The Chicago Bears ran the ball for 243 yards in their dominant 33-14 win against the New England Patriots on Monday night.

Four Bears rushed for at least 29 yards on the night, with receiver Dante Pettis taking a jet-sweep 29 yards on his only carry, while quarterback Justin Fields rushed 14 times for 82 yards, and running backs David Montgomery (15 carries for 62 yards and a touchdown) and Khalil Herbert (12 carries for 62 yards) both received strong workloads.

Their 243 yards on the ground are the third most this season by any team in a single game, trailing only the New York Giants (262 yards) against the Bears in Week 4, and the Bears themselves (282 yards) in their Week 3 win against the Houston Texans.

Fields ran in for a three-yard touchdown in the first quarter to give the Bears a 10-0 lead after returning Patriots quarterback Mac Jones struggled, and when he was pulled to begin the second quarter, rookie Bailey Zappe seemed to win the starting job.

Zappe led two quick touchdown drives – culminating in a 30-yard touchdown pass to Jakobi Meyers and a four-yard Rhamondre Stevenson touchdown run – to put the Patriots up 14-10 with six minutes remaining in the first half, but they would not score the rest of the game.

The Bears continued to have success, with Khalil Herbert taking a screen pass 25 yards into the endzone for Fields' only passing touchdown of the night, and Montgomery rammed in the last score of the game in the fourth quarter from the one-yard line.

Fields completed 13 of his 21 passes for 179 yards, one touchdown and one interception, while defensively, Bears linebacker Roquan Smith finished with a sack and an interception.

In the wake of a season-ending ACL injury to rookie running back Breece Hall, the New York Jets have traded a late-round draft pick to the Jacksonville Jaguars for 24-year-old running back James Robinson.

Robinson, who went undrafted in 2020, burst onto the scene as a rookie with 1070 rushing yards and 49 catches for 344 receiving yards, totaling 10 touchdowns.

Despite his success, the Jaguars opted to draft running back Travis Etienne Jr in the first round of the 2021 draft, but his rookie season ended before it began after a Lisfranc injury to his foot in the preseason.

Robinson's follow-up to his terrific rookie season was less spectacular, and ended abruptly with a torn Achilles in Week 16 late in December. Through two seasons, he carried the ball 404 times at 4.54 yards per carry.

Robinson opened this season as the starter, but slowly began to cede work to the former college teammate of star quarterback Trevor Lawrence, and that culminated in Week 7 where an even split turned into the Etienne show.

Etienne took full advantage, turning 14 carries into 114 rushing yards and his first career touchdown, marking the third consecutive game he has totaled at least 100 yards from scrimmage. Robinson did not receive a single carry in their loss to the New York Giants.

Meanwhile, the Jets have been one of the most surprising teams in the NFL this season, boasting a 5-2 record despite beginning the season without starting quarterback Zach Wilson, winning four games in a row since his return in Week 4.

A big part of the Jets' success has been the breakout performances of Hall, who quickly emerged as the star of this year's rookie running back class and had a real chance of winning Offensive Rookie of the Year.

The Jets still have Michael Carter II in the backfield, who has been sharing the workload with Hall, but lack any real depth behind him, prompting a proactive move for the now out-of-favour Robinson.

It was a small price to pay, with ESPN's Adam Schefter reporting the Jets only sent the Jaguars a sixth-round draft pick, with a chance it becomes a fifth-rounder if certain benchmarks are met.

The Los Angeles Chargers lost two strong players at important positions in Sunday's disappointing 37-23 loss to the Seattle Seahawks, with All-Pro cornerback J.C. Jackson and starting wide receiver Mike Williams both suffering injuries.

While still not great, the news is better for Williams, who was diagnosed with a high-ankle sprain that will keep him out of action for "a matter of weeks, not days", according to Chargers head coach Brandon Staley.

Unfortunately for Jackson – who had not missed a game for the past three seasons – his campaign is over after rupturing his patella tendon. The Chargers signed Jackson to a five-year, $82.5million deal in free agency after he played four seasons with the New England Patriots and led the NFL over that span with a league-high 25 interceptions.

