Tampa Bay Buccaneers superstar Tom Brady was non-committal on his playing status after suffering a hand injury in his five-touchdown performance against the Miami Dolphins.

Brady threw five TD passes to fuel Super Bowl champions the Buccaneers' 45-17 rout of the Dolphins in Week 5 of the NFL season on Sunday.

The 44-year-old was 30-of-41 passing for 411 yards without throwing an interception against the struggling Dolphins (1-4) in Tampa, where the Bucs improved to 4-1.

Among Brady's touchdown passes was a 62-yard TD throw to Antonio Brown – the longest pass TD he has completed with the Buccaneers, while it was the seven-time Super Bowl champion's 25th career pass TD of 60-plus yards, which is tied for ninth-most in NFL history.

But afterwards, Brady was seen with his right hand bandaged as the Bucs quarterback provided an update on his injury.

"Yeah in my younger days I probably [would have] never showed you guys that I wrapped it up, because I'd probably try to keep it a secret, but I think in my old age I don't care as much," Brady told reporters post-game, with the Bucs due to meet the Philadelphia Eagles on Thursday.

"I mean it's just a kind of a football injury. So, do my best you know to get ready for this game. We'll see what happens."

In the win, Bucs wide receiver Brown became the fastest NFL player to 900 receptions in just his 143rd career game, eclipsing Hall of Famer Marvin Harrison (149 games).

Brown – a seven-time Pro Bowler and four-time first-team All-Pro – finished with two touchdowns from 124 yards on seven receptions against the Dolphins.

"I take so much inspiration from Tom. As a professional, as a leader, making sure that I'm doing my job, making sure that all the other 10 guys are doing their job," said Brown, who played alongside Ben Roethlisberger at the Pittsburgh Steelers.

"He just continues to up the standard and raise the bar."

Brown, 33, added: "I've played with some great quarterbacks. Roethlisberger. Tom Brady. It's a blessing."

Brady, who played alongside Brown briefly at the New England Patriots before reuniting in Tampa last season, said: "It's pretty amazing. Just give him a lot of credit.

"He's been through a lot and he's shown a lot of mental toughness, a lot of resilience. Everyone just wants him to succeed.

"We've got a unique group of guys. Very talented, but very selfless too. All those guys are getting opportunities to make plays, and just fun to see when everyone's involved how fun it can be."

The Green Bay Packers went 4-1 for the 2021 season after Mason Crosby's overtime field goal secured a dramatic 25-22 victory over the Cincinnati Bengals.

Crosby missed two field goals in the final quarter as Cincinnati pegged back the visitors at 22-22, with the Packers #2 then squandering another chance early in overtime.

His third miss came sandwiched in between Bengals rookie Evan McPherson twice hitting the post with field goal attempts of his own.

Yet a brilliant pass from the superb Aaron Rodgers – who threw for two touchdowns to take him into outright fifth place in the all-time list for quarterbacks with 422 – to Randall Cobb teed up the game-winning moment.

Bengals QB Joe Burrow also threw for two touchdowns, having got Cincinnati started when he picked out Samaje Perine from close range in the first quarter. 

Burrow collected his second TD pass of the game in style, throwing 70 yards (the longest pass of his NFL career) for Ja'Marr Chase to cross.

Chase's score came after Rodgers had propelled the Packers ahead with passes to Davante Adams and AJ Dillon, and although Joe Mixon forced OT, Crosby held his nerve at the fourth time of asking.

Brady downs Dolphins

A week on from breaking Drew Brees' NFL passing record, Brady was at his imperious best again for the Tampa Bay Buccaneers, throwing for five touchdowns and 411 yards in a 45-17 win over the Miami Dolphins.

His 72 touchdown passes against the Dolphins mean he is the joint-leader, alongside Dan Marino (72 v. the New York Jets) for TD passes against a single opponent in the Super Bowl era, while his 62-yard pass for Antonio Brown on Sunday was the longest he has thrown while at the Buccaneers. 

Pitts stars in London

The NFL returned to London on Sunday, with the Atlanta Falcons overcoming the New York Jets 27-20. Rookie receiver Kyle Pitts was the star of the show at the Tottenham Hotspur Stadium, taking nine catches for 119 yards and a touchdown, the first of his NFL career.

Star tight end George Kittle has been placed on injured reserve by the San Francisco 49ers.

On the same day he turned 28, the Niners confirmed their two-time All-Pro had been subject to the roster move due to an ongoing calf problem.

The decision means Kittle must miss at least three matches, including the upcoming NFC West divisional matchup at the undefeated Arizona Cardinals, a game for which he had initially been listed as doubtful.

