Arsenal's assault on the Premier League title suffered a hit at Goodison Park as Sean Dyche provided the new manager bounce for Everton.
The Toffees secured a first league win since October to condemn the Gunners to defeat, opening the door for Manchester City to cut the gap to the leaders to just two points if they beat Tottenham on Sunday.
Sean Dyche's side were not the only relegation-threatened team to pick up a major scalp, as Wolves stunned Liverpool at Molineux to extend a miserable run of form for Jurgen Klopp's Reds.
There was no similar result for Southampton, who were picked apart by in-form Brentford, while Manchester United maintained their fine home run with a hard-fought win against Crystal Palace.
Here, Stats Perform looks at the most interesting facts to emerge from Saturday's Premier League action.
Everton 1-0 Arsenal: Goodison gloom for Gunners
Goodison Park is a ground that used to hold many happy memories for Mikel Arteta, who started his Premier League career at the club, but three consecutive league defeats for Arsenal at the venue may have changed that.
Arteta has lost all of his three Premier League away matches to Everton, the first Gunners manager to endure such a run, while the Toffees boast three consecutive home league victories against Arsenal for the first time since March 1977 to August 1978.
It handed Arsenal just their second defeat in their last 21 Premier League matches (won 17, drawn 2), with the loss ending a streak of 14 unbeaten top-flight games for the league leaders.
Dyche, meanwhile, became just the second manager to beat a side starting the day top of the table in his first Premier League game in charge of a club, after Alan Curbishley defeated Manchester United in his first match with West Ham in December 2006.
Wolves 3-0 Liverpool: Dawson delight amid Klopp rot
Craig Dawson is not a name that would usually strike fear for opposition defenders in the Premier League but the Wolves defender has established a habit of haunting Liverpool, his latest goal representing his third against the Reds.
Each of those goals have come for a different side (West Brom, West Ham, Wolves) and he has scored more goals against Liverpool than he has versus any other side.
Klopp's side have now lost three consecutive away games in the Premier League for the first time since a run of four in April 2012 and have lost back-to-back Saturday 3pm kick-offs in the competition for the first time since March 2012.
A horror start was their downfall against Wolves, with Liverpool conceding more Premier League goals in the opening five minutes of matches than any side this season (five), while Joel Matip's own goal was his first in 135 Premier League appearances.
Brentford 3-0 Southampton: Bees buzzing at home
Unbeaten in their last nine Premier League games (won five, drawn four), only Newcastle United are currently on a longer run without defeat – extending their streak to 16 with a draw against West Ham in the late kick-off.
The Bees' trio of goals against Southampton took their tally to 23 goals in 11 Premier League home games this season, already surpassing the tally of 22 last term. In fact, only Manchester City (38) and Arsenal (25) have scored more at home this term.
On target with a header yet again, 10 of Ben Mee's 12 Premier League goals have come in that fashion and no side has conceded more headed goals in the top-flight this season than Southampton (10), two of them being on Saturday.
Pressure upon Saints boss Nathan Jones continues to rise, with Southampton losing eight of their last nine in the Premier League, winning just once, while they have just a single clean sheet in their last 27 matches in the competition.
Manchester United 2-1 Crystal Palace: Penalties on point for United
With 13 consecutive home wins in all competitions, Manchester United are in their stride and are enjoying their longest such run at Old Trafford since a 20-match streak between December 2010 and September 2011.
While Marcus Rashford scored in five consecutive Premier League home games for the first time, it was Bruno Fernandes' opener from the penalty spot that sent Erik Ten Hag's side on their way – and took the Portugal midfielder's tally of penalty goals in the Premier League to 14.
Only Wayne Rooney (20) and Ruud van Nistelrooy (18) have scored more from the spot for United than Fernandes, with his latest effort being the club's 173rd all-time spot-kick in the Premier League – the joint-highest total alongside Liverpool.
The red mist descended on Casemiro, however, with the Brazilian shown a straight red card for the first time in Europe's top-five leagues; the dismissal coming in his 366th such appearance.
That provided a late charge for Palace, who saw eight of their 10 shots come in the final 20 minutes after Casemiro's dismissal, but Patrick Vieira's side remain winless in the Premier League in 2023 (drawn 2, lost 3), scoring just once in the process.
Man City title hopes rocked by Shaw injury
Manchester City's title hopes took a blow with the announcement that Khadija Shaw has been ruled out for the remainder of the season with a foot injury.
