World number one Novak Djokovic explained that he could just not get up to the level of sharpness required in his shock defeat at the Monte Carlo Masters.

Djokovic slumped out in the second round on Tuesday when he lost 6-3 6-7 (5-7) 6-1 to world number 46 Alejandro Davidovich Fokina.

The Serbian's status as an unvaccinated player has limited his ability to compete on the ATP Tour this year and he has played in just one tournament so far, getting to the quarter-finals in Dubai. 

Yet his preparations for the French Open, which starts at the end of next month, hardly got off to a good start as he made 51 unforced errors in what was still, despite his rustiness, a surprise defeat.

"I didn't like the way I felt physically in the third. I just ran out of the gas completely," Djokovic told the media. 

"Just couldn't really stay in the rally with him. I mean, if you can't stay in the rally, not feeling your legs on the clay, it's mission impossible.

"I'm going to look with my team into reasons why that was the case and go back to the drawing board. Hopefully next week will be better in Belgrade."

Though Djokovic has won twice in Monte Carlo, it has not been a happy hunting ground for him in recent years. He has not advanced past the quarter-final stage since 2015.

He added: "It's going to take some time for me to really feel my best on the clay.

"That's historically always been the case. [I have] never played very well in the opening tournaments of the clay season.

"But it's okay. Obviously it is what it is. I have to accept the defeat and keep working."

While unhappy with his own performance, Djokovic had nothing but praise for his opponent. 

"I would like to congratulate Alejandro. He was the better player," Djokovic said. "He managed to find a better rhythm I think in the first two sets. I was hanging on the ropes the entire match. I was really chasing the result constantly.

"I always believed that I could come back and win the match, and I stayed there even though a lot of things were against me in terms of how I felt on the court. Game-wise, physically I was just far from my best.

"I expected this match to be [a] really tough match, [a] physical battle, and that's what it was. Unfortunately I'm on the shorter end of the stick, and my week ends here."

Djokovic's defeat also means a mouthwatering contest with teenager sensation Carlos Alcaraz, who he might have met in the quarter-finals, will not be taking place.

Novak Djokovic suffered a stunning defeat in his first ATP Tour match since February, the world number one losing in the second round of the Monte Carlo Masters to Alejandro Davidovich Fokina.

Djokovic's status as an unvaccinated player has limited his ability to compete on the tour this year. He missed the Australian Open in January after a saga surrounding his visa eventually resulted in his deportation on public health grounds, while laws around vaccination against COVID-19 in the United States prevented him from playing at Indian Wells and Miami.

Despite his inactivity, the Serbian - whose sole appearance on tour this year came during a run to the quarter-finals in Dubai - was expected to prevail on the clay against his Spanish opponent after receiving a bye in the first round.

But there were evident signs of rust in a mistake-riddled display against the world number 46, who remarkably emerged victorious to set up a meeting with either Dan Evans or David Goffin.

The tide looked to have turned in the second set tie-break, when an exquisite whipped forehand from Djokovic sent the match to a decider.

However, Djokovic, who committed 51 unforced errors, immediately surrendered the momentum by dropping serve in the first game of the third and he was broken twice more as Davidovich Fokina powered to a 6-3 6-7 (5-7) 6-1 victory in just under three hours.

"I knew that Nole hasn't had that confidence because he didn't play a lot," Davidovich Fokina said.

"This win is so special for me. I look at him every tournament. Here in Monte Carlo, full people [capacity], against the number one, I enjoy every moment."

Earlier, Evans saw off Benjamin Bonzi while Goffin, fresh off his triumph in Marrakech, came through against Jiri Lehecka to set up their second-round meeting.

Tenth seed Taylor Fritz defeated Monegasque wild card Lucas Catarina in three sets and 16th seed Lorenzo Sonego saw off Ilya Ivashka in straight sets. Laslo Djere, a semi-finalist in Marrakech, also progressed to the second round.

Carlos Alcaraz is hopeful of meeting Novak Djokovic in the Monte-Carlo Masters, but his first focus is on a second-round tie with Sebastian Korda. 

Alcaraz is one of the brightest prospects on the ATP Tour, with the 18-year-old Spaniard having won his first Masters title at the Miami Open and become the youngest men's champion of that tournament. 

That was Alcaraz's second title of 2022 and third overall. He is now up to 11th in the ATP world rankings. 

Seeded eighth, Alcaraz has been handed a bye to the second round but is in the same quarter of the draw as world number one Djokovic, who has triumphed twice in Monte Carlo. 

