Tournament organisers and the Cameroon government on Thursday stated the Africa Cup of Nations "must take place" as they revealed only fans who are fully vaccinated can enter stadiums.
There have been increasing concerns the competition may be called off due to the emergence of the Omicron strain of COVID-19.
The tournament was due to be staged in January and February this year but was postponed due to the pandemic.
Just over three weeks before the opening ceremony at the Complexe Sportif d'Olembe, the government, Confederation of African Football (CAF) and Cameroonian Football Association (FECAFOOT) released a statement vowing that the rearranged AFCON 2021 will go ahead.
The statement said: "In Cameroon, as has been the case elsewhere, effective and reliable measures have been taken as part of a coherent and tried-and-tested approach to counter the pandemic.
"The government has set up a special health protocol to combat COVID-19 that applies to the AFCON.
"In less than 25 days, the best 24 African football teams will participate in the AFCON 2021 and special measures must be taken in connection with this important and prestigious event.
"As is widely known, organised football plays an important role in fostering integration and peace, as well as bringing people together.
"It is also a catalyst of hope, a vehicle for shared values and a conduit for joie de vivre, making it possible to transcend difficulties and see beyond our differences. Therefore, despite the additional challenge posed by the pandemic, the AFCON must take place."
The statement also made clear that supporters will not be allowed into venues unless they are fully vaccinated, while they must also show a negative PCR test result that is no older than 72 hours or a negative antigen test result no older than 24 hours.
CAF will use an independent, internationally recognised laboratory to test players and their delegations.
Coventry City 2-3 Hull City: Tigers win five-goal thriller to keep play-off hopes alive
Hull City kept their hopes of gatecrashing the Championship play-offs alive with a thrilling 3-2 win over beaten FA Cup semi-finalists Coventry City on Wednesday.
Noah Ohio scored the winner with his first touch after coming on as a second-half substitute as Hull moved within three points of sixth-placed Norwich City with two games to play.
Coventry, meanwhile, saw their own hopes of returning to Wembley Stadium for a second successive play-off final all but ended, as they sit six points further back with three matches remaining.
Three days on from their remarkable comeback against Manchester United, the Sky Blues twice fought back to level things at Coventry Building Society Arena. