Kaoru Mitoma and Tariq Lamptey were both on target in the second half as Arsenal were knocked out of the EFL Cup in the third round after a 3-1 home defeat to Brighton and Hove Albion.
The Gunners faltered for just a second time in their last 20 appearances in the third round of the competition, despite dominating for large periods at Emirates Stadium on Wednesday.
Danny Welbeck's first-half penalty had cancelled out Eddie Nketiah's opener, before Mitoma and Lamptey struck in the space of 13 second-half minutes to end Arsenal's nine-match home winning run.
Julio Enciso headed just off target before Jeremy Sarmiento fired narrowly wide but Arsenal struck in the 20th minute when Reiss Nelson found Nketiah, who curled a smart first-time finish past Jason Steele.
Debutant Karl Hein's slip offered Brighton their equaliser, though, as the goalkeeper brought down Welbeck, who coolly converted his spot-kick into the bottom-right corner.
A fizzing Nketiah right-footed drive cannoned against the left post after the interval, before Steele kept out Nelson's header with a stretching stop.
Brighton hit the front as Sarmiento danced through the middle before laying off for Mitoma to whip a right-footed effort into the bottom-right corner from inside the area.
Former Chelsea defender Lamptey sealed victory soon after as he drilled under Hein after being teed up by Billy Gilmour.
What does it mean? Gunners blunted by Seagulls
Brighton had lost all five of their all-Premier League clashes in the EFL Cup since reaching the top flight in 2017-18, but produced a resolute showing to earn another victory at Arsenal.
The Seagulls have now won three of their last four trips to Arsenal, having lost all eight of their previous visits to the Gunners between November 1979 and May 2019.
Arteta's side will be frustrated to drop out of the EFL Cup so early on but have much bigger tasks to focus on as they compete for Premier League and Europa League glory.
Welbeck scores on return again
Welbeck showed all of his experience to draw Hein into the foul for the first-half penalty he calmly dispatched by sending the goalkeeper the wrong way.
The striker became the first player to score at Emirates Stadium with four different clubs (Manchester United, Arsenal, Watford and Brighton) as he came back to haunt his former side.
Hein mistake proves costly
Hein was made to wait for his first chance at Arsenal since leaving his native Estonia to join from FC Nomme United in 2018.
But the 20-year-old goalkeeper failed to impress when called upon, with his erroneous decision to rush out before slipping to bring down Welbeck allowing Brighton a way back into the game after going a goal down.
What's next?
Arsenal play their final Premier League game before the World Cup break at Wolves on Saturday, while Brighton host Aston Villa the day after.
Tuchel insists Bayern Munich coach search not affecting team's focus
Bayern Munich's search for coach Thomas Tuchel's successor is not distracting the team from their preparations for next week's Champions League semi-final first leg against Real Madrid or their final Bundesliga matches.
That was the vow from Tuchel before Bayern first face Eintracht Frankfurt on Saturday with the league title already secured by Bayer Leverkusen.
Bayern will part ways with Tuchel at the end of a disappointing domestic season, a year earlier than his contract.
Austria coach Ralf Rangnick confirmed this week there had been contact with Bayern while several other coaches have been linked with the club.
Tuchel, however, said the team was shutting out any such distractions as they chase a spot in the Champions League final.
"In the next 11 days it can only be football and the goals we can still reach," Tuchel told a press conference.
"We want to collect points [in the Bundesliga] to get the best result and reach the Champions League final.
"For anything else, there is just no capacity at the moment, whether it is comfortable or uncomfortable despite the many issues."
With no chance of domestic silverware and Bayern battling to hold on to second place, three points ahead of third-placed Stuttgart whom they face in 10 days, Tuchel said it was clear Tuesday's game against Real Madrid was on everyone's mind already.
"I can accept and it is important that we all accept it that there is this background noise against Frankfurt," Tuchel said.
"We don't have to tell ourselves a fairytale that we are only thinking 100% about Eintracht.
"There is this background noise that the Real Madrid game plays a role. When I get my coffee in the morning people don't say 'good luck for tomorrow' they say 'good luck for Tuesday' to me."
Bayern still have some injury concerns for the coming games with Dayot Upamecano doubtful after twisting an ankle in training and Leroy Sane racing to get fit in time for Tuesday.
Tuchel said: "We have a test [against Frankfurt] and either we are distracted or we find solutions. Put on ear plugs or headphones and study for the test. That is my task."
The former Chelsea and Paris Saint-Germain boss was also asked about over 12,000 Bayern supporters signing a petition asking for him to remain at the club.
"Even though this topic is good for me when they [the fans] wish you to stay, it's not something that is a priority and it isn't allowed to be a priority," he said.
"Whether it's pleasant or unpleasant, I don't allow myself to be influenced by it. We're only focusing on every day counting towards our goals and there is no exception here.
