Kai Havertz and Christian Pulisic put Chelsea in control of their Champions League last-16 tie against Lille with a 2-0 win, but Mateo Kovacic and Hakim Ziyech went off injured.
Despite Romelu Lukaku being dropped to the bench after a dismal showing against Crystal Palace on Saturday, Chelsea needed just eight minutes to find the net through Havertz.
The reigning champions saw in-form duo Kovacic and Ziyech hobble off before the hour mark, casting doubt over their chances of featuring in the EFL Cup final against Liverpool on Sunday.
Pulisic finished off a quick break after 63 minutes to secure a strong first-leg lead for Thomas Tuchel's side, with the return leg to come in France next month.
Havertz wasted little time in making his mark as the central striker, nodding home from Ziyech's corner after failing to take a couple of early chances.
Antonio Rudiger almost turned a Renato Sanches cross into his own net and Lille threatened with a flurry of chances from the resulting corner as they started to get a foothold in the game.
Chelsea were dealt a blow when they lost Kovacic and Ziyech in quick succession early in the second half, but they doubled their advantage in the 63rd minute.
N'Golo Kante surged forward from inside the Chelsea half and fed Pulisic for a delightful dink over the onrushing Leo Jardim and into the bottom-right corner.
Lille tried to reduce the arrears with a push for a late goal, but Edouard Mendy was never really tested and Chelsea remained in charge of the tie.
What does it mean? Advantage Chelsea
The Blues were always going to be the favourites in this match-up and they got the win that was expected of them despite being far from dominant.
Chelsea have a good record when winning the first leg of a Champions League tie; in the 11 occasions they have won the opening encounter, they have reached the next round nine times.
However, the two exits followed first-leg victories at Stamford Bridge against Barcelona in 1999-2000 and Liverpool in 2006-07.
No room for Romelu
Lukaku was dropped after having just seven touches across 90 minutes at the weekend. Havertz needed just five to have three attempts on goal and find the net with the last of them, showing he is more than capable of being a potent threat through the middle.
Sanches shines in defeat
Sanches proved he has come a long way as he returned to the ground where he infamously passed to a logo on an advertising board, which he had mistaken for a team-mate during an underwhelming loan spell at Swansea City in 2017. He bossed the midfield in the first half and played some lovely passes.
What's next?
Chelsea face Liverpool in the EFL Cup final at Wembley on Sunday, when Lille travel to Lyon in Ligue 1.
Slot gets Klopp's nod of approval as Liverpool close in on Feyenoord coach
Jurgen Klopp has given his nod of approval to Liverpool's pursuit of Feyenoord head coach Arne Slot.
Klopp has just four games remaining as Liverpool manager, having announced his intention to leave back in January.
Liverpool's season is in danger of fizzling out, with Wednesday's 2-0 defeat to Everton in the Merseyside derby having dealt their Premier League title hopes a blow, while they also crashed out of the Europa League earlier this month.
This week, reports emerged Liverpool, who were disappointed in their pursuit of Bayer Leverkusen boss Xabi Alonso, had elected to move for Feyenoord's Slot as Klopp's replacement.
Slot confirmed on Thursday that the clubs were in talks and he was confident a deal would be completed soon, and Klopp believes the Dutchman is an ideal fit.
"I'm not involved in the process, but I like a lot about it, if he is the one and wants to take the job," Klopp said at a press conference ahead of Saturday's meeting with West Ham.
"I like the way his team plays football. All the things I hear about him as a guy – a good guy. Some people I know, know him. I don't know him, but some people who know him say he's a good guy. I like that a lot. So good coach, good guy. Looking forward for the club, if he is the solution, if he is the man, I am more than happy."
Expanding on what his replacement would be walking into at Anfield, Klopp added: "Best job in the world. Best club in the world.
"Great job, great team, fantastic people. [Slot] 'would' be taking a really interesting job."
