Phil Foden scored twice as Manchester City leapfrogged Liverpool and kept the Premier League title race in their own hands by thrashing Brighton 4-0.
Foden moved onto 16 league goals for the season with a first-half brace at the Amex Stadium, seeing a free-kick deflect past a wrongfooted Jason Steele before stroking home after some reckless play from the Seagulls.
De Bruyne had earlier given City the lead with what was his 68th Premier League goal but the first with his head, as Pep Guardiola's men made light of Erling Haaland's injury-enforced absence.
Julian Alvarez added a fourth as City pulled two points clear of Liverpool and within one of Arsenal with a game in hand, knowing five further wins will guarantee they retain their crown.
Brighton, meanwhile, stay in the bottom half with 44 points, having been surpassed by Bournemouth on Wednesday.
Nathan Ake could not keep his shot down when presented with the first half-chance after a low-key start, but City went ahead with a brilliant goal after 17 minutes.
Foden slipped Kyle Walker in on the right flank, and De Bruyne watched the full-back's cross all the way before sending a wonderful diving header into the top-right corner.
There was more fortune about City's second, which arrived just nine minutes later as Foden's free-kick deflected in off Pascal Gross amid Brighton complaints about how Foden won the set-piece.
Brighton only had themselves to blame when Foden got his second after 34 minutes, though. Valentin Barco conceded possession cheaply on the edge of his area, and Foden swept the loose ball into the bottom-left corner.
Ederson denied Joao Pedro as Brighton improved in the second half, but City had further daylight just after the hour mark, Walker breaking in behind and beating Steele to a loose ball, with Alvarez on hand to turn home.
Brighton were enraged when Josko Gvardiol avoided conceding a penalty for a clumsy challenge on Pedro, who skewed wide late on as City – who went close to a fifth through Jeremy Doku late on and face struggling Nottingham Forest next – claimed a statement win.
Foden's star still rising
Foden has emerged as the favourite to be crowned Premier League Player of the Season, and he has gone up a gear in the run-in, also scoring a hat-trick on his last league appearance when City thrashed Aston Villa 4-1 earlier this month.
He was in imperious form again on Thursday, even if Brighton's fans were not happy with the way he went down for the free-kick that ultimately resulted in his first goal.
That strike was Foden's 50th in the Premier League, making him just the third player to score 50 top-flight goals under Guardiola while aged 23 or younger, after Lionel Messi and Erling Haaland.
It is no wonder Brighton's fans are sick of the sight of the England man; he has eight goals in his last eight Premier League appearances against the Seagulls, more than he has scored against any other club in the competition.
Seagulls' wings clipped
Hampered by injuries to the likes of Pervis Estupinan, Kaoru Mitoma and Evan Ferguson, Brighton have seen their European hopes falter in recent weeks and now appear to be limping to the finishing line.
Roberto De Zerbi's team are winless in their last five Premier League games (two draws, three defeats) and sit six points adrift of the top seven with matches against Bournemouth, Aston Villa, Newcastle United, Chelsea and Manchester United to come.
Brighton have even seen their supply of goals dry up, scoring just four times in eight league matches since thrashing Sheffield United 5-0 in February.
'It hurts to lose' - Inzaghi apologises after Sassuolo defeat
Simone Inzaghi admits "it hurts to lose" following Inter's surprise 1-0 defeat by relegation-threatened Sassuolo.
The newly crowned Scudetto winners suffered only their second loss of the season in Serie A, as Armand Lauriente's first-half goal was enough to give the 19th-place hosts victory at Mapei Stadium.
Sassuolo, who boosted their survival hopes, subsequently completed the league double over the Nerazzurri, having also prevailed 2-1 at San Siro in September.
Meanwhile, Inter were beaten by a team in the bottom two for the first time since November 2014, with Inzaghi urging his players not to be distracted by their title triumph.
"We started sluggish and didn’t have the right approach to the game," he told Sky Sports Italia. "I'm sorry for the defeat, but credit must be given to Sassuolo for a performance of great effort and sacrifice.
"It's right to enjoy [our Scudetto victory], but there are still three games to go and we have to focus. It hurts to lose, and it should hurt."
After guiding Inter to their 20th Serie A crown, Inzaghi is hopeful he can keep the majority of his squad intact ahead of next season.
However, the Nerazzurri boss did emphasise the club's need to strengthen before launching their Scudetto defence.
"I already told the club that I want to go into next season with all the players I had this term, not losing a single one," he said. "Considering all the games we need to play and the length of the season, we do need a bigger squad."
Inter Miami 6-2 New York Red Bulls: Messi makes more MLS history as Suarez scores hat-trick
Lionel Messi had a hand in all six goals while Luis Suarez scored a hat-trick as Inter Miami overcame the New York Red Bulls 6-2 at Chase Stadium.
The Eastern Conference leaders were on a three-match winning streak in MLS, but fell behind to Dante Vanzeir's opener in the 30th minute.
However, the hosts turned the match on its head after the break, with Messi assisting a brace for half-time substitute Matias Rojas either side of getting on the scoresheet himself.
Suarez then took centre stage with a hat-trick inside 13 minutes - all assisted by his former Barcelona team-mate - while Emil Forsberg's stoppage-time penalty was a mere consolation for the visitors, who are now without a win in four.
Data debrief
Messi broke two more MLS records following yet another inspirational display for the Herons.
The eight-time Ballon d'Or winner's six goal contributions and five assists were both the most recorded by a player in a single game.
Haaland pinpoints collective Man City quality after four-goal blitz of Wolves
Erling Haaland blasted four goals past Wolves in a one-man Premier League show but the Manchester City forward says it would not be possible without manager Pep Guardiola or his team-mates.
The City talisman took his top-flight tally to 25 for this season, moving five clear of his nearest challenger in the Premier League Golden Boot race, after Saturday's 5-1 thrashing of Wolves.
Haaland was twice on target from the penalty spot as part of his first-half hat-trick, adding another after the interval with an arrowed strike into the top-left corner.
It was the first time the Norway star has managed four goals in one Premier League game, with his quartet of strikes coming in 54 minutes. Only Gabriel Jesus has scored as many earlier in one match, doing so in 53 minutes against Watford in April 2022.
Haaland also became the third player to score multiple first-half hat-tricks in Premier League history (also against Nottingham Forest last season), along with Andrew Cole and Michael Owen (two each).
Yet the superstar attacker says his exploits would not be possible without his City colleagues or boss Guardiola.
"I've got a not-too-bad manager who pushes me and look at the players around me," Haaland told Sky Sports when asked about his motivations.
"Without them, it would not be possible. Look ahead, look to next one – four finals left for the season. We're going to go for it and focus on Fulham."
It was Haaland's sixth Premier League hat-trick for City, with only seven players netting more in the competition’s history. All six of those trebles have been at the Etihad, only three have more at a single venue.
Haaland's second strike came from a towering header following Rodri's right-wing centre, which he suggested would delight his father Alfie.
"That's a beautiful goal," the Norwegian said of his headed finish. "My father is going to be happy with that one.
"A nice celebration, I enjoyed that one. I'm scoring more headers, I try to develop and keep going."
City are within a point of Premier League leaders Arsenal and Guardiola's side still have a game in hand against Tottenham on May 14.
Despite the thrashing of Wolves, Haaland insists Guardiola remains intent on winning the remaining games, rather than calculating the probabilities needed on goal difference.
"First of all it's about winning the games but, of course, you want to have the best possible goal difference," he added. "Let's not think about that. Think about Fulham."
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