Arsenal's assault on the Premier League title suffered a hit at Goodison Park as Sean Dyche provided the new manager bounce for Everton.
The Toffees secured a first league win since October to condemn the Gunners to defeat, opening the door for Manchester City to cut the gap to the leaders to just two points if they beat Tottenham on Sunday.
Sean Dyche's side were not the only relegation-threatened team to pick up a major scalp, as Wolves stunned Liverpool at Molineux to extend a miserable run of form for Jurgen Klopp's Reds.
There was no similar result for Southampton, who were picked apart by in-form Brentford, while Manchester United maintained their fine home run with a hard-fought win against Crystal Palace.
Here, Stats Perform looks at the most interesting facts to emerge from Saturday's Premier League action.
Everton 1-0 Arsenal: Goodison gloom for Gunners
Goodison Park is a ground that used to hold many happy memories for Mikel Arteta, who started his Premier League career at the club, but three consecutive league defeats for Arsenal at the venue may have changed that.
Arteta has lost all of his three Premier League away matches to Everton, the first Gunners manager to endure such a run, while the Toffees boast three consecutive home league victories against Arsenal for the first time since March 1977 to August 1978.
It handed Arsenal just their second defeat in their last 21 Premier League matches (won 17, drawn 2), with the loss ending a streak of 14 unbeaten top-flight games for the league leaders.
Dyche, meanwhile, became just the second manager to beat a side starting the day top of the table in his first Premier League game in charge of a club, after Alan Curbishley defeated Manchester United in his first match with West Ham in December 2006.
Wolves 3-0 Liverpool: Dawson delight amid Klopp rot
Craig Dawson is not a name that would usually strike fear for opposition defenders in the Premier League but the Wolves defender has established a habit of haunting Liverpool, his latest goal representing his third against the Reds.
Each of those goals have come for a different side (West Brom, West Ham, Wolves) and he has scored more goals against Liverpool than he has versus any other side.
Klopp's side have now lost three consecutive away games in the Premier League for the first time since a run of four in April 2012 and have lost back-to-back Saturday 3pm kick-offs in the competition for the first time since March 2012.
A horror start was their downfall against Wolves, with Liverpool conceding more Premier League goals in the opening five minutes of matches than any side this season (five), while Joel Matip's own goal was his first in 135 Premier League appearances.
Brentford 3-0 Southampton: Bees buzzing at home
Unbeaten in their last nine Premier League games (won five, drawn four), only Newcastle United are currently on a longer run without defeat – extending their streak to 16 with a draw against West Ham in the late kick-off.
The Bees' trio of goals against Southampton took their tally to 23 goals in 11 Premier League home games this season, already surpassing the tally of 22 last term. In fact, only Manchester City (38) and Arsenal (25) have scored more at home this term.
On target with a header yet again, 10 of Ben Mee's 12 Premier League goals have come in that fashion and no side has conceded more headed goals in the top-flight this season than Southampton (10), two of them being on Saturday.
Pressure upon Saints boss Nathan Jones continues to rise, with Southampton losing eight of their last nine in the Premier League, winning just once, while they have just a single clean sheet in their last 27 matches in the competition.
Manchester United 2-1 Crystal Palace: Penalties on point for United
With 13 consecutive home wins in all competitions, Manchester United are in their stride and are enjoying their longest such run at Old Trafford since a 20-match streak between December 2010 and September 2011.
While Marcus Rashford scored in five consecutive Premier League home games for the first time, it was Bruno Fernandes' opener from the penalty spot that sent Erik Ten Hag's side on their way – and took the Portugal midfielder's tally of penalty goals in the Premier League to 14.
Only Wayne Rooney (20) and Ruud van Nistelrooy (18) have scored more from the spot for United than Fernandes, with his latest effort being the club's 173rd all-time spot-kick in the Premier League – the joint-highest total alongside Liverpool.
The red mist descended on Casemiro, however, with the Brazilian shown a straight red card for the first time in Europe's top-five leagues; the dismissal coming in his 366th such appearance.
That provided a late charge for Palace, who saw eight of their 10 shots come in the final 20 minutes after Casemiro's dismissal, but Patrick Vieira's side remain winless in the Premier League in 2023 (drawn 2, lost 3), scoring just once in the process.
'Nobody is perfect' – Pioli insists Napoli not 'unbeatable' ahead of Champions League showdown
Stefano Pioli insisted "nobody is perfect or unbeatable" as Milan prepare to overthrow Napoli in the all-Italian Champions League quarter-final clash.
Milan and Napoli will meet for the first time in European competition on April 12 in the first leg at San Siro, with Luciano Spalletti's side flying high in Serie A and UEFA's top club competition.
The Partenopei are 19 points clear at the Italian top-flight summit and suggested by many as a potential challenger for the European crown.
But Milan have only lost one of their nine all-Italian showdowns in Europe (W4 D4) and Pioli sees no reason why the Rossoneri cannot dream of progressing past Spalletti's in-form side.
The Milan coach said: "Honestly, I'd rather not meet an Italian side. In the Champions League it's better to face a foreign club. Napoli are very strong but we want to play for it.
"They have shown great consistency, strength and quality, they have all the characteristics of a great team, but nobody is perfect or unbeatable."
