Gareth Southgate described Trent Alexander-Arnold's injury as "heartbreaking" for the Liverpool full-back, who will miss Euro 2020.
Alexander-Arnold sustained a thigh injury late on in England's friendly win over Austria on Wednesday, and scans the next day confirmed he will face around six weeks out.
His place in the 26-man squad for Euro 2020 had been the subject of fierce debate in the media, but the 22-year-old made the cut.
With three other right-backs in his squad, Southgate will make a call on who replaces Alexander-Arnold in his selection after Sunday's friendly against Romania in Middlesbrough.
But for now, the England manager offered his support to Alexander-Arnold, whose focus will be on returning to fitness ahead of Liverpool's 2021-22 campaign.
"Well it's heartbreaking really, for any player to get to the eve of a major tournament, be named in the squad and then to miss out through injury," Southgate told a news conference.
"You know how rare these opportunities are, even though he's a young player who's going to have these opportunities again, that's a really difficult moment for him especially.
"It's a big disappointment for us of course, as well, but you can't help, first and foremost, to feel for Trent in this situation.
"The one thing I was pleased about immediately after the game, I didn't like the look of the injury but at least it sounds like he'll be fine for pre-season and next season, but that is a very small positive. Of course he was very upset, bitterly disappointed and in those moments everybody is thinking about him."
England have six players available on standby – James Ward-Prowse, Ben Godfrey, Ben White, Ollie Watkins, Jesse Lingard and goalkeeper Aaron Ramsdale.
The Three Lions still seem well stacked in defence, though midfield is an area they look to be short in, with Jordan Henderson's fitness still in question, albeit centre-back Harry Maguire is also working his way back from injury and seems unlikely to be able to feature in the Group D opener against Croatia on June 13.
Pressed on whether it would definitely be a defender who replaces Alexander-Arnold, Southgate replied: "We want to see how we get through tomorrow's game, be able to assess everything and we'll make a decision from there.
"It's important to have time to consider everything, we're obviously talking about that as a coaching staff. We'll know more after tomorrow's game where everybody is physically, whether there's any more issues, it's important we get the positional balance right for the whole squad."
Asked for an update on Maguire, who is still not training with the team, Southgate said: "With any injury it's impossible to predict 100 per cent.
"Our medical team are pleased with his progress, particularly over the last couple of days, so we know there is always that risk, but all of the guide is that he should be available. It's a case of when he can slot back into training with the group.
"There's always that risk with any injury that you only have to have one minor setback, I am very realistic about that. If he's fit and available, that's a bonus for us."
Des Buckingham feels heavy schedule caught up with Oxford
Oxford boss Des Buckingham felt the heavy schedule of three games in six days took its toll on his team as they were held 1-1 by Stevenage at the Kassam Stadium.
It means it is effectively no longer in Oxford’s hands to reach the League One play-offs because Lincoln are three points behind them with a game in hand and a superior goal difference.
Buckingham felt the decision not to award the U’s a penalty when Marcus Browne appeared to have been fouled by keeper Craig MacGillivray in the first half was crucial.
They had to come from behind as Stevenage went in front through a Sam Long own goal in the 32nd minute, Cameron Brannagan replying from the penalty spot on 58 minutes when Carl Piergianni fouled Ruben Rodrigues – though that appeared to have been outside the box.
Buckingham said: “To play three games in six days is a big ask.
“We had 26 shots but couldn’t get that second goal we needed.
“There was a clear penalty not given in the first half, and for us that’s the second game in a row that one hasn’t been given when it should have been. It was a huge moment in the game, and very frustrating.
“The referee told me he couldn’t see it, but the linesman was only 15 yards away and had a clear view.
“I’m delighted with the performance but ultimately we’ve got just the four points from these three home games, now we need to make sure we prepare right and get three in the last one at Exeter.
“When we looked to rearrange the Lincoln game we chose this week because it was a free week, then Sky told us they wanted to bring this Stevenage one forward and show it on the Friday night which meant three games in six days.
“There was nothing we could do about it, but had we known they were going to do that, we would have played the Lincoln game another week.
“It’s going to be a tight finish – I wouldn’t rule out Blackpool either, and they’ve got to play Barnsley.”
Stevenage had lost manager Steve Evans in the week, with Evans heading north to become Rotherham boss.
Caretaker boss Alex Revell said: “Steve always had two clubs very much in his heart – this one and Rotherham. Believe me, making the decision was probably the hardest thing he’s had to do, he said.
“I wanted to take today and make the players ready. I really enjoyed it because they gave everything.
“I’m very proud of what the lads did tonight.
“We had a great day yesterday in terms of training and getting ready and trying to get a few bits into them.
“They came to a really tough place and worked so hard for each other.
“In spells we created some half-chances, probably not enough, but it was about showing our togetherness as a club and our spirit.
“I think we showed why we have caused teams problems this season, especially with our energy and our workrate.
“The first penalty shout against us was a penalty and should have been given so we got away with that.
“But it doesn’t mean that something that started outside the box should be a penalty. Two wrongs don’t make a right.”