"This question is like the neighbour that is noisy at three in the morning, if we're honest! I'll set my headphones to noise-cancelling mode and ignore that.
"This topic won't help me on Saturday and won't help me on Tuesday - and it is not my topic."
Slot gets Klopp's nod of approval as Liverpool close in on Feyenoord coach
Jurgen Klopp has given his nod of approval to Liverpool's pursuit of Feyenoord head coach Arne Slot.
Klopp has just four games remaining as Liverpool manager, having announced his intention to leave back in January.
Liverpool's season is in danger of fizzling out, with Wednesday's 2-0 defeat to Everton in the Merseyside derby having dealt their Premier League title hopes a blow, while they also crashed out of the Europa League earlier this month.
This week, reports emerged Liverpool, who were disappointed in their pursuit of Bayer Leverkusen boss Xabi Alonso, had elected to move for Feyenoord's Slot as Klopp's replacement.
Slot confirmed on Thursday that the clubs were in talks and he was confident a deal would be completed soon, and Klopp believes the Dutchman is an ideal fit.
"I'm not involved in the process, but I like a lot about it, if he is the one and wants to take the job," Klopp said at a press conference ahead of Saturday's meeting with West Ham.
"I like the way his team plays football. All the things I hear about him as a guy – a good guy. Some people I know, know him. I don't know him, but some people who know him say he's a good guy. I like that a lot. So good coach, good guy. Looking forward for the club, if he is the solution, if he is the man, I am more than happy."
Expanding on what his replacement would be walking into at Anfield, Klopp added: "Best job in the world. Best club in the world.
"Great job, great team, fantastic people. [Slot] 'would' be taking a really interesting job."
'It's a poor season, not a poor football club' – Blades boss Wilder
Sheffield United manager Chris Wilder has defended Sheffield United, acknowledging it has been a bad season, but dismissing that the Blades do not have a positive future.
A midweek defeat to Manchester United means the Blades can be relegated back to the Championship should they lose to Newcastle United on Saturday.
The Blades are 10 points from safety with four games left, but even a point would not realistically be enough given they have a goal difference of -59, 41 worse than Nottingham Forest’s -18.
To make matters worse, the Blades will start their next season in the Championship with a two-point deduction for financial discrepancies.
"We're not saying everything is great," said Wilder.
"What we are saying is there is a load of optimism about the future of the football club.
"It's a poor season, not a poor football club. We've been in far worse positions than this as a football club, certainly over my time as a supporter, player and manager.
"So, we'll come again if the inevitable happens on the weekend. We'll try our best, as we did, like we did on Wednesday night at Old Trafford, to get a result for our club and our supporters – who yet again were magnificent."
Newcastle, meanwhile, are in the hunt for European football, and Eddie Howe wants a response following the 2-0 defeat at Crystal Palace in midweek.
Howe said: "We must learn and absorb all the lessons from Wednesday. Every game is so difficult, it is up to us to go into the game with the right mentality and let our players express themselves in the right way. We have to finish the season strongly, we are under no illusions on how important these fixtures are."
PLAYERS TO WATCH
Newcastle United – Alexander Isak
Isak has scored in each of his last six Premier League home games, with only Andrew Cole (eight in 1993-94) and Alan Shearer (15 in 1996-97) netting in more consecutively for Newcastle in the competition.
Sheffield United – Ben Brereton Diaz
Brereton Diaz scored in Sheff Utd’s 4-2 defeat at Old Trafford – his fifth Premier League goal of the season since he joined on loan from Villarreal in January. With Oli McBurnie set to miss the rest of the season, Diaz will be the Blades’ biggest attacking threat.
MATCH PREDICTION: NEWCASTLE UNITED WIN
Newcastle are overwhelming favourites, and it is no surprise given Howe have lost just one of their last 25 Premier League games kicking off at 3pm on Saturday (W16 D8), going down 1-0 at Luton Town earlier this season.
The Magpies have scored in all 17 of their Premier League home games this season, with their 43 goals in total their most at St James’ Park in a top-flight campaign since 1996-97 (54).
Newcastle have lost none of their eight Premier League home games against promoted sides under Howe (W3 D5), with their last such defeat coming against Leeds United under Steve Bruce in January 2021. They also beat Sheffield United 8-0 in the reverse fixture at Bramall Lane – the most goals they have ever scored against an opponent in a single Premier League campaign is 10, doing so against the Blades’ rivals Sheffield Wednesday in 1999-00.
The Blades have lost three of their four Premier League away games against Newcastle, failing to score in each defeat. The exception was a 1-0 victory under Neil Warnock in November 2006.
OPTA WIN PROBABILITY
Newcastle United – 71.6%
Sheffield United – 9.7%
Draw – 18.7%
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