Pioli's side have not reached the last eight in the Champions League since the 2011-12 term when they were eliminated by Pep Guardiola's Barcelona.
Milan last went beyond that stage in the 2006-07 season en route to lifting the trophy but overcoming Napoli will prove an incredibly difficult challenge.
Napoli have won each of their past three away matches against the Rossoneri, their best such run against them, although they have not triumphed in any of their past five trips to Milan in cup competitions.
Pioli wants to build on Milan's Champions League history but says the Rossoneri cannot take their eyes off the Serie A top-four battle, leading fifth-placed Roma by just a point.
"It's part of the history of this club and the path it has always followed," he added. "We are beginning to write our history, that of Milan in the Champions League is a different path from ours.
"When you go to San Siro to play the Champions League it is something exciting and spectacular that involves everyone.
"We are very busy but we are also focusing on the league. To make this season a positive one, we have to play in the Champions League next year. We have to be careful."
Before the mouthwatering European meeting, Milan visit Napoli in Serie A on Sunday with the Rossoneri's Scudetto soon seemingly heading for Naples.
Pioli's side have been unable to replicate their exploits from last season's title-winning campaign, though the Italian suggested Milan's young side would always struggle to defend their title.
"I don't think there are many teams in Europe that immediately win the second league," he continued. "We won with a very young team, thanks to a project and a club path we are proud of.
"We are one of the few clubs with a sustainable project; only a few teams manage to win and be competitive in Europe.
"That is a leap that we have not yet been able to make but this year too gives us the opportunity to understand great things, to improve and be the strongest club."
Rashford rubbishes 'nonsense' reports he is seeking £500k a week from Man Utd
Marcus Rashford has denied "nonsense" claims he is holding out for a huge £500,000-a-week deal to stay at Manchester United.
The England international, who has scored a career-best 27 goals in 44 games this campaign, is due to be out of contract at Old Trafford at the end of next season.
According to British publication the Daily Star, Rashford's United future is in limbo due to the ongoing sale of the club and his big wage demands.
However, the 25-year-old directly replied to the article on his personal Twitter page on Wednesday to deny that is the case.
"Just before this one starts to do the rounds! It's complete nonsense," he posted. "The club and make self [sic] have been respectful to one another, and that's how it will remain.
"My focus is purely on finishing as well as possible in the league and winning trophies."
Rashford added on Instagram: "Another non-story flying around about my advisors and me making demands. It's complete nonsense!
"My aim and the club's aims are to finish as high as possible in the league and to try and win a cup or two."
Rashford's goals tally this season has been bettered only by Kylian Mbappe (31) and Erling Haaland (42) among players across Europe's top five leagues.
He has spent eight seasons as part of United's first team since making his big breakthrough with two goals on his debut against Midtjylland in February 2016 as an 18-year-old.
Speaking last month, United manager Erik ten Hag confirmed the club are working on tying down the academy product to fresh terms.
"Of course [Rashford's new contract] is a priority," he said. "We are working on that. Just sit and wait. In the background. we are working hard."
Rashford missed England's two Euro 2024 qualifiers during the international window, but he is expected to be fit to feature against Newcastle United on Sunday.
Fulham duo Mitrovic and Silva apologise after FA Cup red cards against Manchester United
Aleksandar Mitrovic and Marco Silva have issued apologies over their dismissals during Fulham's FA Cup loss to Manchester United earlier this month.
The pair were both shown red cards by referee Chris Kavanagh during a seismic passage of play in the Cottagers' 3-1 quarter-final exit at Old Trafford.
Having been called over to the pitchside monitor to check for a handball offence by Willian, who was subsequently sent off, the match official also dismissed Silva for dissent before showing red to Mitrovic after the forward pushed him, reducing them to nine men.
Bruno Fernandes then scored the resulting penalty as Fulham swiftly collapsed from holding a 1-0 lead going into the closing stages.
On Wednesday, both player and manager revealed they had spoken to Kavanagh to apologise, and stressed they will accept the punishments handed down against them.
"I have been away with my national team and have had some time to reflect on the Manchester United match," Mitrovic told the club's website.
"As everyone knows, it was a very emotional one, in which the team gave absolutely everything on the pitch to try to reach the semi-final of the FA Cup.
"On a personal level, I regret my actions that led to me being sent off. I allowed my frustration to get the better of me, and how I reacted was wrong.
"I have accepted the three-match ban for my red card, I have spoken to Chris Kavanagh to apologise, and I have volunteered to accept a club fine.
"I now want to do what I can to put this incident behind me and get back to helping my teammates on the pitch as soon as possible."
Silva echoed his player's sentiments, adding: "Emotions were high at Old Trafford and, as I said in my press conference after the game, I should have controlled my own emotions better.
"It was a very difficult moment, in a match that we had dominated, but I could have handled the situation better.
"I regret what happened, and I have spoken to Chris Kavanagh to apologise.
"He knows that I respect him and the job he has to do. I am sorry that I was not on the pitch to try to lead the team to Wembley, but I am thankful for all the support I have received from Fulham fans over the last few days."
The FA will review issuing a longer ban than the traditional three games for Mitrovic's actions, while Silva is likely to face a touchline suspension too.
Fulham return to action with a trip to Bournemouth in the Premier League on Saturday.
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