Inter have a chance to become the first Italian side to ever beat Barcelona twice in a Champions League campaign when they meet at Camp Nou on Wednesday.
Meanwhile, Club Brugge are on the brink of their first trip to the knockout stages as they play Atletico Madrid.
Mohamed Salah can make history with one more Champions League goal for Liverpool on their trip to Scotland to take on Rangers, and Bayern Munich are one win away from their own record as they try to win an 11th consecutive group stage match.
Tottenham will look to break out of a scoring slump when they host Eintracht Frankfurt, while Porto and Bayer Leverkusen are battling it out in Group B.
With plenty of important matchups, Stats Perform has parsed through the data to preview the eight fixtures on Wednesday and shine a light on some of the more interesting angles.
Barcelona v Inter
Inter's 1-0 victory against Barcelona at San Siro last week was their first triumph over the Spanish giants since April 2010, with Barca collecting four wins and one draw since.
With another win, Inter can become the first Italian side to ever beat Barcelona twice in the same Champions League campaign, although they have lost all five of their away fixtures at Camp Nou – their most losses at any away venue in the competition.
In fact, Camp Nou has not been a happy hunting ground for Italian sides in general, with a 3-0 victory for Juventus in 2020 marking the country's only win at the venue in the last 17 tries (L13 D3).
It is not just Barcelona who have given Inter trouble on away days, with their last away win in the Champions League against a Spanish opponent coming back in 2004 against Valencia.
Working in Inter's favour is road warrior Lautaro Martinez, who has scored six of his seven Champions League goals away from home.
Tottenham v Eintracht Frankfurt
After banking four consecutive wins against Borussia Dortmund between 2017 and 2019, Tottenham are now winless in their past five Champions League fixtures against German sides (D1 L4).
On the other side, Eintracht have enjoyed success when travelling to England in European competition, winning both of their previous two attempts – against Arsenal in 2019, and West Ham in April this year – in the Europa League.
However, this is a clear step up from the Europa League, and after winning their first ever Champions League away game last month (1-0 at Marseille), Frankfurt will be looking to become the only German team to ever win their first two away fixtures in the competition.
The 0-0 draw between these two sides in Frankfurt a week ago was the second consecutive Champions League game where Tottenham have failed to score a goal – also losing 2-0 to Sporting. The last time they went three games in the competition without scoring was back in 2011.
Striker Harry Kane will be key, as he boasts the best minutes-per-goal figure – 20 goals in 27 appearances for a goal every 118 minutes – of any English player with at least 10 goals in the Champions League.
Atletico Madrid v Club Brugge
Not many, if any, would have tipped Club Brugge to top Group B ahead of Atletico Madrid, Bayer Leverkusen and Porto, but they have defeated all three to lead with a perfect nine points and zero goals conceded.
One more win for Brugge would see them progress past the group stage for the first time, in their 10th Champions League campaign. By defeating Atletico, they would become the first Belgian side since Anderlecht in 2000 to win four games in a row in the competition.
Brugge are also one goal away from matching their highest goal tally from a single Champions League campaign, with eight goals in 2020-21.
Surprisingly, Atletico have struggled at home in the Champions League, snapping a streak of eight games without a win (D5 L3) by defeating Porto this season.
Brugge's Ferran Jutgla has registered a goal and an assist in each of his past two Champions League games, and if he can manage to do it again, he will join Robert Lewandowski and Leroy Sane as the only players since 2003-04 to have a goal and an assist in three straight games in the competition.
Bayer Leverkusen v Porto
With Brugge seemingly cruising, Porto, Leverkusen and Atletico are likely fighting it out for one automatic qualification spot, and Leverkusen will feel good about their chances as Porto are winless in their last seven away games against German teams (D2 L5).
After defeating Atletico at home on the second matchday, Leverkusen will be looking to win consecutive Champions League home fixtures in the same campaign for the first time since 2014.
Patrick Schick is Leverkusen's focal point going forward, attempting more than twice as many shots (12) as any of his team-mates this Champions League season, but he is yet to score, having missed a penalty against Porto in last week's 2-0 loss.
Porto's Mehdi Taremi assisted both goals in the reverse fixture, marking the first time he has been involved in multiple goals in a Champions League game, while the sending-off of Jeremie Frimpong gave Leverkusen their 11th red card in their history in the competition, trailing only Bayern Munich (21) amongst German sides.
Other fixtures:
Napoli v Ajax
5 – Napoli beat Ajax 6-1 in the reverse fixture at Johan Cruyff Arena, with the five-goal margin marking the heaviest defeat Ajax have ever suffered in European competition.
10 – With one more win, Napoli would become the fourth Italian club to ever mount a 10-game unbeaten streak in the Champions League, with six wins and three draws from their past nine fixtures.
Rangers v Liverpool
5 – Rangers have failed to score in their past five European games against English competition, including a 2-0 loss against Liverpool last week.
35 – Mohamed Salah has scored 35 Champions League goals for Liverpool – only Didier Droga (36 for Chelsea) and Sergio Aguero (36 for Manchester City) have scored more for a single Premier League club in the competition.