It adds to a troubling injured list for the Chargers, who are already without stars Rashawn Slater at left tackle and pass-rusher Joey Bosa after the pair were placed on the injured reserve at the end of Week 3, and five-time Pro Bowl receiver Keenan Allen was only able to return to the field in Week 7 in a limited fashion.

Speaking to the media on Monday, Staley said the Chargers would weigh up whether they need to make any significant moves before the rapidly approaching trade deadline on November 1.

"I think in the next couple days, we'll be able to assess our team a lot better," he said. "We'll take the next couple days and... make those types of discussions happen, and we'll see.

"We're always going to look for avenues to enhance our team and make it better."

On Bosa, Staley said he is "making progress" without providing any timetable for his return, while he also added that he limited Allen's work in his first game back from injury due to a visible lack of "burst".

"I just didn't feel like he could really burst the way that he wanted to and didn't want to risk anything happening," he said. "So no setback yesterday, but just didn't want to push it."

By stunningly trading Tyreek Hill in the offseason, the Kansas City Chiefs parted with a player whose unparalleled speed consistently served as their easiest avenue to explosive plays.

Juju Smith-Schuster may have initially seemed a curious fit as his replacement but, after back-to-back 100-yard receiving performances, he is proving to be the ideal number one wideout for the Chiefs to attack how defenses are attempting to defend them in 2022.

While tight end Travis Kelce is Patrick Mahomes' unquestioned top target in the post-Hill era, Smith-Schuster is rapidly developing an increasingly potent rapport with a quarterback who is in a seemingly ceaseless battle with Josh Allen for the title of the league's most frightening signal-caller.

The San Francisco 49ers will spend the early part of the week before Halloween trying to learn the lessons from their previously top-ranked defense's nightmare showing against the Chiefs, one in which Smith-Schuster produced another demonstration of his increasing comfort level in an offense that has designs on overcoming the loss of Hill to right the wrongs of their playoff disappointments in the previous two seasons.

A serial separator

Having caught all five of his targets for 113 yards and a touchdown in the Chiefs' narrow defeat to the Buffalo Bills last week, Smith-Schuster enjoyed another sensational display at Levi's Stadium.

He finished with seven catches on eight targets for 124 yards and a touchdown that was the knockout blow in the Chiefs' 44-23 win over the 49ers.

Smith-Schuster produced a burn, which is when a receiver wins his matchup on a play where he is targeted, on seven of his eight targets against San Francisco and averaged 15.5 burn yards per target. Among receivers targeted at least five times in Week 7, only Jaylen Waddle and Tyler Boyd averaged more as of Sunday.

Those numbers are a continuation of a theme from the Week 6 meeting with the Bills, in which Smith-Schuster registered a burn on each of his targets and averaged 22.6 burn yards per target.

For the season, Smith-Schuster now has a burn rate of 72.3 per cent, which is third among wide receivers with at least 25 targets.

In other words, he is creating separation at an elite level and, as he displayed versus the 49ers, he is doing so regardless of the coverage he is facing.

Smith-Schuster was outstanding in Week 7 when attacking both man and zone coverage.

Against man, he used his physicality and his 215-pound frame to win his matchups with the 49ers' cornerbacks.

He ran a pivot route on third down and relied on his superior bulk to get free of Deommodore Lenoir and convert with a five-yard gain to set up the Chiefs' first touchdown to Mecole Hardman.

Smith-Schuster then converted on second down on a six-yard slant, getting physical with former Chief Charvarius Ward to keep Kansas City out of a third down situation on a drive that ended with another touchdown for Hardman.

The former Pittsburgh Steeler ended the first half with a 19-yard reception on a back shoulder throw, which he brought in by easily beating backup corner Ambry Thomas at the catch point.

In the second half, though, Smith-Schuster thrived through his ability to exploit zone coverage.

The Chiefs proved near-unstoppable on third down, and Smith-Schuster came up with a key conversion on 3rd-and-2 that eventually culminated with a Mahomes strike to Justin Watson to put them up 28-16.

San Francisco rotated to a two-deep safety zone coverage at the snap, but it was they who were fooled by Mahomes, who never turned his eyes to Smith-Schuster until the last second, the Chiefs quarterback and a route by tight end Travis Kelce holding nickel defender Jimmie Ward and creating a big hole in the zone into which Smith-Schuster ran an out-breaking route.