Alcaraz, though, is making sure not to get ahead of himself and think too much about a maiden meeting with Djokovic, with American Korda – who defeated Botic van de Zandschulp in his first-round match – first up. 

"I don't want to be in a rush, I just focus on the first [match]," Alcaraz told reporters ahead of what is a rematch of the Next Gen ATP Finals championship match which he won in straight sets. 

"Obviously, it would be a great match against Novak. 

"Playing against the number one player in the world [would be] amazing for me, but I hope to play well in the first [matches] and hope to meet him in the quarter-finals." 

Alcaraz seems set to have a future at the very top of the game but is insisting everything must be taken step by step. 

"Sometimes it is difficult, but I am trying to make it easy," he said. 

"Doing everything for the first time, I am trying my best, trying to manage the nerves of the first time well." 

Taylor Fritz, who won a Masters title at Indian Wells earlier this year, could also be standing in the way of Alcaraz and the quarter-finals, should the American defeat wildcard Lucas Catarina and Marin Cilic. 

Djokovic, on the other hand, faces Alejandro Davidovich Fokina in his first match. 

Stan Wawrinka's ATP Tour return at the Monte-Carlo Masters ended in defeat, while Jannik Sinner came through a tense encounter with Borna Coric. 

The former world number three made his comeback after more than a year out with a left foot injury that required two surgeries but fell to a 3-6 7-5 6-2 defeat to Alexander Bublik in the first round. 

Wawrinka, who entered the tournament as a wildcard having slipped to 236 in the world rankings, came from a break down to take the opening set but fatigue eventually set in and he was eliminated after two hours and seven minutes. 

"I think the body's getting much better," said Wawrinka, who lost in straight sets to Elias Ymer at a Challenger tournament in Marbella two weeks ago. 

"I'm still far away from where I want to be, but I think I'm [going in] the right direction. I think today was a positive match. It was a tough loss, of course, but I'm happy with the way I was playing today. 

"I was playing better, feeling better on the court physically. I spent a lot of mental energy to focus, to stay there as it was tough at the end. But I'm happy with what I have done."

Ninth seed Sinner was taken the distance by Coric before completing a 6-3 2-6 6-3 victory to advance to the second round. 

Sinner took a medical timeout in the second set while he dealt with some apparent abdominal pain, but he was able to battle back and take the win. 

Diego Schwartzman needed over three hours to come from behind and defeat Karen Khachanov 6-7 (5-7) 6-3 6-3, while his fellow Argentine Federico Delbonis set up a clash with second seed Alexander Zverev by besting Jaume Munar 6-4 3-6 6-4. 

Reigning champion Stefanos Tsitsipas faces a meeting with Fabio Fognini in the second round after the Italian overcame Arthur Rinderknech 7-5 4-6 6-3.  

There were also wins for Hubert Hurkacz, Pablo Carreno Busta, Marin Cilic, Alex de Minaur, Albert Ramos-Vinolas and Sebastian Korda. 

American Reilly Opelka defeated compatriot John Isner 6-3 7-6 (9-7) to win a history-making final of the US Men's Clay Court Championships in Houston.

In a clash between two of the tour's elite servers, and two of the tallest men to ever play professional tennis, break points were hard to come by, and even harder to convert, as Opelka saved all eight opportunities he faced, while Isner saved four out of five.

That one break decided the first set, as 6ft 10in Isner fought back from 40-0 down to force deuce, but the fourth break point of the game was converted by 6ft 11in rival Opelka.

The ATP said their respective heights made it the tallest tour final in the Open Era.

In a match that was always likely to be decided by whoever served best, Opelka had five aces to Isner's two in the first set, while Isner also had the only double fault.

Isner was much stronger in the second set, creating seven break-point opportunities, but he just could not win the important points as Opelka's serve repeatedly got him out of trouble.

Isner then had three opportunities at set point in the tie-break to force a decider, but it was Opelka's day, as he saved all three and converted his first chance at match point.

After dropping a set in his first-round match against Mitchell Krueger, Opelka was perfect the rest of the tournament, beating Gijs Brouwer and Nick Kyrgios in straight sets on his way to the final.

David Goffin secured his sixth ATP Tour title by coming from behind to beat Alex Molcan in the Grand Prix Hassan II final on Sunday.

Slovakian Molcan, in search of a first triumph at main tour level, came flying out of the blocks, but ultimately Belgian Goffin's experience showed as he recorded a 3-6 6-3 6-3 victory.

