Rafael Nadal was forced to pull out of his singles and doubles matches on day three of the Laver Cup with an "inflamed hand".

The French Open and US Open champion had been set to feature in a high-profile doubles pairing with Roger Federer against John Isner and Jack Sock in the opening match of Sunday's play.

Nadal was also set to take on Nick Kyrgios in singles later in the day, having been beaten by the Australian in a doubles contest late on Saturday.

But that match the previous day, in which Nadal and Stefanos Tsitsipas lost to Kyrgios and Sock, meant the Spaniard was not able to recover in time.

He complained of inflammation to his left hand on Sunday morning - an issue he says he has dealt with for "a couple of years" - and Tsitsipas was called in to take his place alongside Federer.

Thiem will play Kyrgios, meanwhile, with Team Europe aiming to wrap up a third straight title, carrying a narrow 7-5 lead into the final day.

Nadal said: "I am sad, of course. I was excited to play the doubles with Roger obviously - that's the thing that makes me more sad because, in singles, I know Dominic is going to be there and he's going to do unbelievably.

"Since a couple of years ago, I've had this bad feeling on the hand. It's an inflamation of the hand - not the wrist.

"Yesterday, I played and sometimes the next day you are a little bit better, sometimes you are a little bit worse. Today, I think it's a little bit more inflamed.

"This morning, I woke up with that feeling that something is inflamed on the hand and I texted Roger and Thomas [Enqvist, vice-captain] and Bjorn [Borg, captain].

"We needed to find a solution because I don't think I'm the right one to play today and we have a great team without me being 100 per cent. All the guys are unbelievable."

He added: "Now, let's support and hopefully we can achieve this."

Nick Kyrgios bounced back from a tough defeat to Roger Federer to keep Team World in the mix for a breakthrough Laver Cup victory in a doubles success alongside Jack Sock.

Europe, who have won the prior two editions of the competition, lead 7-5 heading into the final day, but they might have had one hand on the trophy already if not for Kyrgios.

A home side able to name a line-up where each of their six players are ranked higher than John Isner, their opponents' top star, celebrated singles triumphs for Federer and Rafael Nadal but found Kyrgios in determined mood late on Saturday evening.

Team World had struck first to level the contest at 3-3, with wins on the second day worth two points - double their first-day value, while third-day victories earn three.

Isner saw opponent Alexander Zverev fall apart and clinched a 6-7 (2-7) 6-4 10-1 success.

Pegged back, matters looked to be going from bad to worse for Europe when the dangerous Kyrgios took the first set against Federer.

But the Swiss veteran recovered to triumph 6-7 (5-7) 7-5 10-7 and it appeared to be plain sailing from there, with Nadal winning the final singles contest of the day, easing past Milos Raonic 6-3 7-6 (7-1) to regain complete control of the competition.

"Being here for me is a very positive energy," Nadal said. "I like being around such a great team and the crowd is amazing.

"I feel very lucky [to win] the first set. I started to play better later in the match and I think I played a very good tie-break in the end."

The Spaniard was back on court to close out Saturday's play, teaming up with Stefanos Tsitsipas, to take on Kyrgios and Sock.

However, Kyrgios gave an early indication of what was to come as he started in impressive fashion again with some blistering winners in an opener Team World dominated, breaking swiftly and protecting the serve with ease.

The Australian was guilty of gifting away the decisive first break in the second set, making a mess of a seemingly straightforward volley, before coming into his own again with the match level.

Nadal was too often left to plough a lone furrow by Tsitsipas and Kyrgios excelled at the net, greeting each European error in typically extravagant fashion.

Fittingly, after a one-sided tie-break, the match was clinched on Kyrgios' serve 6-4 3-6 10-6 to set up an intriguing final day.

Roger Federer and Alexander Zverev put Team Europe into a 3-1 lead against Team World in the Laver Cup after claiming victory in the doubles.

Heading into the first doubles match of the tournament leading 2-1, Europe extended their advantage as two of their heavyweights held off a fight back from Jack Sock and Canadian Denis Shapovalov.

A break of serve in the fourth game handed Federer and Zverev a chance they did not need a second invitation to grasp, going on to win the first set 6-3, wrapping it up in 37 minutes.

Set two looked to be heading Europe's way in similarly simple fashion when the North American duo lost their serve in game one before passing up six break points. However, they finally fought back to draw level at 4-4.

But with Federer and Zverev hanging on by their fingertips, Sock and his partner squandered six set points, with Shapovalov then double-faulting to hand a break to the men in blue.

Europe took full advantage, Federer – playing in front of a buoyant home crowd in Geneva – serving out the match.

Stefanos Tsitsipas' hard-fought victory had nosed Europe ahead in the final singles match of the opening day of the showpiece team event.

The Greek triumphed 6-2 1-6 10-7 over Taylor Fritz in a thrilling contest, after Sock's win against world number 11 Fabio Fognini had cancelled out Dominic Thiem's earlier victory.

Tsitsipas was rallied on by the rest of Europe's players, including Rafael Nadal, who had strapping on his left hand – the Spaniard having honoured his commitment to play in the tournament despite his exertions in the US Open.

Grigor Dimitrov's tough year continued with a first-round loss at the Atlanta Open, while Jack Sock's return ended in defeat on Tuesday.

Dimitrov has struggled throughout 2019 and the former world number three went down to qualifier Kevin King 7-5 6-4 at the ATP 250 event.

The Bulgarian now holds an 11-12 win-loss record this year, a run that has seen him drop to 53rd in the world.

Sock, making his first appearance since January after being sidelined due to a thumb injury, was edged by Miomir Kecmanovic 7-6 (11-9) 7-6 (7-5).

There were three seeds in action, with Frances Tiafoe suffering a surprise 4-6 6-3 7-6 (7-4) loss to Bernard Tomic.

Radu Albot, however, avoided an upset defeat, getting past Tennys Sandgren 6-4 7-6 (7-4), and Ugo Humbert was too good for Cole Gromley 7-6 (7-2) 6-2.

Reilly Opelka sent down 17 aces in a 6-3 7-6 (7-1) victory over Alexander Bublik and Daniel Evans thrashed Jason Jung 6-1 6-1 inside an hour.

Matthew Ebden overcame Kamil Majchrzak 7-6 (7-5) 6-3 and qualifier Kwon Soon-woo edged Prajnesh Gunneswaran 6-7 (4-7) 7-5 6-0.

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