Ireland centre Garry Ringrose has been ruled out of their Six Nations trip to Italy after failing to overcome a calf injury in time.

Ringrose suffered the problem during their week two victory over holders France but was named in the starting XV for Saturday's game at Stadio Olimpico.

He has failed to overcome the issue however and has now been withdrawn, with Stuart McCloskey now in line to start and utility back Jimmy O'Brien elevated to the bench.

Andy Farrell will hope Ringrose recovers in time to take part in their final two games next month, against Scotland and England.

Ringrose had been in line to win his 50th cap for Ireland in this weekend's fixture and was looking to score on his third consecutive visit to Rome.

The centre has been a standout performer for Ireland in the Six Nations too, beating more defenders than any of his team-mates in the tournament so far, on eight occasions.

Warren Gatland is keen to "draw a line in the sand" ahead of Wales' Six Nations clash with England, saying the threat of strike action had taken the team "to the brink of disaster" this week.

Saturday's fixture at the Principality Stadium was in serious doubt as Wales players considered making themselves unavailable amid a dispute with the Professional Rugby Board (PRB) and Welsh Rugby Union (WRU). 

On Wednesday, however, PRB chair Malcolm Wall confirmed an agreement had been reached with the Welsh Rugby Players' Association on several key issues, including wages and changes to the 60-cap rule that governed international selection.

Wales coach Gatland was forced to delay naming his team due to the uncertainty, and he says the effects of Saturday's game not taking place would have been dire. 

"Looking back now, few people realise just how close we came to the brink of disaster," Gatland wrote in a column for The Telegraph. "What took me by absolute surprise was the level of frustration and anger that boiled over from the players on Monday morning.

"Learning the extent of their frustration was one of the hardest things I had to deal with. I have always prided myself on putting the demands of the players first.

"I was caught in the middle. You want to support the players as much as possible, but you've got to be very careful about how much of the line you cross from that perspective.

"I'm not sure that they had thought about the potential consequences or the long-term effects of the game not going ahead. It would have had such an impact on all rugby in Wales, and potentially led to one or two of the regions going under.

"What hurt me most was hearing a couple of emotive comments from players, second hand, that I didn't care about them. That was the hardest thing because I have always been about putting the players first and looking after them. I just think it was the emotions of the time."

Gatland was eventually able to name his team on Thursday, as Wales look to respond to defeats against Ireland and Scotland in their first two Six Nations contests.

While the 59-year-old is acutely aware of the impact this week's events have had on Wales' preparations, the team are now keen to move on.   

"I am pretty sure I would have easily got a team if I had walked up St Mary Street and asked who was up for beating England. But thankfully we never got that far," Gatland said.

"On Thursday morning I finally named the team. I said it had been a challenging week and we needed to draw a line in the sand and focus entirely on playing against England.

"In fairness to the boys, given what has been going on, they have trained hard and been good in the sessions. It has probably been a welcome distraction to them and I have to take my hat off to them.

"The difficult thing to assess is what impact the mental stress of this week has had on the players. One thing I can promise the Welsh supporters is that the players know how much it means to you. Armageddon or not."

Wales captain Ken Owens said the ordeal had made Welsh rugby "a laughing stock" as he urged the players to pull together in order to get a much-needed result in Cardiff.

France head coach Fabien Galthie has selected Mohamed Haouas as the replacement for the suspended Uini Atonio for France's Six Nations clash with Scotland.

Atonio was handed a three-week ban for a high tackle on Ireland's Rob Herring, with Haouas coming in at tighthead despite not featuring in France's first two games.

That is the only change made by Galthie from the 32-19 defeat in Dublin on February 11.

Captain Antoine Dupont will play alongside Romain Ntamack in the half-backs, while Yoram Moefana and Gael Fickou remain as the centre pairing.

France have won 18 of their last 19 Test matches on home soil, including their last nine in a row, with their only defeat in that spell coming against Scotland in 2021. They will be aiming to win 10 straight home games for the first time since 1986-1989.

Scotland are looking to make it three wins from three after victories over England and Wales, and coach Gregor Townsend has also made just the one alteration to his side from last time out.

The 2021 Six Nations Player of the Championship Hamish Watson comes in to replace Luke Crosbie after recovering from a head injury sustained against New Zealand in December.

Crosbie and Chris Harris are not even named on the bench, with Sam Skinner coming in, while Ali Price is also back and among the replacements.

Stuart Hogg went off with a head injury in Scotland's defeat of Wales in round two, but has been passed fit to start.

