Dominic Thiem has been ruled out of Wimbledon after tests on a wrist injury and faces a race to be fully fit in time to defend his US Open title.

The world number five retired from his match against Adrian Mannarino in the Mallorca Championships on Tuesday, when 5-2 up in the opening set.

Checks on the wrist by a specialist in Barcelona have shown Thiem needs time away from tennis, meaning Wimbledon is off the table along with tournaments in Hamburg and Gstaad in July.

According to a medical bulletin issued on Thiem's social media accounts, it will be five weeks before he can remove a wrist splint and begin to step up his recovery.

With the US Open beginning on August 30, that does not leave a lot of time for Thiem to recover physical fitness and find his best tennis. He would have been seeded number four at Wimbledon.

The medical bulletin read: "Tests found that there is a 'detachment of the posterior sheath of the ulnar side of the right wrist', an injury that will not allow him to compete in the circuit for several weeks.

"Thiem will wear a wrist splint for five weeks before beginning a progressive process of specific, functional rehabilitation to regain mobility as well as muscle strength in his wrist and ultimately return to training on court."

Thiem, who had already decided against playing at the upcoming Tokyo Olympics, appears to be hoping his lay-off is not as long as the experts have forecast.

He will undergo MRI scans and tests as his recovery progresses, and the 27-year-old Austrian said: "I'm going to do everything the doctors say in order to recover as quickly as possible.

"They've informed me that I might be out for several weeks, but I will do my best to be back on court soon.

"I'm really sorry for pulling out of the upcoming three tournaments I had in my calendar: Wimbledon, Hamburg and Gstaad.

"They are very important tournaments for me. I appreciate all the support from the fans in these difficult moments – I'm determined to come back stronger."

Thiem's absence is another blow for Wimbledon, with Rafael Nadal and Naomi Osaka having already announced they would not be playing the tournament.

Dominic Thiem will seek the advice of a specialist in Barcelona after suffering an injury scare ahead of Wimbledon next week.

Number two seed Thiem retired due to a wrist injury when 5-2 up in the opening set against Adrian Mannarino in the Mallorca Championships on Tuesday.

An MRI conducted at a Mallorca hospital was inconclusive, so the US Open champion will now undergo further tests.

In an update on Wednesday, Thiem wrote on social media: "Yesterday during the match I had a problem with my wrist.

"I went immediately to do an MRI at the hospital in Palma de Mallorca. The results weren't that clear and I have decided to go to Barcelona to check with a specialist.

"I hope I can get the results and a clear diagnosis in the next days."

The ATP 250 event continued without him in Mallorca, as Roberto Bautista Agut moved into the quarter-finals with a 6-3 7-5 triumph over Italian Stefano Travaglia.

More Spanish success on home soil arrived as Pablo Carreno Busta won 6-4 6-4 against Jiri Vesely.

In the doubles, Novak Djokovic and Carlos Gomez-Herrera saw off top seeds Marcel Granollers and Horacio Zeballos to reach the last four in that competition.

Djokovic appears to be enjoying himself as he continues to prepare for Wimbledon, saying: "This was a huge win for us, beating one of the best doubles players in the world after losing the first set.

"We are having a lot of fun on the court. I thought we played well even though we lost the first set."

There was a major upset at the Viking International in Eastbourne, meanwhile, with number one seed Gael Monfils suffering a shock last-16 defeat to Australia's Max Purcell – ranked number 283 in the world.

Purcell, who is only in the tournament as a lucky loser, claimed a huge 6-4 5-7 6-4 win in a battle lasting over two hours.

Monfils fired down 16 aces and fought back after being within two points of defeat in the second set but was ultimately beaten and has not made an ATP quarter-final since February 2020.

"It feels unbelievable," said Purcell. "I thought I'd come out and have a go. 

"I've struggled to get into any singles events over the past nine months and primarily played doubles, so to get on a run here, on my favourite surface, is great."

Purcell will take on Andreas Seppi – a comfortable winner over Emil Ruusuvuori – in the last eight.

While Monfils crashed out, there was less drama for the second and third seeds. 

Alex de Minaur won 6-3 6-4 against home hope Liam Broady, while Lorenzo Sonego was a 6-4 6-2 victor in his contest with John Millman.

