West Ham were breached by two late goals as they slipped to a 2-0 defeat in the first leg of their Europa League quarter-final at Bayer Leverkusen.
The Hammers had defended heroically for 83 minutes before goalkeeper Lukasz Fabianski was finally beaten by substitute Jonas Hoffman.
A one-goal deficit might have given David Moyes’ side hope going into next week’s second leg at the London Stadium, despite facing a side unbeaten all season.
But disaster struck in stoppage time when a second substitute, Victor Boniface, headed home Hofmann’s cross, to leave West Ham’s hopes of a third consecutive European semi-final looking horribly slim.
A yellow card for Lucas Paqueta, ruling the Brazil international out of the second leg, only adds to the task facing the east Londoners.
The Hammers, without injured top scorer Jarrod Bowen and defensive midfield linchpin Edson Alvarez through suspension, were almost undone in the seventh minute when Josip Stanisic’s wayward shot was flicked towards goal by Patrik Schick but the ball went straight to Fabianski.
But Leverkusen were given a warning of West Ham’s prowess on the counter-attack moments later when Michail Antonio outstripped Jonathan Tah on the left wing and produced the best chance of the first half.
The burly frontman squared the ball to Mohammed Kudus, but the Ghana winger’s first-time strike was comfortably held by Matej Kovar.
However, West Ham were largely camped in their own penalty area and Fabianski palmed away Jeremie Frimpong’s curler before Exequiel Palacios’s drive was deflected over.
Paqueta’s over-enthusiastic challenge on Amine Adli earned him his booking – the Brazilian survived a red card check – and provoked a mild skirmish on the touchline.
Fabianski might have suspected he was in for a busy evening and he was proved right, making big saves to keep out dangerous efforts from Alejandro Grimaldo, Shick and Edmond Tapsoba.
Early in the second half Emerson Palmieri was shown a yellow card after catching Adli on the ankle, meaning the left-back will also sit out next week’s return leg.
Frimpong, a former Manchester City youngster, hit a low angled drive straight at Fabianski, before the 38-year-old Pole made a stunning save to tip Shick’s instinctive header over the crossbar.
But with seven minutes remaining Fabianski was powerless to prevent Hoffman’s shot bouncing through a sea of white shirts and into the net after a corner was only half-cleared.
Tomas Soucek cleared two Tah efforts off the line in a desperate finale before Boniface headed the second to leave the Hammers devastated.
Hayes concedes title race is over as Chelsea suffer dramatic Liverpool defeat
It has been a difficult week for Chelsea and their boss Emma Hayes.
After seeing their Champions League dreams dashed by holders Barcelona on Saturday, they had no margin for error when they travelled to Liverpool in the Women's Super League on Wednesday.
Six points behind Manchester City with two games in hand but an inferior goal difference, the Blues needed three points to stop Hayes' final season in charge from totalling unravelling.
But there was to be no respite for the Blues, who were at one point tipped for a quadruple but have been stuck in a downward spiral since losing Sam Kerr to an anterior cruciate ligament injury during the winter break.
Matt Beard's Liverpool put on a tremendous display to win 4-3, with Gemma Bonner scoring a stoppage-time equaliser to leave Hayes certain the title is out of reach.
"I think the title is done," she said after Wednesday's game.
"Of course mathematically it's not, but I think the title is done. Our job between now and the end of the season is to keep pushing until the end, but I think it will be very difficult.
"This team has done a tremendous job in my time here to push for titles.
"I don’t know if we have ever conceded four goals in a half before. Three from set pieces is just unforgivable. But I'm going to credit Liverpool."
Chelsea now need an almighty collapse from City, who may only require three points from their remaining two matches to seal the title, if their goal difference advantage holds firm.
Hayes believes fighting on multiple fronts has not helped her team, adding: "We looked exhausted but I don't want to make excuses.
"I want to remind our fans how much success we have brought over the years. It's just not to be this year."
Next up, Chelsea face relegated Bristol City in their final home game before Hayes departs to take the United States job, with City taking on Arsenal in Sunday's headline fixture.
Sancho outshines Mbappe as Dortmund seize initiative against PSG
Manchester United loanee Jadon Sancho issued a reminder of his star quality as Borussia Dortmund beat Paris Saint-Germain 1-0 in the first leg of their Champions League semi-final tie on Wednesday.
Niclas Fullkrug scored the winner after 36 minutes, taking in Nico Schlotterbeck's floated pass before driving a low shot beyond PSG goalkeeper Gianluigi Donnarumma.
Fullkrug has now been involved in six Champions League goals this season (three goals, three assists), the joint-most by a German player in their debut campaign in the competition, alongside BVB team-mate Marco Reus in 2012-13 (four goals, two assists).
The star of the show, however, was undoubtedly Sancho.
He tormented Nuno Mendes throughout a lively performance, creating three chances for his team-mates – a game-high tally alongside Julian Brandt, Kylian Mbappe and Achraf Hakimi.
Sancho had completed seven dribbles by the halfway point, more than he managed in any full game for the Red Devils.
By full-time, that number had crept up to 12, the most by any player in a Champions League semi-final since Lionel Messi completed 16 for Barcelona against United in April 2008, and the most on record by an Englishman at any stage of the competition (since 2003-04).
Sancho even outshone Mbappe, who struck the far post with a curling effort early in the second half but was limited to just three shots totalling 0.17 expected goals (xG).
PSG did have their chances, though, with their total of 14 shots their most without scoring in any Champions League game since the second leg of their 2020-21 semi-final against Manchester City (also 14), when they were beaten 2-0 and eliminated from the competition.
Dortmund are now unbeaten in 11 straight Champions League home games, winning seven and drawing four.
It's their longest ever such streak at Signal Iduna Park, and they have also won four straight knockout games on their own turf for the first time in their Champions League history.
While Dortmund have a valuable lead to protect in Paris next Tuesday, Edin Terzic will be expecting a strong reaction from PSG.
The Ligue 1 champions have progressed from two of their last four Champions League knockout ties when losing the first leg, with the first of those successes coming against Dortmund in the last 16 in 2019-20 (1-2 away, 2-0 at home).
Borussia Dortmund 1-0 Paris Saint-Germain: Fullkrug hands hosts first-leg win
Niclas Fullkrug fired home a first-half winner as Borussia Dortmund claimed a 1-0 victory over Paris Saint-Germain in the first leg of their Champions League semi-final tie in Germany.
Nico Schlotterbeck floated a pass into Fullkrug's path and the Germany international brought the ball under his spell with a wonderful touch before drilling a low shot past Gianluigi Donnarumma in the 36th minute.
PSG, on the back foot for much of the first half, improved after the break and struck the woodwork twice in a matter of moments just after the restart.
Kylian Mbappe curled an effort against the right-hand post before Achraf Hakimi scuffed a shot against the other upright on the rebound as Edin Terzic's side escaped with a first-leg lead.
The teams will meet again at the Parc des Princes next Tuesday, with the winners of the tie facing either Bayern Munich or Real Madrid – who drew 2-2 in their first leg on Tuesday – in the final at Wembley Stadium.
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