Smith-Schuster broke his route to the outside at the perfect depth to ensure safety Tashaun Gipson had too much ground to make up, with Mahomes putting the ball high where only his receiver could get it as they connected for a 15-yard gain.

Mahomes was able to hold the defense with his eyes because of obvious faith Smith-Schuster would be in the right spot to make the play, and that confidence in the Chiefs' new top wideout will keep blossoming if he continues to make plays after the catch, on which he has racked up 210 yards so far this season -- 13th most in the NFL.

He did so on the drive that set up Hardman's third and final touchdown, Mahomes settling for a short throw to Smith-Schuster on an underneath crosser against the 49ers' Cover 6 look protecting the endzone. Smith-Schuster broke one-tackle and gained 20 yards to put the Chiefs on the three-yard line.

The final scoring drive was dominated by Smith-Schuster, who on a second-and-20 got the Chiefs in position to convert on third down, gaining more yards after the catch on a 14-yard completion from Mahomes on a stop route. Corner Charvarius Ward was again playing zone, but dropped deep to guard against a corner route from Hardman, giving Smith-Schuster an easy reception.

His defining contribution came on the next play on another routine catch that Smith-Schuster turned into a long touchdown, capitalising on a zone coverage bust to surge 47 yards into the endzone. Smith-Schuster was left alone to settle into a huge void in the middle of the field. That space should have been occupied by All-Pro linebacker Fred Warner, but he had vacated the area to cover Kelce, leaving Smith-Schuster free to cap a dominant day for the Chiefs' offense in style.

Hardman's three touchdowns and Mahomes' 423-yard day may have attracted more attention, but it is the astute acquisition of Smith-Schuster that is unlocking this latest version of Andy Reid's offense.

Smith-Schuster offers Mahomes a receiver who excels attacking zone coverage and who can consistently turn short throws into plays that wear down a defense even when it has succeeded in forcing him to take the underneath option through the use of the two-high zones that have become the default reply to the Chiefs' attack.

Despite not having top-end speed, Smith-Schuster can critically also win against man when defenses take a more aggressive approach to the persistently infuriating challenge of trying to stop Mahomes. He could scarcely be a more different receiver to what Mahomes had when Hill was his number one wideout, but Smith-Schuster's skill set is one that gives the Chiefs answers to the variety of tests defenses are throwing at them.

And, as the burgeoning chemistry between Mahomes and Smith-Schuster grows, it will once again be defenses who are left desperately searching for a solution.

The New York Jets have lost two key members of their offense to season-ending injuries, head coach Robert Saleh announced on Monday.

Rookie running back Breece Hall and offensive lineman Alijah Vera-Tucker will not take to the field again in the 2022 season, having suffered injuries in Sunday's victory over the Denver Broncos.

"Breece is out; he's torn his ACL," Saleh told reporters. "AVT is gone; he has a tricep that requires surgery, so he is done for the year."

Second-round pick Hall had rushed for 463 yards and four touchdowns this year, adding 218 yards and a score from 19 catches.

Hall only started for the first time against the Green Bay Packers in Week 6, finishing with 116 rushing yards in a shock win, and he was influential again against the Broncos prior to his injury as the Jets improved to 5-2.

A 62-yard run gave Hall a rushing TD in a fourth straight game – the first Jet to do that since Thomas Jones in 2009 – but he soon went down.

Meanwhile, Vera-Tucker has been a mainstay of the Jets' O-line since being taken with the 14th overall pick in 2021. He has allowed just 1.5 sacks in 23 starts.

The Indianapolis Colts have seen enough of Matt Ryan and are making a change at quarterback.

The Colts are benching Ryan and will start Sam Ehlinger for Sunday's game against the Washington Commanders.

Ryan has a Grade 2 shoulder strain, but his demotion has nothing to do with the injury, as coach Frank Reich said turning the offense over to Ehlinger would have happened anyway regardless of Ryan's health.

"Right now the move is for Sam to be the starter for the rest of the season," Reich said, via the Colts' website.