Feliciano Lopez reached the milestone of 500 ATP Tour wins with a comeback victory over Karen Khachanov at the Mallorca Championships.

Lopez, who turns 40 in September, prevailed 4-6 6-2 6-4 against the sixth seed.

He is the 10th active player to reach 500 wins, after Roger Federer, Rafael Nadal, Novak Djokovic, Andy Murray, Richard Gasquet, Fernando Verdasco, Marin Cilic, Stan Wawrinka and Tommy Robredo.

"More than the 500 wins, the important thing to me is the chance to keep playing in these kinds of tournaments and to keep being competitive," Lopez told ATPTour.com.

"I didn’t expect to be able to play at the level I am on the ATP Tour at 40 years of age, which I will be in September."

Spanish veteran Lopez would have expected to be taking on Dominic Thiem next, but the world number five retired due to a wrist injury when 5-2 to the good in the opening set against Adrian Mannarino.

"It's nice for me to be in the quarter-finals, but winning this way is not so cool. I really like Dominic, he's such a nice guy and I hope he will be feeling better soon," Mannarino said. "I hope it is not so serious, especially right before Wimbledon."

Elsewhere on the Balearic island, top seed Daniil Medvedev breezed past Corentin Moutet 6-4 6-2, while Casper Ruud defeated Tennys Sandgren in straight sets.

At the Viking International in Eastbourne, there were mixed fortunes for Lopez's countrymen Alejandro Davidovich Fokina and Albert Ramos-Vinolas.

Fokina, seeded sixth, saw off Mikael Ymer 7-5 6-1, but number seven seed Ramos-Vinolas fell 6-4 6-3 to Emil Ruusuvuori.

Alexander Bublik defeated fellow Kazakh Mikhail Kukushkin is straight sets, while Jo-Wilfred Tsonga went down in similar fashion against Egor Gerasimov.

Dominic Thiem has joined Rafael Nadal in announcing he will not compete at the Olympic Games in Tokyo.

The 27-year-old US Open champion pinned his decision on the belief he would struggle to find his best form, having endured a tough 2021 season so far.

Thiem has lost his last three matches, including a first-round defeat to Pablo Andujar at the French Open, and has an overall 9-8 win-loss record for the year.

World number five Thiem confirmed, however, that he intends to play Wimbledon, which begins on June 28, and will then focus on getting in the best possible shape for his grand slam title defence at Flushing Meadows.

Nadal said earlier on Thursday that he would play neither Wimbledon nor the Olympics, where the tennis tournament starts on July 24, because he wished to recover from his clay-court season efforts.

Women's tour superstar Naomi Osaka has elected to miss Wimbledon but said on Thursday she would represent Japan at her home Olympics.

Thiem revealed his Olympics decision in a statement posted on his Twitter page, saying: "After talking with my team and analysing the situation I have taken the very difficult decision to withdraw from competing in the Tokyo Olympics.

"For me, like all athletes, taking part in the Olympics and representing my country is a huge honour and that makes this decision even tougher. However, 2021 did not start as expected and I don't feel ready to play my best in Tokyo.

"These last two weeks I have been training hard – and I’m starting to improve my conditioning and concentration little by little. My goal is to work hard the coming weeks, give my best at Wimbledon and keep training and hopefully defend my US Open title.

"I wish the entire Austrian team traveling to Tokyo all the best. I am young and I hope to be able to play for Austria at the Olympics in Paris 2024."

Dominic Thiem conceded his game was "just not there" after he let a two-set lead slip in a shock first-round loss to Pablo Andujar at the French Open.

Thiem had looked in command against a player with no previous top-five wins to his name. However, he crumbled thereafter, further opening a bottom half of the draw that is there for the taking with Novak Djokovic, Rafael Nadal and Federer all in the top half.

It left the two-time finalist at a loss to describe a massive upset that was the defining story of a day that saw Alexander Zverev, the man Thiem beat in last year's US Open final, battle to a five-set win.

There were no such exertions for Stefanos Tsitsipas, who cruised to a straight-sets win over Jeremy Chardy after the 9pm (local time) curfew in Paris robbed his opponent of the backing of the home crowd at Roland Garros.


"JUST NOT GOOD ENOUGH"

Thiem denied any talk of him lacking motivation against Andujar, the Austrian instead pointing to a complete loss of form as the reason for his collapse.

