Top seed Dan Evans was knocked out of the Sardegna Open as Lorenzo Musetti saved four match points to progress to the quarter-finals.
NIneteen-year-old Musetti trailed 6-3 in the third-set tie-break after letting an earlier match point slip through his grasp.
But Evans could not convert any of his first three match points and, after Musetti let another one go begging, the Briton failed to take advantage of his fourth opportunity.
Evans' profligacy eventually proved costly, Musetti converting his third match point with a well-executed forehand drop shot to clinch a 6-1 1-6 7-6 (10-8) triumph.
Seven of Musetti's 12 ATP Tour level wins have now come against players in the top 35 of the rankings.
"The secret for me is not to think about [their ranking], to just play them like other opponents," said Musetti, quoted on the ATP website. "I try to play my game… and try to play as good as I can.
"That is what I did. With them, I always play good. I don't know why. I have no pressure and I feel free. I have no pressure to win and today was the same."
Sixth seed John Millman lost in straight sets to Laslo Djere, but third seed Lorenzo Sonego eased past Gilles Simon 6-4 6-1 to set up a meeting with Yannick Hanfmann, who overcame Marco Cecchinato.
At the Andalucia Open, the seeds tumbled out in Thursday's action.
Second seed Fabio Fognini was thrashed 6-2 6-1 by Jaume Munar, Alejandro Davidovich Fokina lost in straight sets to Ilya Ivashka and sixth seed Feliciano Lopez was undone by a comeback from Carlos Alcaraz.
Seventeen-year-old Alcaraz recovered after losing the first set to beat veteran Lopez 4-6 6-2 6-4. Bucking the trend of the day, third seed Casper Ruud prevailed 6-3 6-2 against Gianluca Mager.
World number one Swiatek sees off Xiyu in Madrid opener
World number one Iga Swiatek overcame Wang Xiyu with the minimum of fuss on Thursday to progress to the third round of the Madrid Open.
Swiatek has yet to win the title in Madrid, which is the only clay-court European event at which the Pole has not triumphed, but she got off to a flying start with a 6-1 6-4 victory over Xiyu.
"I love this place. I got to know the city a little better last year," Swiatek said. "So this time I feel more comfortable around."
Next up for the 22-year-old is a third-round tie against 27th seed Sorana Cirstea on Saturday.
Data Debrief
Swiatek has registered 150 match wins on the WTA Tour since the start of 2022. Elena Rybakina and Coco Gauff are the next best with 108 wins each.
She also became the first player born this century to claim 50 combined match wins in Madrid, Rome and Roland-Garros, since the inaugural women's singles event at the Madrid Open in 2009.
Dominant Gauff double bagels Rus at Madrid Open
Coco Gauff made a flying start to her Madrid Open campaign on Thursday, recording the first double bagel main-draw win of her career as she cruised past Arantxa Rus to reach the round of 32.
Gauff needed just 51 minutes to see off 33-year-old Rus as she booked a meeting with Ukraine's Dayana Yamstremska for Saturday.
The US Open champion lost just 18 points throughout the match – eight in the opener and 10 in the second set – as she put any doubts over her recent form to bed in emphatic fashion.
Gauff's power proved too much for Rus in the opener, the third seed winning 88 per cent of points behind her first serve and converting three of four break points to go a set up in just 23 minutes.
Rus brought up four break points midway through the second set, but when she failed to convert them, Gauff punished her in ruthless fashion by reeling off another three games then finishing things with a terrific forehand winner.
Speaking after her win, the American said: "I played really well today. It was just one of those days for me… 6-0 6-0, I've never done that before, I'll probably never do it again."
Data Debrief: Gauff matches Azarenka, Halep feat
Gauff is just the third player to register a 6-0 6-0 win in the women's singles draw at the Madrid Open, following in the footsteps of two former world number ones in Victoria Azarenka and Simona Halep.
The American, who only turned 20 last month, is also the youngest player to double bagel an opponent in any main-draw match on the WTA Tour since Iga Swiatek did so against Karolina Pliskova in the 2021 Italian Open final in Rome.
Nadal cruises past teen Blanch to tee up De Minaur rematch in Madrid
Darwin Blanch presented little challenge for Rafael Nadal, who dropped just one game in a convincing 6-1 6-0 triumph at the Madrid Open.
Nadal is feeling his way back to fitness, but 16-year-old qualifier Blanch offered little resistance to the 22-time major champion on Thursday.
Making his farewell appearance at the Madrid Open, where he has won five titles, Nadal needed just 64 minutes to progress to round two.
"I think today I played against an opponent with a great future in front [of him], but today, still making mistakes," said Nadal.
"I just tried to be there, be solid all the time without taking a lot of risks. It worked well. I'm happy to be through and I wish him all the very best for the future."
Nadal's reward is a rematch with Alex de Minaur, who he lost to last week in Barcelona.
Data Debrief
This game saw the largest age gap (21 years, 117 days) between two opponents in the history of ATP Masters 1000 events.
Nadal has now registered 57 wins at the Madrid Open, which is 20 clear of any other player.
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