Warren Gatland told Wales to "be brave" as he made six changes to his starting XV for Saturday's Six Nations tussle with fellow strugglers Italy.
The match in Rome, a likely Wooden Spoon decider, will see Rhys Webb make his first Test start since October 2020, stepping in at scrum-half to replace Tomos Williams.
Rio Dyer replaces wing Louis Rees-Zammit, who Gatland backed to be a useful impact replacement, with full-back Liam Williams also coming in.
Dafydd Jenkins, Jac Morgan and Wyn Jones come into the pack, with former captain Alun Wyn Jones among those missing out.
After defeats to Ireland, Scotland and England, head coach Gatland is determined Wales give a better account of themselves against the Azzurri at Stadio Olimpico.
Gatland said: "We feel that having watched Italy and how they'll tend to play from everywhere, including their own 22, getting guys on the ball is going to be pretty important.
"We've been disappointed with the results so far and for me it's hard to take as it's the first time I've lost three games in the Six Nations with Wales. We've had a lot of things going on off the field as well, but there are no excuses.
"The message to the players has been that we have to be smart in terms of the way we play, but we've also got to be brave and make sure that when the opportunities are on we shift the ball. We have to keep scanning and looking at options and if there's a chance to move the ball then be brave and do that."
Teams:
Italy: Tommaso Allan, Edoardo Padovani, Juan Ignacio Brex,Tommaso Menoncello, Pierre Bruno, Paolo Garbisi, Stephen Varney; Danilo Fischetti, Giacomo Nicotera, Simone Ferrari, Niccolo Cannon, Federico Ruzza, Sebastian Negri, Michele Lamaro (captain), Lorenzo Cannon.
Replacements: Luca Bigi, Federico Zani, Marco Riccioni, Edoardo Iachizzi, Giovanni Pettinelli, Manuel Zuliani, Alessandro Fusco, Luca Morisi.
Wales: Liam Williams, Josh Adams, Mason Grady, Joe Hawkins, Rio Dyer, Owen Williams, Rhys Webb; Wyn Jones, Ken Owens (captain), Tomas Francis, Adam Beard, Dafydd Jenkins, Jac Morgan, Justin Tipuric, Taulupe Faletau.
Replacements: Scott Baldwin, Gareth Thomas, Dillon Lewis, Rhys Davies, Tommy Reffell, Tomos Williams, George North, Louis Rees-Zammit.
All Blacks captain Cane to retire from international rugby
New Zealand captain Sam Cane has announced he will retire from international rugby at the end of 2024, having agreed a three-year contract with Japan Rugby League One team Tokyo Sungoliath.
Cane made his All Blacks debut in 2012 and has represented his country 95 times, including through the team's triumphant run at the 2015 World Cup.
The flanker succeeded Kieran Read as captain in 2020, though his most recent international outing ended with him suffering the ignominy of becoming the first man to be sent off in a Rugby World Cup final, as New Zealand were beaten by South Africa last year.
Cane will be eligible to represent the All Blacks through the second half of 2024 after returning from an initial spell in Japan but will then head there permanently after New Zealand Rugby agreed to release him from his contract.
"A good opportunity came my way with Sungoliath willing to offer me a three-year contract," Cane said. "I had to weigh up everything and, in the end, with a young family it seemed like the best decision to help set us up for our future.
"I had my time as captain and it was a huge honour and privilege. If I'm fortunate enough to be selected for the All Blacks this year then I'll still be myself.
"I love that team, and if part of my role is contributing leadership-wise, I'll be happy to support the new captain as best I can to help with a speedy transition."
Seales takes second five-wicket haul in a row for Sussex; Holder smashes 123* for Worcestershire
Jayden Seales continued his excellent form so far for Sussex CCC in this season’s County Championship Division Two with another five-wicket haul, this time against Glamorgan at Sophia Gardens in Cardiff.
Seales has, so far, taken 5-101 in 23 overs as Glamorgan have advanced to 411-9 off 102 overs, replying to Sussex’s 278 all out off 87.2 overs on day one.
Glamorgan’s batting effort was led by excellent centuries from Colin Ingram and Kiran Carlson.
Ingram led the way with a 248-ball 170 including 23 fours and three sixes while Carlson made 148 off 217 balls and hit 21 fours in the process.
Seales and Sussex will enter day three on Sunday trailing Glamorgan by 133 runs looking to dismiss them as quickly as possible.
Full scores:
Sussex 278 off 87.2 overs (Fynn Hudson-Prentice 48, Cheteshwar Pujara 41, Jack Carson 39, Aristides Karvelas 39, Mir Hamza 4-70, James Harris 4-93)
Glamorgan 411-9 off 102 overs (Colin Ingram 170, Kiran Carlson 148, Jayden Seales 5-101)
Elsewhere, Jason Holder was one of three Worcestershire batsmen to make centuries as they piled up a massive 618-7 declared in their first innings against Kent on day two at the St. Lawrence Ground in Canterbury.
Holder made a brilliant 123* off just 110 balls including seven fours and three sixes while Gareth Roderick and Matthew Waite both also reached three figures with 117 and 100*, respectively.
Adam Hose fell just ten runs short of a century himself.
Joey Evison and Matt Parkinson each ended with three wicket-hauls for Kent.
In reply, Kent reached 111-2 at stumps with Captain Daniel Bell-Drummond (54*0 and Jack Leaning (43*) at the crease.
Joe Leach has taken both wickets to fall so far.
Full scores:
Worcestershire 617-8 dec. off 158.5 overs (Jason Holder 123*, Gareth Roderick 117, Matthew Waite 100*, Adam Hose 90, Joey Evison 3-58, Matt Parkinson 3-201)
Kent 111-2 off 33 overs (Daniel Bell-Drummond 54*, Jack Leaning 43*, Joe Leach 2-12)
Rees-Zammit relishing Mahomes advice as former rugby star eyes spot on Chiefs roster
Louis Rees-Zammit has likened Patrick Mahomes to an extra coach as he looks to make an impact in the NFL with the Kansas City Chiefs.
Rees-Zammit shocked rugby union fans in January when he announced he was turning his back on the sport to enter the NFL's International Player Pathway programme.
He was signed by two-time defending Super Bowl champions Kansas City in March and is now looking to earn a place on their roster for 2024, learning the role of running back at the Chiefs' rookie minicamp after attending another training camp alongside Mahomes.
Rees-Zammit has made sure to pick the brains of Mahomes, who has led the Chiefs to six straight AFC Championship games and won three Super Bowl rings since being drafted in 2017.
"It was amazing, all the quarterbacks and receivers were there, we were running routes, we were working in the gym", Rees-Zammit said of his experience at that camp in Texas.
"It was a great two weeks, I definitely learned a lot with Pat and the other boys."
Asked if Mahomes was acting like an extra coach, he said: "100 per cent.
"I'm new to the game so I'm trying to pick everyone's brains and try and pick up the sport as quick as possible because I want to be out there playing.
"The way I can do that is picking the brains of everyone that's currently here and trying to learn the game as quickly as possible."
Chiefs head coach Andy Reid has been impressed by Rees-Zammit's attitude, saying: "He's so diligent with everything and wants to be so good at everything. I appreciate that.
"I like the fact he's got shorter steps initially, that's a good thing as a running back. If you're a long strider in there you've got to really work on making it through those tight adjustments you have to make. He seems to have a nice feel."
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