Chelsea must produce another Champions League fightback to avoid being knocked out by Borussia Dortmund and Benfica will be expected to advance to the quarter-finals on Tuesday.
Dortmund start the second leg at Stamford Bridge riding on the crest of a wave following 10 consecutive victories, sitting level on points with Bayern Munich at the top of the Bundesliga after beating RB Leipzig 2-1.
Karim Adeyemi's goal gave Edin Terzic's side a 1-0 win over Chelsea and they have a great record in the competition after winning the first leg of knockout stage ties.
The Blues eased the pressure on head coach Graham Potter by beating Leeds United 1-0 on Saturday and have progressed more often than not after losing a first leg in Europe's premier club competition.
Benfica hold a 2-0 lead over Club Brugge heading into the second leg at Estadio da Luz and Joao Mario will attempt to extend his impressive scoring run in the competition.
Stats Perform pick out the standout Opta data to preview the two matches on Tuesday.
Chelsea v Borussia Dortmund
Dortmund may need the slender advantage they gained in the first leg, given they have lost five consecutive away games against English sides in the Champions League since beating Arsenal 2-1 in October 2013.
Chelsea lost the first leg of a Champions League knockout tie for the eighth time in Dortmund, but on the previous seven occasions that has happened they have gone on to progress four times.
That said, of the previous six ties in which Dortmund have won the first leg they have finished off the job to advance – Paris Saint-Germain being the only team to mount a second-leg fightback and knock them out at this stage in 2020.
The Bundesliga title contenders will be looking to win both legs of a Champions League knockout tie for the first time since the 1996-97 season, when they beat both Auxerre and Manchester United twice en route to lifting the trophy for the only time.
Benfica v Club Brugge
Brugge have it all to do when they face Benfica, who are unbeaten in their 10 previous home games against Belgian sides in the Champions League with eight wins and two draws.
Only one of the 45 teams to have won a first leg away from home in a Champions League knockout tie by at least two goals has failed to make it through, when PSG were dumped out by Manchester United in 2019.
Benfica have won three consecutive games in this competition, their best since reeling off six in a row back in the 1989-90 campaign.
Brugge have not scored in their past four Champions League games, which represents their longest drought in the competition.
They will have to keep a close eye on Joao Mario, who will attempt to become the first player to score in five consecutive games in either the European Cup or Champions League since the great Eusebio netted in seven on the spin between May 1963 and September 1964.
Al-Khaleej 0-1 Al-Nassr: Ronaldo misfires on return as Laporte nets winner
Cristiano Ronaldo returned from suspension but failed to find the net as Al-Nassr secured a 1-0 win over Al-Khaleej on Saturday, with Aymeric Laporte coming up with the decisive goal.
Ronaldo was in action for the first time since being sent off for an elbow in a 2-1 Saudi Super Cup loss to Al-Hilal earlier this month, with his initial two-match ban being reduced to one on appeal.
He missed three good chances as Al-Nassr threatened to fall further behind runaway Saudi Pro League leaders Al-Hilal, but former Manchester City defender Laporte spared his blushes by nodding Marcelo Brozovic's deep free-kick into the bottom-left corner with 68 minutes gone.
Al-Nassr remain nine points adrift of Al-Hilal at the summit in spite of their win, with Jorge Jesus' team unbeaten through 28 games this season as they close in on a record-extending 18th title.
Data Debrief: Ronaldo misfires on return
Ronaldo was presented with the Saudi Pro League's Player of the Month award for March ahead of kick-off, having scored four goals in three league appearances last month.
However, his sights were off on Saturday as he failed to net despite three of the visitors' four big chances, as defined by Opta, falling his way. He led all players on the pitch for expected goals (1.27 xG), shots (five), shots on target (three) and touches in the area (nine) without reward.
Huddersfield all but relegated from Championship while League Two play-off spots decided
Huddersfield Town saw their relegation from the Championship all but confirmed after a 1-1 draw with fellow strugglers Birmingham City on Saturday.
The Terriers avoided a defeat that would have seen them relegated on Saturday, but even a win on the final day over promotion hopefuls Ipswich Town will not be enough unless they overcome a huge goal difference of 15 goals with Plymouth Argyle.
Birmingham remain in the other relegation place and now must beat Norwich City to stand a chance of staying up with Sheffield Wednesday, Plymouth and Blackburn Rovers also still in danger.
At the other end of the table, the Canaries dropped points in a 2-2 draw with Swansea City, leaving the door open for Hull City, who face Ipswich Town later today.
RB Leipzig 4-1 Borussia Dortmund: Hosts strengthen grip on fourth with crushing win
Champions League semi-finalists Borussia Dortmund suffered a crushing 4-1 Bundesliga defeat at the hands of RB Leipzig on Saturday, denting their hopes of a top-four finish.
Manchester United loanee Jadon Sancho put Dortmund ahead after 20 minutes with a curling effort from the left corner of the box, but Edin Terzic's team couldn't hold on.
Lois Openda levelled within three minutes, and Benjamin Sesko pounced with a close-range finish to put Leipzig ahead on the stroke of half-time.
Mohamed Simakan made it 3-1 just one minute after the restart, then Christoph Baumgartner came off the bench to add a fourth with 10 minutes to play.
Dortmund, who host Paris Saint-Germain in the first leg of their Champions League semi-final tie on Wednesday, stay fifth, five points behind fourth-placed Leipzig.
They will likely have to wait on confirmation of Germany earning a fifth Champions League qualification place for next season, which was made more likely by a dismal set of results for England's clubs throughout the European quarter-finals earlier this month.
Data Debrief: Dynamic duo lead Leipzig to victory
Goals from Openda and Sesko ensured Leipzig turned Saturday's game around before the halfway point, both players netting in their fourth successive Bundesliga game together.
They are the first pair of team-mates to achieve that feat since Dortmund's Marco Reus and Pierre-Emerick Aubameyang did so in February 2015.
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