Andy Murray's stay in San Diego was short-lived, as the veteran fell to second seed Casper Ruud in straight sets Thursday. 

World number 10 Ruud prevailed 7-5 6-4 over the three-time grand slam winner, rolling to victory after a shaky start. 

Murray broke Ruud in the 22-year-old's second service game of the match, but could not maintain the advantage as Ruud converted five of six break points in the match. 

Ruud will face ninth seed Lorenzo Sonego, who defeated Sebastian Korda 6-4 6-3, saving six of seven break points against his own serve while converting all three of his chances on Korda's. 

Fourth seed Denis Shapovalov defeated Taylor Fritz 7-6 (9-7) 6-2, saving six set points in the process. 

The Canadian moves on to a quarter-final meeting with Cameron Norrie, who downed Daniel Evans 7-6 (7-3) 6-3. 

Grigor Dimitrov dominated August Holmgren 6-1 6-1 in 56 minutes, winning 83 per cent of his service points.

Dimitrov next faces Aslan Karatsev, who rallied to upset fifth seed Hubert Hurkacz 5-7 6-4 6-2. 

This time, Rafael Nadal could not summon the third-set magic he needed.

Coming off an epic three-hour duel Wednesday in his first match since the French Open final, Nadal fell to Lloyd Harris 6-4 1-6 6-4 on Thursday at the Citi Open. 

After a short-lived maiden appearance at the Washington, D.C. tournament, the Spaniard will look ahead to Toronto and Cincinnati as he continues his preparations for the U.S. Open. 

Harris, meanwhile, heads to a quarter-final matchup against veteran Kei Nishikori after recording the biggest win of his career. 

Facing Nadal for the first time, the 24-year-old South African slammed 16 aces Thursday and saved four of six break points. 

The 20-time grand slam winner, who battled a foot injury to outlast Jack Sock in his first match, did not have enough to answer the world number 50 on Thursday.

In addition to the top-seeded Nadal's defeat, second seed Felix Auger-Aliassime also went down Thursday, falling 6-3 6-4 to American wild card Jenson Brooksby. 

With their exits, the tournament is now without its top four seeds. 

That leaves fifth seed Jannik Sinner as the top player remaining after he defeated Sebastian Korda 7-6 (7-3) 7-6 (7-3). 

Nishikori advanced by downing seventh seed Cameron Norrie 3-6 6-3 6-3, while John Millman knocked out eighth seed Reilly Opelka 6-3 7-6 (7-4). 

Among unseeded players, Denis Kudla defeated the red-hot Brandon Nakashima 3-6 7-6 (7-3) 6-4, while Steve Johnston eased past Ricardas Berankis 6-2 6-1 and Mackenzie McDonald beat Illya Ivashka 6-4 6-4. 

In addition to Harris-Nishikori, Kudla will face McDonald in the other quarter-final in the top half of the draw, while Sinner meets Johnson and Millman takes on Brooksby in the bottom half. 

Top seed Matteo Berrettini has his sights set on the Queen's Club Championships title after beating Dan Evans in the quarter-finals.

After a delay of more than four hours because of rain in London, Berrettini overcame Evans 7-6 (7-5) 6-3 to reach his third ATP grass-court semi-final.

The Italian hit 13 aces and won 81 per cent of his first-serve points against Evans to set up a last-four clash with Alex de Minaur. 

Berrettini improved his win-loss record to 24-6 for the season and laid out his ambition to walk away from the tournament with the trophy.

"I didn't serve that well, but I was returning well and I just played better in the last few points of the tie-break," he said.

"After that, I felt more confident. The conditions were really tough, windy and cold, so I took time to adapt a little bit. I am pretty happy with my performance.

"The court condition was really good. I expected slippery conditions, but it was like yesterday.

"I came here to win the tournament, that is my goal. Now I am two steps away. I am happy with the way I am playing, and my mental attitude is really good."

Up next for Berrettini is Australian De Minaur, who came from behind to defeat Marin Cilic 3-6 6-3 6-4.

The 22-year-old won 73 per cent (22/30) of his second-serve points and saved six of the seven break points he faced as he moved to 16-12 for the season.

In the battle of the British players, Cameron Norrie beat Jack Draper 6-3 6-3, while Denis Shapovalov was leading Frances Tiafoe 6-3 when their match was suspended due to fading light. They will resume on Saturday.

At the Halle Open, Andrey Rublev reached his sixth ATP Tour semi-final of the year thanks to a 7-6 (7-4) 6-2 win over 2011 champion Philipp Kohlschreiber.

"I am happy with my performance to reach the semi-finals for the first time," Rublev said. "The first set was really tough. He was 3-0 up in the tie-break and I came back, which was the key.

"After the first set, I think he mentally went down and I was pumped up. I hit a couple of good returns in the first game of the second set."

Russian Rublev will face Nikoloz Basilashvili in the last four after the Georgian defeated Lloyd Harris 6-4 7-6 (7-5). 