San Francisco are already without quarterback Jimmy Garoppolo, who also has a calf problem, against the Cardinals, meaning rookie Trey Lance will start.

The team, who are 2-2 after losing two straight games, will hope Kittle is good to go again by Week 8 when they meet the Cardinals once more.

Kittle has struggled with his nagging injury for much of the 2021 season and has made just 19 catches for 227 yards, as he waits to score his first touchdown of the year.

He was restricted to just eight regular season games last year after suffering a broken foot.

Prior to those injury problems, Kittle had been utterly dominant in 2018 and 2019, helping the Niners to the Super Bowl in that period with 2,430 yards and 10 receiving TDs across 30 regular season games.

Kittle was a fifth-round draft pick ahead of the 2017 season.

So far, so good, Dak Prescott. At least from a personal perspective, though, it was a similar story through four weeks in 2020.

The Dallas Cowboys quarterback set a record-breaking pace last year, his 1,690 passing yards comfortably the most by any player over the first four weeks of a season since 1960. In fact, in at least the past 40 years, no QB can match that total across any four-game span.

Going back to 1960, only Jameis Winston had previously thrown for 450 yards in consecutive games. Prescott became the first to do so in three in a row against the Atlanta Falcons (450), the Seattle Seahawks (472, a career high) and the Cleveland Browns (502, another career high) in Weeks 2, 3 and 4.

Yet the Cowboys were only 1-3, and when Prescott went down for the year against the New York Giants in Week 5, any hopes of recovering their season were dashed. Dallas went from averaging a league-leading 509.5 total net yards and third-ranked 31.5 points per game through Week 4 to 325.9 yards and 22.5 points over the rest of the year — ranking joint-21st and 25th.

In 2021, however, they are 3-1 heading into another Week 5 matchup with the Giants, despite having played three other 3-1 teams. And although Prescott has again been outstanding, this year's Cowboys do not look quite so fragile.

'The best I've ever played'

Of course, Dallas' excellent start begins with the man under center. Prescott is back this season having finally signed a four-year, $160million extension, and he is quickly proving worth that investment.

Although his 1,066 yards pale next to last year's early efforts, the 28-year-old has thrown 10 touchdown passes, up on 2020's nine and the second-most ever at this stage of a season by a Cowboys QB, behind Tony Romo's 11 in 2007. Only Don Meredith (twice — in 1966 and 1968) has bettered Prescott's 116.9 passer rating to this point.

After three TDs and no interceptions in the Week 3 win against the Philadelphia Eagles, Prescott said he had gained "a different perspective" from his spell on the sidelines. "I feel like I'm playing the best I've ever played," he added. He then had four TDs and no interceptions versus the Carolina Panthers in Week 4.

Prescott is undoubtedly excelling — he has delivered a well-thrown, accurate ball with 84.7 per cent of his passes this year, third among QBs with 100 or more attempts — but he is also getting help. In the Panthers game, he did not take a single sack. His seven for the year are fewer than 21 other QBs through four weeks.

Indeed, the Dallas number four said coming into the season offensive linemen Zack Martin, Tyron Smith and La'el Collins, who all missed at least large chunks of 2020 through injury, were "the most important" members of the offense.

Of the 32 pressures Prescott has faced this season, 20 came in the opener against the Tampa Bay Buccaneers when Martin was on the COVID list. He has won 57 of 58 pass protection attempts, allowing only a single hurry. Smith has won 90 of 93 attempts, giving up a sole adjusted sack. The Cowboys still have the suspended Collins to come back in.

Even when Prescott is pressured, he is performing well, getting the ball out quickly and accurately, his 2.84-second release time the fourth-fastest under duress (minimum 10 attempts) and his 81.3 well-thrown percentage the fourth-best.

Having top-level talents to give the ball to makes the job easier, though.

Sharing the ball around

Prescott completed at least 80 per cent of his passes in consecutive weeks against the Los Angeles Chargers (85.2) and the Eagles (80.8), while the Cowboys also put up more than 150 rushing yards in both matchups (198 and 160). The 1984 San Francisco 49ers, led by Joe Montana, had been the last team to achieve that feat in back-to-back games.

That statistic speaks to the threat Dallas pose on offense this year.

Through the air, Prescott has had three outstanding weapons to target at the start of this season. Wide receivers Amari Cooper (22) and CeeDee Lamb (20) and tight end Dalton Schultz (20) have each made at least 20 catches, making the Cowboys the only team to have three players reach this mark through four weeks in 2021.

In just Lamb's second season in the league, he and Cooper have already established themselves as one of football's premier wide receiver duos — they are one of seven pairs of team-mates to each have 250 receiving yards at the position through Week 4 (258 for Cooper, 264 for Lamb).

