Manchester City extended their lead at the top of the Premier League to four points as they beat Sheffield United 1-0 to make it a club-record 12 wins in a row in all competitions.
Pep Guardiola's side continued a renaissance that has restored them to the summit of the English top flight and marked them out as clear favourites to clinch the title.
Gabriel Jesus' ninth-minute strike decided the game but, while City failed to add to their advantage as a result of a blunt performance in the final third, they never looked like conceding an equaliser.
Sheffield United arrived at the Etihad Stadium with a renewed sense of hope following their shock midweek victory away to Manchester United.
But City quickly set about extinguishing any optimism, Ferran Torres capitalising on a defensive mix-up before showing great feet to beat his man on the byline and teeing up Jesus for a tap-in.
Although the nature of the opener will have disappointed Blades boss Chris Wilder, he will have been pleased with his players' response to such an early setback.
They restricted the hosts to just one more shot on target before the break thanks to more of the sort of solidity that had earned them three points across Manchester on Wednesday evening.
Unsurprisingly, City looked to up the tempo following the restart, and went close through a Ruben Dias header from Ilkay Gundogan's cross within two minutes.
But they continued to struggle to carve out clear opportunities, their next big chance again coming from a corner as Aymeric Laporte's header forced Aaron Ramsdale into a save.
Sheffield United enjoyed their best spell of the match in the final five minutes, with a John Fleck long-distance effort whistling just past the post in that period.
However, they had left it too late to put sustained pressure on the hosts, who saw out the remaining minutes to claim yet another victory in a remarkable run of form.
What does it mean? City juggernaut rolls on
City's previous title successes under Guardiola have been built on a simply unstoppable attack occasionally covering for a less-than-convincing defence, but that certainly isn't the case with this team.
The Blues have conceded the fewest goals (13) and kept the most clean sheets (12) of any side in the Premier League this season, and that is driving a renewed charge to regain the title.
Laporte proves worth
Ruben Dias' role in City's recent defensive improvement means only the spot next to him is up for grabs when it comes to Guardiola picking a team.
Laporte strengthened his case to start more regularly, winning a team-high eight aerial duels out of the nine he contested against physical opposition.
The defender also took more touches than any player on the pitch (137) and completed the most passes (119).
Brewster struggles continue
Brought into a team that pulled off a huge shock at Old Trafford, Rhian Brewster failed to stake a claim to more regular starts.
The Englishman managed just one speculative shot from distance and fewer touches than any other starter (20).
What's next?
Manchester City will look to extend their winning run against Burnley at Turf Moor on Wednesday, while Sheffield United must try to get back to winning ways at home to West Brom 24 hours earlier.
Coventry City 2-3 Hull City: Tigers win five-goal thriller to keep play-off hopes alive
Hull City kept their hopes of gatecrashing the Championship play-offs alive with a thrilling 3-2 win over beaten FA Cup semi-finalists Coventry City on Wednesday.
Noah Ohio scored the winner with his first touch after coming on as a second-half substitute as Hull moved within three points of sixth-placed Norwich City with two games to play.
Coventry, meanwhile, saw their own hopes of returning to Wembley Stadium for a second successive play-off final all but ended, as they sit six points further back with three matches remaining.
Three days on from their remarkable comeback against Manchester United, the Sky Blues twice fought back to level things at Coventry Building Society Arena. Jaden Philogene's shot squirmed under goalkeeper Bradley Collins to put Hull ahead 31 minutes in, but Kasey Palmer levelled within five minutes with a stunning free-kick.
Hull went back ahead in controversial circumstances on the stroke of half-time, Liverpool loanee Fabio Carvalho converting from the penalty spot despite replays showing Joel Latibeaudiere's foul on Liam Delap took place outside the area.
Mark Robins' men again dragged themselves back into the game as Bobby Thomas headed Jay Dasilva's cross in just before the hour mark, but it was Liam Rosenior's visitors who found a winner.
Thomas went from hero to villain as his poor back pass sold Collins short, and Ohio got a toe to the ball to score the winner, keeping Hull's hopes of Premier League football intact.
Van Dijk: Liverpool have 'no chance' in title race after derby defeat
Virgil van Dijk conceded Liverpool might be out of the Premier League title race after they suffered a surprise 2-0 defeat to Everton in Wednesday's Merseyside derby.
Jarrad Branthwaite and Dominic Calvert-Lewin scored in either half to give the Toffees their first win over Liverpool at Goodison Park since 2010.
Liverpool struggled to find a way through the Toffees' defence despite dominating for long periods, and the Reds' captain says they will not outlast Arsenal and Manchester City without major improvements.
Speaking to Sky Sports, Van Dijk said: "If we play like today, then we have no chance to consider ourselves in the title race.
"We have to just focus on the next game and that will be a tough one anyway, so we will see.
"We're very disappointed, in so many ways. I think everyone has to look at their own performances. Did they really give everything, and do they really want to win the league?
"We're still fighting and there are still games after tonight, but if we play like we did overall in the game today – not winning challenges and giving the referee a chance to give free-kicks like he did many times, then you have no chance to win the title."
Howe: Newcastle performance in Palace defeat 'way off' Spurs win
Eddie Howe admitted Newcastle United's performance in the 2-0 loss at Crystal Palace on Wednesday was "way off" the one that saw them thump Tottenham in their previous game.
Howe's men hammered Spurs 4-0 in their last match, but they never got close to matching the attacking verve from that outing and a Jean-Philippe Mateta double condemned the Magpies to defeat at Selhurst Park.
Newcastle didn't even manage a shot on target until the 87th minute, accumulating just 0.42 xG (expected goals) as the likes of Alexander Isak and Anthony Gordon struggled to make an impact.
Only against Manchester City in August (one) have Newcastle recorded fewer shots on target in a Premier League game this season than their two against Palace, and Howe was critical of his team's display in the loss, one that all but ends their hopes of finishing in the top four.
"[It is a] bad day for us," Howe told Newcastle's club media.
"I thought we were disappointing today, especially in the first 60 minutes. We were way off our levels against Tottenham and our best levels.
"I thought technically we didn't deliver a good performance, and out of possession I don't think it was a particularly good performance either."
Newcastle were unlocked twice for Mateta to score by a Palace side who themselves only generated 0.88 xG.
Howe was left frustrated by the manner in which his side conceded, adding: "I think we'll be disappointed with our performance technically today, and that's probably epitomised by the two goals where we're disappointed with how we've given them the ball in those situations and then how we defended.
"I think the goals sum up aspects of our performance where there was some good, lots of moments that could have led to opportunities, but we were slow to shoot around the box," he said.
The defeat, combined with Manchester United's 4-2 win over Sheffield United, means Newcastle drop to seventh, while eighth-placed West Ham are two points behind with a game in hand.
Newcastle have now lost eight of their last 11 Premier League away games, while they have lost on four occasions in London in the league this term, only doing so more times in a Premier League season in 2000-01 and 2005-06 (both five).
It's been a disappointing season for Howe and his side, especially compared to the heroics of last term when Newcastle finished in the top four, and the Magpies boss knows there's work to be done to get back to those levels.
"It's a day that we have to take our punishment, deal with it, and then try and improve," Howe continued. "It's frustrating because we know we're capable of much better."
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