Mauricio Pochettino not expecting a vulnerable Man City in FA Cup semi-final
Mauricio Pochettino warned his Chelsea players not to expect to come up against a vulnerable Manchester City side when the teams meet in Saturday’s FA Cup semi-final.
City go into the game off the back of playing extra time against Real Madrid in the Champions League on Wednesday night before eventually being knocked out on penalties, leaving less than 72 hours recovery time ahead of stepping out at Wembley.
Pep Guardiola has had to deal with fatigue amongst his ranks in recent weeks, with midfielder Rodri admitting to needing a rest earlier this month. He was subsequently left out of the team for last weekend’s win over Luton at the Etihad Stadium but returned to the starting XI for the defeat to Real.
They are still in contention to retain two of the three trophies they won last season, holding a two-point lead over Arsenal and Liverpool in the Premier League title race in addition to Saturday’s meeting with Pochettino’s side as they seek a third FA Cup triumph in six seasons.
Chelsea will return to the scene of their Carabao Cup final loss to Liverpool in February, after which they were heavily criticised for failing to overcome a Reds team decimated by injury.
Jurgen Klopp’s side triumphed in extra time despite finishing the game with four highly inexperienced academy graduates aged 21 or under on the pitch.
And Pochettino insisted there will be no easy ride for his players as City lick their European wounds.
“The good example is Liverpool,” he said. “People were talking about too many injured players, how many young kids they had playing. Look what happened after.
“From our point of view, we are going to compete against Manchester City. If you ask me about their situation, I can give my opinion, but we are not talking about that. We are going to compete against them.
“Today we were preparing, doing meetings, about the Manchester City that played against Real Madrid, that played against us in the Premier League.
“We are not talking about playing one (City line-up) or playing another. For me, the strength of Manchester City is that they keep the same idea and the same philosophy.
“In the last five, six, seven years, even with different players, they play in the same way, they have the structure to dominate and to create chances and to win games and to win trophies.
“I understand the situation is tough for them after playing 120 minutes in the Champions League. Emotionally, you expend a big energy. It’s about how they recover now.
“They are going be competitive and they have an amazing staff that look after the players. They’re going to put 11 players that will play with full energy to try and win the game.”
Pochettino will have Enzo Fernandez available for selection after he missed Monday’s 6-0 demolition of Everton.
The manager said the World Cup winner’s fitness will be carefully managed following reports this week in Argentina that he requires a hernia operation.
“We are not looking for heroes,” said Pochettino.
Pep Guardiola says Cole Palmer is one of the players of the season
Pep Guardiola admits Chelsea’s former Manchester City starlet Cole Palmer has been one of the players of the season.
The City manager has also revealed the 21-year-old England midfielder had been trying to leave the Etihad Stadium for two years prior to his £42.5million switch to Stamford Bridge last summer.
Palmer, who was considered one of City’s brightest Academy products, has been Chelsea’s most influential performer since he moved south in search of more first-team opportunities.
Palmer has scored 25 goals this season, 11 of which have come in his last six appearances.
He heads into Saturday’s FA Cup semi-final showdown with former club City at Wembley fresh from a four-goal salvo against Everton on Monday.
Guardiola said: “Cole has been the decisive player, maybe of the season, in many aspects.
“He’s an exceptional player. We knew that when he was here.
“We know how he’s proving (himself), but he has had a lot of minutes. I said many times, I didn’t give him the minutes when maybe he deserved it. He wanted the minutes he now has at Chelsea.
“I understand completely. I’m happy for him because he’s a lovely guy, a shy guy. He has an incredible potential, otherwise he would not have been here.
“He’s playing good. He’s an incredible threat. He’s playing fantastically.”
Palmer was a member of the City squad that won the treble last season and he began the current campaign strongly with goals for Guardiola’s side in the Community Shield and European Super Cup.
Yet despite attempts to persuade the Wythenshawe-born player to stay with his hometown club, his mind to move on before the end of the summer transfer window had long been made up.
Guardiola said: “So what can I say? The decision has been made for many reasons. He was asking for two seasons to leave.
“I said, ‘No, stay’. At the end, (he said), ‘No, I want to leave’. What can we do? I said in pre-season, ‘Stay because Riyad (Mahrez) has gone’. He said, ‘No, I want to leave’.
“After two seasons, what can you say? So go there. Playing at that level is exceptional. Everybody knows it.”
City’s hopes of winning a second successive treble were dashed on Wednesday as they suffered an agonising penalty shoot-out defeat to Real Madrid in the Champions League quarter-finals.
Their focus is now on defending the domestic double, a feat no side has previously achieved, but Guardiola prefers not to view the targets in those terms.
Guardiola said: “We were close again (to the treble) but it didn’t happen.
“So my advice about trebles or doubles or these things is, why are we not focused on Chelsea? It’s enough of a target to think about.
“When you have one or two games left to the end of the Premier League and you are already in the FA Cup final, I can answer you perfectly.
“We’ve felt, two times, how strong Chelsea are. They are really, really difficult.
“So, win that game and see what happens the next three, four, five games in the Premier League and after we will see.”
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