France XV: Thomas Ramos, Damian Penaud, Gael Fickou, Yoram Moefana, Ethan Dumortier, Romain Ntamack, Antoine Dupont (c); Cyril Baille, Julien Marchand, Mohamed Haouas, Thibaud Flament, Paul Willemse, Anthony Jelonch, Charles Ollivon, Gregory Alldritt.

Replacements: Gaetan Barlot, Reda Wardi, Sipili Falatea, Romain Taofifenua, Francois Cros, Sekou Macalou, Baptiste Couilloud, Matthieu Jalibert.

Scotland XV: Stuart Hogg, Kyle Steyn, Huw Jones, Sione Tuipulotu, Duhan van der Merwe, Finn Russell, Ben White; Pierre Schoeman, George Turner, Zander Fagerson, Richie Gray, Grant Gilchrist, Jamie Ritchie (c), Hamish Watson, Matt Fagerson.

Replacements: Fraser Brown, Jamie Bhatti, WP Nel, Jonny Gray, Sam Skinner, Jack Dempsey, Ali Price, Blair Kinghorn.

Courtney Lawes is poised to make his England return at the Principality Stadium, while Dan Biggar drops to the bench as Warren Gatland has made nine changes to his team for the Six Nations clash on Saturday.

Lock Lawes has been named among the replacements after recovering from injury and is set to make his first appearance for the Red Rose since captaining his country for the series victory in Australia last year.

Anthony Watson has got the nod to start on the left wing ahead of Ollie Hassell-Collins in the only change to the team that beat Italy 31-14 before the weekend off.

That means Marcus Smith is on the bench once again, with captain Owen Farrell staying at fly-half.

Warren Gatland has wielded the axe following a 35-7 hammered at the hands of Scotland, fly-half Biggar among those to lose his place. George North, Liam Williams and Wyn Jones miss out altogether.

Centre Mason Grady will make his senior bow, Owen Williams comes in at number 10 and the fit-again Louis Rees-Zammit is back on the wing.

It was confirmed on Wednesday that the game will go ahead following a threat of strike action from Wales players, who will attempt to get up and running following defeats to Ireland and Scotland.

Wales team: Leigh Halfpenny, Josh Adams, Mason Grady, Joe Hawkins, Louis Rees-Zammit, Owen Williams, Tomos Williams; Gareth Thomas, Ken Owens (captain), Tomas Francis, Adam Beard, Alun Wyn Jones, Christ Tshiunza, Justin Tipuric, Taulupe Faletau.

Replacements: Bradley Roberts, Rhys Carre, Dillon Lewis, Dafydd Jenkins, Tommy Reffell, Kieran Hardy, Dan Biggar, Nick Tompkins.

England team: Freddie Steward, Max Malins, Henry Slade, Ollie Lawrence, Anthony Watson, Owen Farrell (captain), Jack van Poortvliet;  Ellis Genge, Jamie George, Kyle Sinckler, Maro Itoje, Ollie Chessum, Lewis Ludlam, Jack Willis, Alex Dombrandt.

Replacements: Jack Walker, Mako Vunipola, Dan Cole, Courtney Lawes, Ben Curry, Alex Mitchell, Marcus Smith, Henry Arundell.

Craig Casey and Ross Byrne will make their first Six Nations starts for Ireland when they travel to Rome to face Italy on Saturday.

With Johnny Sexton out with a groin injury and Conor Murray dropped to the bench, Casey and Byrne will pair at half-back as coach Andy Farrell makes six changes to the team that beat France last time out.

Ronan Kelleher replaces Rob Herring at hooker, while Jack Conan comes in for Peter O'Mahony and Bundee Aki earns a start after coming off the bench in the first two games, replacing Stuart McCloskey.

Dan Sheehan is fit again and has been named among the replacements.

James Ryan will captain the side in Sexton's absence as Ireland look to make it three wins from three following victories against Wales and France.

Ireland have won 22 of their previous 23 matches against Italy in the Six Nations, including the last nine in a row, with their only defeat in that spell coming in Rome in 2013, which was the last time Italy won at home in the competition against anyone.

Italy have made three changes from the side that lost to England in their last game, with fly-half Paolo Garbisi back in for Tommaso Allan.

Coach Kieran Crowley has also recalled Pierre Bruno to the left wing, while Simone Ferrari is in for Marco Riccioni at tighthead prop.

Italy XV: Ange Capuozzo, Edoardo Padovani, Juan Ignacio Brex, Tommaso Menoncello, Pierre Bruno, Paolo Garbisi, Stephen Varney; Danilo Fischetti, Giacomo Nicotera, Simone Ferrari, Niccolo Cannone, Federico Ruzza, Sebastian Negri, Michele Lamaro (c), Lorenzo Cannone.

