Arsenal face another major obstacle in their quest to land a first Premier League title in 19 years when they travel to Liverpool on Sunday.
The Gunners have historically struggled at Anfield, though Mikel Arteta's men have passed most tests this season en route to opening up a healthy lead over Manchester City.
While Arsenal will be looking to continue their good form, having won seven league games in a row, it is the start of another new chapter for Chelsea when they head to Wolves.
Frank Lampard was this week appointed as caretaker manager for the rest of the season following the sacking of Graham Potter, with Chelsea way down in 11th place.
There are plenty of other big games at the top and bottom of the division this weekend, not least at Old Trafford where Manchester United and Everton face off.
United got their top-four hopes back on track in midweek and will be seeking some momentum when they take on an Everton side sitting level on points with the bottom three.
Here, with the help of Opta data, Stats Perform has provided some key insights and predictions.
Manchester United v Everton
United have dominated this fixture down the years, with their 38 Premier League wins against Everton the second most one team has over another after the Red Devils themselves against Tottenham (39 wins).
Erik ten Hag's men have won both meetings with Everton in all competitions this term – 2-1 in the league at Goodison Park and 3-1 in the FA Cup on home soil – and could make it three wins in a single campaign against them for the third time (after 1993-94 and 2015-16 seasons).
Everton have improved since Sean Dyche took charge, picking up 12 points from their nine league games under him, with that seven more than they managed in their final 12 games under Lampard.
Best bet – Everton to score at Old Trafford: The Toffees' away form this season may be terrible, as is their overall record at United, but they have scored in each of their past nine Premier League games at Old Trafford, with that the Red Devils' longest run without a clean sheet against a single opponent in the competition.
Long shot – Everton to avoid defeat: Scoring away at United is one thing; holding on for a point or more is another. Everton have won just one of their past 29 away league meetings with United, but their past three visits to Old Trafford have finished all square.
Opta prediction: United failed to win any of their six matches in the early Saturday kick-off slot last season, but they have won all three such games this campaign, including a 2-1 win over Manchester City in January. Everton have won just two of their past 31 away league games, meanwhile, and Opta's model gives them only a 20.6 per cent chance of winning at Old Trafford. United are given a 52.7 per cent chance of success, meanwhile, and the draw is rated at 26.7 per cent.
Wolves v Chelsea
Chelsea have failed to win on their past two league visits to Molineux, but the good news is that their most recent victory there came in September 2019 under Lampard.
Wolves are unbeaten in their three Premier League games against opponents from London under the watch of Julen Lopetegui, having failed to win any of their previous 11 such matches prior to the Spaniard's arrival.
The Blues have picked up just 16 points from 14 away top-flight matches, which is their lowest return after 14 road games in a single campaign since 2000-01 (nine).
Best bet – Wolves to win without conceding: Given Chelsea's form, a Wolves win this weekend would hardly be the biggest of surprises – especially considering Lopetegui's men have won their past three league games against sides starting the day above them without letting in a goal (1-0 v West Ham, 3-0 v Liverpool and 1-0 v Tottenham).
Long shot – Raheem Sterling to score or assist: The Chelsea winger has been directly involved in just one goal in his past six matches, but since the start of the 2019-20 campaign, only Manchester City playmaker Kevin De Bruyne (nine) has been directly involved in more league goals at Molineux than Sterling among visiting players (three goals, two assists).
Opta prediction: Wolves are winless in their past four Premier League games against Chelsea since beating them 2-1 at Molineux in December 2020. The Blues will be hoping the new (well, returning) manager bounce pays off and the Opta model makes them favourites to win with a 42.3 per cent backing, compared to 27.9 per cent for Wolves and 29.8 per cent for the draw.
Liverpool v Arsenal
Arsenal are facing Liverpool as Premier League leaders for the ninth time, with the previous eight occasions producing a total of 33 goals at an average of over four per game.
Since briefly surrendering top spot to Man City following a 3-1 defeat in February, Arsenal have won their last seven Premier League games. They have scored at least three goals in six of these, including the last five in a row.
Liverpool have won five of their last six Premier League home games (D1), including each of the last three by an aggregate score 11-0. The Reds have not conceded in any of their past seven hours and 26 minutes of league football at Anfield, since Kiernan Dewsbury-Hall's strike for Leicester City in December.
Best bet – Mohamed Salah to score or assist: The Egypt international is expected to be recalled by Jurgen Klopp and that could spell bad news for Arsenal. Salah has been involved in 105 league goals in 105 games at Anfield for Liverpool (74 goals, 31 assists) and has scored in three successive home league appearances for the Reds.
Long shot – Arsenal to lose without scoring: The Gunners have lost on their last six league visits to Anfield, conceding at least three goals each time. They have failed to score against the Reds on 20 occasions in the Premier League era, which is their worst record against any team in the division.
