Dallas Cowboys quarterback Dak Prescott has undergone thumb surgery on Monday after suffering the injury in Sunday's 19-3 season-opening loss to the Tampa Bay Buccaneers.

Prescott fractured his right thumb when his hand struck the helmet of Tampa Bay pass rusher Shaquille Barrett with about six minutes remaining in the game.

Cowboys team owner Jerry Jones said the injury would keep Prescott sidelined for "several weeks", while ESPN has reported he will miss "six to eight weeks as he goes through rehabilitation". That length would see him out until November 13 against the Green Bay Packers.

Prescott missed most of the 2020 season with a fractured right ankle, and the Cowboys went 4-7 in his absence with three different quarterbacks making at least one start, with veteran Andy Dalton getting the bulk of playing time.

Cooper Rush, who stepped in after Prescott's injury on Sunday, is expected to make his second career start when the Cowboys host the defending AFC Champion Cincinnati Bengals next Sunday.

Cowboys head coach Mike McCarthy said: "The nice thing about Cooper is Cooper's been in our system, knows our system inside and out.

"We won't be in that position of trying not to do too much or vice versa. Cooper gives us the ability to keep playing [our offense]."

Dallas Cowboys quarterback Dak Prescott will be sidelined indefinitely after fracturing his right thumb during Sunday night’s 19-3 season-opening loss to the Tampa Bay Buccaneers, team owner Jerry Jones announced following the game.

Jones said Prescott’s injury would require surgery and will keep the star quarterback out for "several weeks" when speaking to reporters afterward. Prescott said he would undergo the procedure Monday while wearing a brace on his right hand during his postgame press conference.

"I was told it was much cleaner than it could have been," Prescott said.

Prescott sustained the injury when his hand struck the helmet of Tampa Bay pass rusher Shaquille Barrett with about six minutes remaining in the game. Cooper Rush replaced the two-time Pro Bowl selection for the rest of the contest.

The seventh-year veteran struggled prior to departing, completing just 14 of 29 passes for 134 yards and an interception.

Dallas, who played without one of its top receivers in Michael Gallup, and traded wideout Amari Cooper to the Cleveland Browns in the offseason, managed only 244 total yards and finished 3-of-15 on third-down attempts.

After missing most of the 2020 season with a fractured right ankle, Prescott bounced back with an outstanding 2021 campaign in which he threw for 4449 yards and a career-high 37 touchdown passes in leading the Cowboys to a 12-5 record and an NFC East title. Dallas signed the 29-year-old to a four-year, $160million extension in March.

"It’s not the worst thing that has happened to me," Prescott said of this injury. "It’s just a bump in the road, and I will keep moving forward."

The Cowboys went 4-7 in Prescott’s absence in 2020 with three different quarterbacks making at least one start, with veteran Andy Dalton getting the bulk of playing time.

Rush is expected to make his second career start when the Cowboys host the defending AFC Champion Cincinnati Bengals next Sunday. The former undrafted free agent helped Dallas to a 20-16 win at Minnesota in Week 8 of last season by throwing for 325 yards and two touchdowns with one interception.

The Dallas Cowboys had no answer for the swarming Tampa Bay Buccaneers defense in the first Sunday night football matchup of the season, going down 19-3.

In a low-scoring contest, the only scores in the first half came from field goals, with Tampa Bay's Ryan Succop hitting four-of-five tries while the Cowboys only made it into field goal range once, with their first drive.

After their initial field goal to open the game, the Cowboys had nine more offensive drives in the game. They resulted in five punts, three turnovers-on-downs and one interception.

The only touchdown in the game came on a spectacular one-hand snag from Mike Evans on a five-yard goal-line fade in the endzone late in the third quarter, which would be the last score of any kind in the game.

It was far from Tom Brady's best performance, but the 45-year-old was more than serviceable, completing 18-of-27 passes for 212 yards with one touchdown and one interception.

Evans was his top receiver, catching five of his seven targets for 71 yards and a touchdown, while Julio Jones had an impressive debut with his new team, catching three of his five targets – including a 48-yard bomb down the sideline – for 69 yards.

In his return from a torn ACL, Tampa Bay's other elite receiver Chris Godwin left the game after suffering a hamstring injury in the second quarter.

Leonard Fournette was excellent running the ball for the Bucs, tallying 127 yards from his 21 carries while also adding two catches for 10 yards.

For the Cowboys, Noah Brown (five catches for 68 yards) and Dalton Schultz (seven catches for 62 yards) were the only players to have more than Ceedee Lamb's 29 receiving yards, while Ezekiel Elliot led the way on the ground with 52 rushing yards from 10 carries.

