Billy Vunipola has been left out of new head coach Steve Borthwick's 36-man England squad for the upcoming Six Nations, though Owen Farrell will be kept on as captain.

Other notable omissions alongside Vunipola are Jonny May and Jack Nowell, with a combined 180 England Test appearances between the three players.

Dan Cole is included, having received the most recent of his 95 caps in the 2019 Rugby World Cup final defeat to South Africa, while Northampton Saints fly-half Fin Smith is among the five uncapped players Borthwick has picked.

The other potential debutants are London Irish's Ollie Hassell-Collins and Gloucester hooker George McGuigan, as well as Harlequins duo Cadan Murley and Jack Walker.

Farrell and Marcus Smith were also named, with the former set to remain captain having occupied the role under previous head coach Eddie Jones.

England's first game with their new boss will be against Scotland in the Six Nations at Twickenham on February 4, though they likely already have one eye on the 2023 Rugby World Cup, which begins in September.

Borthwick said: "This is an exciting squad, with a blend of Six Nations experience and young talent, and includes players who are in excellent form in the Premiership.

"We are all looking forward to the challenges of the Six Nations and we will approach this great tournament with a spirit of courage and total commitment.

"I know the players can't wait to get back to Twickenham and give our fans a performance they can be proud of.

"The hard work for the Scotland game starts now."

England squad: Forwards: Ollie Chessum, Dan Cole, Ben Curry, Alex Dombrandt, Ben Earl, Ellis Genge, Jamie George, Joe Heyes, Jonny Hill, Nick Isiekwe, Maro Itoje, Courtney Lawes, Lewis Ludlam, George McGuigan, Bevan Rodd, Sam Simmonds, Kyle Sinckler, Mako Vunipola, Jack Walker, Jack Willis.

Backs: Elliot Daly, Owen Farrell (captain), Tommy Freeman, Ollie Hassell-Collins, Dan Kelly, Max Malins, Joe Marchant, Alex Mitchell, Cadan Murley, Henry Slade, Fin Smith, Marcus Smith, Freddie Steward, Manu Tuilagi, Jack van Poortvliet, Ben Youngs.

Sam Simmonds and Jack van Poortvliet will start for England against Japan at Twickenham on Sunday.

Eddie Jones has named five changes from the shock 30-29 defeat to Argentina last weekend as they prepare to face Japan, who he coached between 2012 and 2015.

Number eight Simmonds has not featured for England since the Six Nations in March but comes in for Billy Vunipola, who drops to the bench.

Alex Coles is replaced by debutant David Ribbans at lock while Van Poortvliet, who scored within 30 seconds of coming on the pitch against Argentina, will start at scrum-half.

Jonny May also comes in for Joe Cokanasiga and Guy Porter is the final introduction as he is chosen to start over Manu Tuilagi at outside centre.

Owen Farrell will captain England and earn his 99th international cap, while hooker Jamie George is on the bench after recovering from a foot injury.

England team to face Japan: 15. Freddie Steward, 14. Jack Nowell, 13. Guy Porter, 12. Owen Farrell (c), 11. Jonny May, 10. Marcus Smith, 9. Jack van Poortvliet; 1. Ellis Genge, 2. Luke Cowan-Dickie, 3. Kyle Sinckler, 4. David Ribbans, 5. Jonny Hill, 6. Maro Itoje, 7. Tom Curry, 8. Sam Simmonds.

Replacements: 16. Jamie George, 17. Mako Vunipola, 18. Joe Heyes, 19. Alex Coles, 20. Billy Vunipola, 21. Ben Youngs, 22. Henry Slade, 23. Manu Tuilagi.

Billy Vunipola and Danny Care have returned to the England fold as head coach Eddie Jones announced the squad for the upcoming tour to Australia.

Vunipola has not featured for England since last year's Six Nations, but comes into the squad after injuries to Alex Dombrandt and Sam Simmonds.

The 29-year-old suffered a head injury in Saracens' Premiership final loss to Leicester Tigers on Saturday but is fit to join up with an England side that were hammered 52-21 by the Barbarians at Twickenham on Sunday.

Care also features, having not earned a cap since 2018, as England's most-capped international and fellow scrum-half Ben Youngs stays at home due to family reasons.

