Tuesday's Champions League fixtures feature two of the tournament favourites, but there are no easy games when the competition reaches the quarter-finals.
Manchester City are the bookmakers' favourites to lift the trophy but will need to safely navigate their way past 2020-21 LaLiga champions Atletico Madrid, starting with Tuesday's first leg at the Etihad Stadium.
Liverpool are right behind City in the odds, but the Reds face a tough trip to Portugal where they will play Benfica after the home side triumphed over a strong Ajax team in the previous round.
While the English teams are well fancied, the Opta facts show Atleti coach Diego Simeone should not be daunted by City boss Pep Guardiola, and Benfica's Estadio da Luz has been anything but a happy hunting ground for Liverpool.
Manchester City v Atletico Madrid
This will be the first ever meeting between City and Atleti in European competition, but the fourth between the respective bosses of the two clubs. None of the previous three games ended in a draw, as Guardiola won two and Simeone triumphed in the other.
While Simeone is down on the head-to-head record, his Atleti side eliminated Guardiola’s Bayern Munich in the semi-finals of the 2015-16 Champions League (2-2 on aggregate), progressing on away goals.
Showing his side can win ugly, across the two legs, Atletico averaged just 27 per cent possession and scored their two goals from 18 shots, while Bayern netted the same number of goals from 53 attempts.
City should have some reliable avenues to goal, as only Vinicius Junior (44) has been directly involved in more shots than Riyad Mahrez (42 – 29 shots, 13 chances created) in the Champions League this season.
One of Mahrez's chief suppliers is likely to be Kevin De Bruyne, who will make his 50th Champions League appearance for City if he plays in the first leg.
Since his first season at the club in 2015-16, he has more assists than any other player for an English club (17) in the competition.
However, Atleti may be uniquely positioned to repel some of City's attacking firepower, as no goalkeeper has kept more Champions League clean sheets since 2014-15 than Jan Oblak, with 30 clean sheets in 67 appearances.
Meanwhile, City have only failed to score in one of their 28 home games under Guardiola.
Atleti are also the first side to face both Manchester United and Manchester City in the knockout stages of a European competition in a season since Juventus in the 1976-77 UEFA Cup – the Italian side would go on to progress from both of those ties before winning the whole thing.
Liverpool v Benfica
Liverpool are aiming to win a fifth consecutive away game in Europe's premier competition for only the second time in their history, having last done so between 1983 and 1984 under Joe Fagan.
While Liverpool are a very different beast in recent years under Jurgen Klopp, they have lost on each of their last three away trips to face Benfica in European competition, with the most recent of those coming in the Europa League in 2009-10 under Rafa Benítez.
On the other hand, Benfica are winless in their past four homes matches against English sides in the Champions League since beating Liverpool in 2006, with one draw and three losses.
The home side will need a big performance from Darwin Nunez, who is Benfica’s top scorer in the Champions League this season, having netted four times so far. He is just one goal shy of equalling Nuno Gomes as the player with the most goals for Benfica in a single Champions League campaign (five goals in 1998-99).
Meanwhile, Liverpool boast one of the main hopes for the Ballon D'or in Mohamed Salah, who has scored eight goals in the Champions League this season and could become the first player to score 10+ goals in multiple seasons for the Reds in the competition.
The only other player from an English club to reach double-figure goals in a European Cup/Champions League campaign on more than one occasion was Ruud van Nistelrooy in 2001-02 and 2002-03 for Manchester United.
Benfica will need to be efficient going forward, as their 40 per cent possession in the Champions League this season is the lowest of any remaining team, while only Real Madrid (23) have recorded more direct attacks than the Portuguese side.