Andy Murray reveled in a raucous Centre Court atmosphere after he fought back to keep himself in Wimbledon contention.

Murray had to defy the odds once more to overcome qualifier Oscar Otte 6-3 4-6 4-6 6-4 6-2 in a thrilling contest which lasted almost four hours.

Having led by a set and a break, Murray squandered his advantage to Wimbledon debutant Otte, who capitalised on the Scot's slip ups to take a 2-1 lead by the time bad light forced the players off.

But the break did Murray the world of good, with the former world number one winning seven of the next nine games with the full backing of a thoroughly one-sided crowd under the closed roof.

The 34-year-old was leaping in joy and punching the air when he held off Otte to hold serve and take a 5-2 lead in the deciding set, before he sealed the win with a deft lob shot to prove he still has the quality to go with his spirit.

"I enjoyed the end! The middle part, not so much! What an atmosphere to play in at the end. The whole crowd was amazing but there was a few guys in there getting me fired up," a thrilled, yet drained, Murray told BBC Sport. 

"I needed everyone's help tonight, they did a great job. I hit some great shots at the end to finish it but it was a tough match."

Murray's battle with Otte came just two days after a similarly tough contest against Nikoloz Basilashvili, and despite starting Wednesday's second-round tie well, the two-time Wimbledon champion knows he almost let the match slip away.

"I had to do something differently and started going for my shots more, dictating more of my points, I was being a little bit negative," Murray said when asked if the break in play helped him recover.

"Because of the lack of matches, in the important moments I didn't make the right decision a lot of the time but I think I played the right way in the last couple of sets. The first set and a half was really good but there was just bits in the middle I'd like to change.

"Obviously tired, I fell over a couple of times, they're pretty slick courts but considering everything I feel all right, hips feel pretty good, I get a rest day tomorrow and hopefully will come out on Friday and play in another atmosphere like this and perform well."

Murray has already accumulated over seven hours of time on court over his first two matches, and he now faces 10th seed Denis Shapovalov, who was handed a walkover on Wednesday due to Pablo Andujar's rib injury.

Roger Federer came from two sets to one down to survive a Wimbledon scare from Adrian Mannarino, who was forced to retire after suffering a knee injury.

Federer was expected to come through his first match at the All England Club since losing the 2019 final to Novak Djokovic with little difficulty.

That anticipation was increased when he claimed the first set, only for Mannarino to fuel hope of a first win over Federer in their seventh meeting by taking the next two sets.

The 20-time grand slam champion had re-established a measure of control in the fourth set when Mannarino was left in agony after his knee buckled at 4-2.

Mannarino attempted to continue but conceded the injury was too much to overcome in the opening game of the fifth with the score 6-4 6-7 (3-7) 3-6 6-2.

Federer lost just five points on serve in taking the opener, though he took only one of his six break points, with Mannarino proving a significantly tougher nut to crack in the second set.

The Frenchman did not face a break point and was surprisingly dominant in the tie-break, and he carried that confidence into the third, making six unforced errors to Federer's 10.

At that point, the biggest shock of the tournament looked to be on the cards, but Federer was back to his best in the fourth.

Imperious at the net, Federer hit 18 winners in the fourth and a decider already looked an inevitability by the time Mannarino's misfortune meant the Swiss could save energy before a second-round clash with either Richard Gasquet or Yuichi Sugita.

Andy Murray made clear he is far from finished after overcoming a fourth-set wobble to upset 24th seed Nikoloz Basilashvili in the first round at Wimbledon.

The two-time champion at SW19 has seen his career beset by injury issues in recent years, with this his first appearance in the main draw since reaching the quarter-finals in 2017.

However, he won two matches at Queen’s Club ahead of the third grand slam of the season and treated the Centre Court crowd to a trip down memory lane on Monday, including a dramatic twist when seemingly on the brink of victory.

Having taken the first two sets, Murray somehow contrived to lose the third despite at one stage holding a 5-0 lead. The sudden collapse sent nerves jangling among the spectators as the roof was closed at the venue, but he responded impressively to the setback to triumph 6-4 6-3 5-7 6-3.