Speaking in the media conference after his 4-6 5-7 6-3 6-4 6-4 loss in nearly four and a half hours, Thiem said: "The game was just not there today.

"All the shots are missing power, they're not accurate enough. [I am] moving not well enough. Everything in my game, there are some percents missing, I actually don't really know why because since I stepped back on court it's already two months and I was really practising well."

Andujar might not have a top-five win, but he beat Federer – currently at number eight in the rankings after an injury absence – recently in Geneva.

Still, Thiem felt it was his own failings that were pivotal.

"Shots were there in practice and it got better in Madrid and Rome, but Lyon and here, the shots and how I moved was not the real me or my version who is able to play for big titles," Thiem said. "It's just not good enough at the moment. It's a very tough situation."

ZVEREV MAINTAINS PERFECT FIVE-SET RECORD

Zverev appeared set to join world number four Thiem in falling at the first hurdle when he fell two sets down to German compatriot Oscar Otte, the qualifier making just his third main draw appearance at a slam and playing in his first tour-level match this year.

But Zverev racked up 50 winners as he fought back to claim a 3-6 3-6 6-2 6-2 6-0 victory, stretching his perfect record in five-setters at Roland Garros to seven matches.

It marked the second time Zverev has produced a turnaround from two sets down, having achieved that feat to reach the US Open final by beating Pablo Carreno Busta, who overcame Norbert Gombos in straight sets on Sunday.

TSITSIPAS SEES OFF CHARDY

In terms of laying down an early marker, it was Tsitsipas who perhaps produced the greatest statement of intent on day one, though the coronavirus restrictions meant there were no fans on court to see it.

Had there been spectators, they might have helped Chardy prevail in the key moments in a tight opening set that saw Tsitsipas save a set point and then win it on a tie-break.

From there, the fifth seed was always in command and surged to a 7-6 (8-6) 6-3 6-1 triumph.

HURKACZ HIT BY BOTIC BLITZ

Roberto Bautista Agut and Karen Khachanov were routine winners on day one while Cristian Garin prevailed in four sets against Juan Ignacio Londero.

Dan Evans, the 25th seed, went out as he lost in four sets to Miomir Kecmanovic and injury ended the hopes of 16th seed Grigor Dimitrov.

Dimitrov had three match points at 6-2 6-4 5-1 against American Marcos Giron but let them slip and promptly lost the next eight games before retiring with a back problem.

Also crashing out was Hubert Hurkacz, the 19th seed undone by Dutch qualifier Botic van de Zandschulp, who came from two sets down in a stunning display.

Van de Zandschulp won seven of his 14 break points and reeled off 55 winners in an incredible turnaround to seal a 6-7 (5-7) 6-7 (4-7) 6-2 6-2 6-4 win.

Dominic Thiem crashed out of the French Open in the first round as the US Open champion and two-time Roland Garros finalist suffered a stunning loss to Pablo Andujar.

Thiem looked to be easing to a routine win on the opening day of main draw singles action in Paris, having claimed the first two sets.

However, Andujar staged a remarkable fightback to end the world number four's bid for a third appearance in the final.

The Spaniard claimed a 4-6 5-7 6-3 6-4 6-4 win, his first victory over a top-five opponent at the age of 35.

Thiem hit 66 winners over the course of an epic that lasted four hours and 28 minutes, but his efforts were undermined by 61 unforced errors to Andujar's 47.

It is another low point in an underwhelming year to this point for the fourth seed, who has won only nine of his 17 matches in 2021.

And it is a result that opens up the bottom half of the men's singles draw, with Novak Djokovic, Rafael Nadal and Roger Federer all in the top half.

Andujar, who has never progressed beyond the third round at Roland Garros, will face Radu Albot or Federico Delbonis in round two.

In this world, nothing can be said to be certain, except death and taxes – a statement largely true until Rafael Nadal emerged on the scene and made the French Open his own.

Since breaking through for his first Roland Garros triumph in 2005, only three other men – Roger Federer, Stan Wawrinka and Novak Djokovic – have managed to interrupt Nadal's dominance in Paris.

Nadal has won 13 French Open men's singles titles, seven more than any other player in the Open era (Bjorn Borg, six) heading into this year's edition.