Replacements: Luca Bigi, Federico Zani, Marco Riccioni, Edoardo Iachizzi, Giovanni Pettinelli, Alessandro Fusco, Luca Morisi, Tommaso Allan

Ireland XV: Hugo Keenan, Mack Hansen, Garry Ringrose, Bundee Aki, James Lowe, Ross Byrne, Craig Casey; Andrew Porter, Ronan Kelleher, Finlay Bealham, Iain Henderson, James Ryan (c), Caelan Doris, Josh van der Flier, Jack Conan.

Replacements: Dan Sheehan, Dave Kilcoyne, Tom O'Toole, Ryan Baird, Peter O'Mahony, Conor Murray, Jack Crowley, Stuart McCloskey.

Wales' Six Nations clash with England will go ahead this weekend after strike action was avoided following crunch talks on Wednesday.

Professional Rugby Board (PRB) chair Malcolm Wall confirmed an agreement had been reached with Welsh Rugby Players' Association (WRPA) chief executive officer Gareth Lewis over a series of key issues that had led to a realistic threat of the fixture not taking place.

The settlement of a significant contract dispute came after the PRB agreed a reduction to the 60-cap rule that governs international selection and revised the fixed-and-variable contract offer for players.

Only 25 international caps will be required for players before being able to play freely outside of Wales, and still be available for the national side, while Lewis will attend all PRB meetings.

A new contract agreement, under the newly proposed new Professional Rugby Agreement (PRA), will contain a fixed-only option, as well as a fixed-variable deal that Wales' professional sides will work under.

"We have listened to our players and have been able to resolve the three issues presented, quickly and efficiently," said Wall after the announcement.

"The six-year framework we have agreed has always had the players' best interests at heart and we have been happy to allay their understandable concerns with the adjustments described.

"Negotiations at PRB will continue in earnest as we seek to sign our new six-year PRA as soon as possible and we continue to be grateful to our professional players for their understanding and patience at this most critical time for the game in Wales."

Warren Gatland delayed his squad announcement on Tuesday amid ongoing discussions, with Wales players reportedly keen to have matters sorted by the following day.

Those plans came to fruition after negotiations between the four Wales professional sides and WRPA representatives at Principality Stadium, and a further meeting among international and club players.

"I'm grateful to PRB members for the meaningful consultation that has taken place over the past days and weeks and for the compromises they have made in getting to this point," said WRPA's Lewis.

"The impasse that was reached this week is of course regrettable for all parties but, having now been granted a place within PRB, the players' voices can now be heard which will avoid any repeat of situations like this in the future.

"The players are now keen to put this matter behind them and concentrate on preparations for one of the biggest matches in the international sporting calendar in Cardiff on Saturday."

Welsh Rugby Union interim chief executive officer Nigel Walker added: "The PRB has been agile and receptive to the players' requests and the players have, equally, been responsible and reasonable in their dealings with the PRB which is a credit to all parties.

"We will all now put this matter behind us and I know the nation will also unite as one behind the team when they face England.

"The game is on and, whilst there is still some detail to discuss and some fine tuning to be done in our negotiations at PRB, this is undoubtedly been a linchpin moment from which we can build."

Wales are bottom of the table after losing to Ireland and Scotland at the start of Gatland's second spell as head coach.

Tom Curry will not return before the end of the Six Nations due to another hamstring injury.

Curry had been in line to return for England against Wales this week after missing time with a tear to his right hamstring.

But after making his comeback for Sale Sharks on Saturday, he injured the same muscle in his left leg.

On Tuesday, England confirmed Curry would be replaced in the squad by brother Ben.

An update followed from Sale director of rugby Alex Sanderson, who ruled the back rower out for the remainder of the tournament.

"It's a grade 2c hamstring injury on the opposite side to the one that he did six weeks ago," Sanderson said.

"It's a soft muscle injury that extends into the tendon. It's four to six weeks."

Sanderson explained the injury had been sustained after linking up with England this week rather than in the club match against Northampton Saints.

He attributed the setback to "something to do with the loading and the physical demands of an international camp compared to your club".

Defending the decision to involve Curry against Northampton, Sanderson said: "Tom knows his body and his mind better.

"This is not a guy who needs two or three games to warm up. He can just go straight in and be at the top of his game."

Ireland second row James Ryan will captain the side in the absence of Johnny Sexton when they face Italy in the Six Nations on Saturday.

Andy Farrell's team head to Rome looking to preserve their perfect start to this year's championship, having so far picked up wins over Wales and France.

Fly-half and regular skipper Sexton suffered a groin injury against Les Bleus in week two however and has been ruled out of the trip to Stadio Olimpico.