Speaking during his on-court interview after the triumph, the Scotsman once again reiterated he has no plans to make this year his Wimbledon swansong.

"It's been extremely tough. Even these last few months. It has been extremely frustrating not being able to get on the court," Murray said.

"I've had such little momentum over these last few years. I've kept trying, doing all the right things to be back in this position. I feel very lucky I get to do it again.

"I keep getting asked is this going to be my last Wimbledon. I don't know why I keep getting asked, though. No, I'm going to keep on playing.

"I want to play, I'm enjoying it. I can still play at the highest level. He is ranked 28th in the world and I beat him, so I will keep going."

Basilashvili saved two match points as he somehow survived in the third set by winning seven games in a row, though Murray responded to the setback impressively.

"I did well to win the fourth set in the end because that was mentally not easy going to the locker room after losing that third," Murray added.

Next up will be either Oscar Otte or Arthur Rinderknech, their contest having been locked at 9-9 in the deciding set when play on the opening day was suspended on the outside courts.

Frances Tiafoe is confident he can cause further shocks at Wimbledon after he claimed the impressive scalp of third seed Stefanos Tsitsipas in the opening round on Monday.

Unseeded American Tiafoe ousted Tsitsipas in straight sets, winning 6-4 6-4 6-3 to make the Greek the first major casualty of the men's draw.

Tsitsipas was in action for the first time since losing the French Open final to Novak Djokovic on June 13 and struggled to cope with Tiafoe's aggressive style, suffering a break of serve in the very first game.

While that was the only break of the first set, it gave Tsitsipas a deficit he never recovered from, and he was broken again at 4-4 in the second as Tiafoe made his lead even more commanding.

Tiafoe then saw things out impressively, his 17 winners to his opponent's 10 in the third set reflecting the American's greater confidence as he made Tsitsipas the first third seed to lose in the opening round of the grass-court tournament since Andre Agassi in 1996.

And Tiafoe reckons there is more where that came from.

"Definitely one of my best [performances], from start to finish it was pretty clean," the 23-year-old told the BBC.

"This is what you train for this is what it's all about. I live for these kind of moments.

"I'm not even close to where I want to be. I've had a lot of great achievements but I haven't even scratched the surface I feel personally.

"Today was big, I definitely needed that, a guy at his level, that guy's special, he's going to do a lot of great things, win a ton of grand slams but not today."

Tiafoe will face Vasek Pospisil or Roberto Carballes Baena in the next round.

Novak Djokovic came from a set down to start his Wimbledon defence with an ultimately comfortable victory over Jack Draper in the first round.

Djokovic can move level with Roger Federer and Rafael Nadal on a record 20 grand slam singles titles if he prevails again at the All England Club.

But he found himself unexpectedly trailing against the British teenager after a rusty first set, Djokovic having had little time to adapt to the grass following the clay-court season that saw him win the French Open.

However, Djokovic soon found his rhythm despite an admirable display from the wildcard and will now face either Kevin Anderson or Marcelo Barrios Vera in the second round after a 4-6 6-1 6-2 6-2 win.

A shaky service game saw Draper claim the first break of the match, an advantage he was able to cling on to as Djokovic failed to take any of his seven break points.

But the world number one was ruthless in the second, taking his first opportunity to break as he surged into a 3-0 lead en route to levelling the match emphatically.

A mishit overhead from the big-serving Draper helped Djokovic forge ahead in the third and there was no way back for Draper thereafter.

Indeed, by the fourth, Djokovic was in full flow, excelling with his serve, his footwork and the accuracy of his groundstrokes, the slickness of a Centre Court not played on for two years causing more problems than Draper as he clinched triumph in just over two hours.

Andy Murray plays his first Wimbledon singles match in four years on Monday – with the journey back to Centre Court hailed as an equivalent achievement to his grand slam titles.

The former world number one has battled through injuries that threatened to end his career, so it will be a remarkable feat when he walks out to face Nikoloz Basilashvili.

Murray, who has won Wimbledon twice and the US Open once, as well as landing two Olympic gold medals in singles, underwent hip resurfacing in 2019 but has continued to be plagued by fitness problems.