Sporting v Marseille
9 – Marseille have lost their past nine away fixtures in the Champions League, and with one more loss they would become the sixth team to ever post 10 consecutive away defeats in the competition, and the first from France.
18 – It has been 18 years since Sporting lost a home fixture against a French side in European competition, with that loss coming against Sochaux in the 2004 UEFA Cup.
Viktoria Plzen v Bayern Munich
31 – Bayern Munich are undefeated in their past 31 Champions League group stage matches (28W 3D) – which is an all-time high – and with one more win they will set the new record for consecutive group stage wins with 11.
32 – Viktoria Plzen have faced 32 shots on target in their first three games of this Champions League campaign – more than any other side. In the reverse fixture, Bayern had 13 shots on target.
Liverpool 1-0 Real Betis: Szoboszlai gets Slot era up and running
Dominik Szoboszlai's goal was the difference as Arne Slot's first game in charge of Liverpool with spectators present ended in a 1-0 win over Real Betis in Pittsburgh.
Liverpool lost 1-0 in a behind-closed-doors meeting with Preston North End last week, but they were victors in sweltering conditions when their pre-season tour of the United States got under way on Friday.
Szoboszlai scored the only goal after 34 minutes, stroking his finish past Adrian after Mohamed Salah slipped a pass through to the Hungary international.
That goal came four minutes after Curtis Jones was forced off through injury, being replaced by 17-year-old Trey Nyoni.
Former Reds goalkeeper Adrian denied Conor Bradley as a strong Liverpool side chased a second, while Harvey Elliott nodded wide from a Kostas Tsimikas cross.
After Slot rang the changes with 63 minutes gone, Kaide Gordon missed Liverpool's best chance to make it 2-0 by dragging his effort wide, but it did not matter as a controlled performance saw the Reds home.
Data Debrief: Reds in cruise control
Slot had been expected to bring a slightly more measured approach than the "heavy metal football" preached by his predecessor Jurgen Klopp, and that was on full display on Friday as Betis were held at arm's length.
Liverpool enjoyed 62.7% of the possession throughout the match, though Slot will be looking for more penetration when they face Arsenal in the next game of their tour on Wednesday, having only recorded 12 touches in the penalty area to Betis' 10.
Sessegnon rejoins boyhood club Fulham after Tottenham departure
Ryan Sessegnon has resigned for Fulham on a free transfer, five years after leaving the club.
The 24-year-old signed a two-year contract with the Cottagers with the option to extend for a further year following his departure from Tottenham last month.
In his first spell at the club, Sessegnon worked his way through the academy over 11 years, scoring 25 goals in 120 first-team appearances.
He then moved to Spurs in a £25million deal in 2019, though struggled to nail down a place in North London, making just 57 appearances in all competitions, and scoring three goals.
"It's amazing to be back. Emotional, as well," he told FFCtv. "It's where it started for me, where everything began, and it's amazing to be back.
"It will always be home for me. I think it had the feeling that it was meant to be, coming back here, so I'm delighted to get it done."
Sessegnon is Fulham's first signing of the transfer window, though they have seen plenty of first-team departures already, with Joao Palhinha, Tosin Adarabioyo and Bobby De Cordova-Reid all leaving the club.
Dewsbury-Hall: Maresca will surprise people at Chelsea
Kiernan Dewsbury-Hall believes new Chelsea manager Enzo Maresca will "surprise a lot of people" when they watch the Blues this season.
The Italian led Leicester City straight back to the Premier League as Championship winners in his only season in charge and succeeds Mauricio Pochettino at Stamford Bridge.
The Foxes topped the second division table with 98 points, with Dewsbury-Hall a key figure in his squad as he netted 12 goals and provided 14 assists last season – his best tally in a single campaign.
Dewsbury-Hall was also named Leicester's Player and Players' Player of the Year.
The midfielder made the switch to West London earlier this month for £30million and is confident that Maresca will have Chelsea challenging for trophies in no time.
"The manager was a big catalyst in wanting me to come," Dewsbury-Hall told BBC Sport.
"I knew from Leicester, a club that went down and had a lot of problems, how he managed to galvanise that if everyone manages to buy into the system.
"I genuinely think in a short space of time we can be pushing for minimum top four - but more than that.
"He may be unknown for a lot of people, but he is top, top level. He will surprise a lot of people."
Chelsea's pre-season got off to a frustrating start as they were held to a 2-2 draw by League One side Wrexham in Maresca's first game in charge on Wednesday.
Dewsbury-Hall did not play in that match but is training with the squad in the United States and could feature in their next outing against Celtic on Saturday.
The 25-year-old is confident the manager's tactics will come across soon, with the players buying into his style.
"We've only been doing it for two or three weeks, but the combination plays are really quick and tidy," he added.
"That's after two weeks. I remember he said to us at Leicester after six months or a year, there might be teething problems at the start, but it will improve.
"Within the first week at Leicester, I was convinced this was top, top level. I felt a bit stupid; I thought I knew a lot about football, but he was teaching me things on a daily basis that I didn't really know before. He has an aura, he can be strict, or gentle and soft - he has both sides.
"I am getting the same feedback here with the lads. They've bought into it here from minute one which is exciting. With a system and philosophy, you need everyone to buy in because, if they do, you can really achieve something."
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