Serena Williams will face Danka Kovinic in the first round as the American great begins her final US Open campaign.
It will be a final grand slam for 40-year-old Williams, who has won six singles titles in New York and been a runner-up on four occasions.
Her first singles crown in a major came as a 17-year-old at Flushing Meadows, when she beat Martina Hingis in the 1999 final.
Now the end of a glorious career is beckoning for the 23-time singles major winner, who has also landed 16 doubles grand slam titles.
Kovinic is the world number 80 from Montenegro, with the 27-year-old having only won two matches at the US Open in four previous main-draw appearances.
The winner of that match will likely face Estonian second seed Anett Kontaveit in round two. Kontaveit's first-round opponent will be Romanian Jaqueline Adina Cristian.
Defending champion Emma Raducanu, who was a shock winner last year, faces a tricky first-round assignment against France's Alize Cornet.
Cornet is the tour veteran who beat Iga Swiatek at Wimbledon, ending the Pole's 37-match winning streak, and this will be her 64th consecutive grand slam appearance, a record for WTA Tour players.
World number one Swiatek starts against Italian Jasmine Paolini and could face 2017 US Open champion Sloane Stephens in round two.
Former champion Naomi Osaka, unseeded this year, was paired with Danielle Collins, the 19th seed who was an Australian Open runner-up at the start of the year.
The tournament gets under way on Monday.
Men's defending champion Daniil Medvedev faces American Stefan Kozlov in his opener, while Rafael Nadal, who has not lost a grand slam match all year, faces Australian wild card Rinky Hijikata.
Nadal won the Australian Open and French Open titles before pulling out of Wimbledon ahead of his semi-final against Australian Nick Kyrgios due to an abdominal tear.
That handed Kyrgios a bye through to face Novak Djokovic, who got the better of the Australian, but the Serbian must miss the US Open because his refusal to be vaccinated against the COVID-19 virus meant he would not be allowed to enter the United States.
Djokovic's absence was confirmed shortly before the draw was revealed.
Fast-rising Spanish teenager Carlos Alcaraz begins against Argentina's Sebastian Baez, while fourth seed Stefanos Tsitsipas will face a yet-to-be-determined qualifier.
Jarry defeats Paul to set up Zverev showdown in Italian Open final
Nicolas Jarry defeated Tommy Paul in three sets on Friday to set up a showdown with Alexander Zverev in the Italian Open final.
The men's world number 24 prevailed 6-3 6-7 (3-7) 6-3 in a little under three hours in Rome to reach his first ATP Masters 1000 final.
Jarry earned the only break of serve in the eighth game of the opening set, but Paul - who dropped just one set in four matches en route to this stage - hit back in the second.
Birthday boy Paul lost serve to trail 4-2 at one stage, but he produced one of the shots of the tournament at the ideal moment and soon dragged it back to 4-4.
A gruelling set concluded with Paul taking the tie-break 7-3, but Jarry was unperturbed and won the deciding set with his fifth match point to see off Paul in a gruelling contest.
Data Debrief:
Jarry is the third male Chilean in the Open Era to reach the singles final of the Italian Open after Marcelo Rios (1997-98) and Fernando Gonzalez (2007).
The 28-year-old registered 13 aces against Paul to his opponent's seven and hit 35 winners to 19 in a deserved victory.
Zverev ends Tabilo's dream run to reach Italian Open final
Alexander Zverev fought back from the brink to reach the Italian Open final on Friday, overcoming Alejandro Tabilo by a 1-6 7-6 (7-4) 6-2 scoreline in the last four.
Zverev was punished for a slow start as Tabilo took the opener within 32 minutes, but the German fought back in a one-hour, 15-minute slog of a second set.
The 2017 Italian Open champion put his foot down from 3-3 in the second-set tie-break, with Tabilo potentially feeling the effects of a fine run that included a last-32 upset of Novak Djokovic.
Zverev upped the intensity in the final set and won a huge 94 per cent of points behind his first serve as his opponent wilted, the third seed reaching the Rome final for a third time.
Data Debrief: Zverev draws level with Becker
Zverev will now face either Nicolas Jarry or Tommy Paul in Sunday's final, which will be his 11th at ATP 1000 Masters level.
That tally pulls him level with Boris Becker for most such finals by a German player since the format's 1990 introduction.
Sabalenka defeats Collins to set up Swiatek rematch
Aryna Sabalenka defeated Danielle Collins 7-5 6-2 to set up yet another meeting with Iga Swiatek at the Italian Open.
Having defeated Collins en route to the final of the Madrid Open, which she lost to Swiatek, Sabalenka repeated the trick with a straight sets win over the American in Thursday's semi-final.
And the Belarusian's reward will be an immediate rematch with Swiatek.
The duo have met 10 times, including in Madrid earlier this month, with Swiatek winning seven times and Sabalenka claiming three victories.
This will be Sabalenka's first appearance in the Italian Open final.
She is the sixth player, along with Simona Halep (2017), Dinara Safina (2009), Serena Williams (2013), Ons Jabeur (2022), and Swiatek (2024) to have reached the final of both Madrid and Rome in the same season.
Data Debrief: Perfect record
Collins is the only player against whom Sabalenka has registered six wins without a loss in WTA events, while only against Maria Sakkari and Elise Mertens does she have more wins in her career in such events (seven each).
The final will mark the fourth meeting on clay between Swiatek and Sabalenka as world number one and two, equalling Chris Evert and Martina Navratilova for the most meetings on the surface as the WTA's top-two ranked players.
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