The tribute to the resilience of the 34-year-old came from women's British number one Johanna Konta, who was cruelly ruled out of Wimbledon on Sunday when a close contact tested positive for COVID-19.

Konta, who spoke to Stats Perform before receiving that painful news, reached the Wimbledon semi-finals in 2017, the last year Murray played singles at the All England Club.

He was fit enough to play doubles in 2019, partnering Serena Williams in the mixed event, but a billing on the main show court promises to be an emotional occasion for a player who is struggling to repeat past glories.

"I think Andy really represents tenacity and perseverance," said Konta, a Jaguar ambassador.

"He loves this game, he loves winning in this game, he loves being good and great in this game. I think he will keep doing everything he can to keep putting himself back into position to be great."

"I think maybe bringing the attention more on the fact he is trying to do that, with the challenges he's had, is what we should be celebrating and we should be really acknowledging.

"I think this is probably equally as difficult as when he won his slams and his gold medals.

"I think it's on a par with that achievement. I think and hope people can see that and really acknowledge it because he really deserves that."

:: Johanna Konta is a Jaguar ambassador. Jaguar is the Official Car of The Championships, Wimbledon. To discover Jaguar’s unmatched experiences visit jaguar.co.uk/Wimbledon

After an enforced hiatus in 2020 due to the coronavirus pandemic, tennis returns to SW19.

Novak Djokovic makes his way back to Wimbledon as the defending champion and with the men's grand slam record firmly in his sight.

Djokovic conquered Rafael Nadal en route to French Open glory and his 19th slam crown – one shy of the record shared by rivals Nadal and Roger Federer.

With Nadal and Dominic Thiem absent, Djokovic's path to a 20th major trophy has opened up in London.

The women's title is up for grabs after holder Simona Halep withdrew, and Serena Williams can still dream of making history.

As all eyes shift to the All England Club, Stats Perform looks at the numbers behind this year's slam, using Opta data.

Dominant Djokovic

World number one and top seed Djokovic begins his title defence against promising Briton Jack Draper in the first round.

French Open champion Djokovic has won four of the last six Wimbledon tournaments, including each of the past two – the last player to win more at Wimbledon in a row was Federer between 2003 and 2007 (five).

A five-time Wimbledon winner, Djokovic is the only man to have won the first two grand slam tournaments of a calendar year over the last 25 years, doing it in 2016 and 2021. The last man to win the first three grand slams of a calendar year was Rod Laver during his Grand Slam in 1969.

The 2019 Wimbledon final was the first slam decider to be decided by a final set tie-break, with Djokovic beating Federer 7-3 in that tiebreak, while it was also the longest final in Wimbledon history (four hours, 57 minutes).

No man has won Roland Garros and Wimbledon in the same year since Nadal in 2010.

Federer farewell?

The curtain appears to be closing on all-time great Federer, who withdrew from the French Open after a draining four-set win over Dominik Koepfer to preserve his body for the grass season.

This year's Wimbledon could be the 39-year-old's final realistic shot at a grand slam as Djokovic bids to become the greatest of all.

Seeded sixth, Federer – who meets Adrian Mannarino first up – has won the most Wimbledon titles among all male players in the slam's history.

Federer will aim to win his 21st grand slam, which would break a tie with Nadal for the outright men's record.

The 'Big Four' and their stranglehold

Injuries have forced two-time Wimbledon champion Andy Murray to fall out of the equation but there has been no getting past the original 'Big Four'.

Among the men, the last 17 years of Wimbledon has been dominated by the same four players – Federer (eight titles), Djokovic (five), Nadal (two), Murray (two). The last winner at Wimbledon before them was Lleyton Hewitt in 2002.

Since Wimbledon in 2004, only one of the 68 slams has not seen at least one of Federer, Djokovic and Nadal in the semi-finals – it was at the US Open last year.

The new generation is headlined by grand slam runners-up Daniil Medvedev and Stefanos Tsitsipas.

Medvedev has never passed the third round at Wimbledon, though his two defeats at that stage have both been in five sets. The Russian second seed has reached at least the quarter-finals in three of his last four major tournaments, after reaching that stage in only one of his previous 13.

