Arsenal head coach Mikel Arteta acknowledged it will be "very hard" for the Gunners to secure Champions League qualification via the Premier League after crashing out of the Europa League.

Pierre-Emerick Aubameyang's stunning late miss in the final seconds saw Arsenal eliminated by Greek visitors Olympiacos, who sensationally prevailed 2-2 on away goals following Thursday's 2-1 extra-time victory.

Arsenal won the last-32 first-leg 1-0 but extra time was needed after Pape Abou Cisse's restored parity for Olympiacos across two legs at the Emirates Stadium.

Aubameyang looked to have settled the contest with seven minutes remaining in extra time but Youssef El-Arabi's silenced the London crowd before the former remarkably squandered a last-gasp opportunity.

Winning the Europa League would have gained Arsenal access to the Champions League, having not featured in Europe's premier club competition since 2016-17, but the Gunners now face an uphill battle as they sit ninth in the Premier League – seven points adrift of the top four.

"Very hard because looking at the table we're still far from the objectives that we all have, but we've been far all season from it and we have to keep fighting," Arteta, who replaced Unai Emery in December, told reporters post-match when asked about the difficulties of reaching the top four.

"The most important thing now is that the dressing room has to be strong and we have to keep going and react. First of all, I have to convince them about what happened in the game and why they are not through in the tie.

"If they continue to do that, there will be rewards like we have done in the last 10 games that we played."

Arteta added: "I just want to concentrate now on lifting those players and getting back the belief, and convince them that there is still a lot to play for, and move on.

"It's part of this sport that a big disappointment can happen and it happened. We have to learn and react as a team and as a club."

While it was a heartbreaking evening for Arsenal, it was a memorable outing for Pedro Martins and Olympiacos.

"It's a historic night for Olympiacos. We deserved this qualification, not only for these two games against Arsenal but also for our spirited performances in Europe throughout the season regardless of the results," Martins said.

"We were determined, we believed we could qualify and we made it. Tactical intelligence, effectiveness, inner strength, courage… they all weighed in this success."

Pierre-Emerick Aubameyang was left stunned after he missed a golden chance in the final seconds of Arsenal's dramatic Europa League defeat to Olympiacos.

Aubameyang, who had restored parity with a sublime overhead kick earlier in extra-time, sliced wide of a gaping goal moments after Youssef El-Arabi had prodded Olympiacos into a 2-1 lead in the 29th minute of extra-time at Emirates Stadium.

The miss ultimately proved the last action of the match, as Olympiacos – who had cancelled out Arsenal's 1-0 lead from the first leg early in the second half – progressed on away goals from a tie which finished 2-2 on aggregate.

And Aubameyang, who moved level with Jamie Vardy at the top of the Premier League scoring charts with a double against Everton on Sunday, offered no excuses for his error.

"I don't even know. I feel very, very bad," the striker told BT Sport as he attempted to explain the miss. "This can happen. I don't know how I missed this chance.

"I was tired and I had some cramps as well, but it is not an excuse. I have to score this goal, but it can happen."

Aubameyang added on Arsenal's exit from the competition: "What can I say? It's very, very hard, very tough. It was a tough game again.

"I think we missed putting some pace in the game – that cost us a little bit. Then the last minute goal was unlucky for us. That's it.

"We try to keep improving in the league and we'll try to win as many games as possible, and we'll see how many chances we have to qualify [for the Champions League]."

Arsenal coach Mikel Arteta conceded his side created their own issues in Thursday's encounter, but he is now focusing on the next step of rallying the Gunners.

"It hurts a lot. We had a lot of intentions in this competition. It was very important for us," he told BT Sport.

"Emotionally, it's been a very difficult game. We were in complete control. Again we conceded [from] a set-piece and it put the tie in a difficult position.

"It is a massive disappointment. But at the same time, I'm very proud of the players. I think the effort that they put in tonight has been incredible, how patient they are.

"It would have been an incredible lift if we had managed to win the game and go through the tie. We have to swallow that and we have to react as a team. They have my backing, completely, for the way they have played. But it's painful."

Arsenal crashed out of the Europa League as Youssef El-Arabi's late strike in extra-time secured a stunning 2-1 victory for Olympiacos, who progressed to the last 16 courtesy of the away goals rule.