Against the Panthers, when Lamb was limited to just two catches, four other Cowboys caught TD passes — among them breakout star Schultz, who has three scores in four games after four in his first three years in the league.

Two of those prior four TDs came in the first four games of 2020, though, with Prescott targeting Schultz with 28 passes, leading to a career-high four-game span of 219 receiving yards. Of those, 105 yards came after the catch, showing his power as he ranked fifth at TE in the NFL. So far this year, his 131 yards after the catch trail only Travis Kelce and George Kittle — good company to be keeping.

Crucially, however, Dallas also have multiple options on the ground. Ezekiel Elliott looks back to his best and is boosted by having Tony Pollard emerge as an effective alternative.

"We've got some younger guys who can play and produce, so it's not necessary for Zeke to run the ball 25, 30 times a game," head coach Mike McCarthy said in July. "When you get to December, January football, you want him to be in top form to be able to run the ball 25, 30 times if needed."

Elliott is certainly being used more efficiently; his 342 rushing yards fall well short of the Week 4 marks set in 2016 (412) and 2018 (426), but only in the latter year (5.84) has he averaged more yards per carry than this year's 5.34. The 26-year-old's four rushing scores are his most at this stage of a season. He still played a key role against Carolina, with 143 rushing yards his most in a game since 2018.

The Cowboys are difficult to stop, with Pollard (4.29) and Elliott (4.00) ranking third and fourth among running backs for yards per carry on plays where run disruption occurs and defenders get the better of the O-line. It is easy to see why Dallas are now running the ball on 47.0 per cent of plays, fifth-most in the league, easing the burden on Prescott.

Young defense delivering

This outstanding offensive production would all count for little if the Cowboys were not also showing improvement on the defensive end. The reasons for their 1-3 start in 2020 were the 430.5 total net yards (third-most) and league-high 36.5 points allowed per game.

Happily, with Prescott returning and faith in the offensive options, the Cowboys were able to focus almost solely on defense in the draft. Their first six picks, including 12th overall selection Micah Parsons, were on that side of the ball.

Linebacker Parsons has quickly established himself, leading the team with 2.5 sacks and 32 sack yards while registering 13 pressures on 46 pass rush attempts — a strong 28.3 per cent. At defensive tackle, third-round pick Osa Odighizuwa has been similarly impressive, pressuring at a 21.4 per cent rate and registering an adjusted sack on 7.1 per cent of plays when lined up on the interior. With Jaylon Smith released, fourth-rounder Jabril Cox could also now get an opportunity.

The undoubted star of the season so far, however, is second-year cornerback Trevon Diggs. Dallas have registered 10 total takeaways, only behind the Buffalo Bills, and Diggs' five interceptions — at least one in each game, including a pick-six against the Eagles — account for half of them. Since 1960, only three players have had more interceptions heading into Week 5; since 1980, just two have had a longer streak of games with picks to start a season.

As a team, the Cowboys had 10 interceptions in the whole of 2020, with Diggs, then a rookie, contributing three.

The Cowboys have now given up 24.3 points per game, tied for 16th in the league, but they have allowed just six points — from two field goals — in the fourth quarter of one-score games, giving Prescott every opportunity to win the game.

Unlike the QB, the key men in the defensive unit are largely too young to have worked with former Cowboys coach and current Giants offensive coordinator Jason Garrett, but on the evidence of this season so far they will relish making life hell for his man Daniel Jones on Sunday.

In their last game against weak NFC East rivals until a kind end to the schedule starting in Week 14, the Cowboys will look to lay down a marker, extending this strong start and encouraging hopes they can be a genuine contender this year. Getting Jones off the field and allowing Prescott, Elliott and Co to get to work should ensure they do that.

The Buffalo Bills' 2020 season came to an end as their defense was gashed by Patrick Mahomes and the Kansas City Chiefs. After an offseason seemingly geared towards preventing that from happening again, in Week 5 they will get the clearest indication yet of whether their moves were the right ones.

Buffalo and Kansas City will renew acquaintances on Sunday for the first time since the Chiefs crushed the Bills 38-24 in the AFC Championship Game.

Kansas City put together a typically prolific offensive performance, Mahomes averaging 8.55 yards per pass attempt as he racked up 325 yards and threw for three touchdowns in a game that was not much of a contest after the Chiefs responded to falling 9-0 behind early by scoring 21 unanswered points.

The Bills pressured Mahomes 12 times, having tallied 33 across the first two rounds of last season's playoffs, and sacked him only once.

That anaemic pass-rush display prompted Buffalo to spend major draft capital on the defensive front this year.