Beaten by Djokovic in the Roland Garros final, Tsitsipas has reached the semi-finals in his last three slams, having done so only once in his previous 12. The third seed has never reached the quarter-finals at Wimbledon, however.

Wimbledon is the only slam where fourth seed Alexander Zverev is yet to reach the quarter-final, his best result being a fourth-round performance in 2017. Since the beginning of 2020, he has advanced to the semi-finals in three slam tournaments, after never doing it in his previous 18 such major main-draw appearances.

Serena's ongoing quest

The queen of WTA tennis for so long, Serena Williams is one slam success away from matching Margaret Court's record of 24 major singles championships. But the 39-year-old has been stuck on 23 since reigning supreme at the Australian Open in 2017.

Williams, who lost in the French Open fourth round, has won seven Wimbledon titles (level with Steffi Graf) – only Martina Navratilova has more in the Open Era (nine).

American superstar Williams has been a Wimbledon runner-up in 2018 and 2019. Chris Evert is the only player in the Open Era to have lost three consecutive Wimbledon finals (between 1978 and 1980).

Williams, the sixth seed who will clash with Aliaksandra Sasnovich in the opening round, is looking to become only the second woman to win 100 Wimbledon singles matches (currently 98), alongside Navratilova (120). She could also become the first woman to reach 100-plus wins in two different majors (106 wins at the US Open).

From the first Wimbledon final reached by one Williams sister in 2000 (won by Venus against Lindsay Davenport), only in four of 20 editions has neither of the two sisters reached the decider – in 2006 (Amelie Mauresmo-Justine Henin), 2011 (Petra Kvitova-Maria Sharapova), 2013 (Marion Bartoli-Sabine Lisicki) and 2014 (Kvitova-Eugenie Bouchard).

Barty party?

Former French Open champion Ash Barty heads to Wimbledon as the top seed and will kick off her title bid against veteran Carla Suarez Navarro.

However, world number one Barty has never reached the Wimbledon quarter-finals. Reaching the 2019 fourth round was her best result. The last Australian woman to reach the quarters at Wimbledon was Jelena Dokic in 2000.

The top seed in the Wimbledon women's singles main draw has been eliminated in the first round just three times in the Open Era – Graf in 1994, Martina Hingis in 1999 and Hingis again in 2001.

Wimbledon is the only major won by Kvitova in her career (2011 and 2014). She is one among the three current players with multiple titles at the All England Club, alongside Serena and Venus Williams.

Karolina Pliskova was the woman with the most aces per match made on average at Wimbledon 2019 (9.0, 36 in total) among players who reached the third round.

Novak Djokovic spent the week before Wimbledon enjoying a challenge for a most unlikely title in Mallorca.

The Serbian reached his first men's doubles final for 11 years when he and Carlos Gomez-Herrera knocked out the third seeds on Thursday. Were it not for an injury to the Spaniard forcing them to withdraw, you would not have put it past Djokovic, a man with 83 singles titles, to have lifted what would have been just a second doubles trophy in his career.

"I don't think we expected to reach the finals," Djokovic admitted after an unexpected, liberating week. "Everything clicked quite amazingly."

That Djokovic could prepare to defend his Wimbledon title by experimenting in the doubles in the Spanish sun should serve as a warning to the rest of the draw. He has not played a Tour-level singles match since that exhausting, extraordinary win at the French Open where he inflicted on Rafael Nadal just the third Roland Garros defeat of his career before recovering from two sets down to beat Stefanos Tsitsipas in the final. That treacherous transition from clay to grass is no problem at all, such is Djokovic's belief in his own powers.

And why not? He has been close to untouchable in 2021: 27 wins and as many titles as defeats, his three trophy wins including the first two grand slams of the year. He has 19 now, just one behind all-time record holders Nadal – who withdrew from Wimbledon and the Olympics after a gruelling clay season – and Roger Federer, who has played only eight matches since the 2020 Australian Open following two knee operations. Djokovic has won four of the past six championships at SW19 and is bidding to become the first man to win three in a row since Federer managed four from 2004 to 2007.

