England hooker Luke Cowan-Dickie could miss the Six Nations after suffering an ankle injury.

The 29-year-old will definitely be sidelined when the Red Rose start the tournament against Scotland at Twickenham on February 4.

Cowan-Dickie sustained the injury during the second half of Exeter Chiefs' win against Northampton Saints on Saturday after scoring two tries.

Exeter director of rugby Rob Baxter told BBC Radio Devon on Tuesday: "Luke's injury looks relatively serious.

"He's seeing a surgeon today; that will maybe give us a more definitive outcome and timing."

Baxter is optimistic British and Irish Lion Baxter can still play a big part for the Chiefs before joining Montpellier at the end of the season.

He added: "It does look like an operation is going to be required but that said, at this stage, it wouldn't be a season-ending situation.

"We could still see him back for a good chunk of the season if rehab and everything goes well."

Luke Cowan-Dickie will end his England career after the Rugby World Cup next year by joining Top 14 heavyweights Montpellier.

The hooker, who has won 42 England caps and three for the British and Irish Lions, will end his 12-year spell with Exeter Chiefs to move to France at the end of the season.

Cowan-Dickie follows his Exeter team-mate Sam Simmonds in making the switch from Sandy Park to Montpellier.

"It's gutting to be leaving," said the 29-year-old, who has made 163 appearances for the Chiefs.

"I've been at the Chiefs for 12 years and it's all I've known. That said, this opportunity came up and it was one that I had to think long and hard about. I spoke a lot with my family about it and it wasn't an easy decision to make in the end.

"Obviously, it's a different competition, a different language – which I'll have to learn – but I think it's time for a change.

"Hopefully, I've still got plenty of years left in my career, but this is an opportunity for me to go over there and show what I am all about."

Fellow England international Joe Marchant has also joined the exodus of Premiership players to France, the centre opting to join Stade Francais next season from Harlequins.

England have lost Luke Cowan-Dickie for the remainder of the Six Nations due to a knee injury and Ireland prop Andrew Porter will also play no further part in the tournament.

Exeter Chiefs director of rugby Rob Baxter on Thursday confirmed Cowan-Dickie could be out for the rest of the season as he requires surgery.

The hooker did the damage in a 23-19 win over Wales at Twickenham last weekend and England forwards coach Richard Cockerill says his absence is a blow for the Red Rose in their quest to win the title.

Cockerill said: "We're disappointed for him, for Exeter and obviously ourselves. He's a really important player to the team and a leader to the group as well.

"So it's a bit of a blow to the team, but we've got cover and that's the game isn't it, players get injured, you have to deal with that and someone else gets an opportunity.

"Jamie [George] is a fantastic player; he's proven that for the last 10 years or so. He did a great job when he came on at the weekend and I'm sure he’s looking forward to doing that again."

Ireland will have to do without Porter when they travel Twickenham to face Eddie Jones' side a week on Saturday.

The prop sustained an ankle injury during the 57-6 round three rout of Italy, which left Ireland just a point behind leaders France in second place.

Ireland are hopeful centre Robbie Henshaw is passed fit to take on England after he suffered a head injury in the thrashing of the Azzurri.

George North will become the youngest player in world rugby to reach 100 caps after being named in Wales' starting line-up for Saturday's Six Nations showdown with England.

The 28-year-old, who won his first cap in November 2010, returns to the side at outside centre as one of five changes from the 25-24 win over Scotland on February 13.

Wing Josh Adams is back from suspension while Josh Navidi, Jonathan Davies and scrum-half Kieran Hardy are also included in the XV, the latter making his first Six Nations start.

Wales have won their opening two games in this year's tournament and are three points ahead of England, who beat Italy 41-18 last time out after losing to Scotland in their opener.

Eddie Jones makes two changes to the England line-up, with hooker Jamie George and flanker Mark Wilson replacing Luke Cowan-Dickie and the injured Courtney Lawes respectively.

Elliot Daly retains his place and is set to win his 50th cap for England, who have named the uncapped George Martin among their replacements for the Principality Stadium clash. 

"We know we'll be up against a strong Welsh challenge on Saturday, but we've worked really hard in training this week and have got a very good team to face it," Jones said.

"We want to show people what we are capable of, keep building our performances and show the best is yet to come from this England team."

Wales XV: Liam Williams; Louis Rees-Zammit, George North, Jonathan Davies, Josh Adams; Dan Biggar, Kieran Hardy; Wyn Jones, Ken Owens, Tomas Francis, Adam Beard, Alun Wyn Jones, Josh Navidi, Justin Tipuric, Taulupe Faletau.

Replacements: Elliot Dee, Rhodri Jones, Leon Brown, Cory Hill, James Botham, Gareth Davies, Callum Sheedy, Uilisi Halaholo.

England XV: Elliot Daly, Anthony Watson, Henry Slade, Owen Farrell, Jonny May, George Ford, Ben Youngs; Mako Vunipola, Jamie George, Kyle Sinckler, Maro Itoje, Jonny Hill, Mark Wilson, Tom Curry, Billy Vunipola.

Replacements: Luke Cowan-Dickie, Ellis Genge, Will Stuart, Charlie Ewels, George Martin, Ben Earl, Dan Robson, Max Malins.

England head coach Eddie Jones has named a new-look front row and recalled George Ford for the Six Nations game against Italy on Saturday.

The reigning champions went down 11-6 to Scotland on the opening weekend of the 2021 tournament, their first defeat to their Calcutta Cup rivals at Twickenham in 38 years. 

As he looks for a response following that setback, Jones has selected Ford at fly-half in his starting XV, meaning captain Owen Farrell switches to inside centre for the clash with the Azzurri. 

In the pack, the fit-again Mako Vunipola comes in to play opposite fellow prop Kyle Sinckler, while Luke Cowan-Dickie gets the nod at hooker ahead of Jamie George, who is on the bench. 

Courtney Lawes also gets a start at flanker, joining Tom Curry and Billy Vunipola in the back row.  

Ollie Lawrence – who was handed his first Six Nations start against Scotland – is absent from the 23-man squad entirely, with Henry Slade picked to play next to Farrell in midfield.  

"As always, we've picked what we think is our strongest 23 to try and win the game," Jones said.

"We're pleased to have Mako and Kyle back into the team and we've made some changes to our starting XV, but our finishers are just as important to our gameplan. We look at the whole 80 minutes.  

"We've trained very well this week, I've been very pleased with the players' attitudes and work-rate. We're hoping to put on a good performance on Saturday and kick on with our Six Nations campaign." 

England team to face Italy at Twickenham:

Elliot Daly, Anthony Watson, Henry Slade, Owen Farrell (captain), Jonny May, George Ford, Ben Youngs; Mako Vunipola, Luke Cowan-Dickie, Kyle Sinckler, Maro Itoje, Jonny Hill, Courtney Lawes, Tom Curry, Billy Vunipola

Replacements: Jamie George, Ellis Genge, Will Stuart, Charlie Ewels, Ben Earl, Jack Willi, Dan Robson, Max Malins.