Chelsea will host Manchester United and Liverpool will face Arsenal as four of the EFL Cup favourites were drawn against each in round four.

Chelsea - who were beaten 4-0 by Ole Gunnar Solskjaer's Red Devils last month - thrashed Grimsby Town 7-1 on Wednesday, while United only scraped past League One club Rochdale 5-3 in a penalty shoot-out after a 1-1 draw at Old Trafford.

Liverpool found life easier against MK Dons, with Jurgen Klopp's much-changed side winning 2-0, and in the last 16 they will welcome Arsenal, who crushed Nottingham Forest 5-0 on Tuesday.

Holders Manchester City - who saw off Preston North End on Tuesday - will face Southampton, while Everton and Watford were drawn to meet at Goodison Park.

Aston Villa will take on Wolves in another all-Premier League encounter, with Colchester United, surprise winners over Tottenham, travelling to Crawley Town.

Wednesday was a rough night for Premier League sides, with West Ham thrashed 4-0 away at League One club Oxford United, who will play Sunderland in the last 16 after the Black Cats' win over Sheffield United.

Manuel Pellegrini made nine changes from the West Ham side which started in the 2-0 win over Manchester United on Sunday, but the Hammers collapsed in the second half as Oxford claimed a famous win.

Bournemouth also dropped out of the competition, going down 2-0 to 2018-19 semi-finalists Burton Albion in a game which at one point was put on hold due to a power outage causing the floodlights to go out.

Play was eventually restarted, with 30 minutes of added time played, but from 1-0 behind there was no way back for the Cherries as Nathan Broadhead made sure of the hosts' progression, with Leicester City travelling to the Pirelli Stadium in round four, which will be played in the week commencing October 28.

EFL Cup fourth-round draw in full:

Everton v Watford

Aston Villa v Wolves

Manchester City v Southampton

Burton Albion v Leicester City

Crawley Town v Colchester United

Chelsea v Manchester United

Oxford United v Sunderland

Liverpool v Arsenal

Mauricio Pochettino was at a loss to explain Tottenham's penalty shoot-out defeat to Colchester United in the third round of the EFL Cup on Tuesday.

Colchester frustrated Spurs throughout a goalless 90 minutes, restricting their Premier League visitors' chances and keeping defenders Davinson Sanchez and Eric Dier busy on the break.

The game went to penalties and Christian Eriksen had his spot-kick saved by Dean Gerken before Lucas Moura crashed an effort against the crossbar as the League Two team triumphed 4-3.

Pochettino assured there was no lack of desire to progress from his side and offered no excuses for their exit.

"First of all, congratulations to Colchester," said Pochettino.

"They made a fantastic game and of course made it difficult [for us to play] our game.

"We are so disappointed we could not score in 90 minutes and on penalties they beat [Crystal] Palace [in the last round] and that can happen.

"In this kind of competition, the beauty is there's always something that can happen but we're disappointed because we wanted to go further. We are out and we cannot explain."

The result left Tottenham with just one win from their last seven matches in all competitions and their away form has been a major barrier to success.

Since January, Tottenham have won just two games on the road in all competitions: a 1-0 win at Borussia Dortmund in March and a 3-2 victory at Ajax in May.

Pochettino said: "We had some chances but not enough to score and then on penalties we lose the game. Of course [we are] very disappointed.

"We are disappointed because it is important to be in all competitions fighting for trophies. We did everything to try to win today, we cannot complain.

"It was only that we didn't score and on penalties we lost."

Christian Eriksen and Lucas Moura missed in the shoot-out as Tottenham were dumped out of the EFL Cup by League Two Colchester United, who won 4-3 on penalties after holding their Premier League opponents to a 0-0 draw.

Mauricio Pochettino's men failed to break down their fourth-tier opponents despite having Dele Alli, Lucas and Victor Wanyama in their starting line-up and were punished by John McGreal's side, who knocked Crystal Palace out on penalties in the previous round.

Promising young players Oliver Skipp and Troy Parrott were given rare starts but found themselves embroiled in a real battle with a Colchester side who defended resolutely and gave their Premier League visitors more than the odd scare at JobServe Community Stadium.

Eriksen, on as a second-half substitute, had his penalty saved before Lucas hit the crossbar to prompt wild celebrations among the home fans, but Tottenham are now without a victory in five away games across all competitions.

Premier League sides Norwich City and Crystal Palace were knocked out of the EFL Cup second round by League Two opposition on Tuesday.

Norwich – who made 11 changes from the side that lost to Chelsea in the Premier League at the weekend – were undone by Crawley Town, with Beryly Lubala scoring the only goal of the game.

Palace, meanwhile, were dumped out on penalties by Colchester United after playing out an uninspired 0-0 draw at Selhurst Park.

Fellow Premier League sides Aston Villa, Sheffield United, Brighton and Hove Albion, Southampton, West Ham and Watford all fared better, however, progressing through to the third round unscathed.

Meanwhile, England goalkeeper Jack Butland went from zero to hero at Elland Road as Stoke City knocked out Championship rivals Leeds United on penalties.

Butland – who has endured a difficult start to the season and was dropped for the league match between the two sides at the weekend – was at fault for Eddie Nketiah's goal during the 2-2 draw, but successfully converted a penalty during the 5-4 shoot-out win.

Retired Jamaica international Jamal Campbell-Ryce has embarked on a career in coaching with the Colchester United under-23 team.

The 36-year-old winger, who made some 18 appearances for the Jamaica national team, is expected to work with the club’s youth players who he will mentor on a one and one basis.

Jon de Souza the club’s director of performance has tipped the Jamaican to have a positive impact on future generations.

"Jamal will be joining us as an U23s player/coach, working in training with the U18s and U23s, to play in the U23s fixtures and to mentor players on a one to one basis,” he told the club’s official website.

"He was a flair-based forward in his career, and we believe that they are often the type of players who need help within our squad to develop the right application and desire to continue to progress,” he added.

"Through his career, Jamal has learned a lot and knows that, in that position and at that young age, you have to learn to do a lot more off the ball and to apply yourself fully on and off the pitch to end up having a long life in the game.”

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