For Federer, 2021 has been about building for these next two months, for another fortnight in London and a final shot at Olympic singles gold. He pulled out of Roland Garros after a draining four-set win over Dominik Koepfer to preserve his body for the grass season, but his bid for an 11th title in Halle ended in a dispiriting second-round loss to Felix Auger-Aliassime.

Federer would not admit it publicly, nor perhaps even to himself, but Wimbledon 2021 represents his best remaining chance at winning a major, not least with Nadal and fourth seed Dominic Thiem having pulled out. He should have taken the title the last time the event was played two years ago, when Djokovic survived two match points to win the longest final in history in four hours and 57 minutes. Now 39, having to pick and choose his matches to prolong his career, that unpalatable moment when Federer puts down his racquet for good is starting to loom large on the horizon.

It leaves things beautifully poised at the top of the men's game. Djokovic has always been hindered in conversations around the 'big three'. The 34-year-old has never won the hearts of the wider tennis public in quite the same way as Roger and Rafa, in spite of his best – and occasionally misguided – efforts.

Yet the fact remains we are entering a critical point in this particular GOAT debate. Djokovic leads the head-to-head record against Federer (27-23) and Nadal (30-28). He is the only man in the Open Era to win all four grand slams twice. Nobody has won more Masters 1000 titles (36, level with Nadal), and nobody else has won all nine of those events. He has been world number one for 326 weeks – also a record. And all of his major titles bar one have come in the past 10 years, a time in which Nadal has won 11 and Federer four. This has truly been his decade – at least, if you ignore the doubles.

Should Djokovic win a sixth Wimbledon title, and should he follow that with major number 21 at the US Open, there will be little objective reason not to crown him the greatest men's player ever to play the sport. He knows that.

Perhaps Federer does, too. The lingering regret of losing three finals here to Djokovic, the lure of lifting this trophy for a ninth time, the prospect of halting the Serbian's conquest of the game –perhaps that will inspire the Swiss to what would surely be the greatest triumph of his career. Perhaps, just once more, everything will click.

Alex De Minaur claimed the first grass-court title of his career with a hard-fought three-set victory over Lorenzo Sonego in the Viking International final.

De Minaur lost the first set against his Italian opponent, who reached a career-high ranking of 26 earlier this month, but the Australian fought back to prevail 4-6 6-4 7-6 (7-5).

Having forced a decider, it was De Minaur who had the most left in the third-set tie-break, which decided an entertaining contest that lasted two hours and 40 minutes.

It marked De Minaur's second title of 2021 following his success at the Antalya Open back in January.

Prior to Saturday, all four of De Minaur's ATP titles had come on hard courts.

However, an excellent backhand return of a second serve set him up for a forehand smash to clinch a triumph that should give him great confidence heading into Wimbledon.

De Minaur starts his campaign at the All England Club on Monday with a testing opening clash against Sebastian Korda while Sonego faces Pedro Sousa.

Speaking at the presentation, De Minaur paid tribute to Sonego, who recently lost his grandmother.

"Everyone should congratulate Lorenzo for an incredible week. Everyone should be scared of you at Wimbledon next week," said De Minaur.

"It's been a long week, I've played some great tennis, I've managed to pull through a very tough win.

"Hopefully I can keep it going through Wimbledon, I can't wait to go there next week."

Daniil Medvedev made light work of sealing his first grass-court title, as he defeated Sam Querrey in straight sets at the Mallorca Championships.

The world number two was playing in his first final on grass, and took just 63 minutes to win 6-4 6-2 and warm up for Wimbledon in emphatic fashion.

It brings up Medvedev's second title of the season and his 11th in total, though he had failed to progress beyond the quarter-finals in his last five tournaments since winning in Marseille in March.

Medvedev suggested he was clicking into gear after his win over Pablo Carreno Busta on Friday, and he backed up his point on Saturday, cruising to victory without offering up a single break point.

The 25-year-old broke world number 60 Querrey – seeking his first ATP Tour title since 2017 – on three occasions, and an ace, his 10th of the match, sealed victory.