Shaw currently sits top of the Women’s Super League golden boot race with 21 goals in 18 games this season, a total which puts her well ahead of closest rival Lauren James, who is eight behind.
But she picked up her injury during Man City's 5-0 WSL victory over West Ham last weekend, a match in which she had scored twice in the first half, and will now miss the crucial final weeks of the top-flight campaign.
City have been reliant on the Jamaican's goals this season and will miss her in what is likely to be one of the most exciting run-ins in WSL history.
Chelsea sit three points behind City, however they have a game in hand and goal difference could end up being the determining factor if both teams are able to win all their remaining games.
The Citizens’ manager Gareth Taylor confirmed the Shaw blow in his pre match press conference ahead of Sunday’s clash with Bristol City, saying: “We have an issue with Bunny, she’s sustained a foot injury which will keep her out of the game for certain and potentially longer.
“It’s such a difficult one for Bunny because she’s had an incredible season.
“We had a feeling it might be an issue when she came off the pitch [against West Ham] even though it was non-contact.
“She’ll be well looked after by the medical team.”
City will have to think about who can fill the shoes of their star striker, but Taylor was confident about his team’s options despite the injury to Shaw.
"Bunny is our main number nine, but Mary [Fowler] has played there, Lauren [Hemp] has played there. Chloe [Kelly] is capable of playing there, Jess [Park] can do a really good job there," he said.
"Of course, we all understand what Bunny brings, she is such a box player, she gives us a different way of playing. Now, we will have a different kind of number nine."
City did, however, have some good news to share as they have tied down Lioness Lauren Hemp on new three-year contract extension keeping her at the Joie Stadium until 2027.
Hemp has won four trophies, while scoring 65 goals in 157 appearances, and has been a key player in the evolution of Taylor’s side.
Man City have secured the winger, who was out of contract at the end of the season and has attracted the attention of some of Europe's elite clubs such as Barcelona.
This term she has proved as productive as ever for City, scoring nine goals and adding six assists. She will also be key in the coming matches after the news of Shaw's injury misery.
"I feel at home here in Manchester," Hemp said after signing the deal.
"With the squad we have here, we are always learning and it’s so special to be involved at a club where we’re capable of achieving anything.
"I’m so passionate about this club and there’s no place I’d rather be. I’m very excited to keep this journey going for the next few years."
Al Hilal 3-1 Al Fateh: Neves on target as Saudi giants close in on title
Al Hilal moved 12 points clear of Cristiano Ronaldo's Al Nassr at the top of the Saudi Pro League as Ruben Neves scored in a 3-1 win over Al Fateh on Friday.
Former Wolves star Neves slotted in from the penalty spot in the 74th minute, as Al Hilal completed a rapid comeback.
Having fallen behind to Lucas Zelarayan's 57th-minute opener, Al Hilal responded swiftly through Micheal before Salem Al Najdi fouled Mohammed Al Qahtani in the penalty area.
Ex-Barcelona winger Cristian Trello and Al Fateh coach Slaven Bilic were booked for their complaints, with Neves making no mistake, paving the way for Ali Al Bulayhi to seal victory in the 15th minute of an extended period of stoppage time.
Data Debrief
Al Hilal have now won 21 games on the spin in the league. They have scored 86 goals across their 28 matches this season, winning 26 in total.
They had 19 shots on Friday, accumulating 2.34 xG to Al Fateh's 0.25, with pass-master Neves creating three chances to go along with his goal.
Edwards urges Luton Town to ignore scrutiny on relegation battle
Rob Edwards is keen for Luton Town to ignore the scrutiny surrounding them in the relegation battle as they prepare for another big game against Wolves.
The Hatters sit one point from safety in the relegation zone after back-to-back 5-1 defeats against Manchester City and Brentford.
While Nottingham Forest also lost last weekend, being beaten 2-0 by Everton, Burnley beat Sheffield United to move them two points behind Luton.
Asked how he is handling the pressure of the relegation battle with only four games left, Edwards said: “The stakes are high already, we all know what it means and it's really important to everyone that's in this at the moment, a number of clubs that are still fighting to try and avoid it and be in the league next season, it's so important.
“Everyone wants to try and stoke the fire I think. We've got a title race on at one end and obviously, there's a relegation battle we're involved in. It's exciting, it's good that we're in the fight, and we've got a chance to get out of it, but really, all I am concerned about right now is our performance tomorrow.”
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