Miami edge rusher Gregory Rousseau was selected with the Bills' first-round pick, and they followed that up by adding Carlos Basham from Wake Forest to their defensive line in the second.

Those additions have not seen the Bills leap to the top of charts when it comes to total pressures – their tally of 60 is 22nd in the NFL – however, they are doing a significantly better job of getting to the quarterback.

Buffalo's 11 sacks for negative yardage is a total bettered by only six teams so far this year, with Rousseau registering two sacks in an encouraging start to his career despite having a year away from competitive football after his college career effectively ended in 2019 due to his decision to opt out in 2020.

With Buffalo excelling in preventing opponents from getting going on the ground and through the air, the Bills are first in the NFL in opponent yards per play allowed with an impressive average of 4.00, while their 11 takeaways are also a league high.

The issue is that the Bills haven't faced an opponent close to the calibre of Mahomes and the Chiefs, who lead the league in yards per play. Of the four teams they have played this year in a 3-1 start, only the Washington Football Team (eighth) rank in the top half of the league in yards per play. The Pittsburgh Steelers, the Houston Texans and Miami Dolphins are all in the bottom seven.

Similarly, none of the four quarterbacks the Bills' defense has gone against is above the league average for signal-callers with at least 10 attempts in well-thrown percentage (78.5). Mahomes is third in the NFL in that metric, delivering an accurate, well-thrown ball 84.8 per cent of the time and performing at the kind of level that saw him named MVP in the 2018 season.

When a quarterback of Mahomes' physical gifts is displaying that kind of accuracy, he can be near-impossible to stop. If the Bills cannot do it this time, then Buffalo quarterback Josh Allen and Mahomes would likely end up in another shootout expected to tilt in the direction of the Chiefs star.

Early signs against inferior opposition have been encouraging, but Sunday's primetime duel at Arrowhead Stadium will provide a true picture of whether the Bills' defensive improvement is for real.

No franchise wants to rebuild. Tanking your immediate hopes of success to collect assets that can eventually propel the team back to the top can be a miserable experience. However, the Miami Dolphins attacked rebuilding with remarkable zeal and have endured relatively little pain as they have constructed their roster on a new foundation.

Brian Flores oversaw a 5-11 season not short on reasons for encouragement in 2019 even amid a fire sale that saw the likes of Laremy Tunsil and Minkah Fitzpatrick sent off to pastures new in exchange for major draft capital. Last season, the Dolphins finished 10-6 and narrowly missed the playoffs, raising hopes that their project would imminently yield dividends.

As such, this season was always likely to be seen as a measuring stick for the franchise, with Flores entering his third year as head coach and the man they picked to be the quarterback of the future faced with a make-or-break campaign, the Dolphins entered 2021 with expectations with which they are unfamiliar.

And, following a 1-3 start, with a franchise quarterback at least temporarily on the shelf and the defending champions coming to town to potentially put Miami in a deeper hole, tough questions will start to be asked about the direction of the organisation.

Few teams recover from a 1-4 start to reach the postseason. There is the unlikely possibility the Dolphins could upset the Tampa Bay Buccaneers on Sunday, but the more plausible scenario is a fourth successive defeat that would beg the question: is Miami's rebuild a failure?

Defense developing, but results declining

The biggest feather in the cap of this Dolphins' regime has been the play of Miami's defense, which last season led the NFL in takeaways with 29.

Yet those turnovers masked the fact that the Dolphins' defense was one teams generally had success moving the ball against. Indeed, Miami ranked 24th in opponent yards per play allowed in 2020, giving up an average of 5.90.

The Dolphins have improved in that regard so far this season, sitting 13th with 5.51 yards per play allowed, but are 23rd in offensive points allowed despite generating six turnovers through four games.

Miami's defense is one that appears to have grown more efficient when it comes to stopping the progress of offenses on a per-play basis and still takes the ball away but is not keeping offenses from putting up points.

Why is that the case? Put simply, they are on the field too long because of the failures of an offense that is not living up to the amount the Dolphins have invested.

A lack of possession

Miami's offense ranks 30th in average time of possession, having control of the ball for just 26 minutes and eight seconds. Their defense, as a result, has been on the field for an average of 33 minutes and 52 seconds. Only the defenses of the Jacksonville Jaguars and Seattle Seahawks have had to exercise greater endurance this season.

And the offense has shown little in the way of efficiency when on the field.

The Dolphins rank last in yards per play with an average of just 4.05. The New York Jets (5) are the sole team to have scored fewer offensive touchdowns than the Dolphins' six while only 10 of Miami's 42 offensive drives have ended in points.

That level of offensive ineptitude is unacceptable for a team looking to compete, and much of the blame can be pinned on an offensive line where the Dolphins have spent a large portion of their resources.