Like at the French Open, Medvedev heads to Wimbledon as the second seed. He is the same half of the draw as 20-time grand slam champion Roger Federer, and has a first-round encounter with Jan-Lennard Struff, who knocked the Russian out of the Halle Open last week.

Roger Federer will not make a final decision on whether he will play at the Olympic Games in Tokyo until after Wimbledon.

An Olympic gold medal is the one major honour to have eluded Federer during his decorated singles career.

The 20-time grand slam champion won gold in doubles alongside Stan Wawrinka in 2008 but was beaten by Andy Murray in the singles final in 2012 and pulled out of the tournament in 2016 to recover from a knee injury.

Rafael Nadal will not feature in Tokyo, having decided to skip Wimbledon and the Olympics to help him recuperate after the clay-court season.

Federer has grown significantly more selective over his schedule in the latter stages of his career as he has sought to look after his body.

Asked about his participation at the delayed Games, which begin next month, Federer told a media conference: "It's still my intention to go to the Olympic Games.

"But we will reassess everything after Wimbledon. It is my goal to play as much tournaments as possible. But it really depends on results and how the body is feeling.

"I wish I could tell you more. At the moment things are not as simple as in the past. With age, we have to be more selective, I can't play it all."

Federer starts his campaign for a ninth Wimbledon title when he faces Adrian Mannarino on Tuesday.

The Swiss has won all six of his meetings with Mannarino, including matches at Wimbledon in 2011 and 2018.

Daniil Medvedev reached the first grass-court final of his career as he saw off Pablo Carreno Busta at the Mallorca Championships.

Medvedev, the top seed, had to come from a set down against his Spanish opponent, winning 3-6 6-3 6-2 to tee up a showdown against Sam Querrey.

The world number two has won 10 ATP Tour titles, but they have all come on hard courts.

"I know that I can play well on grass," said Medvedev, who followed up a quarter-final run at Roland Garros with a first-round defeat to Jan-Lennard Struff at the Halle Open.

"Unfortunately we don't have that many tournaments, only one ATP 500 and one grand slam. It's going to be a special feeling [if I] win my first title on grass.

"I still don't have one on clay, even if I have one final. Adding these titles, especially on different surfaces, can help your confidence and it’s just a great thing for your career."

World number 13 Carreno Busta had looked sharp in successive straight-set wins en route to the semi-finals, and started Friday's encounter in good form.

He had not dropped serve across the first four sets of his campaign in Mallorca and extended that streak by saving three break points in the opening set.

However, Medvedev – who has been drawn in the same half as Roger Federer at Wimbledon – rallied and served out the one-hour, 56-minute victory with an ace.

Querrey, meanwhile, will be going for his first ATP Tour title since 2017 after he cruised to a 6-4 6-3 win over unseeded Adrian Mannarino.

Another player who is hunting for his first Tour triumph on grass is Alex de Minaur, who defeated Soon Woo Kwon 6-3 7-6 (7-2) to progress to the Viking International final.

The world number 18 has won four hard-court titles and will go up against Lorenzo Sonego for the crown in Eastbourne.

Sonego beat De Minaur's compatriot Max Purcell 6-1 3-6 6-1. The Italian triumphed at the Sardegna Open in April.

Novak Djokovic will start the defence of his Wimbledon title against British wildcard Jack Draper, and Serena Williams takes on Aliaksandra Sasnovich in the first round.

Djokovic is just one grand slam title away from matching Roger Federer and Rafael Nadal's record tally of 20 after winning the Australian Open and French Open this year.

The world number one will take on 19-year-old Draper, a quarter-finalist at Queen's Club last week, in his first match at SW19 for two years after the 2020 championships were called off due to the coronavirus pandemic.

Djokovic faces a potential quarter-final against Andrey Rublev, while Federer could come up against second seed Daniil Medvedev in last eight.

First up for eight-time Wimbledon champion Federer is an encounter with Adrian Mannarino, while injury-plagued two-time winner Andy Murray will start his home major against the 24th seed Nikoloz Basilashvili.

