Real Madrid and Villarreal have it all to do when they host Manchester City and Liverpool respectively in the second legs of their Champions League semi-final ties in midweek.
Fresh off the back of winning a second LaLiga title in three seasons, Madrid are aiming to overturn a 4-3 deficit against City following last week's thrilling first leg in Manchester.
That was the joint-highest scoring semi-final first leg in the competition's history, along with Liverpool 5-2 Roma in 2017-18, and more drama awaits in the Spanish capital.
Villarreal face an even bigger task, meanwhile, as they trail Liverpool 2-0 through an unfortunate Pervis Estupinan own goal and a Sadio Mane strike at Anfield.
However, only once before have the Reds won both legs of a knockout stage tie against Spanish opposition in the Champions League or its former guise as the European Cup.
So will it be an all-English final in Paris on May 28, or can the LaLiga pair turn things around on home turf?
Ahead of the second legs, Stats Perform digs into some of the best Opta numbers around the two semi-final ties.
Villarreal v Liverpool
To put the size of Villarreal's task into some perspective, only once before – Liverpool versus Barcelona in 2019 – has a team overturned a two-goal first-leg deficit at this stage of the Champions League.
Villarreal are unbeaten at home in Champions League knockout ties, albeit having won just two of their seven such games. The bad news, though, is that across those seven matches, neither side has managed to score more than once on any occasion.
If they are to have any hope of advancing then Unai Emery's men need to display far more attacking impetus than was on show last week, having attempted only one shot and failed to hit the target at Anfield. The last team to fail to record a shot on target across two legs of a Champions League semi-final was Deportivo de La Coruna in 2003-04, against Jose Mourinho's Porto.
Should Liverpool see the job through, they will become only the fourth side to reach the final of the European Cup/ Champions League on 10 or more occasions after Real Madrid (16), Bayern Munich and Milan (both 11), with their current tally of nine the most of any English side.
Jurgen Klopp's side have been formidable on the road in Europe this season, scoring 15 goals and conceding five across their five away Champions League matches, all of which have ended in victory. Should they win on Tuesday, they will boast the longest 100 per cent away record by any team in a single European Cup or Champions League campaign.
After netting in the first leg it is likely that Mane will again be selected in Liverpool's star-studded front three. The Senegal international has scored 14 knockout-stage goals for the Reds in the Champions League, leaving him one short of Chelsea legend Frank Lampard's record for the most for an English club.
Real Madrid v Manchester City
The omens are good for City as they have progressed from nine of their previous 10 knockout ties in the Champions League after winning the first leg, the only exception being against Monaco at the last-16 stage in 2016-17 after squandering a 5-3 advantage to lose 6-6 on away goals.
Madrid have been eliminated from all five previous Champions League semi-finals in which they have lost the first leg, meanwhile, though they have advanced from two of their past three knockout ties when losing the first leg – against Wolfsburg in the 2015-16 quarter-finals and versus Paris Saint-Germain in this season's last 16.
Los Blancos, the competition's most successful side, have lost their past two Champions League games, though only once before have they lost three on the spin. Head coach Carlo Ancelotti, incidentally, has never lost three in a row with this his 178th match.
A draw would be enough to see City through, but they have won their last three matches against Madrid in the Champions League and could become the third side to win four in a row against them in UEFA's showpiece competition, the only previous sides to have done so being Ajax (between 1973 and 1995) and Bayern Munich (between 2000 and 2002).
City boss Pep Guardiola has had his fair share of battles with Madrid down the years, not least in the Champions League. The Catalan coach has won four matches against Los Blancos in the competition – only Ottmar Hitzfeld (seven) has won more – with half of those wins coming at the Santiago Bernabeu.
Karim Benzema has rescued Madrid a number of times in Europe this season, the Frenchman having netted nine times in the knockout stage alone. Only former team-mate Cristiano Ronaldo (10) has ever scored more in a single season, while Benzema could become the fourth player to score in both legs of the quarter-finals and semi-finals in a single season after Fernando Morientes (2003-04), Neymar (2014-15) and Edin Dzeko (2017-18).
While Benzema has rightly received plenty of plaudits, strike partner Vinicius Junior has himself played a huge part in Madrid's charge for a record-extending 14th European Cup. The 28 open-play chances created by the Brazil international is the most of any player in the Champions League since Dusan Tadic (36) in 2018-19.
'It's a poor season, not a poor football club' – Blades boss Wilder
Sheffield United manager Chris Wilder has defended Sheffield United, acknowledging it has been a bad season, but dismissing that the Blades do not have a positive future.
A midweek defeat to Manchester United means the Blades can be relegated back to the Championship should they lose to Newcastle United on Saturday.