Despite being seeded third, it would take a brave person to bet against defending champion Nadal adding to his mammoth and unprecedented haul in the French capital, where the second grand slam of the year gets underway on Sunday.

On the women's side, defending champion Iga Swiatek is looking to follow in the footsteps of Belgian great Justine Henin.

As all eyes shift to Court Philippe Chatrier and its surroundings, Stats Perform looks at the numbers behind this year's slam, using Opta data.

 

The 'King of Clay'

Nadal will open his title defence against Australian Alexei Popyrin. Since 2000, only Nadal (13) and Gustavo Kuerten (two) have won the French Open more than once.

The 34-year-old swept aside world number one Djokovic in straight sets last year for his fourth consecutive French Open crown and 20th slam trophy, equalling Roger Federer's all-time record. Nadal maintained his stranglehold on the major, having not dropped a set throughout the fortnight. Only three players have previously won the French Open without losing a single set: Ilie Nastase in 1973, Bjorn Borg in 1978 and 1980 and Nadal in 2008, 2010, 2017 and 2020.

Nadal is the only player to have won the same slam more than 10 times. He has lost just two of the 102 matches played in Paris (excluding walkovers), losing to Robin Soderling in the 2009 fourth round and Djokovic in the 2015 quarter-finals, while has won each of the last 30.

The record for most slam titles on the men's circuit will also be up for grabs, with Nadal and the returning Federer seeking to snap their tie.

In the last 25 years, the number one seed has won the French Open on only five occasions – Nadal (2018, 2014 and 2011), Djokovic (2016) and Kuerten (2001). It does not bode well for top seed and 18-time major champion Djokovic, who is looking to close the gap on foes Nadal and Federer.

Australian Open champion Djokovic, who will face Tennys Sandgren in the first round, has reached the final in seven of the last 10 slams he contested, claiming six titles. However, the Serbian star has only featured in five French Open deciders (W1 L4) – fewer than in any of the other three major tournaments.

 

Declining Federer, Nadal challengers?

The French Open will be a welcome sight for tennis fans as Swiss great Federer, who has not played a slam since the 2020 Australian Open due to his troublesome knee and the coronavirus pandemic, makes his comeback.

Seeded eighth ahead of his opener against Denis Istomin, 2009 French Open champion Federer has only contested nine slam finals over the last 10 years (W4 L5) after reaching that stage in 22 major events in the previous decade (W16 L6). Since the beginning of 2016, the 39-year-old has only taken part in one French Open, in 2019, where he reached the semi-finals.

Daniil Medvedev has been flirting with a breakthrough slam triumph. The second seed is a finalist at the Australian Open (2021) and US Open (2019). Medvedev has reached the semi-finals in two of his most recent three appearances at a grand slam after going further than the fourth round in only one of his previous 13 major tournaments. However, the Russian has lost in the first round in each of his four Roland Garros appearances.

US Open champion and fourth seed Dominic Thiem has played two finals at Roland Garros (2018 and 2019) – more than in any other slam – but lost both of them against Nadal. He has won 80 per cent of his games at the French Open, his best win rate in any of the four majors.

Andrey Rublev is the only player to have taken part in the quarter-finals during each of the past three grand slams, including the 2020 French Open. But the seventh seed – who fired down 53 aces at Roland Garros last year, at least 14 more than any other player – is yet to progress further than that round.

Aslan Karatsev enjoyed a fairy-tale run at Melbourne Park in February, the Russian qualifier making it all the way to the semi-finals. Only one qualifier has reached the semi-final stage at the French Open: Filip Dewulf in 1997.

 

Iga in 14-year first?

Having never progressed beyond the fourth round of a major, Polish teenager Swiatek broke through for her maiden slam title via the French Open last year, upstaging Sofia Kenin.

The 19-year-old Swiatek – who will return as the eighth seed in her defence, starting against Kaja Juvan – could become the first woman to win consecutive titles at Roland Garros since Henin in 2005-2007 (three in a row). Only three players have won multiple titles in the women's tournament at the French Open in the 21st century: Henin (four), Serena Williams (three) and Maria Sharapova (two).

Swiatek could claim the French Open and Rome's Internazionali d'Italia in the same campaign. Only Serena Williams (2002 and 2013), Sharapova (2012), Monica Seles (1990), Steffi Graf (1987) and Chris Evert (1974, 1975 and 1980) have achieved the feat previously.

