Rafael Nadal and Novak Djokovic could meet at the semi-final stage of the French Open, while Iga Swiatek and Ash Barty are in the same half of the draw.
Nadal will start his quest to win the Paris grand slam a staggering 14th time with a first-round encounter against Australian Alexei Popyrin next week.
Defending champion Nadal, the third seed, is in the same half of the draw as fellow all-time greats Djokovic and Federer, who could face the Serbian world number one in the last eight.
Top seed Djokovic, who is two major titles shy of the record of 20 held by Federer and Nadal, will take on Tennys Sandgren in the first round.
Swiss great Federer will come up against a qualifier in round one at Roland Garros, while two-time runner-up Dominic Thiem is up against Pablo Andujar.
Pole Swiatek claimed her maiden grand slam title at the French Open last year and takes on her close friend Kaja Juvan in the first round.
World number one Barty, who did not travel to Paris to defend her title in 2020 due to the coronavirus pandemic, has will make her return at the clay-court major against Bernarda Pera.
Serena Williams comes up against Irina-Camelia Begu, while last year's runner-up Sofia Kenin must do battle with the 2017 champion Jelena Ostapenko in a standout first-round match.
Carla Suarez Navarro can expect plenty of support when she takes on Sloane Stephens in her first tournament since successfully completing cancer treatment.
Alcaraz begins Madrid Open campaign with emphatic win
Carlos Alcaraz continued his fine record at the Madrid Open with an emphatic 6-2 6-1 victory over Alexander Shevchenko on Friday.
The two-time defending champion made it 12 straight wins at his home tournament to ensure he will face Brazilian Thiago Seyboth Wild in the last 32.
Alcaraz was playing his first match on the ATP Tour since March 28 after being unable to compete in the Monte-Carlo Masters and Barcelona Open due to an arm injury.
But he was still able to make a fine start to his clay-court season, breaking serve in the first game and racing to victory in only one hour and eight minutes.
Data Debrief
Sometimes the scoreline can be harsh on a beaten player, but on this occasion Alcaraz was clearly dominant, breaking the Kazakh seven times in the match and forcing 11 break-point opportunities while conceding only three for his opponent.
That allowed the Spaniard to claim a dominant victory despite being broken once in each set. He will now turn his attention to a clash with Seyboth Wild, who battled past Lorenzo Musetti with a 6-4 6-4 win.
Reigning champion Sabalenka pushed by Linette at Madrid Open
Aryna Sabalenka got her Madrid Open campaign started with a 6-4 3-6 6-3 win over Magda Linette on Friday.
Sabalenka could not quite hit her peak form against Linette, but the world number two nevertheless got the job done after going the distance.
The Belarusian is hunting a record-equalling third title in Madrid, where she is the reigning champion, though she has not won back-to-back matches at a tournament since winning the Australian Open.
"It's not about being confident," Sabalenka said. "It's about how much you're ready to do to get it. It's about the hard work and to be ready, be ready for the big fights. I feel like confidence is not going to help you in those big matches. It's about staying there and fighting for it."
Data Debrief
Sabalenka (70 per cent, 56-24) is now one of five active players since 2020 to hold a winning percentage of 70 per cent or higher at WTA-1000 events.
Iga Swiatek, Simona Halep, Elena Rybakina and Jessica Pegula are the other players to feature on that list.
Rybakina continues clay winning streak with victory over Bronzetti
In-form Elena Rybakina has moved into the last 32 of the Madrid Open after a straight sets victory over Italian Lucia Bronzetti.
Number four seed Rybakina triumphed 6-4 6-3 on Friday and will next face either Marta Kostyuk or Mayar Sherif.
Rybakina was broken early in each set but ultimately had few problems getting over the line, converting four of her five break points to continue an impressive run of results after winning the Stuttgart Open last week.
She has now won five consecutive WTA matches and has 13 straight wins on clay courts to her name in a superb streak that started one year ago.
Data Debrief: Rybakina in elite company
Since the start of 2020, only two other players have claimed as many 13 consecutive WTA wins on clay, and they are Iga Swiatek and Simona Halep, so Rybakina is in elite company.
Rybakina's last defeat on this surface came in the 2023 edition of the Madrid Open, when she fell to Anna Kalinskaya in her first match, so this win represented a better start to her campaign in the Spanish capital.
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