Despite having a first-round pick and two second-rounders starting up front, the Dolphins have allowed 80 pressures through four games, the seventh-most in the NFL.

It is difficult for a quarterback to succeed when under duress that consistently but, if the Dolphins continue to struggle, an apparent misevaluation of the class of signal-callers in the 2020 draft will come under even greater scrutiny.

Tua a costly mistake?

The elephant in the room is quarterback Tua Tagovailoa, whom the Dolphins selected fifth overall in the 2020 draft despite his career with Alabama being ended by a dislocated hip.

Miami backed Tagovailoa to eventually put that injury behind him and develop into the NFL star many expected him to become. Yet he failed to prove a superior option to Ryan Fitzpatrick in his rookie year and, rather than taking season-two strides, seemed to be regressing before a rib injury suffered in the Week 2 loss to the Buffalo Bills saw him placed on injured reserve.

In the small sample size of 30 attempts this season, Tagovailoa has delivered an accurate, well-thrown ball a league-low 63.3 per cent of the time. Only two quarterbacks, rookies Zach Wilson and Davis Mills, have a worse pickable pass rate than Tagovailoa's 6.67 per cent.

Tagovailoa was long since pencilled in as the player the Dolphins' grand rebuild was going to be constructed around. Now reduced to the role of spectator for the time being and struggling to live up to his draft status, going with him over reigning Offensive Rookie of the Year Justin Herbert looks like a serious misstep.

It is not the only premium pick Miami made from that class whose selection is in question. Left tackle Austin Jackson's inability to make the leap to the highest level effectively is a key reason for the offensive line struggles — he has won under 70 per cent of his pass-blocking matchups in 2021 — and their third first-round choice from 2020, cornerback Noah Igbinoghene, has not played a single defensive snap in 2021.

Any judgement on this year's crop would be a premature one but, although there have been some encouraging signs from first-round picks Jaylen Waddle and Jaelan Phillips, the former is being limited by the struggles of the offense, recording a big play on an underwhelming 16 per cent of his targets, and pass rusher Phillips has won only 12 of his 43 rushes this season.

The mediocre starts of Waddle and Phillips are a long way down the list of concerns for the Dolphins, however, and they will not be the primary causes should Miami's poor start lead to a year of unmatched expectations.

Miami's rebuild rested on whom the Dolphins selected to be their quarterback and their fortunes in protecting him. The decisions they made in each of those areas have to this point largely backfired, leaving them with an offense that looks ill-equipped to compete this Sunday with a Buccaneers attack that could hardly be in a better position in the trenches and under center.

There is, of course, time for Miami to right the ship this year and the Dolphins — through their pre-2021 draft trade with the San Francisco 49ers — have more capital with which to improve weaknesses on their roster in the coming years.

But persistent talk of the Dolphins using those resources to strike a deal for quarterback Deshaun Watson is not a sign of a successful rebuild or faith in Tagovailoa to turn things around.

It's becoming increasingly clear the Dolphins bet on the wrong horse at quarterback last year and may have failed to properly evaluate prospects at several other positions. Opportunities for any regime to get the chance to select a second quarterback are rare but, regardless of how the Dolphins try to rescue their best-laid plans to return to prominence, the franchise's future gambles must be more astute.

Las Vegas Raiders owner Mark Davis says the language used by head coach Jon Gruden in an email 10 years ago is "disturbing" amid allegations it was racist.

Davis, who at the time was a lead analyst for ESPN, wrote to the Washington Football Team's president in July 2011 where he said NFL Players' Association executive director DeMaurice Smith had "lips the size of michellin tires" according to The Journal.

Gruden claimed he did not recall the email, while NFL spokesman Brian McCarthy labelled the language as "appalling, abhorrent and wholly contrary to the NFL's values".

The Raiders owner called it "disturbing" and said they were reviewing the matter, suggesting possible disciplinary action.

“The content of an email regarding DeMaurice Smith from Jon Gruden when he worked for ESPN 10 years ago is disturbing and not what the Raiders stand for," Davis said in a statement.

"We were first made aware of the email late yesterday by a reporter and are reviewing it along with other materials provided to us today by the NFL.

"We are addressing the matter with Coach Gruden and will have no further comment at this time."

Gruden claimed that the remark was not intended to be racial, insisting it related to the term "rubber lips" for someone who lies a lot and that he was embarrassed by the situation.

"I'm ashamed I insulted De Smith," Gruden told ESPN. "I never had a racial thought when I used it.

"I'm embarrassed by what's out there. I certainly never meant for it to sound that bad."

