Sam Simmonds and Jack van Poortvliet will start for England against Japan at Twickenham on Sunday.

Eddie Jones has named five changes from the shock 30-29 defeat to Argentina last weekend as they prepare to face Japan, who he coached between 2012 and 2015.

Number eight Simmonds has not featured for England since the Six Nations in March but comes in for Billy Vunipola, who drops to the bench.

Alex Coles is replaced by debutant David Ribbans at lock while Van Poortvliet, who scored within 30 seconds of coming on the pitch against Argentina, will start at scrum-half.

Jonny May also comes in for Joe Cokanasiga and Guy Porter is the final introduction as he is chosen to start over Manu Tuilagi at outside centre.

Owen Farrell will captain England and earn his 99th international cap, while hooker Jamie George is on the bench after recovering from a foot injury.

England team to face Japan: 15. Freddie Steward, 14. Jack Nowell, 13. Guy Porter, 12. Owen Farrell (c), 11. Jonny May, 10. Marcus Smith, 9. Jack van Poortvliet; 1. Ellis Genge, 2. Luke Cowan-Dickie, 3. Kyle Sinckler, 4. David Ribbans, 5. Jonny Hill, 6. Maro Itoje, 7. Tom Curry, 8. Sam Simmonds.

Replacements: 16. Jamie George, 17. Mako Vunipola, 18. Joe Heyes, 19. Alex Coles, 20. Billy Vunipola, 21. Ben Youngs, 22. Henry Slade, 23. Manu Tuilagi.

England wing Jonny May is set to miss Saturday's pivotal second Test against Australia in Brisbane as he makes a "graded return" from a coronavirus lay-off.

The 32-year-old Gloucester player has yet to return to full squad training after emerging from quarantine, and that means he is not expected to figure in Eddie Jones' selection for the weekend.

Defence coach Anthony Seibold said on Tuesday: "It was a long seven days for Jonny. He's been back on his feet today, running, but he didn't join in with the team. It will be a graded return to full training for him.

"We tried to include Jonny while he was in isolation, so sending him the team meetings, the backs meetings. We've used him as a really experienced Test player. We have a really young group in the backs, so he's been a bit of a resource for those guys."

May was absent as England loss the first Test 30-28 in Perth, where two late tries prevented the tourists incurring a heavier defeat. London Irish teenager Henry Arundell made a big impression off the bench as a wing and could come into contention to start in Brisbane, or Jones may elect to use him again as a high-impact replacement.

England will also be without flanker Tom Curry, due to concussion, and the Sale Sharks man will not feature in the third Test in Sydney either.

Seibold said potential replacements Lewis Ludlam, Sam Underhill and Jack Willis were "three really good guys".

Quoted on Skysports.com, Seibold added: "Lewis Ludlam came on and competed really strongly when Tom Curry came off on Saturday.

"He's been a great leader for Northampton this year and when he comes into camp you can certainly tell why he is the captain of his club.

"Jack Willis is really good over the ball and competes really strongly defensively, while Sam Underhill was one of the outstanding players at the 2019 World Cup.

"He missed out on selection for the first Test, but he’s competed really strongly to put himself in the frame for the second. So we've got some options there. Tom's a big part of our team so he'll be a loss, but it's an opportunity for somebody else."

Losing senior figures means a difficult task for England becomes even more complicated. Australia have won their last five Tests on home soil – their best-such run since 2008 – and five of their last eight when hosting European opposition.

Jonny May has tested positive for coronavirus just eight days before the first Test between England and Australia, leaving the winger's availability uncertain.

May was named as part of Eddie Jones' 36-man touring squad for the three-Test series, which starts on July 2 in Perth.

The 32-year-old has played 69 times for England but could struggle to feature in the opening Test, with May having to spend seven days in isolation as local regulations in Australia stipulate.

May, who is England's second top try scorer in history, missed the Six Nations after undergoing knee surgery in January, making his international comeback in the 52-21 thrashing to the Barbarians last Sunday.

Head coach Jones could be without his star winger but refused to rule him out ahead of the clash with the Wallabies.

"We're not going to rule Jonny May out at this stage. We'll just see how he is," Jones said on Friday.

"Potentially he'll be available next Thursday to train, so we'll have a look to see what he's like because he's experienced and he's showed in his first game back against the Barbarians that he's lacking game time and that he's got his best rugby ahead of him.

"We'll just monitor his situation and make an assessment closer to the day when he gets out."

Eddie Jones has included five new faces in a 35-man England training camp ahead of the tour of Australia next month.

Charlie Atkinson, Biyi Alo, Freddie Clarke, Sam Jeffries and Patrick Schickerling have been called up for the first time.

Wing Jonny May is back in the fold after recovering from a knee injury, while Luke Cowan-Dickie (knee) and Anthony Watson (calf) will also be in camp undertaking rehabilitation work.

Players who will feature in Premiership semi-finals this weekend will not report for international duty.

England face the Barbarians at Twickenham a week on Saturday before a three-match series against the Wallabies, starting in Perth on July 2.

Red Rose head coach Jones said: "With a number of players unavailable because of the Premiership semi-finals, we've got the opportunity to call up some new players.

"It's a great opportunity to learn about them and see what potential they have to play a part in the Australia tour.

"We look forward to continuing the good work from our last camp in developing this team on and off the pitch."

England training squad:

Forwards: Biyi Alo, Alfie Barbeary, Jamie Blamire, Callum Chick, Freddie Clarke, Tom Curry, Trevor Davison, Charlie Ewels, Will Goodrick-Clarke, Jonny Hill, Ted Hill, Sam Jeffries, George McGuigan, Tom Pearson, Bevan Rodd, Patrick Schickerling, Jack Singleton, Will Stuart, Sam Underhill, Jack Willis.

Backs: Henry Arundell, Charlie Atkinson, Mark Atkinson, Orlando Bailey, Joe Cokanasiga, Ollie Hassell-Collins, Will Joseph, Jonny May, Jack Nowell, Paolo Odogwu, Max Ojomoh, Tom Parton, Adam Radwan, Harry Randall, Dan Robson.

George Ford is back in the England squad ahead of the upcoming Six Nations as Eddie Jones awaits an update on captain Owen Farrell, but Jonny May is out.

Farrell has endured an injury-hit season so far and suffered a setback in training last week, with his club Saracens revealing he was set to see a specialist about the unspecified issue.

While he is all but ruled out of the Six Nations opener against Scotland on February 5, England are yet to confirm if Farrell can return after the Calcutta Cup clash.

Nevertheless, Ford is back in the selection to make up for Farrell's absence against Scotland, with the Leicester Tigers fly-half seemingly set for his 78th cap.

Ford has not played for England since the 32-18 Six Nations defeat to Ireland last March, with Marcus Smith's emergence nudging him down the pecking order, but he has the chance to stake his claim once again.

Also in Monday's squad update, England confirmed May has withdrawn from the squad with a knee injury, while Courtney Lawes – initially one of the favourites to deputise as captain in Farrell's stead – must sit out training this week because of head injury protocols.

Nick Isiekwe has joined up with the squad as cover for Lawes, while Elliot Daly is in for May.