Jones has included eight uncapped players in the 36-man squad.

Fraser Dingwall, Tommy Freeman, Guy Porter, Patrick Schickerling, Jack van Poortvliet, Jack Walker, Henry Arundell and Will Joseph will hope for their first competitive caps Down Under.

England have not played in Australia since 2016, when they won all three of the games. They also overcame the Wallabies in the quarter-finals of the 2019 Rugby World Cup and are on an eight-match winning streak against their old rivals.

Jones' side ultimately went on to lose the final to South Africa, but they are turning their attention to next year's World Cup in France as they look for their first title since 2003.

England will open the series against Australia in Perth on July 2, before games in Brisbane and Sydney.

England squad in full

Forwards: Ollie Chessum, Luke Cowan-Dickie, Tom Curry, Charlie Ewels, Ellis Genge, Jamie George, Joe Heyes, Jonny Hill, Nick Isiekwe, Maro Itoje, Courtney Lawes, Lewis Ludlam, Bevan Rodd, Patrick Schickerling, Will Stuart, Sam Underhill, Billy Vunipola, Mako Vunipola, Jack Walker, Jack Willis.

Backs: Henry Arundell, Danny Care, Joe Cokanasiga, Fraser Dingwall, Owen Farrell, Tommy Freeman, George Furbank, Will Joseph, Joe Marchant, Jonny May, Jack Nowell, Guy Porter, Harry Randall, Jack van Poortvliet, Marcus Smith, Freddie Steward.

Eddie Jones has left experienced quartet Billy and Mako Vunipola, Jamie George and George Ford out of England's 45-man squad for this month's training camp.

Eight uncapped players – Mark Atkinson, Jack Kenningham, Louis Lynagh, Gabriel Oghre, Raffi Quirke, Sam Riley, Bevan Rodd and Ollie Sleightholme – have been selected.

The large group also contains nine players who made their debuts for England in their last batch of fixtures, including Jamie Blamire, Trevor Davison and Alex Dombrandt.

There are also recalls for Ben Youngs, Manu Tuilagi and Joe Marler, as well as England's 10-strong British and Irish Lions contingent.

Despite overlooking the Vunipola brothers, George and Ford, Jones insists the door will remain open for all four players.

"This is an exciting squad made up of experienced players and young guys who did well in the summer and have earned their place again," Jones said on Tuesday.

"We have left out some experienced players but we're really clear the door isn't closed to them, and we're looking forward to seeing them work hard to get back into contention."

England's training camp will run from Sunday 26 until Tuesday 28 and forms part of their preparations for the internationals against Tonga, Australia and South Africa in November.

England's 45-man training squad

Forwards: Jamie Blamire (Newcastle), Callum Chick (Newcastle), Luke Cowan-Dickie (Exeter), Tom Curry (Sale), Trevor Davison (Newcastle), Alex Dombrandt (Harlequins), Alex Dombrandt (Harlequins), Charlie Ewels (Bath), Ellis Genge (Leicester), Joe Heyes (Leicester), Jonny Hill (Exeter), Ted Hill (Worcester), Maro Itoje (Saracens), Jack Kenningham (Harlequins), Courtney Lawes (Northampton), Lewis Ludlam (Northampton), Lewis Ludlow (Gloucester), Joe Marler (Harlequins), George Martin (Leicester), Beno Obano (Bath), Gabriel Oghre (Wasps), Sam Riley (Harlequins), Bevan Rodd (Sale), Sam Simmonds (Exeter), Kyle Sinckler (Bristol), Will Stuart (Bath), Sam Underhill (Bath).

Backs: Mark Atkinson (Gloucester), Owen Farrell (Saracens), George Furbank (Northampton), Ollie Lawrence (Worcester), Louis Lynagh (Harlequins), Max Malins (Saracens), Joe Marchant (Harlequins), Jonny May (Gloucester), Raffi Quirke (Sale), Adam Radwan (Newcastle), Harry Randall (Bristol), Dan Robson (Wasps), Henry Slade (Exeter), Ollie Sleightholme (Northampton), Marcus Smith (Harlequins), Freddie Steward (Leicester), Manu Tuilagi (Sale), Anthony Watson (Bath), Ben Youngs (Leicester).