Atletico Madrid were the victims of a Copa del Rey giant-killing for a second successive season as Diego Simeone's side went down 1-0 to Cornella.
LaLiga leaders Atleti lost 2-1 to Cultural Leonesa in the round of 32 last season, and slumped out to Segunda B opposition on Wednesday.
The 10-time Copa winners fell behind to Adrian Jimenez's sensational flick seven minutes into the second-round tie in Catalonia.
Saul Niguez hit the woodwork and Lucas Torreira went close with a free-kick, but Ricard Sanchez's second booking compounded Atleti's issues as minnows Cornella claimed a famous triumph.
Sanchez was fortunate not to concede a penalty for handball in the opening minutes, before Jose Gimenez, making his 200th Atleti appearance, scythed down Raul Prieto.
With Gimenez, who was booked for his troubles, off the pitch receiving treatment, Cornella added insult to injury, with Agus Medina's cross flicked home expertly by Jimenez.
Atleti seemed set to restore parity shortly after the 20-minute mark, yet Angel Correa saw two efforts blocked either side of Saul hitting the crossbar.
Though Atleti were seeing over 60 per cent possession, they would have been 2-0 down heading into the break if not for Miguel San Roman's save from Pablo Fernandez.
Vitolo got in behind Cornella's backline early in the second half, only for an errant offside flag to deny him a chance to equalise.
Torreira's curling free-kick was inches away from levelling proceedings, though Atleti were then fortunate that Eloy Gila flicked over from close range at the other end.
Sanchez's frustrating night was made worse when he was deemed to have kicked out at Cornella goalkeeper Ramon Juan – the full-back seeing red just 11 minutes after receiving his first booking as Atleti's comeback efforts proved futile.
Man City title hopes rocked by Shaw injury
Manchester City's title hopes took a blow with the announcement that Khadija Shaw has been ruled out for the remainder of the season with a foot injury.
Shaw currently sits top of the Women’s Super League golden boot race with 21 goals in 18 games this season, a total which puts her well ahead of closest rival Lauren James, who is eight behind.
But she picked up her injury during Man City's 5-0 WSL victory over West Ham last weekend, a match in which she had scored twice in the first half, and will now miss the crucial final weeks of the top-flight campaign.
City have been reliant on the Jamaican's goals this season and will miss her in what is likely to be one of the most exciting run-ins in WSL history.
Chelsea sit three points behind City, however they have a game in hand and goal difference could end up being the determining factor if both teams are able to win all their remaining games.
The Citizens’ manager Gareth Taylor confirmed the Shaw blow in his pre match press conference ahead of Sunday’s clash with Bristol City, saying: “We have an issue with Bunny, she’s sustained a foot injury which will keep her out of the game for certain and potentially longer.
“It’s such a difficult one for Bunny because she’s had an incredible season.
“We had a feeling it might be an issue when she came off the pitch [against West Ham] even though it was non-contact.
“She’ll be well looked after by the medical team.”
City will have to think about who can fill the shoes of their star striker, but Taylor was confident about his team’s options despite the injury to Shaw.
"Bunny is our main number nine, but Mary [Fowler] has played there, Lauren [Hemp] has played there. Chloe [Kelly] is capable of playing there, Jess [Park] can do a really good job there," he said.
"Of course, we all understand what Bunny brings, she is such a box player, she gives us a different way of playing. Now, we will have a different kind of number nine."
City did, however, have some good news to share as they have tied down Lioness Lauren Hemp on new three-year contract extension keeping her at the Joie Stadium until 2027.
Hemp has won four trophies, while scoring 65 goals in 157 appearances, and has been a key player in the evolution of Taylor’s side.
Man City have secured the winger, who was out of contract at the end of the season and has attracted the attention of some of Europe's elite clubs such as Barcelona.
This term she has proved as productive as ever for City, scoring nine goals and adding six assists. She will also be key in the coming matches after the news of Shaw's injury misery.
"I feel at home here in Manchester," Hemp said after signing the deal.
"With the squad we have here, we are always learning and it’s so special to be involved at a club where we’re capable of achieving anything.
"I’m so passionate about this club and there’s no place I’d rather be. I’m very excited to keep this journey going for the next few years."
Edwards urges Luton Town to ignore scrutiny on relegation battle
Rob Edwards is keen for Luton Town to ignore the scrutiny surrounding them in the relegation battle as they prepare for another big game against Wolves.
The Hatters sit one point from safety in the relegation zone after back-to-back 5-1 defeats against Manchester City and Brentford.
While Nottingham Forest also lost last weekend, being beaten 2-0 by Everton, Burnley beat Sheffield United to move them two points behind Luton.
Asked how he is handling the pressure of the relegation battle with only four games left, Edwards said: “The stakes are high already, we all know what it means and it's really important to everyone that's in this at the moment, a number of clubs that are still fighting to try and avoid it and be in the league next season, it's so important.
“Everyone wants to try and stoke the fire I think. We've got a title race on at one end and obviously, there's a relegation battle we're involved in. It's exciting, it's good that we're in the fight, and we've got a chance to get out of it, but really, all I am concerned about right now is our performance tomorrow.”
Glasner challenges Crystal Palace to extend winning run
Oliver Glasner is hopeful that Crystal Palace can maintain their recent winning run when they travel to Fulham on Saturday.
After a run of five games without a victory, the Eagles have won each of their last three games, beating Liverpool, West Ham and Newcastle United.
Their 2-0 win over the Magpies on Wednesday also secured their Premier League safety for another season.
Glasner has given credit to his team’s attitude in turning around their recent run of form but does not want them to slow down despite reaching their goal.
He said: “The players give us confidence because they are listening. Every day we were sitting here and having a meeting and showing them videos and nobody was sleeping, so that gives us good feedback!
"Now we have 39 points and I think it shouldn't be our target to say ‘39 points, oh well done, staying in the Premier League’ because then I would say 'come on guys, go wherever you want and take vacations' – but no.
"We want to improve, we want to win games, and we have the next chance tomorrow at Fulham."
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