Erik ten Hag anticipates Manchester United being without Antony, Anthony Martial and Scott McTominay for at least another week in a key period of the season.
United have played twice already in February and will have another five matches before the end of the month, including a two-legged Europa League tie against Barcelona and the EFL Cup final against Newcastle United.
Injuries have come at a bad time then, with Christian Eriksen out long term, Casemiro suspended and a further trio likely to be missing for at least the next two matches.
United visit Leeds United on Sunday, then Barcelona on Thursday, and Ten Hag was asked if Antony, Martial or McTominay could make the trip to Camp Nou.
"I can't say for 100 per cent, but I don't expect it," he said.
Although Eriksen was injured in a challenge from Reading's Andy Carroll, Ten Hag accepts other issues have occurred as result of a "tough season".
But United have been boosted by Marcus Rashford's stunning form and the return to action of Jadon Sancho, whose midweek goal in the home game against Leeds earned a point.
Sancho has been back in the fold since the start of the month, having previously been absent from any matchday squad since October.
"This is what makes this job so exciting," Ten Hag said of Rashford and Sancho. "It's wonderful to work with young people, to get the best out of them.
"Finally, they have to do it by themselves. But sometimes they need motivation, they need interaction, they need inspiration."
For now, Ten Hag's focus is on getting the best out of his team over this hectic stretch, rather than worrying about the latest talk of a potential European Super League.
"I'm aware of the dynamic, what's going on," Ten Hag said. "If they're coming up with new ideas, I'll have to look at it and make an opinion.
"I'm not aware, because we are playing so many games at this moment. We have to develop this team, we have some problems, some new players to bring in. That's where my focus point is, and it needs all my energy.
"On new European competitions, the people in this club will look at it and inform me if the time is there and the moment is there to make decisions, but the decisions are up to the club.
"I think the current structure [of European football] is good, but there will always be initiatives to make it better, to make the football better.
"That's what life is. People always want to construct better. This is a good thing. If it's in favour of the football, it's always good."
Ten Hag hails 'ketchup bottle' Rashford after ending goal drought
Erik ten Hag saluted "ketchup bottle" Marcus Rashford after the Manchester United forward ended his goal drought in their victory at Southampton.
Rashford doubled United's lead at St Mary's when he curled a 20-yard effort past Aaron Ramsdale, while Matthijs de Ligt and Alejandro Garnacho were also on target for the visitors.
It was the 26-year-old's 132nd goal for the club, but first since he found the net in the Red Devils' FA Cup victory over Liverpool at Old Trafford.
Rashford was the subject of criticism for his performance in United's 3-0 defeat against the Reds prior to the international break.
However, Ten Hag felt that "negativity" was unjustified and is backing his forward to build momentum, referencing an analogy once utilised by Cristiano Ronaldo.
"It's very important we don't pay attention to what the outside world is saying, but there was too much negativity about him," the Dutchman said of Rashford.
"He created two great chances in that game [the defeat to Liverpool]. In other games this season, he has played very well.
"He deserved that goal [against Southampton], but he had to work for it. That is what he is doing, and then you get a reward.
"Once, a striker was talking about a ketchup bottle; once it's going, it’s coming more."
"He has already scored so many goals for Manchester United. At his age, the number of goals is amazing, and I'm sure he will score many more goals."
Burnley end Leeds' unbeaten start in battle of promotion hopefuls
Leeds United suffered their first defeat of the Championship season as they were beaten 1-0 at home by fellow promotion hopefuls Burnley.
Daniel Farke’s side came into Saturday's encounter having won back-to-back matches against Sheffield Wednesday and Hull City, but their momentum was halted by their clinical visitors.
Burnley forward Luca Koleosho scored the only goal of the game the day before his 20th birthday.
Koleosho took advantage of a slip from Manor Solomon after 18 minutes, before sprinting 70 yards and drilling a shot past Leeds goalkeeper Ilan Meslier.
That proved to be enough to inflict on Leeds a third home league defeat in six matches going back to last season, despite the hosts applying plenty of pressure as they sought an equaliser.
Burnley's Bashir Humphreys was sent off eight minutes into stoppage time at the end of the match, but Leeds were unable to find a way through.
Elsewhere in Saturday's early Championship kick-offs, Luton Town claimed their first win since relegation from the Premier League.
Teden Mengi's fine early effort from the edge of the penalty area was enough to beat Millwall 1-0 away from home.
While Luton have ground to make up in the promotion race, Oxford United's surprise challenge continues on the back of their 100% home record.
That was maintained with a deserved 1-0 victory over Stoke City, with Idris El Mizouni netting the winner three minutes into the second half.
Ten Hag: 'Penalty was the turning point' in Southampton victory
Erik ten Hag believes Andre Onana's penalty save was the "turning point" as Manchester United got back to winning ways with a commanding 3-0 victory over 10-man Southampton.
The Red Devils arrived at St Mary's on a two-match losing streak and almost fell behind in the 33rd minute, but Onana guessed correctly to keep out Cameron Archer's tame spot-kick.
The visitors capitalised on their reprieve as goals from Matthijs de Ligt and Marcus Rashford put them 2-0 up at half-time, before Alejandro Garnacho wrapped up the points later on.
Ten Hag was pleased with his team's response and also saluted Rashford, who netted his first goal since March.
"The start was not easy," the United boss told BBC Match of the Day.
"I think the penalty was the turning point in the game and, not so far after, we scored and that was very important. From that moment on, the game was all ours."
On Rashford's goal, he added: "It's very important. We spoke before the game. It is huge for him, for every striker.
"When the season starts, you want to be on the scoring list. Now he has his first, I'm sure more will come."
Onana was also pleased to see Rashford back on the scoresheet.
"We had a tough season last year, and he was not at his best," he told TNT Sports. "But today, he showed he's a great player - one of the best in the world.
"That's football, that's life. It's now how you fall, it's about how many times you stand up again. I'm really happy for him. Hopefully, he will score many more for the team.
On bouncing back with a win, he added: "Every game when you lose is like it's the end of the world. You have to stay strong, stay together and keep fighting.
"It was very good to save that penalty. It was an important moment for us.
"The most important thing for us is victory. We had a great game and a clean sheet. Hopefully, we will continue playing like this."
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