucous fans urging them on at Lusail Stadium, Messi received a pass from Angel Di Maria before hitting a shot from outside the box low and hard to Guillermo Ochoa's left, lighting the touchpaper that would ultimately end with the trophy in his hands at the end of the campaign.
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