Acquired from the Atlanta Falcons in the offseason, Ryan surpassed Hall of Famer Dan Marino for the seventh-most passing yards in NFL history earlier this season, but the 15-year veteran leads the NFL with 11 fumbles and nine interceptions.

He threw a pair of interceptions – one of which was returned 76 yards for a touchdown – in Sunday's 19-10 loss to Tennessee, which dropped the Colts to 3-3-1 and 1.5 games behind the Titans for first place in the AFC South.

On the season, Ryan ranks fourth in the NFL in passing yards (2,008) but 20th in QB rating (84.7) and 22nd in yards per attempt (6.76).

A sixth-round pick by the Colts in the 2021 draft, Ehlinger has yet to take a snap this season and has yet to throw a pass in the NFL. As a backup last season, he appeared on just three offensive plays.

The 24-year-old takes over an offense that ranks 17th in total yards (341.6 per game) and 29th in scoring (16.1 points per game).

The New York Giants continue to have their doubters despite improving their record to 6-1.

But rookie pass rusher Kayvon Thibodeaux has a clear message for those who are still not taking the Giants seriously following their 23-17 win over the Jacksonville Jaguars. 

"F*** 'em, f*** all the people around the league," said Thibodeaux to NJ Advance Media.

"The only people that matter are the people in this room. The only people that are going to dictate what happens on Sunday are the people in this room. Excuse my French.

"I mean, listen, I think the greatest thing we do is we fight for respect in the locker room. When you're on that battlefield, I want you to not respect me."

The Giants came from 17-13 down to see off the Jaguars, who narrowly missed out on claiming a game-winning touchdown as wide receiver Christian Kirk was stopped a yard short of the endzone in the final seconds.

The unconvincing nature of the victory will likely do little to quiet those questioning the Giants' legitimacy. New York have trailed in all seven games this year, with this victory marking their sixth comeback of a remarkable season.

But safety Xavier McKinney echoed the sentiments of team-mate Thibodeaux.

"I really don't even care for that question anymore," McKinney said. "I'm kind of tired of answering it because it's the same thing every week.

"Obviously, we know that. I really don't care. We don't care as a team. The only thing we can do is keep focusing on what we can do and keep getting better."

The Kansas City Chiefs' offense fired on all cylinders against a vaunted San Francisco 49ers defense on Sunday, and Juju Smith-Schuster had an interesting explanation for their success.

Kansas City recovered from an early 10-0 hole to prevail in Week 7, the Chiefs exploding and pulling away in the fourth quarter in a 44-23 triumph.

Quarterback Patrick Mahomes shredded the Niners for 423 yards and three touchdowns, bouncing back in emphatic fashion after his interception on the Chiefs' first drive set up San Francisco's opening touchdown.

Smith-Schuster and Marquez Valdes-Scantling both went over 100 yards receiving and tight end Travis Kelce had 98, while Mecole Hardman found the endzone three times, twice as a rusher and once as a receiver.

San Francisco entered the game as the NFL's top defense, allowing only 255.8 yards per game, and the Chiefs were coming off a Week 6 game in which they were frustrated and held to 20 points in a loss to the Buffalo Bills.

But instead of those point-scoring issues carrying into another tough matchup, the Chiefs found the explosiveness they needed, with Smith-Schuster crediting an online gaming session between Mahomes and his pass-catchers for their devastating display.

"I'm gonna tell you what got us the chemistry when we needed this game," Smith-Schuster told a press conference. 

"So, I think it was Friday night. It was me, Pat, Travis and MVS. We were playing Call of Duty together, we were playing Warzone, and we played three games, and we won three games, back-to-back.

"We got off, and we were like, 'damn'. It's really hard to win a game in Warzone. 

"You could just... the communication between all of us, and then the chemistry? It was like we were in the game. It kind of just led into this game, and it kind of just showed on the field."

Geno Smith believes he can play even better after leading the Seattle Seahawks to a victory that lifted them to the top of the NFC West.

Unfancied and seen as a rebuilding team after the decision to trade nine-time Pro Bowl quarterback Russell Wilson to the Denver Broncos in the offseason, the Seahawks are now 4-3 after the latest success authored by Smith.

