Uncapped pair Guy Porter and Tommy Freeman will make their England debuts after they were named in Eddie Jones' starting XV for the second Test against Australia.
The tourists will also hand a first start to Tigers scrum-half Jack van Poortvliet as they ring the chances for the must-win encounter against the Wallabies in Brisbane on Saturday.
Despite a man advantage after Darcy Swain's first-half dismissal in Perth, Jones' side slid to a 30-28 loss at Optus Stadium last weekend in their first encounter.
That has prompted a flurry of changes from the Australian, in what some may see as a risky gamble as he seeks to level the three-match series in what could be humid winter conditions in Queensland.
Leicester title-winning centre Porter will make his bow, while Freeman – who featured last month in an uncapped game against the Barbarians – will make his international debut proper.
Sam Underhill moves up to take the place of Tom Curry, who has been ruled out of the rest of the tour through concussion, while Owen Farrell has been retained at inside centre.
"We have decided to make changes in our backline, they were tough calls, but we feel they will strengthen the team," Jones said. "There are opportunities to attack against Australia which we can take."
Australia meanwhile have been forced into a slate of swaps, through Swain's suspension and Tom Banks' injury, with Matt Philip in for the former and Jordan Petaia moved to full-back to cover the latter's absence.
In a significant boost, prop Taniela Tupou is back, and makes a like-for-like change with the injured Allan Ala'alatoa.
Australia team: Petaia, Wright, Paisami, Kerevi, Koroibete, Lolesio, White; Bell, Porecki, Tupou, Philip, Neville, Leota, Hooper, Valetini.
Replacements: Fainga'a, Sio, Slipper, Frost, Samu, Gordon, O'Connor, Perese.
England team: Steward, Nowell, Porter, Farrell, Freeman, Smith, Van Poortvliet; Genge, George, Stuart, Itoje, Hill, Lawes, Underhill, B Vunipola.
Replacements: Cowan-Dickie, M Vunipola, Heyes, Chessum, Ludlam, Willis, Care, Arundell.
Foden: De Bruyne the best in the Premier League
Phil Foden hailed Manchester City team-mate Kevin De Bruyne as the Premier League's best player after the pair both netted in the 4-0 win over Brighton and Hove Albion.
De Bruyne opened the scoring in Thursday's contest at Amex Stadium before Foden took over with a couple of goals of his own before half-time.
Julian Alvarez rounded off the scoring just after the hour in a one-sided contest as an Erling Haaland-less City moved to within a point of leaders Arsenal with a game in hand.
Belgium international De Bruyne now has four goals and six assists in just 13 league appearances for City this season.
Speaking to Sky Sports News after the win over Brighton, Foden said: "I think when he is at it, he is the best player in the Premier League."
Foden's first goal came via a deflected free-kick that he himself won, although replays showed he slipped rather than being fouled.
The England international doubled his personal tally with a composed finish after Brighton were caught in possession at the back.
Asked about playing more centrally, Foden said: "I have always said that I see myself there. This year I have moved inside and it has helped me massively.
"I enjoy it in the middle. It's where I want to be. At the moment, I am just enjoying my football and playing with freedom."
De Bruyne had earlier opened the scoring with a brilliant opener - his first headed goal for City in the Premier League - as City made it 30 games unbeaten in normal time across all competitions.
Alvarez then went on to round off the scoring in a game that not only saw the reigning champions close the gap on Arsenal, but also narrow the goal difference margin to eight.
"It was a good game," De Bruyne said. "I think we played really good in the first half and every game is a lot of pressure. All we can do is prepare as we did today and win the game that is in front of us.
"We just want to win game-by-game and push for the title. We don't get ahead of ourselves. Now the next game is coming quickly. Try to recover and we go again."
Kyle Walker assisted the De Bruyne and Alvarez goals - the first time the defender has set up two goals in a single Premier League game in what was his 390th appearance in the competition.
Reflecting on his rare headed goal, De Bruyne said: "It doesn't happen too much. Kyle gave a good cross and I think the only way I could reach it is by jumping to it. I will take it but it's not something I am good at."
