Liverpool can win the Premier League title despite having a tougher run-in than rivals Manchester City, according to former Reds defender Jose Enrique.

Enrique, who made 76 top-flight appearances for the Reds, also believes Jurgen Klopp's team could count the season as a success even if they do not record a second Premier League triumph under the German.

A 4-0 thrashing of Manchester United moved Klopp's men top of the league ahead of City hosting Brighton and Hove Albion on Wednesday, keeping the Reds in contention for an incredible quadruple.

After watching his old team rout United, Enrique believes Liverpool can go on to secure a 20th English top-flight title despite a seemingly less favourable run-in than fellow contenders City.

"I hope so, I really believe they can [win the league]," he told Stats Perform. "Listen, the reality is what Klopp and the players said, you depend on yourself for winning the remaining games, that's what you can do. 

"Let's see what happens, at the moment it's still in Manchester City's hands, that's the reality. They [Liverpool] can [only] do what they say, take it game-by-game and try to win all the remaining games.

"That isn't easy, obviously you're coming into Everton now, they are in a very bad moment, but again anything can happen.

"Obviously the most difficult fixtures on paper are for Liverpool, but I really believe they can do it.

"But it's true that if they win all the remaining games and at the end, they [still] don't win it, for me, it will still be a massive success for the club."

Liverpool's 4-0 thrashing of Ralf Rangnick's side, coupled with a 5-0 rout at Old Trafford earlier this campaign, means Klopp's team have hit nine goals past the Red Devils without reply this term, with only Sunderland in 1892-93 (11-0) ever recording a more dominant combined league triumph over United.

Although Enrique enjoyed watching Liverpool tear their rivals apart at Anfield, he expressed sympathy for Rangnick's team and said he would like to see the rivals face off on a more level playing field.

"You enjoy it, you know, nine goals against them this season, five away from home and four obviously at Anfield, a clean sheet in both of them." he added. 

"Listen, in a way I feel sorry about them [United]. Because the rivalry between both clubs has always been the best in the Premier League, this kind of game is even more important. 

"So, in a way, I would like actually a better game, you know, from that side, a little more complicated [for Liverpool], but at the same time, we're fighting for every single title."

The defeat represented a new low in another frustrating season for United, who are now winless in eight head-to-head clashes with Liverpool (three draws, five losses).

Enrique was exasperated by Bruno Fernandes suggesting his team had nothing to play for after the defeat, the Spaniard stating he has never seen a greater divide between players and fans at United.

"It's like they weren't playing for anything at Manchester," he added. "[But] you have to actually work to try to get in the top four, and then after the game, you see Bruno Fernandes having an interview and saying they aren't playing for anything and Liverpool is playing for a title. 

"They are actually trying to play to get into the top four, I don't know, I think I've never seen a United team like this season before.

"Definitely the difference between the clubs, at the moment, is massive, I really believe they need to get rid of some other players, there will be some of them that finish their contract as well.

"They need to get that manager that they trust, and then you can see the unity between the fans and club. I've never seen that before, you know?

"I think they [United's players and fans] are very very far away from each other… very, very far away. The farthest away I have seen."

Liverpool have nothing to lose in their engrossing Premier League title battle with Manchester City, according to former Reds defender Jose Enrique.

Jurgen Klopp's side trailed City by 14 points on January 15, but 10 wins in a row has moved them within a point of the leaders with eight matches to go.

Liverpool beat Watford on Saturday to move above their rivals for the first time since November 27, but City reclaimed top spot later in the day with victory at Burnley.

The two sides face off at the Etihad Stadium on Sunday in what is being billed as a title decider, and Jose Enrique insists Liverpool are under less pressure than their opponents.

"Before there was a 14-point difference and now they are stuck with Manchester City, so it depends on the fight," the Spaniard, who spent five years at Anfield, told Stats Perform. 

"I think Liverpool have an advantage because they have nothing to lose. In January everything seemed lost and now they are there and it will be very nice. 

"Hopefully they win everything, but if it's just the Premier League or the Champions League it's going to be a very good season."

Indeed, like opponents City, Liverpool are still in the hunt to win the Premier League, Champions League and FA Cup, on top of the EFL Cup they have already secured.

The Reds have been in particularly good form in 2022 and Jose Enrique believes the addition of Luis Diaz in January helped the club's relentless quest for a quadruple.

"April will be the month in which everything will be defined, although the Champions League final is later, and first you have to get there," he said. 

"But in April everything is played: Manchester City, the quarter-finals of the Champions League, and we will have to see what happens. The team is going to go all out. 

"The signing of Luis Diaz in January did the team a lot of good on a mental level because they needed a player who could compete with the other three and also Diogo Jota."

Pep Guardiola must be wary of the "complicated" challenge Atletico Madrid can pose to Manchester City in the Champions League quarter-final, according to Luis Garcia and Jose Enrique.

Atletico battled to a 2-1 aggregate victory over Manchester United in their last-16 clash to tee up a first-ever meeting in Europe between Diego Simeone's side and City.

But Guardiola and Simeone are no strangers to one another given they have faced off four times, and Atleti eliminated the Spaniard's Bayern Munich in the 2015-16 Champions League semi-finals.

Atletico averaged just 27 per cent possession across the two legs and scored twice from 18 shots, while Bayern netted the same number of goals from 53 attempts as the Spanish side progressed on away goals.

Garcia, who enjoyed two spells at Atleti during his playing career, expects Simeone to set up in a familiar fashion when the two teams meet on Tuesday and warned that City could suffer on the counter-attack.

"It is one of the teams that you don't want to face, because of the rhythm and the players that Guardiola has developed, he knows how to use the players in every situation," he told Stats Perform. 

"But Atletico is a complicated team when they have confidence and return to the basics of defending well together.

"With players in attack like Joao Felix and Angel Correa, with players like Yannick Carrasco and Marcos Llorente, they can be dangerous on counter-attacks and we have seen City suffer against teams that sit back."

Former Liverpool defender Enrique echoed his fellow Spaniard's thoughts as he insisted Simeone will not care how his side plays as long as they get a result.

"Sometimes Cholo [Simeone] gets hit, but in this type of competition he knows what he has to do and it won't be easy," he said to Stats Perform. 

"Pep knows Cholo a lot and Cholo knows Pep a lot. Manchester City is going to have possession and that doesn't matter to Cholo, he just wants to win and across two games, Cholo is very complicated and can beat anyone."

After eliminating Ralf Rangnick's United with a 1-0 victory at Old Trafford, Atleti are eyeing consecutive wins on away trips to face English sides in European competition before the second leg in Spain on April 13.