Swiatek celebrated slam glory in the absence of world number one and defending champion Ash Barty in 2020. No player has won more games on clay this season than Australian top seed Barty and Veronika Kudermetova (both 13).

Only Barty (three) has won more titles than third seed Aryna Sabalenka (two) in 2021 – the Belarusian is one of two players currently ranked in the top 20 in the WTA yet to reach a major quarter-final, alongside Maria Sakkari.

In a field also including four-time slam champion and reigning Australian Open winner Naomi Osaka – the second seed – Sabalenka could become only the third woman to win the Madrid Open and French Open in the same season after Serena Williams in 2013 and Sharapova in 2014.

As for fourth seed Kenin, she could be just the fourth American player to reach back-to-back Roland Garros finals, after Serena Williams (2015-16), Martina Navratilova (1984-1987) and Evert (1973-1975, 1979-80 and 1983-1986).

 

All eyes on Serena

The queen of WTA tennis for so long, Serena Williams is one slam success away from matching Margaret Court's record of 24 major singles championships. But the 39-year-old has been stuck on 23 since reigning supreme at the Australian Open in 2017.

While the French clay is not one of her favourite surfaces, it could be the scene of a remarkable achievement following a lengthy wait.

Roland Garros is where Williams has the lowest winning percentage (84 per cent) and where she won the fewest titles (three, at least half as many as the other slams).

Williams won her maiden French Open in 2002 and could hoist the trophy aloft 19 years after her first success in Paris. The longest span between two majors wins for a single player in the Open era is already held by Williams (15 years between 1999 and 2014 at the US Open).

Irina-Camelia Begu awaits the seventh seed in the first round.

Lyon Open top seed Dominic Thiem was stunned in straight sets by Cameron Norrie in the last 16 on Thursday for the "biggest win" of the Briton's career.

Thiem was handed a bye to this stage and fell at the first hurdle on a day of upsets, the world number four sending down four double faults and losing serve three times as he lost 6-3 6-2.

Norrie now has 10 victories on clay in 2021, compared to seven before this year, and will face qualifier Arthur Rinderknech – a surprise 6-7(7) 6-2 7-5 winner against Jannik Sinner – in the quarters.

"I'm so pleased to win. It's the biggest win of my career and my highest-ranked win," Norrie, who had never previously beaten a top-five opponent, said in his on-court interview. 

"It's such a beautiful day in Lyon. I couldn't be happier to get the win today and to get another match on the clay before Roland Garros."

Third seed Diego Schwartzman also exited the competition on Thursday with a 6-3 7-5 defeat to Richard Gasquet, who eased over the line despite letting two match points slip.

Stefanos Tsitsipas is now the strong favourite to triumph in France after starting his campaign with a convincing 6-1 6-4 victory over Tommy Paul.

Yoshihito Nishioka upset Gael Monfils 4-6 6-3 7-6(2) in an impressive comeback victory and now awaits Tsitsipas in the last eight.

At the Geneva Open, rising star Casper Ruud kept his momentum going with a 2-6 6-1 6-4 win over Dominik Koepfer to make it 12-4 on clay this season.

Ruud recovered from a sloppy first set by holding his serve in the following two sets to reach his fourth successive clay court semi-final on the ATP Tour.

Next up for the third seed is a meeting with Pablo Andujar, who beat youngster Dominic Stephan Stricker 4-6 6-4 6-4.

Elsewhere, Laslo Djere overcame Fabio Fognini 6-3 6-7(2) 6-1 to reach the quarter-finals and will face Denis Shapovalov later on Thursday after the Canadian recovered from a set down to beat Marco Cecchinato 6-7 7-5 6-1.

The winner of that match will meet Pablo Cuevas, the Uruguayan having ended Grigor Dimitrov's run with a battling 7-6 6-3 win.

Alexander Zverev can see his rivalry with Dominic Thiem continuing for many years after he came out on top in their latest duel at the Madrid Open.

The German followed up his famous win over home favourite Rafael Nadal by defeating Austria's Thiem 6-3 6-4 in the semi-final on Saturday.

Zverev, who won this event in 2018, will meet either Casper Ruud or Matteo Berrettini in the final.

