Arizona Cardinals linebacker Chandler Jones requires biceps surgery and will sit out the rest of the NFL season.

Jones left Sunday's 30-10 victory over the New York Jets with the injury and is expected to be out of action for three to four months.

The loss of the All-Pro pass rusher, who finished second in the 2019 NFL Defensive Player of the Year voting, is a significant blow for the 3-2 Cardinals.

"He's a tremendous player, as we all know. Great person. Great leader on this team," said head coach Kliff Kingsbury on Wednesday.

"It's not going to be easy, but we have some guys who have seen playing time this year who will continue to play and get more."

Jones led the NFL in sacks in 2017 and had 19 last year, with Shaquil Barrett (19.5) just edging him out for the honour. The Cardinals star had just one sack this season.

Arizona will hope to soon have fellow starting outside linebacker Devon Kennard back from the calf injury that has kept him out of the past two games.

Tennessee Titans head coach Mike Vrabel saw his faith in his team pay off in droves as they improved to 4-0 with a 42-16 thrashing of the Buffalo Bills despite wretched preparation.

The game was postponed to Tuesday following a spate of positive coronavirus tests for the Titans, which led to their training facility being closed.

It meant Vrabel's team had just three practices in 16 days, but that did not stop them dominating at LP Field, where Derrick Henry rushed for two touchdowns and Ryan Tannehill completed 21 of 28 passes for 195 yards and three TDs.

The display filled Vrabel with pride and confidence that his men can overcome any difficulties to prevail.

"I'm never going to question this football team. I'm never going to question the effort," Vrabel said, per ESPN.

"I'm never going to go into a game questioning how we're going to do. I expect us to win and play with great effort.

"You don't all of a sudden galvanise when things are bad. I think that's a testament to the players and what we've tried to build here.

"You don't always say, 'Oh, there's a s***-storm. We better galvanise.' You stay tight throughout, and you hope that the fundamentals and your core beliefs and core values take over when things get difficult."

The clash was tied after the opening quarter, in which Isaiah McKenzie scored after Tannehill and A.J. Brown connected on a 16-yard pass.

Henry surged over to reclaim the lead for the Titans in the second quarter and Tannehill's 10-yard run saw them into a 21-10 half-time advantage.

Quarterback Josh Allen, who went 26 of 41 for 263 yards with two TDs for the Bills, threw one of his two interceptions to Malcolm Butler in the third quarter and the Titans capitalised through a Jonnu Smith TD.

Given plenty of time, Allen found T.J. Yeldon with a 22-yard pass into the end zone in the fourth quarter, but Henry and Smith ensured the Titans pulled away for a comprehensive victory.

The Titans are top of the AFC South, while the Bills (4-1) remain in first place in the AFC East.

The Tennessee Titans improved to 4-0 and handed Buffalo their first loss of the NFL season with a 42-16 thrashing of the Bills on Tuesday.

Derrick Henry rushed for two touchdowns as the Titans dominated at LP Field in a clash that was postponed due to positive coronavirus tests.

Ryan Tannehill completed 21 of 28 passes for 195 yards and three touchdowns, including twice connecting with Jonnu Smith, and the quarterback rushed for one of his own as the Titans scored six TDs.

Buffalo were level after the first quarter, with Isaiah McKenzie scoring after Tannehill and A.J. Brown had earlier connected on a 16-yard pass.

Henry rushed over to restore the Titans' lead in the second quarter and Tannehill's 10-yard run saw them into a 21-10 half-time lead.

Bills quarterback Josh Allen, who went 26 of 41 for 263 yards with two TDs, threw one of his two interceptions to Malcolm Butler in the third quarter and the Titans capitalised through a Smith TD.

Given plenty of time, Allen found T.J. Yeldon with a 22-yard pass into the end zone in the fourth quarter, but Henry and Smith ensured the Titans pulled away for a comprehensive victory.

The Titans are top of the AFC South, while the Bills (4-1) remain in first place in the AFC East.

The New York Jets have released disgruntled running back Le'Veon Bell.

Bell was signed by the Jets on a four-year, $52.5million contract in March 2019, but he struggled under head coach Adam Gase.

The 28-year-old returned from a hamstring injury on Sunday as the Jets fell to 0-5 after a 30-10 loss to the Arizona Cardinals.

Much to the frustration of Gase, Bell liked tweets saying the Jets should trade him, and that they should have targeted him more against the Cardinals.