City have rather ominously won four Premier League games in a row and travel to strugglers Nottingham Forest next up at the weekend, knowing victory in their remaining five games will secure an unprecedented fourth straight title.
"I trust my team. All respect to Liverpool and Arsenal, they are amazing," De Bruyne added. "Arsenal are doing what they need to do and we are also needing to do it. Work hard and be humble enough to keep pushing."
Bellingham alone won't win Euros for England - Desailly
England cannot rely on Real Madrid midfielder Jude Bellingham alone to win them the Euro 2024 crown, according to France great Marcel Desailly.
Bellingham has enjoyed a sensational debut campaign at Madrid that has seen him score 21 goals in all competitions and assist eight more.
Despite still being aged just 20, the youngster will already have the weight of a nation on his shoulders in the European Championship finals.
Desailly is a big fan of Bellingham, but he suggests Gareth Southgate may have to consider tweaking formation if England are to succeed.
"Too much quality can kill the quality," Desailly told Stats Perform. "This is your problem, you see?
"All the players have to be able to perform at the same time and help each other. The Dutch have had this kind of problem in the past.
"The Dutch always have high levels of expertise, but every time it was difficult for them to all unite together at the same time and perform.
"The talent is there for England, even though Fabio Capello has said their defence is a bit weak, which I agree with.
"But too much quality kills the quality. Let's see how the coach is able to adjust the side and make certain choices.
"He may have to remove some of the players into a different tactical system to protect the team for the performances needed."
Bellingham's latest goal came in added time to earn Real Madrid a 3-2 win over Barcelona in a thrilling Clasico clash last weekend.
He is already being mentioned as a frontrunner to win this year's Ballon d'Or, which could depend on how England perform in the Euros.
The ex-Borussia Dortmund ace is also being likened to one of the all-time greats in Zinedine Zidane, but Desailly says there is a long way to go.
"In the game against Barcelona, he wasn't outstanding yet he was still key for his team," the World Cup 98 and Euro 2000 winner said.
"Carlo Ancelotti took Vinicius Junior off because he knew what Bellingham could give him in that position.
"He also has the legs to defend and score the killer goal, or use his cleverness for the collective of the team.
"He's a good player. But trying to compare him to Zidane? It is difficult for us to accept he could be at that level.
"There are differences between them, but the potential of the talents is quite similar."
Liverpool line up Feyenoord coach Slot as Klopp replacement
Arne Slot appears to be at the front of the queue to replace Jurgen Klopp as Liverpool manager.
Klopp confirmed in January that he would be leaving the Reds at the end of the season.
Xabi Alonso, who has led Bayer Leverkusen to their first Bundesliga title, was swiftly established as a leading candidate to take the helm at Anfield, where he starred as a player for the Reds between 2004 and 2009.
The 42-year-old, however, is staying put in Germany, and Liverpool's search for Klopp's successor has taken them to Feyenoord's door.
Slot has been previously linked to jobs in the Premier League. Leeds United wanted to appoint him last season before their relegation to the Championship, while he was targeted by Tottenham before they appointed Ange Postecoglou.
The Dutchman intimated when linked with Spurs: "A normal next step would be to go abroad and I've always said that the best league in the world is the Premier League."
Ideally, Liverpool will be aiming for a coach who can come close to replicating Klopp's style of play, and in particular has a flair for working with and developing young players.
Slot has enjoyed fantastic success in Rotterdam. He became Feyenoord head coach in December 2022, after leaving AZ, and went on to win the Eredivisie title in 2022-23, having reached the Europa League final in the previous season.
The 45-year-old has a 64.4 per cent win record from 146 games in charge, winning 94, drawing 29 and losing just 23.
His Feyenoord team have scored 329 goals, an average of 2.2 per match, conceding 147 in return. Slot's points per game is a hugely impressive 2.13.
Feyenoord are, though, set to relinquish their Eredivisie crown, as they trail leaders PSV by nine points. They have, however, won the KNVB Cup this term.
As there is no break clause in the Dutchman's contract, it has been reported that a compensation fee in the region of €10million (£8.5m) could prise him away from Feyenoord.
Sporting CP boss Ruben Amorim is another coach who has been heavily linked with the Liverpool job, albeit he is reportedly in talks with West Ham.
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