Inter have a chance to become the first Italian side to ever beat Barcelona twice in a Champions League campaign when they meet at Camp Nou on Wednesday.
Meanwhile, Club Brugge are on the brink of their first trip to the knockout stages as they play Atletico Madrid.
Mohamed Salah can make history with one more Champions League goal for Liverpool on their trip to Scotland to take on Rangers, and Bayern Munich are one win away from their own record as they try to win an 11th consecutive group stage match.
Tottenham will look to break out of a scoring slump when they host Eintracht Frankfurt, while Porto and Bayer Leverkusen are battling it out in Group B.
With plenty of important matchups, Stats Perform has parsed through the data to preview the eight fixtures on Wednesday and shine a light on some of the more interesting angles.
Barcelona v Inter
Inter's 1-0 victory against Barcelona at San Siro last week was their first triumph over the Spanish giants since April 2010, with Barca collecting four wins and one draw since.
With another win, Inter can become the first Italian side to ever beat Barcelona twice in the same Champions League campaign, although they have lost all five of their away fixtures at Camp Nou – their most losses at any away venue in the competition.
In fact, Camp Nou has not been a happy hunting ground for Italian sides in general, with a 3-0 victory for Juventus in 2020 marking the country's only win at the venue in the last 17 tries (L13 D3).
It is not just Barcelona who have given Inter trouble on away days, with their last away win in the Champions League against a Spanish opponent coming back in 2004 against Valencia.
Working in Inter's favour is road warrior Lautaro Martinez, who has scored six of his seven Champions League goals away from home.
Tottenham v Eintracht Frankfurt
After banking four consecutive wins against Borussia Dortmund between 2017 and 2019, Tottenham are now winless in their past five Champions League fixtures against German sides (D1 L4).
On the other side, Eintracht have enjoyed success when travelling to England in European competition, winning both of their previous two attempts – against Arsenal in 2019, and West Ham in April this year – in the Europa League.
However, this is a clear step up from the Europa League, and after winning their first ever Champions League away game last month (1-0 at Marseille), Frankfurt will be looking to become the only German team to ever win their first two away fixtures in the competition.
The 0-0 draw between these two sides in Frankfurt a week ago was the second consecutive Champions League game where Tottenham have failed to score a goal – also losing 2-0 to Sporting. The last time they went three games in the competition without scoring was back in 2011.
Striker Harry Kane will be key, as he boasts the best minutes-per-goal figure – 20 goals in 27 appearances for a goal every 118 minutes – of any English player with at least 10 goals in the Champions League.
Atletico Madrid v Club Brugge
Not many, if any, would have tipped Club Brugge to top Group B ahead of Atletico Madrid, Bayer Leverkusen and Porto, but they have defeated all three to lead with a perfect nine points and zero goals conceded.
One more win for Brugge would see them progress past the group stage for the first time, in their 10th Champions League campaign. By defeating Atletico, they would become the first Belgian side since Anderlecht in 2000 to win four games in a row in the competition.
Brugge are also one goal away from matching their highest goal tally from a single Champions League campaign, with eight goals in 2020-21.
Surprisingly, Atletico have struggled at home in the Champions League, snapping a streak of eight games without a win (D5 L3) by defeating Porto this season.
Brugge's Ferran Jutgla has registered a goal and an assist in each of his past two Champions League games, and if he can manage to do it again, he will join Robert Lewandowski and Leroy Sane as the only players since 2003-04 to have a goal and an assist in three straight games in the competition.
Bayer Leverkusen v Porto
With Brugge seemingly cruising, Porto, Leverkusen and Atletico are likely fighting it out for one automatic qualification spot, and Leverkusen will feel good about their chances as Porto are winless in their last seven away games against German teams (D2 L5).
After defeating Atletico at home on the second matchday, Leverkusen will be looking to win consecutive Champions League home fixtures in the same campaign for the first time since 2014.
Patrick Schick is Leverkusen's focal point going forward, attempting more than twice as many shots (12) as any of his team-mates this Champions League season, but he is yet to score, having missed a penalty against Porto in last week's 2-0 loss.
Porto's Mehdi Taremi assisted both goals in the reverse fixture, marking the first time he has been involved in multiple goals in a Champions League game, while the sending-off of Jeremie Frimpong gave Leverkusen their 11th red card in their history in the competition, trailing only Bayern Munich (21) amongst German sides.
Other fixtures:
Napoli v Ajax
5 – Napoli beat Ajax 6-1 in the reverse fixture at Johan Cruyff Arena, with the five-goal margin marking the heaviest defeat Ajax have ever suffered in European competition.
10 – With one more win, Napoli would become the fourth Italian club to ever mount a 10-game unbeaten streak in the Champions League, with six wins and three draws from their past nine fixtures.
Rangers v Liverpool
5 – Rangers have failed to score in their past five European games against English competition, including a 2-0 loss against Liverpool last week.
35 – Mohamed Salah has scored 35 Champions League goals for Liverpool – only Didier Droga (36 for Chelsea) and Sergio Aguero (36 for Manchester City) have scored more for a single Premier League club in the competition.
Sporting v Marseille
9 – Marseille have lost their past nine away fixtures in the Champions League, and with one more loss they would become the sixth team to ever post 10 consecutive away defeats in the competition, and the first from France.
18 – It has been 18 years since Sporting lost a home fixture against a French side in European competition, with that loss coming against Sochaux in the 2004 UEFA Cup.