The Blades are 10 points from safety with four games left, but even a point would not realistically be enough given they have a goal difference of -59, 41 worse than Nottingham Forest’s -18.
To make matters worse, the Blades will start their next season in the Championship with a two-point deduction for financial discrepancies.
"We're not saying everything is great," said Wilder.
"What we are saying is there is a load of optimism about the future of the football club.
"It's a poor season, not a poor football club. We've been in far worse positions than this as a football club, certainly over my time as a supporter, player and manager.
"So, we'll come again if the inevitable happens on the weekend. We'll try our best, as we did, like we did on Wednesday night at Old Trafford, to get a result for our club and our supporters – who yet again were magnificent."
Newcastle, meanwhile, are in the hunt for European football, and Eddie Howe wants a response following the 2-0 defeat at Crystal Palace in midweek.
Howe said: "We must learn and absorb all the lessons from Wednesday. Every game is so difficult, it is up to us to go into the game with the right mentality and let our players express themselves in the right way. We have to finish the season strongly, we are under no illusions on how important these fixtures are."
PLAYERS TO WATCH
Newcastle United – Alexander Isak
Isak has scored in each of his last six Premier League home games, with only Andrew Cole (eight in 1993-94) and Alan Shearer (15 in 1996-97) netting in more consecutively for Newcastle in the competition.
Sheffield United – Ben Brereton Diaz
Brereton Diaz scored in Sheff Utd’s 4-2 defeat at Old Trafford – his fifth Premier League goal of the season since he joined on loan from Villarreal in January. With Oli McBurnie set to miss the rest of the season, Diaz will be the Blades’ biggest attacking threat.
MATCH PREDICTION: NEWCASTLE UNITED WIN
Newcastle are overwhelming favourites, and it is no surprise given Howe have lost just one of their last 25 Premier League games kicking off at 3pm on Saturday (W16 D8), going down 1-0 at Luton Town earlier this season.
The Magpies have scored in all 17 of their Premier League home games this season, with their 43 goals in total their most at St James’ Park in a top-flight campaign since 1996-97 (54).
Newcastle have lost none of their eight Premier League home games against promoted sides under Howe (W3 D5), with their last such defeat coming against Leeds United under Steve Bruce in January 2021. They also beat Sheffield United 8-0 in the reverse fixture at Bramall Lane – the most goals they have ever scored against an opponent in a single Premier League campaign is 10, doing so against the Blades’ rivals Sheffield Wednesday in 1999-00.
The Blades have lost three of their four Premier League away games against Newcastle, failing to score in each defeat. The exception was a 1-0 victory under Neil Warnock in November 2006.
OPTA WIN PROBABILITY
Newcastle United – 71.6%
Sheffield United – 9.7%
Draw – 18.7%
Howe does not want 'constant speculation' over Guimaraes' future
Eddie Howe acknowledged he cannot control speculation over Bruno Guimaraes' future, though the Newcastle United boss wants it to end swiftly.
Reports emerged this week that Manchester City, Arsenal and Paris Saint-Germain are all interested in the Brazil international, who has been crucial to Newcastle's rise under Howe, having been signed from Lyon in January 2022.
According to the rumours, Newcastle value their star player at a minimum of £80million.
And ahead of Newcastle's meeting with Premier League strugglers Sheffield United, Howe conceded the club cannot control the speculation.
"Having that was well planned and structured by the club, in a sense that there’s a sort of finish point," he said.
"We don't want constant speculation, it's not healthy for the player or for us.
"It goes without saying we want to keep him, I want to build our team around him. His form has been very good and he seems very happy and settled.
"He'll be thinking about a very busy summer ahead, where hopefully we can take the team, with him a big part of it. But we aren't in control of that so let's see."
Chelsea midfielder Fernandez undergoes groin surgery
Chelsea will be without Enzo Fernandez for their final six games of the season due to a groin issue.
Fernandez was forced off with an injury during Chelsea's 5-0 defeat at Arsenal on Tuesday.
And it has now been confirmed the 23-year-old World Cup winner has undergone surgery, and will subsequently miss the final month of Chelsea's campaign.
Fernandez has made 28 Premier League appearances this season, scoring three goals. Chelsea did not put a timeframe on his return, though Argentina will be hoping the former Benfica star is fit to feature in the Copa America, which begins in late June.
The Blues sit ninth in the table, though they do have games in hand on all of their rivals for European qualification.
Mauricio Pochettino's team take on Champions League hopefuls Aston Villa on Saturday, with fixtures against Tottenham, West Ham Nottingham Forest, Brighton and Bournemouth to follow.
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