The Jets announced on Tuesday they had released Bell, having tried to trade the three-time Pro Bowler.

"After having conversations with Le'Veon and his agent and exploring potential trade options over the past couple of days, we have made the decision to release Le'Veon," Jets general manager Joe Douglas said.

"The Jets organisation appreciates Le'Veon's efforts during his time here and we know he worked hard to make significant contributions to this team.

"We believe this decision is in the best interests of both parties and wish him future success."

Bell played just 17 games for the Jets, finishing with three rushing touchdowns and 863 yards, as well as 500 receiving yards and one TD.

He previously starred across five seasons with Pittsburgh and he could reportedly return to the Steelers.

Jerry Jones says the Dallas Cowboys must "make it work" in contract negotiations with Dak Prescott as he pointed to a silver lining in the quarterback's injury diagnosis.

Prescott suffered a gruesome compound fracture and dislocation of his right ankle when he went down after a tackle from Logan Ryan in the third quarter of the Cowboys' 34-31 win over the New York Giants.

A tearful Prescott was carted off the field on Sunday with his team-mates clearly distressed and Dallas have since confirmed he has undergone successful surgery and been discharged from hospital.

The timing was awful, as the 27-year-old had made a fantastic start to the 2020 season, throwing for 1,690 yards (422.5 per game) through the first four weeks.

And, after two years of failed contract negotiations, Prescott was playing this season under the franchise tag worth $31.4million, without the security of a long-term deal.

Despite the injury's severity, Cowboys owner Jones has taken solace in the QB's expected recovery inside six months and insisted retaining him on a new contract was a must for the franchise.

"This is one that you can mend, come back and be as good as gold," Jones said about the injury on 105.3 The Fan. "I was just so sorry for the circumstances.

"Physically, I'm told by the doctors and in our experience, there should be no problem with him being back out there in early May or April - he should be ready to go for our spring work and the latter part of the spring work." 

Asked how much the injury changed his plans for Prescott, Jones added: "None.

"Dak is deserving of anything that you want to put on a piece of paper, relatively speaking. He's deserving of that.

"If you evaluate what he can do to help us win championships, you can see that it's there. Plus, he's a leader at the premier leader spot. We've got to make it work.

"We've got to be reminded that to have a team, we've got to really manage how we dole out our resources. So what am I saying? I'm saying exactly the same thing I said the last time I was asked about this before the season started. This is part of the game, the business and the contract part.

"We have known for a long time that you can have a great player at this spot, but then not have him at periods of time during his career.

"We had it with [Troy] Aikman. We had it with [Tony] Romo. You don't always have them. So, you have got to rely on other parts of your team

"That is why we do not go into a contract negotiation with the idea that it stands alone.

"It has to be a part of your tools which you have, which is your salary cap to put a team on the field and try to figure out the best way to win. And really that is the underlying issue here."

Despite his shortened game against the Giants, Prescott still leads the NFL with his 1,856 passing yards. The closest player to him, the Seattle Seahawks' Russell Wilson, is 354 adrift. 

After coming in to replace Prescott and seal the win over NFC East rivals the Giants, Andy Dalton will take over at QB for the rest of the season.

Drew Brees acknowledged the New Orleans Saints' thrilling 17-point comeback to defeat the Los Angeles Chargers was a "wild one" but says the win will help the team become "battle-tested".

The veteran quarterback overcame a deficit of 17 points or greater for just the second time in his career as the Saints earned a 30-27 overtime win at the Mercedes-Benz Superdome.

Brees last achieved the feat against the Miami Dolphins back in the 2009 Super Bowl-winning season and his 12th career overtime victory sees him tie Tom Brady for the most in the NFL as a starting QB.

After finishing with 325 passing yards, a touchdown pass and a touchdown run, Brees told ESPN: "Yeah, this was a wild one.

"The bottom line is we were not playing Saints football in the first half. There were too many mistakes that get you beat.

"We shouldn't have had to mount the comeback we had to mount in order to win this game."

The Saints are enduring a mixed season but now move to 3-2 and once again showed their mettle having come back from 14 points down against the Detroit Lions last time out.

It was a comeback triumph that took the shine off a fine performance from Chargers quarterback Justin Herbert, who became the first rookie to throw for four touchdowns in a Monday Night Football game.

"At the end of the day, these are growing experiences. These are learning experiences," Brees added. 

