Juventus dominated throughout but were held to a 1-1 draw at home to Nantes after Ludovic Blas scored a priceless equaliser in the Europa League play-off.
Massimiliano Allegri's side fell into this competition after a dire Champions League campaign, finishing third in Group H, but looked good value for their early first-leg lead on Thursday.
Dusan Vlahovic tapped home after 13 minutes at Allianz Stadium, only for Blas to finish a flowing counter-attack in the second half before Juve were left aggrieved after a late VAR check deemed Andrei Girotto had not handled for a penalty in the dying minutes.
That left it all to play for in the return meeting at Beaujoire Stadium on February 23 after a wasteful Juve offered Nantes the chance for a memorable European night at home.
Angel Di Maria stung the palms of Alban Lafont with an early drive and Nantes did not heed the opening warning signs from Argentina's World Cup winner.
A delicate Di Maria chipped pass found Federico Chiesa to selflessly nod across for Vlahovic to convert from point-blank range.
Lafont parried another ferocious Di Maria long-range effort as a tepid Nantes were fortunate to head in at half-time just a goal down.
A clinical counter-attack drew Nantes level on the hour as Blas capitalised on Bremer's slip to race onto Mostafa Mohamed's pass and fire past Wojciech Szczesny.
Chiesa rattled the crossbar and Lafont's left post with a venomous left-footed strike that somehow bounced off the line and away from goal as Juve looked to respond.
Danilo blazed over on the volley before Girotto was deemed not to have handled when challenging a late Bremer headed chance, with the referee awarding a free-kick for a push on Girotto instead, leaving it all to play for in France next week.
What does it mean? Juve falter in rare Europa League appearance
Juve had played their last 84 matches in European competition in the Champions League, as has been their dominance in recent years on the continent.
On their first appearance in the Europa League since reaching the 2013-14 semi-finals, Allegri's side failed to make their superiority count and were punished for a profligate outing.
Any hopes in Serie A have diminished due to their points deduction, therefore Juve need to recover in the return leg as a run in Europe or April's Coppa Italia semi-final against Inter could be their only hope of salvaging a positive season.
Chiesa and Vlahovic finally link-up again
Star Juve attackers Chiesa and Vlahovic have rarely played together due to injuries hampering the pair this season, but Allegri will be delighted to see them together once more.
The duo linked up in ruthless fashion for the opening strike, just their second combination together for a goal – the other coming in August 2019 when Vlahovic assisted Chiesa for former side Fiorentina.
Lafont leads the way
Lafont produced a captain's performance as Nantes battled with their backs against the wall to keep their hopes alive in this two-legged affair.
While the majority were far from eye-catching, the France goalkeeper made six saves in a vital performance to stave off Juve's prolonged periods of pressure.
What's next?
Juventus return to Serie A action at Spezia on Sunday, when Nantes travel to Lens in Ligue 1.
Onana willing to take Man Utd criticism 'bullets'
Andre Onana says he is willing to take criticism "bullets" after a poor Premier League campaign for Manchester United.
The Red Devils recorded their lowest-ever finish in eighth place, with the manager and players coming under scrutiny for some of their performances.
One of those singled out was Onana, who joined United from Inter at the start of the season, after an error-strewn start to his life at the club.
Asked how he deals with the criticism coming from fans, pundits, and former players, Onana said it does not bother him.
"For me, I don't pay attention to it. I have come into this team to take bullets because we are under construction – at the moment, we are not the best," he told the Overlap.
"We have other teams who are doing better than us, and we have to be honest and recognise that. If things and when things are going wrong, don't go for the youngest player – I'm here to take it, Bruno [Fernandes], Casemiro and Harry [Maguire] are there, and we are used to it.
"When it's people who were sitting where I'm sitting, who won everything, sometimes it's bizarre – we are in the same boat. We try to follow your thing and what you did. For me, I don't mind, but other people may be affected. For me, to be honest, it's just a part of the game."
United conceded 84 goals in all competitions this season, their worst-ever tally in a single campaign.