The former first-round pick of the New York Jets is penning a remarkable comeback story having beaten Drew Lock to the starting quarterback job in Seattle. 

Smith went 8-8 as a rookie with the Jets in 2013 but saw his career fall apart from there as poor play, a fractious relationship with former coach Rex Ryan and a now infamous locker room fight in 2015 derailed his hopes of being the long-term answer in New York.

He spent seasons with the New York Giants and Los Angeles Chargers before eventually landing in Seattle as Wilson's backup in 2019, playing three games in relief of the injured starter last season.

The Seahawks won only one of those starts, and there was little to suggest he could lead them to playoff contention in 2022. However, they have now won three of their last four games, with Smith leading the NFL with a completion percentage of 73.5.

Sunday saw him complete 20 of his 27 passes for 210 yards, two touchdowns and one interception as the Seahawks saw off the Chargers 37-23.

Asked by Peter King for his Football Morning in America column what surprises him most about his and Seattle's success, Smith replied: "Nothing. Nothing has surprised me. In fact, I know I can play a lot better.

"In my rookie year playing with the Jets, we went 8-8 and missed the playoffs by one game. The reality is it's hard to win the NFL with a young quarterback. That's just the reality of the NFL.

"So much goes on that you have to know in order to be successful. Quarterbacking is a skill more than just a talent. I'm just happy I've just continued to develop.

"I know I might've struggled out the gate in pro football. That's just the reality of the NFL. Sometimes they give up on you fast.

"The numbers at the beginning of my career are kind of skewed, if you ask me. If you look at Peyton Manning, if you just judge his rookie season, you'd never think Peyton Manning would've become what he became. Steve Young, too. Troy Aikman. The list goes on and on and on.

"[You have] just got to have patience with young quarterbacks. You have got to find the right young quarterbacks with the right mentality who are going to continue to work and have a great attitude about the game and the struggle.

"Over the years, not playing was heartbreaking. I’m so competitive, and I love playing so much that I really wanted to be out there every single game. But what's that cliche? 'What doesn't kill you makes you stronger'?

"I know I’m better for all those years. Coming into this year, I wasn't sure what would happen [after the trade of Wilson to Denver].

"When [Seahawks coach] Pete Carroll hit me up and was like, 'Hey I'm giving you opportunity to compete for the job,' I mean, that’s all you have to say to me. That was awesome. He's shown faith in me. That's just what I need.

"You ask me: what am I focused on during the week? Playing hard, doing what I'm coached to do. It's that simple. I don't think about failure.

"My thought process is I need to run on the field with my linemen and play just as hard as they're playing and do exactly what I'm coached to do and then let my talent take over after that. It's that simple in my mind.

"Our success so far starts with the trust and belief of our head coach. Not many coaches would start two rookies on the offensive line, a rookie running back, two rookie cornerbacks.

"Not many coaches would be comfortable starting a quarterback who hasn't played in many years. But Pete does it because he knows what he's looking at. He's played young guys before, lots of times. He's taken chances on players, lots of time. He knows how to coach ball. You can see that this year.

"I think we're built to last for this season and many seasons. But ultimately, it comes down to what we do, not what we say. It's about the work we put in. It's about the consistency. And our preparation and consistency and our togetherness. That's all that matters.

"As long as we continue to build together, the sky's the limit. It takes work. It takes hard work. We have got to embrace that part of it."

Aaron Rodgers is "not worried" about the Green Bay Packers' slump after they were consigned to a 23-21 defeat by the Washington Commanders.

The Packers suffered a third consecutive defeat on Sunday and are 3-4 after the loss at FedEx Field.

Quarterback Rodgers was defiant after Green Bay fell short in the capital and believes they can stop the rot when they face the Buffalo Bills next weekend.

Asked if making the playoffs still seemed possible, he replied: "You're god damn right it does.

"I'm not worried about this squad. In fact, this might be the best thing for us. This week, nobody is going to give us a chance, going to Buffalo on Sunday Night Football, with a chance to get exposed. Shoot, this might be the best thing for us."

Packers head coach Matt LaFleur is backing his team to arrest their slide.

