Benfica could dump Juventus out of the Champions League, while Paris Saint-Germain and Chelsea are among the other clubs who can seal a round-of-16 spot on Tuesday.
Juve must win at Benfica to have any chance from qualifying from Group H, while a victory will be enough to see the home side through. They can also advance with a point if Maccabi Haifa are unable to beat PSG.
The Ligue 1 champions will be through with a victory at the Parc des Princes or if they draw and Juve fail to win in Lisbon.
Chelsea travel to Salzburg as the Group E leaders and are guaranteed to progress if they win, while the Austrian side also remain in the hunt to qualify. The Premier League club can also go through if they draw and third-placed Milan defeat Dinamo Zagreb, who are bottom but only three points behind the leaders.
Borussia Dortmund will be sure to join Manchester City in getting out of Group G if they secure a home win over Pep Guardiola's side, who could win the pool with a game to spare. Real Madrid are in a similar situation to City, while RB Leipzig bid to join the holders in the knockout stage.
Ahead of another tense night of action, Stats Perform picks out the standout Opta numbers for the eight matches.
Benfica v Juventus
Juve have lost all three of their European matches away at Benfica, with their most recent loss a 2-1 Europa League defeat in 2014.
The Turin giants only have one victory home or away in the seven previous meetings between the two famous clubs, Jurgen Kohler, Dino Baggio and Fabrizio Ravanelli on target in a 3-0 UEFA Cup clash in 1993.
Benfica could qualify for the knockout stage for a second consecutive season, a back-to-back feat they have only previously achieved in the 2015-16 and 2016-17 seasons under Rui Vitoria.
Juve could be eliminated in the group stage of the Champions League for the first time since the 2013-14 season, when Antonio Conte was in charge.
Paris Saint-Germain v Maccabi Haifa
Maccabi are winless in three away European games (including qualifiers) in France, losing two and drawing in a Cup Winners' Cup tie at PSG back in 1998.
PSG have only lost one of their past 32 group stage games at the Parc des Princes in the Champions League (W25 D6), with their lone defeat during that run coming against Manchester United in October 2020 (1-2). They have averaged 2.7 goals per game in those fixtures, scoring 86.
Since Kylian Mbappe's Champions League debut in September 2016, only Robert Lewandowski has been directly involved in more non-penalty goals (55) than the France forward (54 – 34 goals, 20 assists).
Omer Atzili has scored twice for Maccabi in the Champions League this season. The last Israeli player to net more in a single campaign in the competition was Eran Zahav, who scored three for Hapoel Tel Aviv in 2010-11.
Salzburg v Chelsea
Chelsea have only played two away European matches in Austria, losing 1-0 at Weiner Sport-Club in November 1965 in the Fairs Cup and drawing 1-1 against Austria Vienna in November 1994 in the Cup Winners’ Cup.
Salzburg are winless in all seven of their European matches against English teams (D2 L5), failing to beat Blackburn Rovers (D1 L1), Manchester City (L2), Liverpool (L2) and Chelsea (D1).
In-form Chelsea have won back-to-back Champions League games, beating Milan 3-0 at Stamford Bridge and 2-0 at the San Siro. The last time they won three games in a row in the competition by a margin of at least two goals was in October-November 2013.
Salzburg have scored exactly one goal in each of their past seven games in the Champions League – only one team have ever had a longer run of scoring a single goal in the competition, with Olympiacos doing so in 10 in a row in a run ending in November 2005.
Borussia Dortmund v Manchester City
No player has been directly involved in more goals than City's Erling Haaland (five goals) or Dortmund's Jude Bellingham (four goals, one assist) during the group stage this season.
Dortmund have won just one of their five Champions League matches against City (D1 L3), a 1-0 home victory in the 2012-13 group stage.
No full-back has been involved in more sequences of play that have ended in shots (29) or goals (five) thans Joao Cancelo in the Champions League this season. The Portugal international has provided three assists in four games, equalling his season-best tally in a Champions League campaign (three in nine games last season).
If Haaland scores on his return to face his former club, it will be the third time he has scored in five or more consecutive appearances in the Champions League. Only five players have achieved that feat on three occasions – Cristiano Ronaldo (five), Lionel Messi (three), Lewandowski (three), Zlatan Ibrahimovic (three) and Ruud van Nistelrooy (three).
Other fixtures:
RB Leipzig v Real Madrid
13 – Madrid are unbeaten in their past 13 games against German sides in European competition (W9 D4), scoring at least two goals in every game during this run (31 in total).
3 – Leipzig will be looking to win three consecutive Champions League games for just the second time – they won three in a row between February and August 2020, beating Tottenham twice and Atletico Madrid once.
Dinamo Zagreb v Milan
5 – Dinamo have lost all five of their matches against Milan in European competition (including qualifiers). Against no side have they lost more games in their European history (also five v Ajax).
