Lionel Messi has tested positive for COVID-19, Paris Saint-Germain have announced.
The Argentine forward and seven-time Ballon d'Or winner will miss the Coupe de France game against Vannes on Monday as a result.
French giants PSG said Juan Bernat, Sergio Rico and Nathan Bitumazala had also tested positive.
"They are currently in isolation and are subject to the appropriate health protocol," the Ligue 1 leaders announced on their website.
Head coach Mauricio Pochettino is expected to field a young side in the domestic cup game, with Neymar also unavailable as he continues to recover from an ankle injury.
PSG said Neymar would continue to be treated in Brazil for another week. "His return to training is still expected to be in about three weeks," the club said.
Pochettino said in a news conference: "We have been living with the virus for two years now, and I think we all know we need to avoid it.
"But it is a virus we have been living with for a long time and there is still a lot that we do not know about how it works.
"Leo Messi has been in regular contact with our medical team and when he has a negative test he will travel to France, and we do not know any more than that."
PSG play their first Ligue 1 game of 2022 against Lyon next Sunday, but with former Barcelona captain Messi currently in Argentina he appears to be a significant doubt for that fixture.
"I do not know if he will be involved against Lyon," Pochettino said. "Until Leo Messi gets a negative test in Argentina, he will not be able to travel to France.
"It is all down to the test in terms of when he can travel. When he does, we will assess when he is ready to play."
Giroud leaving Milan to join MLS at end of season
Olivier Giroud announced he will be leaving Milan to join the MLS at the end of the season when his contract expires.
The Frenchman joined the club in July 2021 from Chelsea, winning the Serie A title in his first season.
Giroud has scored 48 goals in 130 games in all competitions for Milan, netting 16 of those this season to help them to a second-place finish.
In an emotional interview with the club’s media channels, Giroud said: "I'm here to tell you that the next two games will be my last for Milan. My career will continue in MLS.
"I'm very proud of everything I've done here at Milan across three seasons. It's the right time to announce it. I'm a bit emotional. My story with Milan ends this season, but Milan will forever remain in my heart."
Though Giroud did not confirm which team he would be joining in the MLS, previous reports suggested he could be moving to LAFC to link up with his France international team-mate, Hugo Lloris.
Giroud leaving Milan at end of season to join MLS
Olivier Giroud announced he will be leaving Milan to join the MLS at the end of the season when his contract expires.
The Frenchman joined the club in July 2021 from Chelsea, winning the Serie A title in his first season.
Giroud has scored 48 goals in 130 games in all competitions for Milan, netting 16 of those this season to help them to a second-place finish.
In an emotional interview with the club’s media channels, Giroud said: "I'm here to tell you that the next two games will be my last for Milan. My career will continue in MLS.
"I'm very proud of everything I've done here at Milan across three seasons. It's the right time to announce it. I'm a bit emotional. My story with Milan ends this season, but Milan will forever remain in my heart."
Though Giroud did not confirm which team he would be joining in the MLS, previous reports suggested he could be moving to LAFC to link up with his France international team-mate, Hugo Lloris.
Beckham: Man Utd's problems have lasted 'too long'
David Beckham believes Manchester United’s issues have lasted "too long" since Alex Ferguson’s retirement in 2013.
The Red Devils have won just four major trophies since Ferguson’s departure, with their most recent – an EFL Cup win last season – ending a six-year wait for silverware.
United have not won a Premier League title since the Scot’s final season in charge, with six managers failing to reclaim the top-flight crown since then.
This season, Erik ten Hag’s side are at risk of recording their lowest league finish and points tally, as they sit eighth on 54 points with two games remaining.
Beckham, who won 13 trophies, including six Premier League titles and the Champions League, told The Athletic: "I think it has been a difficult time over the last five or ten years, but it was always going to be when the boss left the club.
"It wasn’t just that, we lost players like Ryan Giggs, Roy Keane and Gary Neville, all of these players that had been at United for so long; you lose part of that, and you lose part of the club.
"So it was always going to be a difficult time. But we’d like it to change pretty quickly because I think it’s gone on for too long now."
United have lost 19 games in all competitions this season, their most since 1977-78 (also 19), with nine of those coming at Old Trafford – their joint-most at home in a season and the first time it has happened in the Premier League.
Their 1-0 defeat to Arsenal on Sunday marked the first time they had conceded in 10 successive games in all competitions since October 2021, while the 82 goals they have let in this season is their most since 1970-71 (also 82).
Beckham was speaking at the premiere of 99, the Amazon Prime documentary covering United’s iconic treble-winning season 25 years ago.
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