Opta prediction: Arsenal won the reverse fixture with Liverpool 3-2 in the first major sign they were the real deal this season, though not since the 2009-10 campaign have they pulled off the league double in this fixture. They have a 22.6 per cent chance of doing so this weekend, according to the Opta model, while Liverpool are rated at 51 per cent to pick up the three points. A draw is given a 26.4 per cent chance of happening.
Sessegnon rejoins boyhood club Fulham after Tottenham departure
Ryan Sessegnon has resigned for Fulham on a free transfer, five years after leaving the club.
The 24-year-old signed a two-year contract with the Cottagers with the option to extend for a further year following his departure from Tottenham last month.
In his first spell at the club, Sessegnon worked his way through the academy over 11 years, scoring 25 goals in 120 first-team appearances.
He then moved to Spurs in a £25million deal in 2019, though struggled to nail down a place in North London, making just 57 appearances in all competitions, and scoring three goals.
"It's amazing to be back. Emotional, as well," he told FFCtv. "It's where it started for me, where everything began, and it's amazing to be back.
"It will always be home for me. I think it had the feeling that it was meant to be, coming back here, so I'm delighted to get it done."
Sessegnon is Fulham's first signing of the transfer window, though they have seen plenty of first-team departures already, with Joao Palhinha, Tosin Adarabioyo and Bobby De Cordova-Reid all leaving the club.
Dewsbury-Hall: Maresca will surprise people at Chelsea
Kiernan Dewsbury-Hall believes new Chelsea manager Enzo Maresca will "surprise a lot of people" when they watch the Blues this season.
The Italian led Leicester City straight back to the Premier League as Championship winners in his only season in charge and succeeds Mauricio Pochettino at Stamford Bridge.
The Foxes topped the second division table with 98 points, with Dewsbury-Hall a key figure in his squad as he netted 12 goals and provided 14 assists last season – his best tally in a single campaign.
Dewsbury-Hall was also named Leicester's Player and Players' Player of the Year.
The midfielder made the switch to West London earlier this month for £30million and is confident that Maresca will have Chelsea challenging for trophies in no time.
"The manager was a big catalyst in wanting me to come," Dewsbury-Hall told BBC Sport.
"I knew from Leicester, a club that went down and had a lot of problems, how he managed to galvanise that if everyone manages to buy into the system.
"I genuinely think in a short space of time we can be pushing for minimum top four - but more than that.
"He may be unknown for a lot of people, but he is top, top level. He will surprise a lot of people."
Chelsea's pre-season got off to a frustrating start as they were held to a 2-2 draw by League One side Wrexham in Maresca's first game in charge on Wednesday.
Dewsbury-Hall did not play in that match but is training with the squad in the United States and could feature in their next outing against Celtic on Saturday.
The 25-year-old is confident the manager's tactics will come across soon, with the players buying into his style.
"We've only been doing it for two or three weeks, but the combination plays are really quick and tidy," he added.
"That's after two weeks. I remember he said to us at Leicester after six months or a year, there might be teething problems at the start, but it will improve.
"Within the first week at Leicester, I was convinced this was top, top level. I felt a bit stupid; I thought I knew a lot about football, but he was teaching me things on a daily basis that I didn't really know before. He has an aura, he can be strict, or gentle and soft - he has both sides.
"I am getting the same feedback here with the lads. They've bought into it here from minute one which is exciting. With a system and philosophy, you need everyone to buy in because, if they do, you can really achieve something."
Ederson slams reports of rift with Man City backup Ortega
Ederson has hit out at reports of a rift between himself and fellow Manchester City goalkeeper Stefan Ortega.
The Brazilian was substituted after suffering a fractured eye socket in City's penultimate game of the Premier League season, a vital 1-0 win over Tottenham.
Ortega replaced him and made a brilliant save to deny Son Heung-min as City maintained their slender lead over Arsenal at the top of the table, sealing an unprecedented fourth straight title by beating West Ham five days later.
Ortega was widely lauded for his role in that triumph, and an article published by The Athletic this week suggested Ederson took issue with that praise.
However, the goalkeeper – who missed the Copa America as a result of his injury – has now moved to shut down those suggestions with a post to his Instagram story.
"I would like to clarify that the note published by The Athletic yesterday, referring to my alleged dissatisfaction with a co-worker, is completely false," he wrote.
"The alleged day reported was, without a doubt, one of the most difficult days of my career, when I suffered a fracture that prevented me from playing in the final stretch of the season and, consequently, from representing my country in the Copa America.
"At the time of the injury, my only thought was to continue in the match, defending City in the fight for the title.
"But the emotion of the match would be greater than the reality and, inevitably, I would not be able to continue as I would have liked due to the damage it caused, completely blocking my field of vision. I remain focused on preparing for the season."
Ederson has been linked with a transfer in recent days, reportedly attracting interest from Saudi Pro League clubs.
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