"To have wins like this, where you really have to fight to win – just like we did last week – this is how you grow as a team. This is how you become battle-tested. And I think it pays dividends as you move along here."

The Saints now have some time to recharge with a Week 6 bye, after which star wide receiver Michael Thomas should be back in the fold.

Thomas was not part of the line-up against the Chargers following reports he threw a punch at a team-mate in practice, having missed three games because of an ankle injury.

Brees said head coach Sean Payton had addressed the issue and there will be no lasting ramifications.

"Mike is a big part of this team, and he's going to be a big part of this team moving forward," he said.

"We had an incident, and Sean addressed it and we're gonna be all good."

The New Orleans Saints escaped with a 30-27 overtime victory against the Los Angeles Chargers after fighting back from a large deficit in the NFL.

Drew Brees and the Saints trailed 20-3 with just over four minutes remaining in the second quarter, but New Orleans rallied from 17 points down to prevail on Monday.

The Saints closed within 27-20 with under four minutes of regulation time to play before star quarterback Brees connected with Alvin Kamara for 28 yards and Taysom Hill levelled proceedings 52 seconds from the end in the final quarter.

Wil Lutz then converted a field goal with 5:08 remaining in OT at Mercedes-Benz Superdome to give the Saints (3-2) back-to-back wins.

Brees had entered the game 1-48 in his career when trailing by at least 17 points. The Super Bowl champion and MVP improved to 2-48 in such scenarios.

He finished 33-of-47 for 325 yards, one touchdown, one rushing score and one interception for the Saints, while Chargers QB Justin Herbert was 20-of-34 for 264 yards and four TDs.

Herbert – the sixth pick in the 2020 NFL Draft – made history after becoming the first rookie to throw four touchdown passes on Monday Night Football.

The Chargers (1-4) stormed out of the blocks away from home, Herbert combining with Keenan Allen for a 17-yard score and a 6-0 lead in the opening quarter, though Lutz' 48-yard field goal reduced the deficit.

Herbert continued to cause New Orleans plenty of problems in the second period after throwing TD passes to Mike Williams and Hunter Henry as the Chargers took a 20-10 lead into the interval following Brees' one-yard running score.

Lutz nailed another field goal, a 53-yard effort, for the only score in the third quarter before the Saints completed their comeback in the final period – touchdowns from Jared Cook and Hill, sandwiched in between Williams' 64-yard combination with Herbert – forcing OT.

San Francisco 49ers cornerback Richard Sherman and his return from injury has been put on hold, according to head coach Kyle Shanahan.

Sherman has been on injured reserve with a calf injury since last month, missing four consecutive NFL games for the 49ers.

The 49ers had hoped to have Super Bowl champion Sherman back for practice this week, but the five-time Pro Bowler's comeback has been delayed ahead of the Week 6 clash against the Los Angeles Rams.

"The healing hasn't gone the way we were hoping for," Shanahan said on Monday. "I know we're gonna try a few different procedures this week, but I know I'm not counting on this week. "

"So, we'll see how that goes with the new stuff we're going to try."

Shanahan added: "He's gonna get some shots that he thinks can help in his leg.

"No surgeries or anything, just different types of shots to take to see if they can take the inflammation down and stuff like that."

The 49ers – last season's Super Bowl finalists – are 2-3 following last week's 43-17 humbling at the hands of the Miami Dolphins.

Jimmy Garoppolo returned from an ankle injury, but the 49ers quarterback was later replaced by C.J. Beathard.

Garoppolo had thrown two interceptions and completed just seven of 17 passes for 77 yards, while also being sacked three times.

"We'll see how he is on Wednesday," Shanahan said. "I expect him to be at least the same, if not better.

"So hopefully he can get a week of that and have no setbacks Wednesday, Thursday, Friday; and hopefully we can get him out there Sunday night."

Atlanta Falcons owner Arthur Blank refused to guarantee the future of quarterback and former NFL MVP Matt Ryan following the departures of Dan Quinn and Thomas Dimitroff.

The Falcons are overseeing a period of change after head coach Quinn and general manager Dimitroff were sacked amid Atlanta's 0-5 start to the season.

Raheem Morris will take over as coach on an interim basis following Sunday's 23-16 loss to the Carolina Panthers, with attention now turning to veteran QB Ryan.

Ryan – the number three pick in the 2008 NFL Draft – remains contracted to the Falcons until 2023 and the 35-year-old has stated he would like to play until he is 40.