100 – Milan's 100 per cent record against Dinamo – winning five out of five games against them – is their best against any side in Europe.
Sevilla v Copenhagen
29 – The average age of Sevilla's starting line-up in the Champions League this season is 29 years and 73 days, the second-oldest of any side in the competition this term after Rangers (29 years 96 days).
13 – Copenhagen are winless in all 13 of their major European matches against Spanish teams (D5 L8), losing their last three on Spanish soil.
Celtic v Shakhtar Donetsk
7 – Celtic have lost seven of their past eight games in the Champions League (D1) and are looking for their first win in the competition since September 2017 (3-0 v Anderlecht).
0 – Shakhtar have never won a Champions League away match against a British team, losing on eight of their nine total trips. They did avoid defeat in the most recent one, however, drawing 1-1 against Manchester City in November 2019.
Al-Riyadh 2-2 Al-Nassr: Laporte sent off for punch as Al-Nemer salvages point
Former Manchester City defender Aymeric Laporte was sent off for punching Mohammed Al-Aqel on the arm as Al-Nassr played out a 2-2 draw with Al-Riyadh in the Saudi Pro League.
Meshari Al-Nemer's 97th-minute strike salvaged a point for Al-Nassr, who had trailed for over half the game and played with a one-man disadvantage for over half an hour.
Otavio had put Al-Nassr ahead only for Andre Gray to drag the hosts level, before Al-Aqel gave David Ospina no chance with a terrific overhead kick to make it 2-1.
Al-Nassr's position was put in further jeopardy when Laporte was sent off following a bizarre off-the-ball incident which saw him grab and punch Al-Aqel on the elbow, while Cristiano Ronaldo came up with a glaring miss from Sadio Mane's pass across the six-yard box.
Al-Nemer levelled at the death for Al-Nassr, though they still sit some 14 points adrift of champions Al-Hilal, who could complete an unbeaten season against Al-Wehda on Monday.
Data Debrief: Laporte's horror show
It was a game to forget for Laporte, whose bizarre punch on Al-Aqel put Al-Nassr up against it versus a team still in danger of relegation.
Laporte did not attempt a single tackle in the game while his four duels contested were the joint-fewest of every outfield starter (alongside Khalid Al-Shuwayyi). He was also sent off in Al-Nassr's AFC Champions League quarter-final tie against Al Ain in March.
Bologna confirm Motta departure with Juventus move imminent
Bologna have confirmed head coach Thiago Motta will leave the club at the end of the season, with the former midfielder expected to take over at Juventus.
Motta has overseen an incredible season for the Rossoblu, who have clinched a top-five Serie A finish and Champions League qualification with one game remaining.
He has been touted as a leading contender to succeed Massimiliano Allegri at Juventus, after he parted company with the Bianconeri in the aftermath of last week's Coppa Italia triumph.
Motta's move to Turin now appears imminent after Bologna announced he would not be extending his contract on Thursday.
"In the past two years, I have got to know a well-prepared and winning coach," club president Joey Saputo said in a statement.
"He has instilled a brilliant style of play in this time. Reaching the Champions League means he and all these players will go down in our club’s history.
"I would have liked him to stay at Bologna but I can only ever thank him and his staff for these amazing two seasons and I wish him the best for the future."
Bologna face Genoa – with whom Motta started his senior managerial career – in their final game of the season on Friday, knowing a victory will guarantee a top-four finish.
Postecoglou: There's a deadline on signing Werner
Ange Postecoglou has revealed Tottenham have a deadline if they want to make Timo Werner’s loan deal permanent.
The German joined Spurs on loan in January from RB Leipzig, scoring twice and assisting three goals in 14 matches in all competitions for the North London side.
However, Werner missed the last five games of Spurs’ season due to a hamstring injury he sustained against Arsenal.
Postecoglou admitted that he was relaxed about the situation, but whether a deal was made was out of his hands.
Speaking to reporters following their friendly in Melbourne against Newcastle United, Postecoglou said: "I think from our perspective, there's a deadline there.
"Again, a lot of that will depend on the negotiations between the clubs and how Timo feels.
"Again, from my perspective, I'm comfortable with that situation, and I'll let the other guys steer it to see what kind of outcome there is."
After a strong start to their season, Spurs eventually finished fifth in the Premier League, securing a place in the Europa League next season.
The Australian also believes the club need to bring more attacking players in as a priority to balance the higher workload next season after struggling with injuries this campaign.
"Yeah, absolutely. It's no secret [we need new forwards]. You saw the way we finished the season," he said.
"We obviously lost Richarlison and Timo Werner as well with injuries, but we're fairly light in that area.
"We started last season with Manor [Solomon] and [Ivan] Perisic, and we were quite healthy in that front third in terms of numbers, but as the year went on it became pretty evident that we needed to bulk up.
"We're in Europe as well next year, so we'll have more games, and it's definitely an area of the park we'll need to strengthen."
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