World number 65 Molcan, who defeated Goffin in the first week of the season in Melbourne, was in early control of this meeting in Marrakesh, a set to the good and serving at 2-1 up in the second.

However, former world number seven Goffin responded from that point onwards and did not look back as he won in one hour and 58 minutes.

Goffin feels he can take confidence from this success into the rest of the clay-court segment of the 2022 season.

"I'm very happy, proud of my week. It was not easy, a lot of tough matches," Goffin said. "But at the end, I have my sixth title, here in Marrakesh. It gives me a lot of happiness and confidence for the season on the clay.

"It was the case twice before that match that I lost the first set and I always stayed calm the whole week to turn it around. It was the case again today, because he was playing well.

"He was better than me in the first set, and then I managed to play better and better, serving better, being more aggressive in the middle of the second. I was the better player [after that]."

Quoted on the ATP website, Goffin said: "I was playing even better in the third set, so I'm really happy the way I finished with another break [and] a good match point. I didn't want to serve for the match, I preferred to finish with a break."

Molcan reflected on a positive week in Morocco that saw him most notably beat top seed Felix Auger-Aliassime.

"It was an amazing week for me," he said. "I won a lot of matches and enjoyed it very much."

Reilly Opelka and John Isner will meet in the US Men's Clay Court Championship final in Houston, after they claimed semi-final wins on Saturday.

Opelka kept up his strong early-season form with an imposing 6-3 7-5 victory over Nick Kyrgios in the first semi-final, getting the job done in just one hour and nine minutes.

Opelka slung down 18 aces to 11 from Kyrgios and faced only one break point across the contest.

The 24-year-old Opelka won a title in Dallas in February and followed up with a run to the Delray Beach final, with a third trophy match of the season now awaiting him.

The American world number 18 said he admired the "intangibles" from Kyrgios that "you can't teach."

"He's got one of the best serves in the world and when he turns it on he can come up with some shots that not many guys outside the top 10 can," Opelka said in his on-court interview.

Opelka enjoyed the high-tempo match with Kyrgios, who typically wastes no time between points.

"I prefer to play at that speed rather than, for example, Rafa [Nadal] where it's 50-55 seconds between points," Opelka said.

"It's a totally different speed here and I thought I did a good job managing the whole tempo of the match. I put a lot of returns into play and I came up big with my second serve."

He will face 2013 Houston champion Isner, who came from a set down to defeat defending champion Cristian Garin 4-6 6-3 6-4.

The 36-year-old's serve improved as the match went on and ultimately propelled him to victory, facing four break points in the opening set, one in the second and none in the decider.

Isner also served 17 aces on his way to the final, and won 80 per cent of points on his first serve.

"It's never easy when you have to come back from one set down," he said. "My serve certainly helped me out a lot. I didn't have to hit too many balls there in the end, and I didn't want to.

"I'm so happy to be in the final again here. At my age you never really know when you can get back to a final of a tournament like this."

David Goffin is wary he will face "a great fighter" when he tackles Alex Molcan in Sunday's final of the Grand Prix Hassan II in Marrakesh.

Experienced Belgian Goffin is a five-time tournament winner on the ATP Tour, and his Slovakian opponent is chasing his first title at this level.

However, their one past meeting went Molcan's way when they met in the Melbourne ATP 250 tournament in January, and although that match was on hardcourts and this final is on clay, Goffin respects his left-handed opponent's game.

Goffin made sure of his place in the title match with a 6-3 6-3 win over Argentinian Federico Coria, while Molcan, who beat Felix Auger-Aliassime earlier in the week, was a 6-1 7-5 victor against Serbian Laslo Djere.

Speaking of the threat posed by Molcan, Goffin said: "He's a great fighter, he's moving so well. He's lefty, so he's using his lefty game really well on clay, especially two days ago against Felix, he played well. So it's a tough opponent."

Goffin, quoted on the ATP Tour website, said he was pleased to get his clay season under way in fine style, even if he felt jittery at times against Coria.

"I managed to deal with my emotions at the end to finish the match, so I'm happy to play another final, especially here, the first tournament on clay," Goffin said. "I will give everything tomorrow."

World number 18 Reilly Opelka is through to the semi-final of the US Men's Clay Court Championships in Houston after defeating qualifier Gijs Brouwer 6-3 7-5.