Erik ten Hag’s side also missed out on a European place due to their league finish but have another opportunity to get one if they beat Manchester City in the FA Cup final on Saturday.
Onana is optimistic though as he views the season as a learning curve.
"I'm happy because we have good people around us, especially at this club, who helped me so much," he added.
"That's why I'm still smiling - because the first six months were difficult, but at the same time, it was a good moment to learn.
"After playing the final of the Champions League and the final of the Europa League, you think you are the best – life gives you an opportunity to learn and says, 'You are never too big'.
"You can have a good season, next year you have a bad season, but the year after an amazing season. The ups and downs and being here, you have to deal with them – especially being a goalkeeper."
Howe taking plenty of positives despite frustrating Newcastle campaign
Eddie Howe was keen to look at the positives after Newcastle United secured seventh place in the Premier League on Sunday.
Alexander Isak and Bruno Guimaraes were among the goalscorers as Newcastle won 4-2 at Brentford to finish their Premier League campaign.
The victory ensured a seventh-place finish, and a Manchester City victory over Manchester United in next Saturday's FA Cup final will confirm Newcastle's place in next season's Europa Conference League.
While this season did not quite live up to the heroics of last term, which saw the Magpies finish in the Champions League spots, Howe still feels it has been a successful campaign.
"It summed up our season," Howe told BBC Sport. "We weren't totally secure at the back, but great credit to the players. They've done their job - now we wait and see.
"We anticipated after losing against Manchester United that our control of the [European] situation had gone. It's never a nice situation, but whatever happens, happens.
"We have issues to solve defensively. If we can do that, next season could be another season of really strong performances. This was a season that could have been better, but a good season overall.
"We're a really united club. I think we're still moving forward, so there's a lot to be positive about."
Postecoglou will not settle until Tottenham hit his 'lofty ambitions'
Ange Postecoglou warned Tottenham he will not settle until the club hits the "lofty ambitions" targeted in his mind.
Spurs were 3-0 victors over Sheffield United at Bramall Lane on Sunday, ending their Premier League season with a convincing win to finish fifth in the table.
Postecoglou voiced his frustrations after Tuesday's 2-0 defeat to Manchester City ended their hopes of Champions League football next term.
The Spurs head coach was far more relaxed after his side performed well in Sheffield, with Dejan Kulusevski twice on target, along with a goal for Pedro Porro against the relegated Blades.
Yet Postecoglou insisted his ambitions remain high as the Australian attempts to take Tottenham to the next level.
"Contrary to my general demeanour, I have loved every minute of it," former Celtic boss Postecoglou said of his first season in charge of Tottenham.
"It is a great challenge in the Premier League and taking over a big club that didn't have a great year last year. You understand it is not going to run smoothly, but I have enjoyed the whole season.
"I have got some lofty ambitions for the football club and until we reach that point I am not going to be smiling too much.
"As I said, all any manager wants is maximum effort and I have got that from everyone involved. I have enjoyed it and looking forward to pushing on from here."
Asked to summarise his first campaign in England's top league, Postecoglou continued: "It's been good, it's been eventful, it's had a bit of everything.
"I am obviously not delighted with the way we finished the season but in fairness to the players and staff we have been in the top five all season, in a year where there was a fair bit of upheaval.
"We finished eighth last year, player turnover, different football, different way of training, it is not easy to maintain a level when you are trying to do that.
"Even in our tough periods this year we have still been competitive for the most part."
Kulusevski scored his seventh and eighth Premier League goals of the season (36 outings), more than he managed in his first two league campaigns with Tottenham combined (seven across 48 games).
Only in the 2019-20 season with Parma has the Sweden winger scored more times in a league season (10 in Serie A), and Postecoglou hailed Kulusevski's returns.
He added: "I thought Deki was good. He's worked awfully hard this year without a lot of reward in the front third.
"We thought playing him through middle today would help us with his mobility and ability to run in behind. He did well.
"He always works hard but it's that sort of final third where we need him to get rewards and he got them today so he did well."
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