Things went from bad-to-worse late in the fourth quarter when Cowboys franchise quarterback Dak Prescott was hit awkwardly on the hand as he released a throw, leaving the game with three minutes to play and not returning.

Speaking after the game, Cowboys owner Jerry Jones confirmed Prescott will need surgery on his hand and will miss multiple weeks.

Dak Prescott has just one playoff victory in his first six NFL seasons, but he has every intention of making this a memorable year for himself and the Dallas Cowboys. 

"It will be the golden birthday," said Prescott, who turns 29 on Friday. "I plan for this to be the golden year."

Both Prescott and Cowboys coach Mike McCarthy received plenty of criticism after a disappointing 23-17 wild-card loss to the San Francisco 49ers last season. That game ended when Prescott ran downfield with six seconds left on the clock and was unable to spike the ball for one last play.  

That defeat left Prescott with a 1-3 career postseason record and kept Dallas without a Super Bowl title since 1995. 

Prescott has been unable to do what Hall-of-Famers Roger Staubach and Troy Aikman did – lead the Cowboys to a Super Bowl title.  

"I mean obviously knowing the quarterbacks that played specifically for this team, and knowing their legacy, and the ones that we hold at the highest standard are the ones that have Super Bowl rings." Prescott said.

"It starts there for me, trying to fill the shoes of those guys that have come before me and do something for this organisation that hasn’t been done in a long time."

While playoff success has eluded Prescott, he did throw a franchise-record 37 touchdown passes last season and threw for 4,449 yards – the fourth-highest single-season total of any Cowboys quarterback. 

"When you don’t win games, it goes on our shoulders sometimes and that’s okay,' Prescott said. "I’m a guy that will take it whenever.

"Take the good with the bad and just continue to help my team, help all 53 who will participate in the game, but as coach says, it takes more than that.

"It takes the whole unit, the whole organisation. I don’t really worry about where the criticism or blame or any of that goes."

The Cowboys open their season against the Tampa Bay Buccaneers on September 11. 

Dak Prescott has had his contract with the Dallas Cowboys restructured.

After seeing his 2020 season cut short by injury, Prescott played 16 times in 2021, as the Cowboys clinched the NFC East with a 12-5 record.

The quarterback led a prolific offense that finished the season with a league-high 530 points, yet the Cowboys fell short in the playoffs, losing to the San Francisco 49ers in the Wild Card round.

Prescott's tally of 4,449 passing yards ranked seventh in the NFL, while his completion percentage of 68.8 was fourth and only three quarterbacks threw for more touchdowns than his 37.

In 2021, the 28-year-old restructured his franchise-record $160million deal to create space for the salary cap and it is a similar story this time around.

With a $208.2m cap announced on Monday, teams have until March 16 to create financial wiggle room and the new structure of Prescott's deal will result in roughly $15m being saved before the start of free agency.

Five-time All Pro Zack Martin has also had his deal restructured, which will give the team an additional $7m in cap space.

The restructuring of the deals sees a portion of the players' salaries for 2022 being converted into signing bonuses.

Dallas needed the space after placing a $10.9m franchise tag on tight end Dalton Schultz.

Only four tight ends scored more than Schultz's eight receiving touchdowns last season, as he racked up a career-high 808 receiving yards.

However, Dallas will still need to make more changes to get under the cap.

According to reports, defensive end DeMarcus Lawrence has declined a pay cut, while Blake Jarwin has also been approached by Dallas to take a hit on his salary.

ESPN, meanwhile, reported that Amari Cooper is likely to be released, which would free up $20m in cap space.

Dak Prescott deflected praise after setting new milestones with the most touchdowns in a single season in Dallas Cowboys history and a career-high five touchdowns in Saturday's 51-26 win over the Philadelphia Eagles.

The 28-year-old Cowboys quarterback completed 21 of 27 passes for 295 yards and five touchdowns against the under-strength Eagles.

Prescott, who missed the bulk of last season with an ankle injury, went past Tony Romo (36) for the most touchdown passes in a single season.

"It's special," Prescott told ESPN after the game. "A record like that that's this team, that's this offense.

"All the different guys that caught passes or the guys that protected, everybody played a part in it. I'm just the beneficiary of it.

"But to know where I was 12 months ago and to be where we are now, headed to the playoffs, I'm very excited."

The Cowboys win means they must wait on Sunday's results to learn their playoffs fate but they can be as high as the second seed in the NFC after finishing with a 12-5 record.

Among Dallas' potential playoffs match-ups is the 11-5 Arizona Cardinals who defeated the Cowboys last weekend 25-22.

"It doesn’t matter," Prescott said when asked if he wanted to face the Cardinals again to get revenge.