"I don't think anybody thought we'd be in this spot that we're in right now," said LaFleur. "We're going to find out what we're made of in terms of just how we attack Monday, how we attack Tuesday, Wednesday and every day in practice.

"I do believe that we've got the right kind of guys that will continue to battle."

LaFleur says it is not only down to Rodgers to step up and get Green Bay back on track.

He said: "I think it takes everybody. It takes everybody around him. You've got to have the protection in front of you to be able to hold up.

"You've got to have the guys making plays, too. I feel like we had a ton of drops. We had a lot of penalties that put us back behind the sticks."

Christian McCaffrey was disappointed to suffer defeat on his San Francisco 49ers debut after a "weird week", but wants to focus on what he can control.

McCaffrey only joined the 49ers at the end of last week in a trade from the Carolina Panthers, and was thrown straight into the action against the Kansas City Chiefs on Sunday.

The Chiefs ran out 44-23 winners at Levi's Stadium, with McCaffrey only involved in 21 snaps, making 38 yards from eight carries.

The 26-year-old All-Pro was clearly still getting used to the idea of swapping Carolina for San Francisco, but said after the game he wants to get up to speed quickly.

"This was a weird week for me and for [the team]," he told reporters. "I didn't know what to expect. I know I had a certain list of plays that were up.

"For me, mentally, this was just 'focus on everything I can control and get rolling'. Obviously losing's frustrating, but I'm still getting to know these guys, I gotta do my job, I gotta make a few more plays here and just learn the offense as quick as possible.

"I'm just trying to control what I can control right now and get going."

The Niners are 3-4, having lost their last two games, and tight end George Kittle warned that McCaffrey cannot be expected to "be the saviour".

"He's not going to be the saviour, but he's definitely going to help us out," Kittle said. "I think these next two weeks are going to be huge for Christian to understand our offense and be comfortable out there not to think at all, just go out and run because that's what he's really good at.

"Like I said, penalties, turnovers, giving up big plays on defense, we've got to be better than that. We weren't today. That's how you lose football games."

The New York Jets fear rookie running back Breece Hall could miss the remainder of the season after he suffered a suspected torn ACL on Sunday.

Hall was taken off in the second quarter of the Jets' 16-9 win over the Denver Broncos, and coach Robert Saleh said: "The initial diagnosis is not good," before confirming it was likely to be an ACL injury.

It puts a dampener on an excellent start to the season for the 5-2 Jets and for Hall, who has totalled 681 scrimmage yards and scored five touchdowns (four rushing, one receiving) in seven games.

That included a 62-yard TD run in the first quarter against Denver, making the 21-year-old the first Jets player since 2009 to have a rushing touchdown in four straight games.

However, just two carries later he was tackled near the sideline and appeared to land awkwardly, before being carted off the field for the remainder of the contest.

"He's a heck of a football player," Saleh said. "When you lose great football players, it's not good."

There were further injury concerns for Saleh as right tackle Alijah Vera-Tucker (elbow) and wide receiver Corey Davis (knee) were also unable to finish the game, with quarterback Zach Wilson saying afterwards: "I didn't even know what was going on, but I'm just in the huddle like, 'Where they at?'

"It's tough because all of those guys are great players. They're all balling. But unfortunately, it's part of the NFL, right?"

Tua Tagovailoa returned as the Miami Dolphins snapped their three-game skid with a 16-10 victory over the Pittsburgh Steelers at Hard Rock Stadium on Sunday night.

Tagovailoa had not played since suffering a concussion in Week 4, but threw a first-quarter touchdown for Raheem Mostert as the Dolphins raced to a 13-0 lead.

The Steelers rallied with 10 second-quarter points with rookie George Pickers pulling down a spectacular catch from a Kenny Pickett TD pass to make it 16-10 at half-time.

Miami's defense held firm to thwart two fourth-quarter Steelers' drives with interceptions, firstly by Jevon Holland and then Noah Igbinoghene, the latter settling a game where no points were scored in the second half. The win improved Miami's record to 4-3, sitting third in the AFC East, while the Steelers are 2-5 and last in the AFC North.

In the Steelers' last drive, Pickett had connected with tight end Pat Freiermuth and wide receiver Diontae Johnson for major gains in the final minute, before Igbinoghene's pick.