The giant American, who measures in at six-foot-11, was terrific in the opening set, winning 84 per cent of his successful first serves (16-19) and allowing no break point opportunities.

The second set was much more competitive, as Brouwer broke first to go up 3-1, but Opelka answered instantly and then grabbed the match-winning break when 6-5 up to avoid a tie-breaker.

Opelka will face a fresh Nick Kyrgios in the semi-final after the Australian was gifted a walkover win against Michael Mmoh due to injury.

In a clash between two top-five seeds, world number 29 Christian Garin got the better of world number 13 Taylor Fritz 6-2 6-7 (5-7) 6-3.

What made Garin successful in the first and third sets was his return game, winning more than half of his return points in those sets combined (26-51).

Fritz had chances to get back into the game, but Garin saved 11 of 14 break point opportunities, including six of seven in the deciding third set.

Garin will play American John Isner in the semi-final after Isner triumphed in a three-set battle against Frances Tiafoe 6-4 2-6 6-3.

Isner's trademark serve was inconsistent, and abandoned him in a grim second-set performance, winning just 11 of 21 service points on his way to getting broken twice to allow Tiafoe to force the match into a third frame.

In Isner's two successful sets, he won more than 80 per cent of his first serves (35-41), and allowed no break point opportunities in the third.

David Goffin moved within a match of his first ATP Final in over a year after fighting back to beat Roberto Carballes Baena 6-7 (6-8) 6-4 6-0 at the Grand Prix Hassan II.

The former world number seven saw off the Spaniard in a three-set quarter-final to book his place in the last four, 14 months on from his last title in the Open Sud de France.

Goffin, ranked 74th in the world and unseeded for the event in Marrakech, was forced to fight across a gruelling first set, which Baena edged out in a tie-break.

But he fought back to level things in the second before sweeping through the third set unanswered.

Goffin will face Argentine Federico Coria following the latter's 6-7 (1-7) 6-1 6-4 comeback win over Richard Gasquet.

Elsewhere, Alex Molcan's run continued after the Slovakian won 4-6 6-3 6-4 against Botic van de Zandschulp following his last-16 victory over top seed Felix Auger-Aliassime.

He will now face Laslo Djere in the last four after the Serbian overcame Italy's Lorenzo Musetti in straight sets.

Novak Djokovic could face Carlos Alcaraz for the first time after the Monte Carlo Masters draw put the world number one and the teenage revelation on course to clash in the quarter-finals.

The draw for the tournament that begins on Sunday served up the appetising prospect of a tussle between the reigning French Open champion and a player many expect to enjoy huge Roland Garros success.

Alcaraz, 18, last week became the youngest men's champion at the Miami Open, and he has soared to number 11 in the ATP rankings after sitting outside the top 100 at this time 12 months ago.

He won an ATP 250 tournament on clay last year in Umag, and an ATP 500 on the surface in Rio de Janeiro in February, but earning a Masters 1000 hard court title in Miami highlighted the scale of Alcaraz's rapid improvement.

Both he and Djokovic will receive a first-round bye in Monte Carlo, and they must then win twice to set up a meeting at the last-eight stage.

Alcaraz may have to beat the in-form Indian Wells champion Taylor Fritz in the third round, with Marin Cilic and Sebastian Korda also potential early opponents for the young Spaniard.

Djokovic will not be taking a quarter-final place for granted, either. If he navigates his opening match, the Serbian could face a dicey third-round clash with Spain's Roberto Bautista Agut or the player to whom he lost at the last-16 stage last year, Britain's Dan Evans.

Rafael Nadal is absent after suffering a stress fracture of a rib during his Indian Wells final defeat to Fritz.

Taylor Fritz saw his way past Alejandro Tabilo to advance to the quarter-finals at the US Men's Clay Court Championships, winning 6-1 6-4 on Thursday.

Fresh off his maiden ATP 1000 title at Indian Wells and fourth-round run in Miami, the American world number 13 needed just 62 minutes to win in straight sets, in his first clay court match for the season.

Fritz's serve was not particularly secure, though, with the unseeded Tabilo converting on only one of six break point attempts. Fritz was more efficient and assertive when opportunities presented on the other hand, taking two of three break point chances on Tabilo's serve while winning 12 out of 19 points returning on his second serve.

Despite the Chilean world number 100 fighting back to 4-4 from 3-0 down in the second set, Fritz steadied to close out the match.