In the day's other quarter-finals, Felix Auger-Aliassime beat Marcos Giron 6-3 6-2 and Ugo Humbert overcame Sebastian Korda 6-2 6-7 (5-7) 6-4.

Top seed Matteo Berrettini beat Andy Murray to reach the quarter-finals at Queen's Club and Ugo Humbert upset Alexander Zverev at the Halle Open on Thursday.

Murray, a five-time champion at Queen's, was beaten 6-3 6-3 by Italian Berrettini as the three-time grand slam champion struggled a day on from being given a Wimbledon wildcard.

The former world number one beat Benoit Paire in his first ATP Tour singles match since March on Tuesday, but the 34-year-old revealed he is still being troubled by a groin injury after his loss to Berrettini and knows he must raise his game.

Murray said: "I actually felt my movement was actually quite good for both of the matches. My tennis today was not very good. That's the thing that I'll need to improve the most.

"Then there is still a slight niggle in the groin, so [I have] to try to get rid of that discomfort between now and Wimbledon. I need to be playing points, basically. I played two sets in preparation for this event.

"I do feel like I genuinely have been hitting the ball well in practice, but then like today when you're under a bit more pressure and stuff and you're having to make very split-second decisions when you're on the court, if the guy is serving 140 miles an hour, like, it's difficult to prepare for that."

Dan Evans made history earlier in the day, getting the better of Adrian Mannarino 6-4 7-6 (9-7).

With Jack Draper and Cameron Norrie having already progressed, Evans' win ensured there will be three Britons in the singles quarter-finals for the first time in the Open Era.

Feliciano Lopez will not retain his title in London after the Spaniard went down 6-2 6-3 to second seed Denis Shapovalov. Spanish veteran Lopez won in 2019, with last year's tournament cancelled due to the pandemic.

There will be no glory on home soil in Halle for German Zverev, who was taken out 7-6 (7-4) 3-6 6-3 by unseeded Frenchman Humbert.

Humbert has now beaten a top-10 player on every surface, with Zverev serving 20 aces but bowing out after his 22-year-old opponent claimed the only break of the final set.

Sebastian Korda battled past Kei Nishikori 2-6 6-3 7-5 in Halle, while Lloyd Harris also moved into the last eight at Lukas Lacko's expense.

Sebastian Korda won the first ATP Tour title of his career with a straight-sets defeat of Marco Cecchinato in the Emilia-Romagna Open final on Saturday.

Korda became the first American man to be crowned a champion on clay in Europe for 11 years, beating the Italian wildcard 6-2 6-4 in Parma.

The unseeded 20-year-old son of former world number two Petr Korda did not drop a set this week and will head to the French Open with his confidence sky-high.

Korda won 82 per cent of points behind his first serve and broke three times to get the better of Cecchinato at the President Tennis Club.

The Florida native took just an hour and 15 minutes to become the first American man since Sam Querrey in Belgrade back in 2010 to win a title in Europe on this surface.

His victory ensured the Kordas are the third father-son duo to win ATP Tour-level singles titles in the Open Era, emulating Ramanathan Krishnan and Ramesh Krishnan, and Phil Dent and Taylor Dent.

World number 63 Korda will face Spaniard Pedro Martinez in the first round at Roland Garros next week.

It proved to be a tough day for home players at the Lyon Open as Roger Federer found out who he will face first in the main draw in Geneva.

All four Frenchmen in action on Monday were knocked out in Lyon, including 2018 finalist Gilles Simon.

Aljaz Bedene knocked out the world number 68 in straight sets, two breaks of serve in each enough to secure a 6-2 6-3 triumph after one hour and 13 minutes on court.

Sebastian Korda overcame both Pierre-Hugues Herbert and the rain to progress to the second round, a 7-6 (7-5) 6-4 triumph wrapped up quickly following a delay.

Having been 5-4 ahead in the second set when play was halted, Korda clinched victory on his first match point upon the resumption, in the process snapping a run of four successive defeats on the ATP Tour.

Cameron Norrie will take on top seed Dominic Thiem next after his 7-5 6-3 win against Corentin Moutet, while Ugo Humbert let slip a one-set lead as he was beaten by Yoshihito Nishioka.

Meanwhile, at the Geneva Open, there was a maiden victory for French teenager Arthur Cazaux as he came out on top against compatriot Adrian Mannarino.

The 18-year-old held his nerve in a decider despite this being his first tour-level contest; Reilly Opelka or Pablo Cuevas will be next up in the event.

As for Federer, he will begin his campaign on Tuesday, the 39-year-old having played just two matches so far this year after undergoing two knee operations in 2020.

The Swiss superstar now knows he will be up against Pablo Andujar, who overcame Australia's Jordan Thompson in straight sets.

Tennys Sandgren saw off Salvatore Caruso 6-3 6-4, while Dominik Koepfer came through a tight tussle with Benoit Paire that spanned two hours and 39 minutes.

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