Thiem had won the last four meetings between the two, including in last year's Australian Open semi-final and the US Open final, where he came from two sets down to win in an incredible fifth-set tie-break.

Zverev said after his victory over Nadal that he would be thinking about that crushing loss in New York prior to his meeting with Thiem.

And he was able to gain a small measure of revenge for those recent grand slam defeats in the Spanish capital.

"We have had some fantastic matches," said Zverev. "We have played the biggest matches in the world. We have played Masters 1000 finals, we have played grand slam finals and [the rivalry] is still developing.

"It is still going to go on for a few more years. Hopefully we will play a few more amazing matches. It feels very [sweet to win], it is a rivalry where he kicks my a** most of the time!

"It is going to mean a lot to me [if I can win the final].

"I am definitely looking forward to playing another big final and I hope I can turn it my way this time."

A solitary break of serve was enough for Zverev to claim the opening set.

He recorded two breaks in the second to go 4-1 up and although Thiem got one strike back, two more holds gave Zverev - who forced 11 break points to his opponent's two - a big victory.

The world number six is yet to drop a set this week but has lost his last three Masters 1000 finals going into his latest attempt on Sunday.

Thiem, meanwhile, has reached the Madrid Open semi-finals in four straight years but it still waiting for his first triumph at the tournament.

Rafael Nadal said his shock quarter-final defeat to Alexander Zverev at the Madrid Open was "very difficult to understand". 

Nadal, a five-time champion at the event, was a break up in the first set of his 15th quarter-final at Caja Magica but lost 6-4 6-4 in an hour and 44 minutes.

The win was the biggest of Zverev's career on clay and confirmed his rise to second in the ATP Rankings. 

While Nadal said he was largely pleased with his displays in the Spanish capital, he was at a loss to explain the manner of his defeat on Friday. 

"I'm leaving Madrid with an overall positive feeling, but at the same time with the ugly feeling of having played a match like this today against a great player," Nadal told a media conference. 

"I think for most of the first set, I was playing better than him. And this is the negative part; while playing better than him in the first set, I still lost 6-4.

"This is very difficult to understand, especially for me. When this happens to me, it's usually in the opposite way. I find a way to win sets even though I'm not playing my best or as good as the opponent.

"I felt like I was playing better for much of the first set, but after a couple of errors – unjustifiable errors at the worst times – I found myself down a set.

"The outlook of the match changed there, both for me and for him. I knew then that a lot of suffering was waiting for me [in the second set], and for him, the knowledge that he just took a huge step forward during the match."

Zverev will face Dominic Thiem in the last four after the Austrian overcame John Isner 3-6 6-3 6-4 in an hour and 55 minutes. 

Thiem, who has now made it to the past four Madrid Open semi-finals, said: "I think we all know that he is one of the best servers in history and the altitude here in Madrid makes it even tougher to return his serve.

"I was a little bit surprised by his return games. I think he actually attacked both of my serves, the first and the second, and it took me a while to get used to it."

Casper Ruud will meet Matteo Berrettini in the other semi-final. 

Norwegian Ruud eased past Alexander Bublik 7-5 6-1 to make it three consecutive clay ATP Masters 1000 semis, while Berrettini beat Cristian Garin 5-7 6-3 6-0. 

Rafael Nadal saw off Alexei Popyrin to reach the Madrid Open quarter-finals on a day that saw Daniil Medvedev and Stefanos Tsitsipas suffer surprise defeats.

World number two Nadal, chasing a record-extending sixth title on home soil, advanced 6-3 6-3 in a time of one hour and two minutes on Thursday.

Popyrin, playing in his first last-16 match at a Masters 1000 event, broke Nadal in the sixth game of the opening set but the Spaniard otherwise looked comfortable.

Nadal converted four of his six break points to advance through to the last eight for a 15th time, where Alexander Zverev awaits.

"It was difficult," Nadal said in his on-court interview. "The court today was slippery, it was very fast, very dry conditions. The ball was flying a lot. The beginning was super tough. 

"He was hitting every ball and hitting the spots. I'm happy with the victory. It was an important victory, he came here playing well. Every match is tough."

