Wales go in search of a Triple Crown in a blockbuster battle against England, but France will not have an opportunity to make it three Six Nations wins out of three this weekend.
Wayne Pivac's Wales side are level on nine points with Les Bleus following victories over Ireland and Scotland, both of whom had a man sent off.
George North will become the youngest player in history to win 100 caps, but defending champions England will be determined to spoil the Wales centre's big occasion at the Principality Stadium on Saturday.
The Red Rose beat Italy 41-18 last time out, following a loss to Scotland at Twickenham.
Winless Ireland will be expected to defeat the Azzurri to get up and running in the opening match of round three at Stadio Olimpico.
Sunday's planned showdown between France and Scotland was postponed due to a COVID-19 outbreak in the French squad.
We preview the matches in Rome and Cardiff with help from Opta.
ITALY v IRELAND
FORM
Ireland have scored 45 tries across their last seven games against Italy in the Six Nations (6.4 per game), scoring eight or more tries in three of their last five clashes.
Italy have conceded a try-scoring bonus point in 17 of their 22 matches since those incentives were introduced to the Six Nations in 2017; only England (9) have picked up more bonus points in the championship than Ireland (8). The Azzurri are the only side yet to register one.
Ireland have lost their opening two games of a Six Nations campaign for the first time. The last time they lost their opening three matches was in 1998, when they were beaten in all four Five Nations clashes.
ONES TO WATCH
Sebastian Negri has made 96 metres and made 21 tackles combined in Italy's losses to France and England. Franco Smith will need another strong showing from the flanker.
Ireland back-row CJ Stander has made more carries (36) than any other player in the 2021 Six Nations. He has topped the final rankings for this category in three of the last four editions of the championship.
WALES v ENGLAND
FORM
England have won six of their last seven Six Nations matches against Wales, with the last six of those fixtures all decided by a single-figure margin.
Wales have won their opening two games of the tournament for a sixth time. On four of the previous five occasions when they have started with back-to-back victories, they have gone on to win a Grand Slam (2005, 2008, 2012, 2019, not in 2009).
This weekend's visitors are the only team to have never conceded more than two tries in a Six Nations game played in Wales. They have scored 19 tries in Wales during the Six Nations, no visiting team have scored more (Ireland also 19).
ONES TO WATCH
North will become only the sixth Wales player to win a century of caps. The 28-year-old will form a new pairing with Jonathan Davies and will be looking to bring up his hundred with an all-action display.
Elliot Daly will win his 50th cap for England and coach Eddie Jones will expect the full-back to repay the faith he has shown in him after a slow start to the tournament.
Dykes ruled out of Euro 2024 for Scotland
Scotland striker Lyndon Dykes has been ruled out of Euro 2024 after picking up an injury in training on Friday.
While preparing for their upcoming friendly against Gibraltar, Dykes left the training pitch on a stretcher with an apparent knee injury.
On Saturday, Scotland confirmed that the 28-year-old will miss the tournament, though the injury has not been specified.
Dykes has scored nine goals for Scotland in 36 appearances, and played in all eight of their Euro 2024 qualifiers, scoring once.
Steve Clarke's side will begin the tournament against hosts Germany in the opening match on June 14.
Sabalenka soars past best friend Badosa and into French Open last 16
Aryna Sabalenka recovered from a slow start to eventually advance to the French Open last 16 a commanding 7-5 6-1 victory over best friend Paula Badosa.
The second seed trailed 4-2 and was a break down in the opening set, but went on to win 11 of the next 13 games to seal a fourth-round clash with either Madison Keys or Emma Navarro.
Sabalenka has dropped just seven games in her opening two matches at Roland-Garros.
Although, it looked like she may lose the opening set when a fortuitous net shot gave Badosa a second break and a 4-2 lead on Court Philippe-Chatrier.
However, she dug deep from 5-3 adrift, winning the last four games to draw first blood.
The reigning Australian Open champion broke her opponent a further two times on the way to a commanding 4-0 advantage in the second.
Badosa did well to save three match points from 0-40 in game six, but the Spaniard could not rescue a fourth as her opponent continued her surge into the second week.
Data Debrief: Sabalenka completes top four in last 16
Following on from her victories when they met in Miami and Stuttgart earlier this season, Sabalenka became the first player to beat Badosa three times at WTA events in a calendar year.
Joining Iga Swiatek, Coco Gauff and Elena Rybakina, this marks the first time since 2013 that the top four seeds are through to the last 16 in the women's singles at Roland-Garros.
Rybakina moves past Mertens and into French Open fourth round
Elena Rybakina is through to the second week at the French Open, following another straight-sets victory over Elise Mertens.
The fourth seed wrapped up a 6-4 6-2 win in 67 minutes on Court Philippe-Chatrier, to book a last-16 clash with either Elina Svitolina or Ana Bogdan.
Rybakina was forced to withdraw injured on the eve of her third-round showdown with Sara Sorribes Tormo at Roland-Garros 12 months ago.
A tight opening set ensued with four successive games from 2-2 going against the serve, but a crucial break to love in the 10th saw the former Wimbledon champion draw first blood.
She then broke to 15 in game four of the second set to take control of the match, before another in the eighth saw her into the fourth round in Paris for a second time.
Rybakina is joined in the last 16 by home favourite Varvara Gracheva, who continued her groundbreaking run with a straight-sets win over Irina-Camelia Begu.
The Moscow-born 23-year-old, who obtained French nationality last June, is into round four for the first time at a major.
Extending her stay into the second week, having stunned sixth seed Maria Sakkari in the opening round, Gracheva was serenaded with Les Marseillais by the crowd following her victory on Court Suzanne-Lenglen.
Data Debrief: Rybakina matches Swiatek and Jabeur
Rybakina becomes only the third player to reach the fourth round at multiple majors on clay and grass since the start of the 2020 season.
The 2022 Wimbledon champion joins an exclusive group of players to achieve the feat, along with Iga Swiatek and Ons Jabeur.
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