Russell Wilson's run of 149 straight starts is set to come to an end due to a hand injury that is expected to rule the Seattle Seahawks quarterback out for at least a month.

The 32-year-old injured his finger on his throwing hand in Thursday's defeat to the Los Angeles Rams and flew to Los Angeles on Friday to see a hand specialist.

Wilson's 10-year run of starts is the sixth longest by any quarterback in NFL history, and the longest of any active quarterback, but he is now facing a spell on the sidelines.

According to reports, the injury will require surgery and Wilson could be out for as long as eight weeks.

Providing an update earlier on Friday, Seahawks coach Pete Carroll said: "He's getting looked at by an expert.

"I don't know much more than last night. We've just got to wait and see what they assess.

"We'll know a lot more by the end of the day… But there's something going on.

"There's definitely something going on and we've got to figure out what the extent of it is, and what is the next step to deal with it."

Carroll will now turn to Geno Smith, who last started a game in 2017, against the Pittsburgh Steelers on Sunday.

Smith led two scoring drives after replacing Wilson against the Rams and Carroll has full belief in the backup quarterback.

"I thought Geno did a marvellous job last night," Carroll said. "Geno has been practicing with us for all this time waiting for his opportunity if called upon. 

"The patience that he's shown with us to stay with it, and his relationship with Russ and the coaches, he's been impeccable.

"He's a very talented football player. He's got a great arm, he's got great sense, and he knows the system really well. I totally trust that Geno can do this."

Trey Lance will make his first start for the San Francisco 49ers against the Arizona Cardinals on Sunday.

Head coach Kyle Shanahan confirmed Lance would get the start after Jimmy Garoppolo again missed practice on Friday.

Garoppolo suffered a calf contusion during the first offensive series in San Francisco's 28-21 loss to the Seattle Seahawks last week.

He played the rest of the first half but was replaced by rookie third overall pick Lance for the second half.

Lance completed nine of his 18 passes for 157 yards and two touchdowns while rushing for 41 yards on seven carries.

San Francisco traded three first-round selections to move up from the 12th pick to the third pick in this year's draft for the right to take Lance and make him their quarterback of the future.

Sunday will provide his first opportunity to prove the 2-2 Niners were right to make that move across the course of a full game.

Inexperienced even at the college level, Lance played only one full season as a starter for North Dakota State in 2019, which saw him account for 42 total touchdowns and zero interceptions, with the COVID-19 pandemic limiting him to a one-game exhibition in 2020.

But Lance is undaunted by the challenge of stepping up to start at the highest level this early in his career against an undefeated Cardinals team.

"I feel very prepared. I really do. And I think that's a credit to the coaching staff and the guys around me," Lance told a media conference. 

"Those guys have made me feel very confident this week, and I feel confident in myself, just as I did going into the Seattle game, and just as I did every other week before this."

Lance is unlikely to have one of the 49ers' top offensive weapons available, with tight end George Kittle doubtful with a calf injury. Rookie running back Elijah Mitchell is set to return from a shoulder injury, meaning the running game will be almost exclusively in the hands of three rookies in the form of Lance, Mitchell and third-round pick Trey Sermon.

The Kansas City Chiefs will be out to burst the in-form Buffalo Bills' bubble when they meet in a standout NFL Week 5 showdown.

Buffalo stretched their winning run to three matches with a 40-0 rout of the Houston Texans last Sunday.

Week 4 was also one to remember for the Chiefs and particularly Andy Reid, who became the first coach in NFL history to win 100 games with two teams thanks to a 42-30 defeat of his former employers the Philadelphia Eagles.

As the only team with a perfect record, the Arizona Cardinals will look to make it 5-0 at the expense of the San Francisco 49ers.

Stats Perform previews the pick of the action in the next round of matches and the best of the rest.

 

Buffalo Bills @ Kansas City Chiefs

The Bills are sitting pretty at the top of the AFC East at 3-1, but they have lost five of their past six meetings against the Chiefs.

Buffalo will be on a revenge mission after they were beaten 38-24 by Kansas City in the AFC Championship Game last season, the largest margin of victory for the Chiefs in those five triumphs.

The Bills' thrashing of the Texans was the second time this season they have kept an opponent scoreless, having also done so against the Miami Dolphins in Week 2.

Reid's side prop up the AFC West with a 2-2 record, but their 18 touchdowns is more than any in the NFL and Josh Gordon will be hoping to add to that tally if he makes his debut.

San Francisco 49ers @ Arizona Cardinals

The Cardinals' dream start to the season continued with a 37-20 victory over the Los Angeles Rams in Week 4, taking them to 4-0 for only the second time since moving to Arizona nine years after they previously won their opening four games.