'It's a poor season, not a poor football club' – Blades boss Wilder
Sheffield United manager Chris Wilder has defended Sheffield United, acknowledging it has been a bad season, but dismissing that the Blades do not have a positive future.
A midweek defeat to Manchester United means the Blades can be relegated back to the Championship should they lose to Newcastle United on Saturday.
The Blades are 10 points from safety with four games left, but even a point would not realistically be enough given they have a goal difference of -59, 41 worse than Nottingham Forest’s -18.
To make matters worse, the Blades will start their next season in the Championship with a two-point deduction for financial discrepancies.
"We're not saying everything is great," said Wilder.
"What we are saying is there is a load of optimism about the future of the football club.
"It's a poor season, not a poor football club. We've been in far worse positions than this as a football club, certainly over my time as a supporter, player and manager.
"So, we'll come again if the inevitable happens on the weekend. We'll try our best, as we did, like we did on Wednesday night at Old Trafford, to get a result for our club and our supporters – who yet again were magnificent."
Newcastle, meanwhile, are in the hunt for European football, and Eddie Howe wants a response following the 2-0 defeat at Crystal Palace in midweek.
Howe said: "We must learn and absorb all the lessons from Wednesday. Every game is so difficult, it is up to us to go into the game with the right mentality and let our players express themselves in the right way. We have to finish the season strongly, we are under no illusions on how important these fixtures are."
PLAYERS TO WATCH
Newcastle United – Alexander Isak
Isak has scored in each of his last six Premier League home games, with only Andrew Cole (eight in 1993-94) and Alan Shearer (15 in 1996-97) netting in more consecutively for Newcastle in the competition.
Sheffield United – Ben Brereton Diaz
Brereton Diaz scored in Sheff Utd’s 4-2 defeat at Old Trafford – his fifth Premier League goal of the season since he joined on loan from Villarreal in January. With Oli McBurnie set to miss the rest of the season, Diaz will be the Blades’ biggest attacking threat.
MATCH PREDICTION: NEWCASTLE UNITED WIN
Newcastle are overwhelming favourites, and it is no surprise given Howe have lost just one of their last 25 Premier League games kicking off at 3pm on Saturday (W16 D8), going down 1-0 at Luton Town earlier this season.
The Magpies have scored in all 17 of their Premier League home games this season, with their 43 goals in total their most at St James’ Park in a top-flight campaign since 1996-97 (54).
Newcastle have lost none of their eight Premier League home games against promoted sides under Howe (W3 D5), with their last such defeat coming against Leeds United under Steve Bruce in January 2021. They also beat Sheffield United 8-0 in the reverse fixture at Bramall Lane – the most goals they have ever scored against an opponent in a single Premier League campaign is 10, doing so against the Blades’ rivals Sheffield Wednesday in 1999-00.
The Blades have lost three of their four Premier League away games against Newcastle, failing to score in each defeat. The exception was a 1-0 victory under Neil Warnock in November 2006.
OPTA WIN PROBABILITY
Newcastle United – 71.6%
Sheffield United – 9.7%
Draw – 18.7%
Howe does not want 'constant speculation' over Guimaraes' future
Eddie Howe acknowledged he cannot control speculation over Bruno Guimaraes' future, though the Newcastle United boss wants it to end swiftly.
Reports emerged this week that Manchester City, Arsenal and Paris Saint-Germain are all interested in the Brazil international, who has been crucial to Newcastle's rise under Howe, having been signed from Lyon in January 2022.
According to the rumours, Newcastle value their star player at a minimum of £80million.
And ahead of Newcastle's meeting with Premier League strugglers Sheffield United, Howe conceded the club cannot control the speculation.
"Having that was well planned and structured by the club, in a sense that there’s a sort of finish point," he said.
"We don't want constant speculation, it's not healthy for the player or for us.
"It goes without saying we want to keep him, I want to build our team around him. His form has been very good and he seems very happy and settled.
"He'll be thinking about a very busy summer ahead, where hopefully we can take the team, with him a big part of it. But we aren't in control of that so let's see."
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