Zverev, who won the competition in 2018, beat British number one Dan Evans 6-3 7-6 (7-3) to set up a meeting with Nadal

However, second and fourth seeds Medvedev and Tsitsipas saw their participation come to an end at the hands of Cristian Garin and Casper Ruud respectively.

Medvedev, who is still yet to reach the quarters in Madrid, lost the only break of serve in the third game of the opening set but recovered by taking the second set in a tie-break.

Garin dominated the deciding set, the world number 25 breaking Medvedev twice and, after a short delay to fix a broken net, advanced 6-4 6-7 (7-2) 6-1.

Tsitsipas, who held championship point against Nadal in the Barcelona Open final, failed to break Ruud on a single occasion as he fell 7-6 (7-4) 6-4.

Alexander Bublik is next up for Ruud after beating Aslan Karatsev 6-4 6-3, while Matteo Berrettini - 7-6 (7-4) 6-4 winner against Federico Delbonis - will meet Garin.

Also vying for a place in the semi-finals are John Isner and Dominic Thiem, who are set to face off after beating sixth seed Andrey Rublev and Alex de Minaur respectively.

Dominic Thiem surged to an emphatic victory on his return to the ATP Tour at the Madrid Open.

US Open champion and two-time Madrid Open runner-up Thiem was playing his first match in nearly two months on Tuesday, having taken a break to recharge.

But it did not take him long to get back into the groove, the third seed easing through his second-round match with American qualifier Marcos Giron 6-1 6-3 at the ATP 1000 event.

"I was uncertain how things will be going. The game worked out very well in the past days of practice, but I was always practising on the outside courts which are faster, which are smaller, so I was just not sure how it was going to be in the match," Thiem said.

"But there were some things which I think made [the match] a little bit easier after such a long time, especially the conditions in Madrid, which are great for me.

"Then [I have] amazing memories on this court, where I already played probably some of the best matches of my career. I think that's why things worked out quite well tonight."

Next for Thiem in the last 16 is Alex de Minaur, who was leading 6-2 3-0 when Lloyd Harris retired from their match.

It was a largely strong day for the seeded players in the Spanish capital, home hope and ninth seed Roberto Bautista Agut beating Marco Cecchinato 6-2 6-7 (3-7) 7-5 in a first-round clash.

Andrey Rublev – the sixth seed – came from a set down to beat Tommy Paul 6-7 (5-7) 6-3 6-4 and eighth-seeded Italian Matteo Berrettini joins him in the last 16 after defeating compatriot Fabio Fognini 6-3 6-4.

Jannik Sinner, who is seeded 14th, won in the first round after Guido Pella retired in the second set. However, four seeds did tumble out of the draw.

Felix Auger-Aliassime was thrashed 6-1 6-4 by Casper Ruud in the first round and his Canadian compatriot Denis Shapovalov was beaten 6-4 5-7 6-4 by Alexander Bublik in their second-round encounter.

Miami champion Hubert Hurkacz suffered a second successive second-round exit, the 12th seed defeated 5-7 7-6 (9-7) 6-3 by John Millman in a match that went the distance having lost at the same stage in Monte Carlo.

Top seed Dominic Thiem was beaten in straight sets in the second round of the Dubai Tennis Championships by Lloyd Harris.

The reigning US Open champion, given a bye for the first round, lost 6-3 6-4 to his South African opponent, who sits 77 places further down the ATP rankings.

The Austrian has endured a difficult start to 2021. He lost in straight sets to Grigor Dimitrov in the last 16 of the Australian Open and was beaten by Roberto Bautista Agut in the quarter-finals in Doha.

It was a first win over a top-five player for Harris, who was not once taken to deuce on serve during their 72 minutes on court.

"I'm super, super happy with that win. [He is] by far the highest-ranked player I have beat," said Harris. "I look up to Domi a lot so, for me, it is a special feeling. I am really happy. Just the fact that I am playing good tennis, match in, match out now is giving me a lot of confidence.

"I was serving really well. I don't think I faced any break points. I took control of those games and [in] one or two games on his serve, I gave myself a good look. I played some of the important points very well. I am very proud of that."

While Thiem is struggling for form, things are looking far better for Andrey Rublev, who beat Emil Ruusuvuori 6-4 6-4 to stretch his winning streak at ATP 500 events to 21 matches.

The world number eight, who will face Taylor Fritz in the next round, equalled Andy Murray for the second-best winning run at this level of the Tour. Roger Federer (28) holds the record.