If recent history is anything to go by, there will not be much in their showdown this weekend, as four of the past five meetings between the two sides have been decided by only three points.

The 2-2 49ers travel to State Farm Stadium having come out on top in four of their previous four meetings, having lost their eight clashes beforehand.

Deebo Samuel caught a 76-yard touchdown pass in San Francisco's 28-21 loss to Seattle Seahawks in Week 4, making him the fourth 49ers wide receiver to have multiple receiving touchdowns of 75-plus yards in a single season – joining Torrey Smith, John Taylor, and Jerry Rice.

Cleveland Browns @ Los Angeles Chargers 

The Browns and the Chargers have made promising starts to the season and both come into the game on the back of wins that took them to 3-1.

Cleveland have not beaten the Chargers on the road since back in 1991, losing five on the spin since then – a run that is tied for their third-longest active road losing streak against an opponent (lost 17 straight in Pittsburgh and six straight at New England).

The past two games mark the first time the Browns have allowed seven points or fewer back-to-back since September 10-17, 1995. They have done so in three straight games only once in franchise history (in 1976).

Nick Chubb (388) and Kareem Hunt (355) are the second pair of running backs in the last 30 years to have 350+ scrimmage yards apiece over their team's first four games of a season. The other was the Chargers' Melvin Gordon III and Austin Ekeler in 2018. 

Elsewhere

Tom Brady broke Drew Brees' NFL passing yards record in the Tampa Bay Buccaneers' win over his former team the New England Patriots in Week 4 and could inflict more misery on the Dolphins this weekend. The legendary quarterback has thrown 67 touchdowns against Miami the third-most by a player against any opponent in the Super Bowl era (Dan Marino – 72 v. the New York Jets, Brady – 70 v. the Bills). 

The Green Bay Packers head to Cincinnati to do battle with the Bengals, who they beat 27-24 in their last encounter in 2017. That snapped a three-game winning streak by the Bengals in the series. The Packers' last win in Cincinnati came in Week 3 of the 1998 season.

Urban Meyer has come under fire for his night out after the Jacksonville Jaguars suffered a fourth loss from four last week and he really needs a win when the Florida team host the Tennessee Titans. Tennessee are 7-1 versus the Jaguars since 2017.

NFC East leaders the Dallas Cowboys will go in search of a fifth consecutive home win over the New York Giants.

Pete Carroll described Russell Wilson as "one of the great healers of all time" but is not yet sure how long a "badly sprained finger" will keep the Seattle Seahawks' quarterback out of action for.

Wilson damaged the middle finger of his throwing hand during Thursday's damaging 26-17 loss to the Los Angeles Rams that left the Seahawks 2-3 in the NFC West.

He managed to return for one series only to be replaced by Geno Smith, who led one touchdown drive before throwing for an interception that ultimately sealed the game for the 4-1 Rams.

Seahawks head coach Carroll said he was unsure if Wilson will need surgery and added: "There is a lot of work to be done in assessing all of that. 

"Russell is one of the great healers of all time and he'll do whatever he can to get back as soon as absolutely possible."

Wilson finished with 11-of-16 passing for 152 yards, a touchdown and an interception from a tipped throw, while Smith was 10-of-17 for 131 yards and also added 23 rushing yards.

Television pictures showed Wilson's finger bent in an unnatural position, while he was examined for several minutes by medical personnel on the Seahawks' bench.

"He wasn't able to hold onto the football the way he needed to, to throw it, because we were going to throw the ball, and we needed to throw it all over the place," Carroll added.

"We didn't know what he would be able to do. He was just unsure. If he could have, he would have."

Smith entered the fray early in the fourth quarter and completed a 23-yard touchdown pass to DK Metcalf on the back of a 10-play, 98-yard drive. At that point, Smith was five-for-five and the Seahawks had trimmed the deficit to 16-14.

"Geno did a really, really good job, very much in command," Carroll said. 

"We were able to do all kinds of things with him out there. He handled all the communications beautifully and played really well. 

"We had a chance to win a football game. With all of that, we had a chance to win the football game with the ball in our hands and couple minutes to go."

Matthew Stafford and the Los Angeles Rams got back on track, overcoming the Seattle Seahawks 26-17 to open Week 5 of the NFL season on Thursday.

Bouncing back from a loss to the high-flying Arizona Cardinals, the Rams (4-1) spoiled what would have been a miraculous comeback led by Seattle backup quarterback Geno Smith with a late interception. 

It took both offences time to find their rhythm, as Seattle (2-3) entered half-time with a 7-3 lead, but Stafford led touchdown drives on the Rams' first two possessions after the interval. 