Viktoria Plzen v Bayern Munich
31 – Bayern Munich are undefeated in their past 31 Champions League group stage matches (28W 3D) – which is an all-time high – and with one more win they will set the new record for consecutive group stage wins with 11.
32 – Viktoria Plzen have faced 32 shots on target in their first three games of this Champions League campaign – more than any other side. In the reverse fixture, Bayern had 13 shots on target.
Rybakina wins 12th straight to reach Miami Open semi-finals, Pegula beats Potapova
Elena Rybakina is now two wins away from completing the rare 'Sunshine Double' after defeating Martina Trevisan 6-3 6-0 to reach the Miami Open semi-finals on Tuesday.
Only four women have ever claimed the Sunshine Double – which requires winning both the Indian Wells Open and Miami Open. Steffi Graf did it in both 1994 and 1996, Kim Clijsters did it in 2005, Victoria Azarenka accomplished the feat in 2016 and current world number one Iga Swiatek did it just 12 months ago.
Rybakina knocked off Swiatek and world number two Aryna Sabalenka in consecutive matches en route to the Indian Wells title, and she has now extended her winning streak to 12 with Tuesday's victory. Against Trevisan, Rybakina served another 10 aces compared to zero from the Italian.
In her fourth-round match the Kazakhstan representative became the first WTA player this season to post three consecutive matches with at least 10 aces, and with another she became the first woman since Serena Williams at the 2020 US Open to do so in four consecutive matches at the same tournament.
She needed just 27 minutes to race through the second set, and in the process she booked a semi-final against third seed Jessica Pegula.
America's top hope, Pegula had to come from behind against Russia's Anastasia Potapova in the 4-6 6-3 7-6 (7-2) result, saving two match points in the deciding set to force the pivotal tiebreaker.
The match was delayed for hours due to persistent rain, and the contest lasted two hours and 38 minutes, meaning they did not finish up on court until nearly 1:30am local time.
While consistently making it deep into major tournaments, Pegula only has two WTA singles titles to her name, and only once since the end of 2019.
With one more win she can book her spot in the final, and a chance to claim her second WTA 1000 crown after breaking through at the 2022 Guadalajara Open.
Messi hopes the 'craziness never ends' after 100th international goal and wild celebrations
Lionel Messi hopes the "craziness never ends" after scoring his 100th goal and ninth hat-trick for his country amid Argentina's homecoming World Cup celebrations on Tuesday.
La Albiceleste routed Curacao 7-0 in Santiago del Estero, with Messi's 20th-minute opener bringing up his 100th international goal, joining only Cristiano Ronaldo (122) and Ali Daei (109) in achieving that feat.
Messi became the first world champion to score 100 international goals, and he showed no signs of stopping there with further first-half strikes for a treble, taking him to 102.
The milestone came as Argentina rounded out their first two games back in their homeland since December's World Cup triumph with wild celebrations, initially in Buenos Aires for Thursday's 2-0 win over Panama.
The players emulated their celebrations from Qatar after the Curacao game, hoisting the World Cup trophy again after it came down from the stadium roof and doing a lap of honour to greet the supporters.
Messi was also presented with a plaque by Argentine Football Association president Claudio Tapia to acknowledge his 100th goal.
"What a nice way to close these dates, impressive today all the people in Santiago del Estero," Messi wrote on Instagram.
"I wish we can continue to share together many moments like these and that this craziness never ends!!!"
Messi's achievement comes after netting 21 goals in his 14 games for Argentina, along with seven assists. That has taken him to 156 goal contributions, which is the most in international football.
Argentina head coach Lionel Scaloni added: "As for Lionel Messi, what I want is for him to be on the pitch and be happy."
He added: "These days were different to the previous friendlies because the players were allowed to be with their people.
"We felt that they had that desire to go out to contact the outside, although that meant that it was difficult to prepare these two games. But in the end we got them through by playing with intensity."
Argentina 7-0 Curacao: Messi caps 100th international goal with first-half hat-trick
Lionel Messi scored his 100th international goal before capping his performance with a first-half hat-trick as Argentina routed Curacao 7-0 during Tuesday's friendly in Santiago del Estero.
Messi came into the game on 99 international goals but did not need to wait long to bring up triple figures, netting a 20th-minute opener, in a lopsided match-up where the world champions raced to a 5-0 half-time lead.
The Argentinian captain played the entire 90 minutes, scoring three goals within 17 devastating first-half minutes, while he also laid off the assist for Enzo Fernandez's powerful strike among the flurry.
Messi was denied early on by Curacao goalkeeper Eloy Room's sharp save, but soon after Giovani Lo Celso found him in space inside the box, setting him up to jink past two defenders and fire in a low right-foot shot for his 100th Argentina goal.
Nicolas Gonzalez added a second in the 23rd minute when he out-jumped Room to head home from a corner, before he played provider for Messi's second with a neat left-foot finish in the 33rd minute.
Two minutes later, Messi held up the ball and dished out a deft pass for Fernandez to lash home, with the Paris Saint-Germain star wrapping up his hat-trick when he raced on to Lo Celso's lofted pass and coolly converted after taking two touches.
Room brilliantly denied Lautaro Martinez twice early in the second half, while Leandro Bacuna fizzed Curacao's best chance over the bar from a 63rd-minute free-kick on the edge of the box.
Substitute Angel Di Maria added a sixth goal from the penalty spot in the 78th minute after Cuco Martina's handball, with Gonzalo Montiel side-footing home another from Paulo Dybala's cutback in the 88th minute.
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