Third seed Denis Shapovalov beat Jan-Lennard Struff for the loss of just four games, while Bautista-Agut advanced after opponent Matthew Ebden retired in the first set.

Fifth seed David Goffin was beaten in straight sets by Kei Nishikori, who recorded just his third victory of the year.

Karen Khachanov and Jannik Sinner each advanced after three-setters, while Marton Fucsovics and Aslan Karatsev were also taken the distance before progressing.

Hubert Hurkacz, Lorenzo Sonego, Dusan Lajovic, Aljaz Bedene and Filip Krajinovic also won on Tuesday.

A "tired" Roger Federer was "incredibly happy" to mark his long-awaited return with a battling victory over Dan Evans in the second round of the Qatar Open.

Swiss legend Federer had been out of action for 14 months after undergoing knee surgery, but he was back in business with a 7-6 (10-8) 3-6 7-5 win over Briton Evans.

The 20-time grand slam champion had spent a lot of time practicing with Evans in recent weeks before making his comeback and they spent another two hours and 24 minutes on court in a tight tussle on Wednesday.

Federer was delighted to be back after such a lengthy absence and the 39-year-old's next test will come against Nikoloz Basilashvili in the quarter-finals in Doha.

He said: "I was tired, I was more focused on being tired than winning the points. If I was going to go out, I was going to go out swinging. Dan had more energy left at the end but I was serving well and I thought I played a really good match. I'm incredibly happy about my performance.

"It was a pleasure to share the court with Dan and always nice to finish off with a backhand down the line on match point. The important think is how I feel tomorrow and the next day and so forth for the next six months.

"It's been a long and tough road for me. I enjoyed it though, it's been a huge challenge in my tennis career."

Top seed Dominic Thiem earlier needed three sets to defeat wildcard Aslan Karatsev 6-7 (5-7) 6-3 6-2, while the in-form Andrey Rublev was given a walkover after Richard Gasquet withdrew due to a leg injury.

Denis Shapovalov beat Vasek Pospisil in an all-Canadian encounter, while Roberto Bautista Agut was among the other winners.

Karen Khachanov reached the quarter-finals of the Open 13 Provence with a 7-6 (7-4) 6-4 win over Mackenzie McDonald, while Jannik Sinner ousted Hugo Gaston in straight sets.

Cameron Norrie, Matthew Ebden and Egor Gerasimov were also victorious in Marseille.

Dominic Thiem is relishing Roger Federer's return to action, with the duo taking part in this week's Qatar Open.

Federer has spent the last 13 months out, having elected to take 2020 off – following last year's Australian Open – to undergo two knee operations.

The 40-year-old will compete in Doha this week, returning to play in an event where he has enjoyed plenty of success down the years, winning the tournament three times.

Last year's US Open champion Thiem, who has moved above Federer in the world rankings during the Swiss' absence, will also be in action in Qatar, and is thrilled to see the 20-time grand slam winner make his comeback.

"We are rivals, and of course we want to beat each other in the tournament, [but] I still really love to watch him play tennis," said top seed Thiem, who was speaking to Laureus Sport after his nomination for Breakthrough of the Year.

"[He] looks so nice, the way he plays, the way he approaches the game of tennis.

"On the one hand, I'm also a big fan of his still, and that's why I really love that he's back and that I can watch him again. That's what pretty much everybody is thinking, and I hope that he's coming back strong, as well."

Federer and Thiem have met seven times, with the Austrian holding the advantage, with five wins to his name against the former world number one.

Thiem, a semi-finalist in Doha in 2018, has not played since he lost to Grigor Dimitrov at the Australian Open in mid-February, and the world number four is hoping to make a fast start when he takes on Aslan Karatsev in round two.

"The [Doha] draw is unbelievably strong, so [you] never know what's [going to] happen, but I just try to have a good start and to be there on a good level from the very first point," said Thiem.

"It's going to be my first tournament and [my] first match [in almost] a month, since [a] pretty devastating loss at the Australian Open.

"I needed some time to digest everything, to analyse everything [and] to settle down a little bit. Now it's time to focus on new things. The tournament in Doha is the first chance to play better again, to get good results, to get confidence and to forget a pretty tough start of the season."

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