In his place, Leinster forward Ryan will take charge for the visitors, with the 26-year-old acknowledging he must live up to the responsibility.

"It's obviously a huge honour," he said. "It’s very cool. It’s a great moment for me and my family to captain my country this week. It still hasn’t sunk in.

"We've got a good group, a core leadership group that has been there for the last couple of years. I have big shoes to fill.

"Being named captain is a huge honour, but I've still got to bring the best version of myself."

Ireland are favourites to take the championship crown after defeating France last time out, with the world number one side looking to push on in a World Cup year.

A much-improved Italy are still winless in 2023, but Ryan expects a sterner test than in encounters gone by from the Azzurri.

"They are at home, so they will play with plenty of emotion," he added. 

"They are obviously an improved team, particularly in attack. They seem to be playing with a lot of ambition.

"They've got some genuinely world-class players there. They are a very dangerous side with ball in hand. They are also strong up front.

"We saw them drive the England pack back a few times, which is no easy task. I think it will be a big challenge for us."

Former Australia assistant coach Dan McKellar has departed the Wallabies to take charge of Leicester Tigers from next season.

The former Brumbies boss will become the permanent successor to England coach Steve Borthwick at the Premiership Rugby club.

McKellar exits the backroom staff of new Australia boss Eddie Jones, who returned to the top job at the Wallabies following his own exit at Twickenham.

The 46-year-old's arrival at Welford Road signals the end of a coaching reshuffle between the club and the two nations, just months ahead of the Rugby World Cup.

"We are delighted to be able to confirm Dan McKellar's appointment to the head coach role at Leicester Tigers from next season," club chief executive officer Andrea Pinchen said.

"This has been a rigorous process, over a period of almost six months, and always been about ensuring that we found the very best coach to lead this club into the future.

"His style of coaching, his interactions and passion for wanting to improve players, his interest in developing Tigers-made players and our connection with our community has shown he understands the uniqueness of this club.

"Dan is committed to long-term success at Leicester Tigers, and we are looking forward to welcoming him and his family in the summer, before getting to work together."

McKellar will not take charge until the end of the 2022-23 campaign at Leicester, with the Tigers set to continue under interim boss Richard Wigglesworth.

The former scrum-half is then set to link up with former coach Borthwick and fellow assistant Kevin Sinfield as part of the national set-up ahead of the World Cup.

After losing their opening Six Nations game to Scotland, England bounced back to give their new boss a maiden victory against Italy earlier this month.

They next play Wales on Saturday, before games with holders France and championship favourites Ireland in March.

Tom Curry will not make his England comeback against Wales on Saturday due to a leg injury and has been replaced in the squad by his twin brother Ben.

Curry had hoped to return for the Six Nations battle at the Principality Stadium this weekend after a spell on the sidelines due to a hamstring tear.

But the back rower, who played for Sale Sharks in a win over Northampton Saints on Saturday, will not feature in Cardiff after withdrawing from the squad.

Ben Curry has been drafted in by head coach Steve Borthwick, while Ben Earl has been omitted after coming off the bench in the round-two win over Italy.

Fit-again lock Courtney Lawes is poised to make first England appearance since captaining his country in the series victory in Australia last year. Wing Ollie Hassell-Collins misses out with a knee issue.

Warren Gatland delayed naming his team on Tuesday amid uncertainty over potential strike action from Wales players, but the head coach said he was confident the issues would be resolved and the game would go ahead.

Warren Gatland has delayed naming the Wales team to face England but is confident the Six Nations game will go ahead on Saturday amid uncertainty over potential strike action.

Wales players remain in a contract dispute with the Professional Rugby Board (PRB) and have been considering making themselves unavailable to do battle with England this weekend.

A new six-year financial agreement between the Welsh Rugby Union and the four professional regions – the Dragons, Cardiff, the Ospreys and the Scarlets – has not been signed off as talks continue.

Gatland was due to announce his team for the clash at the Principality Stadium on Tuesday but the head coach had to change his plans.

The players have reportedly stated they want the issues to be resolved by Wednesday and New Zealander Gatland expects a positive outcome.

He said when explaining why he had not named his side: "I think with the uncertainty that was happening, there's a lot of meetings. I just wanted clarity for the boys with tomorrow then we come back [to train] on Thursday.

Gatland added: "I'm confident it'll go ahead. The players have probably had about half a dozen meetings in the last few days. It's been a bit of a challenge but sometimes that galvanises people.

"The players have been given assurances that things will be sorted out, but unfortunately they have not. It finally came to a head.