Stefanos Tsitsipas, beaten by Djokovic in a thrilling French Open final this month, has been drawn to face American Frances Tiafoe in round one of a tournament that gets under way on Monday.

Simona Halep announced just before the draw was made on Friday that she would not defend her title due to a calf injury.

Williams, runner-up to Halep in the 2019 final, must get past Sasnovich of Belarus in the first round and could face third seed Elina Svitolina at the quarter-final stage.

World number one and top seed Ash Barty takes on Carla Suarez Navarro, who made a grand slam return at Roland Garros after recovering from cancer. Barty could come up against Bianca Andreescu in the last eight.

Petra Kvitova against Sloane Stephens is a standout first-round match, while Coco Gauff's first assignment will be a meeting with 20-year-old Briton Fran Jones.

Daniil Medvedev is set for just the third grass-court semi-final of his ATP Tour career at the Mallorca Championships.

Medvedev, who has reached two hard-court grand slam finals, as well as winning last year's ATP Finals, has never been beyond the last four on grass. He has only done so once on clay.

The Russian will get another chance on Friday, though, against Pablo Carreno Busta.

That is his reward for beating Casper Ruud, who Medvedev acknowledged likely also does not favour the grass season.

"I don't think grass is his best surface, but in the first set he was playing top level and I couldn't get any break points," Medvedev said after beating Ruud 7-5 6-1. 

"But as soon as he started serving a bit worse and making some errors, I tried to use it as fast as I could.

"It was important to win the first set and not in a tie-break, this gives me a boost of confidence."

Carreno Busta defeated Jordan Thompson in straight sets but was not followed into the semis by either of the other Spaniards in action.

Third seed Roberto Bautista Agut was toppled by Sam Querrey, as Feliciano Lopez lost to Adrian Mannarino.

At the Viking International in Eastbourne, there is an Australian in each semi-final after wins for Alex de Minaur and Max Purcell.

De Minaur wore down Vasek Pospisil 6-4 6-4 and now faces Kwon Soon-woo, who was similarly comfortable against Ilya Ivashka.

Purcell battled past Andreas Seppi, recovering from a tough second set in which he succumbed 6-1, but must now face another Italian.

Third seed Lorenzo Sonego secured his semis spot by blasting past Alexander Bublik 6-1 7-5.

Dominic Thiem has been ruled out of Wimbledon after tests on a wrist injury and faces a race to be fully fit in time to defend his US Open title.

The world number five retired from his match against Adrian Mannarino in the Mallorca Championships on Tuesday, when 5-2 up in the opening set.

Checks on the wrist by a specialist in Barcelona have shown Thiem needs time away from tennis, meaning Wimbledon is off the table along with tournaments in Hamburg and Gstaad in July.

According to a medical bulletin issued on Thiem's social media accounts, it will be five weeks before he can remove a wrist splint and begin to step up his recovery.

With the US Open beginning on August 30, that does not leave a lot of time for Thiem to recover physical fitness and find his best tennis. He would have been seeded number four at Wimbledon.

The medical bulletin read: "Tests found that there is a 'detachment of the posterior sheath of the ulnar side of the right wrist', an injury that will not allow him to compete in the circuit for several weeks.

"Thiem will wear a wrist splint for five weeks before beginning a progressive process of specific, functional rehabilitation to regain mobility as well as muscle strength in his wrist and ultimately return to training on court."

Thiem, who had already decided against playing at the upcoming Tokyo Olympics, appears to be hoping his lay-off is not as long as the experts have forecast.

He will undergo MRI scans and tests as his recovery progresses, and the 27-year-old Austrian said: "I'm going to do everything the doctors say in order to recover as quickly as possible.

"They've informed me that I might be out for several weeks, but I will do my best to be back on court soon.

"I'm really sorry for pulling out of the upcoming three tournaments I had in my calendar: Wimbledon, Hamburg and Gstaad.

"They are very important tournaments for me. I appreciate all the support from the fans in these difficult moments – I'm determined to come back stronger."

Thiem's absence is another blow for Wimbledon, with Rafael Nadal and Naomi Osaka having already announced they would not be playing the tournament.