Smith came on after Seahawks starter Russell Wilson left the game with a finger injury suffered late in the third quarter and led a 98-yard touchdown drive, hitting DK Metcalf for a 23-yard score for the QB's first touchdown pass since December 3, 2017. 

That score brought the home side within 16-14, but Stafford led the Rams right back down the field and Sony Michel punched it in for a two-yard touchdown run. 

Smith then engineered a drive ending in a field goal to keep the Seahawks in the game, but after a Rams punt his pass for Tyler Lockett was picked off by Nick Scott, setting up a Matt Gay field goal that would seal the win for Los Angeles. 

Stafford finished the game 25-of-37 passing for 365 yards, while Wilson was 11-of-16 for 152 yards and Smith 10-of-17 for 131 yards, with all three QBs recording one touchdown and one interception each. 

Aaron Donald, meanwhile, became the Rams' all-time leader in sacks with number 88.5, eclipsing Leonard Little.

Baltimore Ravens star Lamar Jackson called for all quarterbacks to be protected, insisting he is not seeking any special treatment from referees in the NFL.

Jackson was on the end of some late hits during Baltimore's 23-7 win over the Denver Broncos last week.

Former MVP Jackson was 22-of-37 passing for 316 yards, a touchdown and three sacks on the road in Denver, where the Ravens QB showed no signs of a sore back to snap the Broncos' unbeaten start to the season.

"I just feel we should be protecting all quarterbacks in the league, not just myself," Jackson said Thursday, ahead of the Week 5 clash with the Indianapolis Colts.

"Everyone should be included in that, especially while we're in the pocket – our leg area and stuff like that.

"Football is football. Guys get aggressive sometimes. Stuff happens. Probably don't mean it. I'd like the ref to throw the flag, though, if they catch it."

Against Denver, Jackson had his highest passing yardage total since Week 1 of 2019 (324) – the 2019 Pro Bowler has thrown at least one touchdown pass in 13 consecutive home games.

The Ravens have the chase to break the record for consecutive 100-yard rushing games – Baltimore are currently level on 43 alongside the Pittsburgh Steelers (1974-77).

Baltimore have won their last two games against Indianapolis, including a 24-10 road win last season.

The Ravens have never won three straight games against the Colts, the franchise which began in Charm City before moving to Indianapolis in 1984.

Christian McCaffrey appears likely to return to the Carolina Panthers' line-up against the Philadelphia Eagles on Sunday.

Though McCaffrey was limited in practice for the second consecutive day, the running back said he "definitely" believes he has a chance to play after leaving Carolina's Week 3 win over the Houston Texans with a hamstring injury. 

Panthers head coach Matt Rhule said Carolina will likely wait until Sunday to make the final call but McCaffrey is eager to return after missing 13 games last season with multiple injuries. 

"Yeah, definitely," McCaffrey told reporters. "We'll take it to Sunday and see how it goes from there. But I feel really good."

The Panthers rushed for 113 yards in McCaffrey's absence last week, slightly above their season average going in, but suffered their first loss of the season to the Dallas Cowboys. 

If McCaffrey is ruled out for Sunday, the men who replaced him against the Cowboys – Chuba Hubbard, Royce Freeman and Rodney Smith – will be ready to carry the load again. 

But getting McCaffrey back as an all-around weapon for quarterback Sam Darnold would be a significant boost. 

"Any time you have the opportunity to have 22 on the field, that changes a lot of things," said offensive co-ordinator Joe Brady.

The 2019 All-Pro selection kept his remarks about his status brief, but McCaffrey did have some thoughts when asked about being injured in a Thursday night game. 

"It's extremely frustrating," he said. "I don't prefer Thursday night games. You go through a lot in a football game. And you really get two days to recover, and one of those days is a travel day.

"You get two days to recover; you get on a plane, you go to a hotel, you're playing a football game. It's tough, but it is what it is.

"It's part of the game, but obviously frustrating."

Wide receiver Calvin Ridley will miss the Atlanta Falcons' showdown with the New York Jets in London for personal reasons.

The absence of Ridley is a big blow for the Falcons, as he is the team's leading wide receiver with 255 yards this season.

Atlanta are 1-3 ahead of the Week 5 game at Tottenham Stadium on Sunday and their chances of improving that record have taken a hit with Ridley unavailable.

A Falcons statement said: "Due to a personal matter, Calvin Ridley will not travel to the Falcons game in London this weekend. We are in support of Calvin during this time and will respect his privacy on the matter."

Wideout Russell Gage (ankle) and defensive end Marlon Davidson (ankle) are also out of the game against the 1-3 Jets.

Olamide Zaccheaus will be expected to step up with Ridley not making the trip to England.

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