Billy Vunipola has been left out of new head coach Steve Borthwick's 36-man England squad for the upcoming Six Nations, though Owen Farrell will be kept on as captain.
Other notable omissions alongside Vunipola are Jonny May and Jack Nowell, with a combined 180 England Test appearances between the three players.
Dan Cole is included, having received the most recent of his 95 caps in the 2019 Rugby World Cup final defeat to South Africa, while Northampton Saints fly-half Fin Smith is among the five uncapped players Borthwick has picked.
The other potential debutants are London Irish's Ollie Hassell-Collins and Gloucester hooker George McGuigan, as well as Harlequins duo Cadan Murley and Jack Walker.
Farrell and Marcus Smith were also named, with the former set to remain captain having occupied the role under previous head coach Eddie Jones.
England's first game with their new boss will be against Scotland in the Six Nations at Twickenham on February 4, though they likely already have one eye on the 2023 Rugby World Cup, which begins in September.
Borthwick said: "This is an exciting squad, with a blend of Six Nations experience and young talent, and includes players who are in excellent form in the Premiership.
"We are all looking forward to the challenges of the Six Nations and we will approach this great tournament with a spirit of courage and total commitment.
"I know the players can't wait to get back to Twickenham and give our fans a performance they can be proud of.
"The hard work for the Scotland game starts now."
England squad: Forwards: Ollie Chessum, Dan Cole, Ben Curry, Alex Dombrandt, Ben Earl, Ellis Genge, Jamie George, Joe Heyes, Jonny Hill, Nick Isiekwe, Maro Itoje, Courtney Lawes, Lewis Ludlam, George McGuigan, Bevan Rodd, Sam Simmonds, Kyle Sinckler, Mako Vunipola, Jack Walker, Jack Willis.
Backs: Elliot Daly, Owen Farrell (captain), Tommy Freeman, Ollie Hassell-Collins, Dan Kelly, Max Malins, Joe Marchant, Alex Mitchell, Cadan Murley, Henry Slade, Fin Smith, Marcus Smith, Freddie Steward, Manu Tuilagi, Jack van Poortvliet, Ben Youngs.
Southgate: Man United speculation 'a complete irrelevance'
Gareth Southgate says speculation linking him with the Manchester United job is "a complete irrelevance" as his entire focus is on England's Euro 2024 campaign.
The England manager has been tipped as a contender to succeed Erik ten Hag at Old Trafford should United part ways with the Dutchman at the end of the season.
Southgate is due to be out of contract later this year, with suggestions that the upcoming European Championship finals will be his last tournament as Three Lions chief.
However, amid the talk over where he could end up later this year, the 53-year-old is not looking beyond the Euros.
"I've got one thing to focus on, and that's having as successful a tournament with England as possible," he told ITV News.
"Everything else outside of that is a complete irrelevance to me."
Asked specifically about the United links in a separate interview with BBC Sport, Southgate said: "There will always be speculation about managers.
"If you lose a couple of games, you're in trouble - you win a couple of games and it is a different agenda.
"But for me, [Euro 2024] is a brilliant opportunity. We're looking forward to the tournament. My focus is on how do we go a step further than we went in the last Euros."
Southgate has been England boss since 2016 and previously hinted he contemplated stepping down after the World Cup quarter-final loss to France in December 2022.
Despite the fact his deal expires in the next six months, Southgate insists that is not a concern ahead of the Euros in Germany.
"It's not an issue and never has been," Southgate said. "I have to deliver a successful tournament for England and there's enough work involved in that.
"I think everybody would expect that's where my focus should be."
All Blacks captain Cane to retire from international rugby
New Zealand captain Sam Cane has announced he will retire from international rugby at the end of 2024, having agreed a three-year contract with Japan Rugby League One team Tokyo Sungoliath.
Cane made his All Blacks debut in 2012 and has represented his country 95 times, including through the team's triumphant run at the 2015 World Cup.
The flanker succeeded Kieran Read as captain in 2020, though his most recent international outing ended with him suffering the ignominy of becoming the first man to be sent off in a Rugby World Cup final, as New Zealand were beaten by South Africa last year.
Cane will be eligible to represent the All Blacks through the second half of 2024 after returning from an initial spell in Japan but will then head there permanently after New Zealand Rugby agreed to release him from his contract.
"A good opportunity came my way with Sungoliath willing to offer me a three-year contract," Cane said. "I had to weigh up everything and, in the end, with a young family it seemed like the best decision to help set us up for our future.
"I had my time as captain and it was a huge honour and privilege. If I'm fortunate enough to be selected for the All Blacks this year then I'll still be myself.
"I love that team, and if part of my role is contributing leadership-wise, I'll be happy to support the new captain as best I can to help with a speedy transition."
Broad fears for inexperienced England bowling attack after Anderson retirement
Stuart Broad fears an inexperienced England bowling attack could be exposed to problems after James Anderson announced his Test retirement decision on Saturday.
England's all-time leading wicket-taker Anderson will end his remarkable red-ball career after the first Test against West Indies on July 10.
Anderson has taken 700 wickets in 187 Tests, the most by any pace bowler in history, but the 41-year-old will play for a final time after Brendon McCullum signalled a change of plans for the future.
Matthew Potts, Brydon Carse, Josh Tongue and Gus Atkinson are all potential replacements, though Broad remains concerned for Ben Stokes' bowling options going forward.
"England could easily go into a Test match this summer with a very, very inexperienced bowling group," Broad told Sky Sports Cricket podcast.
"If you don't play a [Chris] Woakes, Mark Wood has a rest and there's no Jimmy Anderson, you could have three seamers and a spinner out there potentially with 20 caps between them.
"That's quite scary as a Test captain I would have thought. We don't know how much [Ben] Stokesy's going to bowl – we hope he does.
"But that could leave you a bit exposed. There's only one way to find out with bowlers, and that's to give them a go."
Anderson's opening-bowler partner Broad retired after last year's Ashes, having finished his illustrious career with 604 Test wickets.
Having neither of the pair available to lead the line with the red ball in future may pose problems and Broad reiterated his concern over the gaping gap Anderson's retirement will leave.
"There's going to certainly be a huge hole left by Jimmy Anderson that someone is going to have to step into," he added.
"And not just by swinging the new ball. But by communicating, by keeping calm if the boundaries are leaking, by tactically being aware of what field works at certain grounds, pitches and times of Test matches.
"Ultimately, you don't learn that unless you're thrown in."
Broad, however, remains hopeful that Stokes and McCullum will find the right combinations to take England into a new era of Test cricket.
"I think exposure for some bowlers now is really important, because there's talent out there," Broad continued.
"There's bowlers out there that need a bit of exposure to see what it's about in Test match cricket.
"They may need time to adjust their training plan and how they operate before a tour in two years' time."
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