Through five games in 2020, the 2016 MVP and four-time Pro Bowler has completed 129 of 204 passes for 1,472 yards, seven touchdowns and three interceptions.

"I love Matt, much like I love Dan, I love Thomas,'' Blank said on Monday. "Matt's been a franchise leader for us, great quarterback; one of the leading quarterbacks in the last 13 years in the NFL.

"I hope he's going to be part of our plans going forward. But that will be a decision that I won't make.

"Matt has the ability to play at a very high level, even at this age. Whether that's going to continue or not, I'm not sure. I appreciate his willingness to consider doing that and the level at what he's played for us for 13 years, which has been incredible. So we'll have to see.

"But then again, that's going to be a decision, at the end of the day, that part of it will be up to the player; part of it will be up to the coaching staff. And whether or not Matt can keep himself together.

"God willing, he'll be able to do that and play at the level that he's capable of playing at.''

Ryan signed a five-year, $150million contract extension with the Falcons in 2018.

He was crowned MVP four years ago after leading the Falcons to Super Bowl LI, which saw the franchise infamously surrender a 28-3 lead against the New England Patriots.

Ryan holds the NFL record for most consecutive 200-plus yard passing games, with 64 between 2013 and 2017.

Since entering the league in 2008, Ryan has completed 4,589 of 7,021 passes for 52,658 yards and 328 touchdowns, while he has rushed for 1,318 yards and nine TDs.

Dak Prescott is still a key part of the Dallas Cowboys' plans despite the quarterback having suffered a serious ankle injury.

Prescott will likely be out for the remainder of the season after sustaining a fractured and dislocated ankle in the Cowboys' win over the New York Giants on Sunday.

The 27-year-old will become an unrestricted free agent at the end of the 2020 campaign unless the Cowboys opt to again place the franchise tag on him.

However, with Prescott having undergone successful surgery on Monday, Dallas executive vice-president Stephen Jones has insisted he remains in the team's plans.

When asked if Prescott's injury had changed the team's approach to his contractual situation, Jones told 105.3 The Fan in Dallas: "Absolutely not.

"He's our future. He's special. If anyone can overcome anything, it would be Dak. This is something that our doctors feel good that he'll overcome and come back better than ever.

"He's our heartbeat. Just to lose him, really just kills you in terms of deep down."

Despite the severity of the injury, Jones has no concerns over Prescott's ability to recover.

"For him, you hurt for everything that he stands for and I think we're still in shock. But certainly, Dak is such a warrior. He's been through a lot. He's always overcome it, and this is going to be no exception.

"He's going to get in there and do what he needs to do, I'm sure. Obviously, everybody's prayers are with him.

"He should be able to do everything you need to do to rehab and come back ready to go. It's just a very difficult setback for him and for us. It's something that we feel great about him totally overcoming and being ready to go next year."

The Cowboys are 2-3 from their opening five games of the regular season.

Another dramatic NFL Sunday saw Dak Prescott go down with a gruesome injury for the Dallas Cowboys as the Kansas City Chiefs suffered a shock loss.

Cowboys quarterback Prescott has made a fantastic start to the 2020 season but had to undergo surgery for an ankle fracture and dislocation after going down in the second half against the New York Giants.

Patrick Mahomes and the Chiefs fell to AFC West rivals the Las Vegas Raiders, meaning there are only five undefeated teams left across the NFL, with one of those being the surging Pittsburgh Steelers.

Here we reflect on an entertaining Week 5 with a look at some of the best statistics from the 11 games played on Sunday prior to the Monday doubleheader and another game on Tuesday.

Mahomes in elite company despite loss

Super Bowl champions the Chiefs went down to an upset as the Raiders won 40-32 at Arrowhead Stadium, Derek Carr's team ending a seven-game losing streak against their divisional rivals.

It was the Chiefs' first loss for 14 games and the largest margin of defeat in Mahomes' young career.

While he only completed 22 of his 43 passes, Mahomes did rack up 340 yards through the air with two touchdowns and one interception.

He became only the fourth quarterback in NFL history to reach at least 20 games with 300 or more passing yards inside his first four seasons.

The only others to achieve the feat are Kurt Warner (26 games), Dan Marino (22) and Andrew Luck (21).

Mahomes' accomplishment is even more significant when you consider he started just one game in his rookie season, while this year – his fourth as a pro - is yet to even reach the halfway stage.