Pierre-Emerick Aubameyang, who remarkably missed a golden chance in the final seconds after El Arabi's winner, had seemed to settle the contest in Arsenal's favour with seven minutes of extra-time remaining with a stunning acrobatic effort.

But Olympiacos, who cancelled out Arsenal's 1-0 lead from the first leg thanks to Pape Abou Cisse's header in the second half, chose to write their own script as El-Arabi bundled in Giorgos Masouras' cross at the Emirates Stadium.

Yet the drama was not finished there – Aubameyang somehow slicing wide of a gaping goal from point-blank range as Olympiacos held onto a famous triumph in a last-16 tie that finished 2-2 on aggregate.

Bayern Munich striker Robert Lewandowski has his sights set on a slice of Champions League history when Tottenham visit the Allianz Arena on Wednesday.

The Poland international needs two goals against Jose Mourinho's side to claim the record for goals in the group stage of a single campaign – an honour held by Cristiano Ronaldo, who scored 11 in 2015-16 for Real Madrid.

Atletico Madrid will book their place in the last 16 if they beat Lokomotiv Moscow, while Shakhtar Donetsk will join Manchester City in progressing from Group C if they overcome Atalanta.

In Group A, already-qualified Paris Saint-Germain host Galatasaray and Real Madrid – who have also booked their place in the knockout stages – travel to Club Brugge.

Here is the pick of the key Opta facts for Wednesday's eight matches.

Club Brugge v Real Madrid

7 - This is the seventh Champions League group stage campaign which Club Brugge have failed to progress from. No side has ever competed in more group stages without progressing from any in the history of the competition.

2 - Karim Benzema has scored two goals in each of his last two Champions League games. Only four players have scored two or more in three consecutive games - Giovane Elber (2001), Filippo Inzaghi (2002), Cristiano Ronaldo (2013, twice in 2017) and Lewandowski (2018).

Paris Saint-Germain v Galatasaray

18 - PSG striker Kylian Mbappe has scored 18 goals in 29 appearances in the Champions League. If he scores twice in this game, Mbappe would become the youngest player in the competition's history to reach 20 goals, aged 20 years and 356 days.

1 - Galatasaray scored their first goal of the 2019-20 Champions League campaign in their last game against Club Brugge, ending a run of 38 shots without scoring from the start of the campaign. In total, they have only scored once from 43 shots in the competition this term.

Bayern Munich v Tottenham

16 - Bayern Munich had 16 shots on target in their 6-0 win over Red Star Belgrade on matchday five; the most by a team in this season's Champions League. Bayern last had more in a Champions League game in October 2013 against Viktoria Plzen (18).

2 - New Spurs manager Mourinho has lost both of his previous away games against Bayern Munich in the Champions League, losing in the quarter-finals with Chelsea in 2004-05 and the semi-finals with Real Madrid in 2011-12.

Olympiacos v Red Star Belgrade

1 - Olympiacos have picked up just one point from their five Champions League games this season. Only in 2017-18 (one) have they picked up one point or fewer from a completed group stage.

19 - Red Star have conceded 19 goals in their five Champions League games this season, more than any other side. There have been just five occasions of a team conceding 20+ goals in a single group stage in the competition, most recently by Legia Warsaw in 2016-17 (24).

Dinamo Zagreb v Manchester City

5 - Dinamo Zagreb have picked up five points in this season's Champions League. Only in 1998-99 (eight points) have they won more in a single group stage in the competition. 

19 - City’s Raheem Sterling has scored 19 goals in 46 appearances in the Champions League. He could become the sixth Englishman to reach 20 goals in the competition after Wayne Rooney (30), Paul Scholes (24), Frank Lampard (23), Steven Gerrard (21) and Harry Kane (20). Should Sterling score in his 47th appearance, he would be the second quickest Englishman to 20 Champions League goals after Kane (24 appearances).

Shakhtar Donetsk v Atalanta

5 - Shakhtar Donetsk are without a win in each of their last five Champions League home games (drawn three, lost two). It is their longest ever winless run at home in the competition.

2 - Atalanta have lost their last two away games in the Champions League, conceding nine goals in the process. They last lost three consecutive away matches in all European competition back in October 1987.

Atletico Madrid v Lokomotiv Moscow

2 - Atletico Madrid have lost consecutive matches in the Champions League; they've never lost three in a row in the competition. The Spanish side last lost three consecutive games in all European competitions back in October 1984 in the UEFA Cup.

