Manchester United goalkeeper David de Gea has been left out of the latest Spain squad by Luis Enrique, while Barcelona's Sergio Busquets is "rested".
La Roja play friendlies against Albania and Iceland during the upcoming international break, and Luis Enrique has replaced De Gea with another goalkeeper from the Premier League, Brentford's David Raya.
From the previous squad for the final World Cup qualifiers in November, in defence, Inigo Martinez and Jose Luis Gaya are replaced by Diego Llorente and Marcos Alonso, while Marcos Llorente and Pedri come in as midfield options in place of Busquets and Mikel Merino.
Raul de Tomas and Ferran Torres are selected among the forwards, with no place for Rodrigo, Pablo Fornals or Brahim Diaz.
Speaking at a media conference after the squad announcement, Luis Enrique said that Busquets' omission was merely to keep him fresh. The 33-year-old has played 39 games in all competitions for Barca this season.
"In the case of Busquets, it is a personal decision," he confirmed. "He is the player who accumulates the most minutes and I want to have the best version of the captain for the games in June, and I have decided to rest him.
"He is having a spectacular season."
The Spain head coach also said the two upcoming fixtures should not be treated like friendlies, and challenged his squad to show their "ambition" and "hunger" as the World Cup at the end of the year draws closer.
He added: "Since November, the wait has been long [to play again]. They are not friendlies for the players nor for us because the World Cup is close. It will help me to see the level of the players, their ambition, their hunger."
Spain squad in full:
Unai Simon, Robert Sanchez, David Raya; Marcos Alonso, Jordi Alba, Aymeric Laporte, Pau Torres, Eric Garcia, Diego Llorente, Cesar Azpilicueta, Dani Carvajal; Rodri, Koke, Pedri, Marcos Llorente, Gavi, Carlos Soler; Dani Olmo, Pablo Sarabia, Alvaro Morata, Raul de Tomas, Ferran Torres, Yeremy Pino.
Villa secure Champions League qualification after Spurs defeat to Man City
Aston Villa will play in Europe's top continental competition for the first time in 41 years next season after qualifying for the Champions League.
Tottenham's 2-0 defeat to Manchester City on Tuesday sealed Villa's fourth-place finish in the Premier League.
Unai Emery's side have not played in UEFA's premier club competition since the 1982-83 season, when they suffered quarter-final elimination to Juventus in the European Cup.
Villa were knocked out of the Europa Conference League in the semi-finals this term by Olympiacos, but will now have their eyes on Europe's top prize in the Champions League next campaign.
Rangers 5-2 Dundee: Cantwell and Wright keep Celtic's title party on hold
Rangers kept Celtic's Scottish Premiership celebrations on ice after Todd Cantwell and Scott Wright inspired a remarkable turnaround to hammer Dundee 5-2 at Ibrox Stadium on Tuesday.
Philippe Clement's side could not afford to drop points in this clash and seemed set to do so after Jordan McGhee bundled home before Antonio Portales headed past Jack Butland in the first half.
Ross McCausland managed to slice the deficit on the stroke of half-time for the hosts, sliding in to convert from Leon King's cross and teeing up a monumental comeback.
The Ibrox crowd were offered further inspiration to keep the title race alive when Cyriel Dessers glanced in from Cantwell's delivery after 52 minutes.
Former Norwich City midfielder Cantwell's fortuitous cross then dipped over Jon McCracken as Rangers hit the front for the first time, before Wright's pair of late finishes sealed the much-needed three points.
Yet this Rangers salvaging act could still matter for little, with Celtic requiring just a point away to Kilmarnock on Wednesday to seal a third successive top-flight trophy.
Data Debrief: Attacking barrage pays dividends
Clement may apportion this victory to Rangers' unrelenting desire to keep the title race ongoing, blasting 31 shots – and 13 of those on target – at the Dundee target for their 3.34 expected goals (xG) tally.
A plethora of attacking opportunities must be credited to star man Cantwell, who created a game-leading six chances – four more than any other Rangers team-mate.
Hayes enjoying tense WSL title race as Chelsea stint winds down
Emma Hayes is determined to enjoy the thrill of a title race going to the wire in her final days as Chelsea boss.
Following their defeat to Barcelona in the Champions League, Chelsea's hopes of winning a trophy to mark Hayes' final season in charge looked slim heading into the run-in of the WSL season.
Yet Manchester City's defeat to Arsenal, combined with an 8-0 victory for Chelsea over Bristol City last time out, has left the Blues in with a great chance.
With the goal difference having swung in Chelsea's favour, victory over Tottenham on Wednesday would see Hayes' team go into the final day of the WSL season in top spot.
And while the pressure is on, Hayes is eager to have fun as she soaks in her final matches of a 12-year tenure.
"I'm going to enjoy being in this position," Hayes said.
"You don't often get into a position where you are competing for a title going into the last two games of a season. For those of us who have won titles, we know how hard it is.
"I’m happy to be in the position we're in. I know we have two tough games but I'm looking forward to them.
"You can't win everything all of the time. But to be in a position to compete for our fifth title in five years, I'd like to see another team do that over the next five years. The reason I say that is nobody really understands how hard that is to keep winning.
"To be in a position to compete for that, that’s all I wanted the team to be in. I just want them to enjoy the next two games."
Tottenham have lost all eight of their WSL games against Chelsea by an aggregate score of 20-5, with the Blues the only team Spurs have never won at least a point against in the competition.
Chelsea, meanwhile, have lost three games in the WSL this season, their most since also recording three defeats during the 2016 campaign.
After facing Spurs, Chelsea round off their season with a trip to FA Cup winners Manchester United, while City take on Aston Villa in their final game.
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