"I think it's a genuine threat [of taking strike action], no doubt about that. But having spoken to a few people today, I'm fairly confident it will be resolved."

Gatland praised the professionalism shown by his players in such a period of uncertainty.

He continued: "In fairness to the players, they've trained well amongst it all. There's been things going on but in training they've applied themselves well."

Wales are bottom of the table after losing to Ireland and Scotland at the start of Gatland's second spell as head coach.

Italy's Jake Polledri will undergo shoulder surgery that is set to rule him out of the rest of the Six Nations, a week after his return against England.

The 27-year-old only made his first appearance for the Azzurri since November 2020 during his side's 31-14 defeat at Twickenham last Saturday.

A long-term lay-off with a knee ligament injury sustained against Scotland kept the forward out for over a year and a half, before his Gloucester form earned a recall this term.

Now, the Italian Rugby Federation has confirmed he will undergo surgery for a shoulder problem that was discovered after he was forced off for a HIA in the closing stages against England.

"Jake Polledri [had a] pain in his right shoulder which led to the discovery of an injury," read a federation statement.

"The examination he underwent revealed the involvement of the rotator cuff tendons. The specialist consultation carried out at his club recommended surgery.

"The prognosis of the injury sustained and the consequent duration of recovery will be evaluated based on the outcome of the scheduled surgery."

Italy have lost both of their opening Six Nations fixtures under coach Kieran Crowley this year, but came close to scoring a major upset in their opener against championship holders France.

Kieran Crowley's side will next face frontrunners Ireland at Rome's Stadio Olimpico next Saturday before another home clash with Wales as they continue to step up preparations ahead of this year's Rugby World Cup.

The Azzurri will compete in Pool A, alongside France, New Zealand, Uruguay and Namibia.

France have recalled Jonathan Danty ahead of their Six Nations clash with Scotland.

Les Bleus' hopes of a second straight Grand Slam faded last week as they went down 32-19 in Dublin.

In-form Scotland head to Paris next week with a third straight win in their sights, but France will have centre Danty to call on.

Danty has won 18 caps for France and seemed set to be a key player for Fabien Galthie until he sustained a posterior cruciate ligament in his right knee in late December.

He was expected to miss the entirety of the tournament, but in a boost to Galthie has recovered ahead of schedule.

Uini Atonio's suspension, meanwhile, means a call-up to the 42-man squad for Thomas Laclayat.

Former Scotland international Blade Thomson has retired from rugby due to a head injury.

Thomson, who has spent the last five years with Welsh side Scarlets, issued a statement on Thursday to confirm his decision.

Scarlets boss Dwayne Peel said at a press conference on Tuesday that Thomson was out with a head problem, adding that it was a "work in progress".

However, the player has now taken the decision to hang up his boots at the age of 32.

New Zealand-born Thomson won 10 caps for Scotland, including playing at the 2019 World Cup in Japan.

In a statement released through Scarlets, Thomson said: "Myself and my family have come to this decision and I'd like to thank everyone, coaches, players, the back-room and medical staff and all the fans for their support.

"We've been made welcome from the moment we came to Llanelli. It's a special place to play and I'm proud of what I've achieved, making more than 50 appearances for the Scarlets and having the honour of representing Scotland.

"We will leave with fond memories of our time here."

Scarlets will honour Thomson with a presentation following Saturday's United Rugby Championship game against Edinburgh.

Former Ireland, Leinster and British and Irish Lions prop Jack McGrath has retired from rugby at the age of 33 as he wants to live "a pain-free life".

McGrath earned 56 caps for Ireland and was part of the side that won the Six Nations in 2014 and 2015, as well as a Grand Slam in 2018.

The Dublin native was also part of the Lions' 2017 tour of New Zealand, winning all three of his caps as a replacement.

He has struggled with a persistent hip injury and had been without a club since being released by Ulster at the end of the 2021-22 season.

In a statement posted on his personal Instagram account on Thursday, McGrath officially brought down the curtain on his playing career.

"This decision has taken a considerable amount of time. It has been one of the hardest I've ever had to make," McGrath said.

"The last few years have been extremely testing for myself and my family, both mentally and physically.

"I feel I have given everything to my rugby career and I have no regrets or anything left to prove. It's been a long road of rehabilitation after two hip resurfacing operations.

"My main focus now is my family and I am excited for this next chapter with them.

"I am in a position now where I have a comfortable, pain-free life and can be an active dad, which I have chosen over going back to play rugby."

McGrath won three domestic titles, along with trophy successes in the European Challenge Cup and European Champions Cup, during nine successful years with Leinster, before joining Ulster in 2019, where appearances were limited.