"I felt like tonight was going to be a really tough match, given he's done really well on clay," Fritz said post-match. "It was my first match [on clay]. I'm pretty happy with how I played. I can't complain, I got out of that pretty solid."

Fritz will now face another Chilean, fifth seed and defending champion Cristian Garin, who came back from a set down to defeat Jordan Thompson 3-6 6-3 6-3.

Entering the Houston event on a five-match losing streak, Garin has come from behind in back-to-back matches to win.

Sixth seed Frances Tiafoe also went the distance on Thursday, earning a 5-7 7-5 7-6 (7-4) win over Uruguayan Pablo Cuevas.

With neither garnering break point chances in the third set, Tiafoe finally created breathing room by winning four straight points at 2-2 in the deciding tie-break, before closing out the match.

It sets up an all-American quarter-final with John Isner, who defeated Steve Johnson 6-7 (1-7) 7-6 (7-4) 6-3 in Thursday's final game.

Top seed Felix Auger-Aliassime crashed out of the Grand Prix Hassan II after he was beaten 6-4 2-6 7-6 (9-7) by world number 65 Alex Molcan.

Making his debut in Marrakech, Auger-Aliassime arrived off the back of an impressive start to 2022.

Indeed, the world number nine had already triumphed in Rotterdam and been runner-up to Andrey Rublev in Marseille.

But he came unstuck at the hands of the player ranked 56 places lower, with Molcan securing his first career win over a top-10 player.

The Slovakian crucially broke in game nine on the way to taking the opening set. Auger-Aliassime, who hit 10 double faults during the contest, responded by dominating the second, while the players exchanged breaks in a decider that went to a tie-break.

The top seed forced match point at 7-6 up, but Molcan held on by reeling off the next three to secure a dramatic victory.

David Goffin, meanwhile, claimed his 300th tour-level win as he came from behind to defeat three-time champion Pablo Andujar.

Andujar had seen off second seed Dan Evans in the first round but, despite making a fast start against Goffin, it was the Belgian who triumphed 5-7 7-6 (7-4) 6-3.

Federico Coria overcame Mirza Basic in straight sets, while Roberto Carballes Baena defeated Portugal's Joao Sousa 6-2 7-6 (7-4) and Richard Gasquet saw off Pavel Kotov.

Dominic Thiem is ready to "get back on track" after testing negative for coronavirus.

The luckless Austrian revealed he had contracted COVID-19 after making a long-awaited return in the Andalucia Open Challenger Tour event last week.

Thiem has not played on the ATP Tour since last June, missing Wimbledon and the US Open in 2021 after undergoing wrist surgery.

The 2020 US Open champion, who was beaten by Pedro Cachin on his comeback in Marbella, on Thursday stated that he is now COVID-free.

"A short update: I am finally negative and I feel much better! Thank you for all your messages! I really appreciate it!" he tweeted.

"I'm going to have a medical check-up, so I can get back on track!"

Thiem has reportedly pulled out of the Monte Carlo Masters this week, but his return to the ATP Tour should be imminent with the French Open on the horizon next month.

Matteo Berrettini could miss the French Open after the world number six was forced to withdraw from three tournaments as he continues to recover from minor hand surgery.

The Italian progressed to the Wimbledon final in 2021 and started the new season in encouraging fashion as he reached the Australian Open semi-finals, where he was well-beaten by eventual winner Rafael Nadal.

However, the 25-year-old has seemingly struggled from then on, with his next best performance coming in Rio – where he made the last eight – as he limped to a 9-6 record so far in 2022.

Further difficulties followed for Berrettini after he sustained an injury to his right hand late in March, forcing him to withdraw from the Miami Open before undergoing a "minor operation".

Berrettini provided another update on Instagram on Thursday, revealing he would not feature at the Monte-Carlo Masters, scheduled to start later this week, or the Madrid Open and Italian Open at the start of May.

The latter tournament in Rome begins just two weeks before the second grand slam of the year, leading to concerns that Berrettini may not feature at Roland Garros.

"UPDATE – following advice from the medical experts, my team and I have decided that it is crucial I do not put time pressure on my recovery process," he posted.

"We have therefore decided I should withdraw from the Monte-Carlo, Madrid and Rome tournaments to ensure I give myself the proper amount of time to return at my highest level.

"Withdrawing from these events, particularly Rome, was an extremely tough decision, however it is the right one to ensure many more years of competing at the highest level for the biggest trophies.

"Thanks very much for all the support. My recovery process is on track and I look forward to seeing you on-court soon."