Miami's defense had only one interception all season but notched three in this game alone from Pickett's throwing with the Steelers QB completing 32 of 44 passes for 257 yards.

Tagovailoa made it four wins from four starts, with 21-of-35 passing for 261 yards with no interceptions, running four times for 15 yards.

Jaylen Waddle had four catches for 88 yards including a brilliant flying catch, while Tyreek Hill was a regular target with seven receptions for 72 yards. Touchdown scorer Mostert had four receptions for 30 yards along with 16 carries for 79 yards.

The Kansas City Chiefs are the highest scoring team in the NFL through Week 7 after a convincing 44-23 road win against the San Francisco 49ers on Sunday.

San Francisco were in the headlines this week after pulling the trigger on a big trade for superstar running back Christian McCaffrey, but it was Chiefs quarterback Patrick Mahomes controlling the contest.

Mahomes threw an interception on the Chiefs' first drive, but turned things around quickly and ended up completing 25 of his 34 passes for 423 yards and three touchdowns.

He tossed second-half touchdown passes to Justin Watson and JuJu Smith-Schuster, and his first touchdown pass to Mecole Hardman was the beginning of a memorable day for the speedy receiver.

After getting on the end of an eight-yard score from Mahomes in the first quarter, Hardman then took a jet-sweep 25 yards down the sideline in the second quarter for the first rushing touchdown of his career. 

Not done yet, Hardman added his second rushing touchdown and third overall score for the game with a three-yard run in the fourth period. He finished with two carries for 28 yards and two rushing TDs, with four catches for 32 yards and a receiving TD.

For the 49ers, Jimmy Garropolo was not to blame for the loss as he finished 25-of-37 for 303 yards, two touchdowns and an interception – with touchdown passes to George Kittle and Ray-Ray McCloud III.

McCaffrey carried the ball eight times for 38 yards, and caught both of his targets for 24 yards through the air.

Seahawks move above .500 with upset in Los Angeles

The Seattle Seahawks rode a spectacular performance from rookie running back Kenneth Walker III to a 37-23 upset win on the road against the Los Angeles Chargers.

Walker rushed 23 times for 168 yards and two touchdowns, capped by a 74-yard rushing touchdown in the fourth quarter to put the game to bed.

Seahawks quarterback Geno Smith was solid, completing 20-of-27 passes for 210 yards and a pair of touchdown passes to Marquise Goodwin as he assumed a major role following a knee injury to key wide receiver D.K. Metcalf.

Chargers star Austin Ekeler remains the top running back in fantasy football, rushing for 31 yards and a touchdown, as well as catching all 12 of his targets for 96 yards and a second score.

Dak Prescott made a slow start on his return to the Dallas Cowboys team, but "a win's a win", the quarterback says.

Prescott had been out of action since fracturing his thumb in the Week 1 loss to the Tampa Bay Buccaneers.

The Cowboys had improved to 4-2 in his absence, led by Cooper Rush, and their fifth win followed in a 24-6 defeat of the Detroit Lions on Sunday.

Prescott was back in the team, although he was far from the star of the show.

The Dallas defense produced five sacks and two interceptions, while Ezekiel Elliott ran in for two touchdowns.

Prescott did not throw a TD pass until the final two minutes of the fourth quarter, finishing with 207 yards on 19-of-25 passing.

The QB was never concerned about his own performance, though, suggesting he might have enjoyed overseeing a comfortable victory without contributing with a TD of his own.

"A win's a win," Prescott said. "I really don't care how it gets done; a win's a win.

"I thought it was going to be pretty cool to leave this game without a touchdown, honestly. That's kind of where my head is right now.

"I know how talented this team is. I know what we can be. It's not about me. It's about all of us, and I'm just trying to make sure I play my part and make sure I put this team in the right situation each and every play."

Crucially, he added: "The thumb feels pretty good."

Cowboys head coach Mike McCarthy said of his QB's display: "I thought Dak performed better as the game went on. It's his first time he's been out there in quite some time.

"Start with the command of the huddle, the whole operation, I thought he was really on point there. He handled the adjustments that were going during the course of the game.

"Those are the big things that don't show up in the stat column."