0 - Lokomotiv Moscow have never won an away game against Spanish opposition in all European competition, losing six of their seven such games and failing to score in each defeat.

Bayer Leverkusen v Juventus

3 - Bayer Leverkusen have benefited from three own goals in this season's Champions League, with only two teams benefiting from more in a single campaign: Inter in 2002-03 (four) and Barcelona in 2017-18 (five).

27 - Juventus forward Ronaldo has scored 27 goals in 24 Champions League appearances against German clubs; the most a single player has accumulated against sides from a particular nation in the competition's history.

Real Madrid still have work to do in their bid to reach the last 16 of the Champions League as they prepare for the visit of Paris Saint-Germain.

PSG are already through to the knockout stages and opponents Madrid can join them with victory at the Santiago Bernabeu.

On-loan striker Mauro Icardi has been in inspired form for the French champions since joining from Inter, scoring 10 times in 11 appearances.

The 26-year-old failed to register in the reverse fixture at the Parc des Princes – a 3-0 win for PSG in September – but he can make some history should he score on Tuesday.

Elsewhere, victory for Atletico Madrid away to Juventus will make certain of a last-16 spot with a game to spare, while Jose Mourinho takes charge of Tottenham in the Champions League for the first time as they welcome Olympiacos to north London.

Here is the pick of the key Opta facts for Tuesday's eight matches.

Galatasaray v Club Brugge

0 - Galatasaray are the only team in this season's Champions League yet to score. There have been six previous occasions in which a team have failed to score in their opening five games, including the Turkish side in the 1993-94 season.

1 - Club Brugge have won just one of their last 18 Champions League games, with that victory coming away at Monaco in November 2018.

Lokomotiv Moscow v Bayer Leverkusen

8 - Since the start of last season, no side have lost more Champions League matches than Lokomotiv.

4 - Leverkusen are without a win in their last four away games in the Champions League, failing to score in their past three outings – the German club's longest-such run in the competition.

Atalanta v Dinamo Zagreb

11 - Only Genk (12) have conceded more goals in open play in this season's Champions League than Atalanta (11).

36 - Dinamo have had the joint-fewest shots of any team in the Champions League this season, level with Galatasaray. They have the best conversion rate of any team, however, scoring with nine of those 36 shots (25 per cent).

Red Star Belgrade v Bayern Munich

11 - Bayern are enjoying their longest ever unbeaten run away from home in the European Cup/Champions League, going 11 matches since last tasting defeat.

7 - Red Star have lost seven of their first 10 Champions League games. Only four teams have lost more in their opening 10 matches - Sturm Graz, Rapid Vienna, Malmo, Maccabi Tel Aviv (eight defeats each).

Juventus v Atletico Madrid

25 - Juventus forward Cristiano Ronaldo has scored 25 goals against Atletico in all competitions - only versus Sevilla (27) has he netted more.

2009 - Atletico, beaten 2-1 at Bayer Leverkusen last time out, have not lost consecutive away games in the group stage of UEFA's showpiece competition since October 2009 when losing to Porto and Chelsea.

Manchester City v Shakhtar Donetsk

6 - City have won their last six home Champions League matches - the longest current run of any side. The last English team to have a longer run were Chelsea, with seven in a row at Stamford Bridge between March 2008 and February 2009.

0 - Shakhtar have lost on both of their visits to the Etihad Stadium, conceding eight goals without replay. The Ukrainian club have never lost each of their first three away games against a single team in the competition. 

Real Madrid v Paris Saint-Germain

8 - Madrid have won eight and lost none of their 11 Champions League home games against French opposition, winning the last five such matches in a row by an aggregate score of 15-1.

5 - PSG striker Icardi has scored against five of the six teams he has faced in the competition, the exception being Madrid (one game).  No player has ever faced as many as six teams and scored against every opponent, with the record currently held Milinko Pantic, who scored against all four opponents in 1996-97 for Atletico.

Tottenham v Olympiacos

0 - Tottenham have never drawn a Champions League group match on home soil, winning 10 and losing four.

8 - Olympiacos have lost their last six away matches in the competition. Not since between September 2001 and December 2003 have they endured a longer wait for victory on their travels.

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