"Line them up. To get to where we wanna go, you've got to beat the best. Whoever it is, wherever it is, we're ready for this run."

The Cowboys piled on seven touchdowns against the Eagles, with five different scorers meaning they set a new NFL record for most players (22) to score TDs in a single season.

"We got some momentum going," Prescott said. "We were able to score some touchdowns on offense. We had some success running the ball and throwing the ball.

"More importantly the momentum, the rhythm and fun. The camaraderie we have, we just played together and wanted to finish the season off the right way. I think we did that in all facets of the game."

Dak Prescott threw a career-high five touchdown passes and broke a franchise-record single-season record as the Dallas Cowboys defeated the Philadelphia Eagles 51-26 on Saturday.

Prescott completed 21 of 27 passes for 295 yards, claiming the Cowboys' record for most single-season touchdown passes, going past Tony Romo's mark of 36.

The win improves means the Cowboys finish the regular season with a 12-5 record but will need to wait on Sunday's result to learn their NFC seeding which could be as high as second and as low as fourth.

Dallas head into the playoffs with a 5-1 run across their past six games after a two-game mid-season losing streak and go 6-0 in the NFC East.

Cedric Wilson (119 yards for five receptions) and Dalton Schultz both scored two TDs, while Corey Clement, Ito Smith and JaQuan Hardy also got on the scoresheet.

Upon Hardy's 22-yard rushing touchdown, the Cowboys broke the record for most players (22) to score a TD in a single season.

The Eagles, who rested numerous key players, are playoffs bound despite a 9-8 record. Eagles QB Gardner Minshew, who stepped in for Jalen Hurts due to an ankle injury, threw 19 of 33 passes for 186 yards and two TDs with one interception.

The Dallas Cowboys are fearing the worst with wide receiver Michael Gallup sustaining a suspected torn ACL in his left knee in Sunday's 25-22 loss to the Arizona Cardinals.

Gallup landed awkwardly when he caught a touchdown in the second quarter of the defeat, before limping off the field and leaving for the locker room on crutches.

Cowboys owner and general manager Jerry Jones confirmed Gallup will undergo an MRI on Monday to confirm the severity of the injury but teammate Dak Prescott and head coach Mike McCarthy feared the worst.

"It was tough, very tough," Prescott said at the post-game news conference. "Coming in at half-time and going to see him, just unfortunate. A guy that I love. Can't get a better teammate than MG. Sick about it."

McCarthy added: "Feel terrible for Michael. Obviously made a huge play, but you could see just the way he came down."

Gallup has had 35 receptions for 445 yards and two touchdowns this season for the playoff-bound Cowboys.

The Arizona Cardinals continued their excellent road form as they edged the Dallas Cowboys 25-22 in a potential-playoff preview with Kyler Murray leading the way on Sunday.

The Cardinals improved their season record to 11-5 and their road record to 8-1, snapping a three-game skid, with Texas-born Murray throwing two touchdowns as he completed 26 of 38 attempts for 263 yards.

The Cowboys had trailed 22-7 at the final charge but stormed back into contention as Dak Prescott threw three TD passes for the game but Murray expertly managed the clock late.

Murray found Antoine Wesley for two TDs including a spectacular catch in the third quarter, while Jonathan Ward made a remarkable helmet catch on a fake punt.

The Cowboys lost Michael Gallup to injury upon his second-quarter receiving touchdown and did not return, not helping their cause.

Prescott, who completed 24 of 38 passes for 226 yards along with 20 rushing yards, found Cedrick Wilson and Amari Cooper for final-quarter TDs to tighten the game but he also had a costly fumble at 22-14.

Chargers snap skid as Williams scores 101-yard return

The Los Angeles Chargers snapped a two-game skid with a 34-13 victory over the Denver Broncos to boost their Wild Card hopes as they improve to a 9-7 record.

Chargers quarterback Justin Herbert threw 22 of 31 passes for 237 yards with two touchdowns, breaking the franchise record for single-season touchdown passes at 35.

Andre Williams scored a 101-yard kickoff return touchdown in the fourth quarter, while Austin Ekeler returned to LA's line-up and was important, with 17 carries for 58 yards and a touchdown, along with three receptions for 54 yards.

Lance leads 49ers to key win in Wild Card race

Trey Lance stepped in for the injured Jimmy Garoppolo and provided two touchdown passes as the San Francisco 49ers won 23-7 over the Houston Texans.

Lance completed 16 of 23 passes for 249 yards with the two TDs and an interception to help the 49ers improve to 9-7 in the NFC Wild Card pursuit.

Deebo Samuel and Elijah Mitchell scored the touchdowns as the 49ers scored 20 second-half points to secure the win.