His teammate Tyreek Hill rushed for a touchdown against the Raiders and now has five career TDs on the ground to go with 36 receiving scores.

Aside from Hill, only the legendary Jerry Rice (197 receiving TDs and 10 rushing TDs) has got past both 35 and five respectively since 1970.

Claypool gives Steelers best start in 41 years

Chase Claypool produced an astonishing performance as the Steelers defeated the Philadelphia Eagles 38-29, moving to 4-0 for the first time since 1979.

The second-round rookie out of Notre Dame exploded for four total touchdowns, three of which came through the air (seven catches for 110 yards).

He is the first rookie receiver since 1979 to score four TDs in a single game and only the third all-time after Jerry Butler (1979) and Harlon Hill (1954).

While Ben Roethlisberger has struck up an impressive connection with Claypool, the Steelers defense has been equally impressive.

Through four games they have registered at least three sacks and an interception in every outing (five sacks and two INTs against the Eagles). 

They are only the third franchise since 2000 to do that, after the Chicago Bears (2018) and Denver Broncos (who achieved the feat twice, doing so in the 2009 and 2016 seasons).

Career day for Kyler

The Arizona Cardinals bounced back from two straight losses with a comfortable 30-10 win at the struggling New York Jets.

It was a historic day for QB Kyler Murray, whose 380 yards passing represented a career high. He had one passing TD, one interception and an impressive passer rating of 103.4.

He also added a rushing TD to move on to five for the season. Only four QBs have ever scored at least five TDs on the ground through their team's first five games in a season, with Cam Newton (2011) the only other to do so since 1997.

Beckham already among the greats

Odell Beckham Jr. had five catches for 58 yards as the Cleveland Browns moved to 4-1 with a 32-23 home win over the Indianapolis Colts.

The former New York Giants wide receiver has now played in 80 NFL games and is setting a magnificent pace.

His 6,805 receiving yards rank third of any player in history through 80 games (behind only Lance Alworth and Julio Jones), while his 485 receptions put him third in that category too (Anquan Boldin and Jones).

Gurley still finding the endzone

Todd Gurley may not be playing at the level he was as Offensive Player of the Year with the Rams, but his 122 yards and a touchdown against the Carolina Panthers brought up a pretty impressive stat.

His TD for the Atlanta Falcons, who fired their head coach and general manager after a 23-16 defeat moved them to 0-5, was his 75th career score in 78 games.

Only three players have ever reached 75 TDs more quickly, and it is a group of Hall of Famers – Jim Brown (72 games), LaDainian Tomlinson (72) and Emmitt Smith (77).

The winless Atlanta Falcons have sacked head coach Dan Quinn and general manager Thomas Dimitroff, the NFL team announced.

Sunday's 23-16 loss to the Carolina Panthers proved the final straw for Atlanta's hierarchy following a 0-5 start to the season.

Quinn oversaw a 43-42 record since the start of the 2015 season, including a painful loss to the New England Patriots in Super Bowl LI after squandering a 28-3 lead, while Dimitroff joined the Falcons in 2008.

The Falcons, who travel to the Minnesota Vikings in Week 6, are set to announce an interim coach on Monday.

"Decisions like these are very difficult, but the previous two seasons and start to this one have been especially hard for me because of the deep love, admiration and respect I and my family have for Dan, Thomas and their families," said Falcons owner and chairman Arthur Blank.

"For many years, they have represented me, our team, organisation and Atlanta with class, commitment and all the passion you would want in the leaders of the team. But as everyone knows, this is a results business and I owe it to our fans to put the best product we can on the field. We have poured every resource possible into winning and will continue to do so, but the results of late do not meet our standard or what I've promised our fans. Therefore, we will install new coaching and personnel leadership of the Atlanta Falcons at the appropriate time.

"Our finish in 2019 earned an opportunity to show that momentum could be continued and built upon, but that has clearly not happened," Blank continued. "And overall, the last 3-plus seasons have fallen short of my commitment to Atlanta and to our fans everywhere. I want them all to know that my commitment to winning has not wavered and I will continue to provide every resource possible to that end."

Falcons president and chief executive Rich McKay added: "We are moving forward and will do everything we can to help this year's team win as many games as possible while putting a strong plan in place to execute these important leadership searches with an eye to positioning the Falcons for success well into the future. We owe that to our fans."

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