The San Diego Padres delivered an unbelievable five-run seventh-inning rally to progress to the NLCS for the first time in 24 years and end the Los Angeles Dodgers' record-breaking season prematurely.

The Padres had lost Game 1 of the NLDS and trailed 3-0 halfway through the seventh inning in Game 4 against the Dodgers, who have dominated them for the past decade and had notched a franchise-best 111-51 regular season.

But San Diego found a way in front of the largest crowd in Petco Park history, booking their maiden NLCS appearance since 1998, where they will take on the Philadelphia Phillies, after they beat the Atlanta Braves 8-3 on Saturday.

Jake Cronenworth delivered a go-ahead two-run single as the Padres rallied with five hits and five runs in the seventh inning after managing only four hits in six innings prior to that.

Freddie Freeman lined a two-run double in the third inning before Will Smith's seventh-inning sacrifice fly for Mookie Betts had put the Dodgers 3-0 up, the latter marking the first run the Padres bullpen had conceded all series.

San Diego responded in a crazy inning, with Austin Nola bouncing to the right side to plate Jurickson Profar, before Kim Ha-seong's left-field line drive drove in Trent Grisham to make it 3-2.

Juan Soto tied the game up with a shot into right field, before Jake Cronenworth's go-ahead two-run double turned the crowd raucous.

Closer Josh Hader struck out Freeman to clinch the win and slay the dragon from down the road at long last.

The defeat ended the campaign for the Dodgers, whose 111 regular-season wins were the fourth-most wins in MLB history and the most by a National League (NL) team since 1906.

Yankees facing elimination after Gonzalez walkoff

Oscar Gonzalez stole the show and the win for the Cleveland Guardians with a two-run single with two outs in the ninth inning to earn a 6-5 win over the New York Yankees and a 2-1 ALDS lead.

Gonzalez hit the walk-off shot when he lined a 1-2 pitch from Clarke Schmidt through the middle to bring home Stevan Kwan and Amed Rosario.

That came after the Yankees had rallied from an early 2-0 deficit as Aaron Judge snapped his postseason skid with a two-run home run. New York had carried a 5-3 lead into the ninth inning.

The Yankees bullpen flopped, meaning they are facing an early exit when the ALDS resumes on Sunday at Yankee Stadium.

Astros advance after Pena ends epic

Jeremy Pena blasted an 18th-inning solo shot to advance the Houston Astros to the ALCS for the sixth straight season, ending an epic 1-0 victory over the Seattle Mariners and completing the sweep.

Luis Garcia closed out six hours and 22 minutes of prolonged postseason action, after Pena sent Penn Murfee into the seats over left-center field with a 415-foot blast.

Mariners starting pitcher George Kirby had been brilliant with five strikeouts across seven innings, but Astros right-hander Lance McCullers Jr overcame illness to send down seven K's across six innings, while Houston's bullpen only allowed five hits and struck out 15.

The game was only the fourth to last 18 innings in MLB postseason history, and the first in postseason history to go scoreless through 17 innings. 

The San Diego Padres tied up the NLDS against the Los Angeles Dodgers with a nail-biting 5-3 victory in a game that included five solo home runs on Wednesday.

Manny Machado played a key role going two-for-five, including a first-inning solo homer along with a third-inning RBI, while Jurickson Profar got his fifth RBI this postseason to put the Padres up 4-3 in the sixth inning.

Jake Cronenworth added another with a solo blast over right-field in the eighth inning before Josh Hader closed it out.

Yu Darvish pitched five innings with seven strikeouts but allowed seven hits and three runs.

The Dodgers had their chances, with nine batters left on base, while they did not have a hit with a runner in scoring position all night.

Freddie Freeman, Max Muncy and Trea Turner all scored solo home runs for the Dodgers. Freeman, who went two-for-four, got on base with a ninth-inning double but Will Smith was caught short of the wall in right-field by Juan Soto to end it.

Clayton Kershaw had six K's across five innings for the Dodgers, restoring his position as the MLB's all-time leading postseason strikeout leader with 213.

Pitcher Brusdar Graterol made a key play down 4-3 in the sixth inning, throwing out Wil Myers at home from a Trent Grisham bunt, but the Dodgers could not capitalise with the Padres' bullpen again exceptional, led by Robert Suarez.

The next two games of the NLDS are at Petco Park where the Padres will be playing in front of their fans in a postseason game for the first time since 2006.

Wright leads Braves to level up with Phillies

Kyle Wright threw six stellar innings as the Atlanta Braves squared the NLDS as they blanked the Philadelphia Phillies 3-0.

After a lengthy rain delay, Wright allowed only two hits with one walk, whilst striking out six Phillies, before reliever A.J. Minter pitched a perfect seventh inning.

The Braves piled on all three runs in the sixth inning with three consecutive two-out singles, as Ronald Acuna Jr overcame a 96mph fastball from Zack Wheeler to his elbow to break the tie, driven in by Matt Olson whose line hit got by first baseman Rhys Hoskins on an in-between hop.

Austin Riley's gentle dribble got Dansby Swanson to home plate, before Travis d'Arnaud grounded to center-field to drive in Olson.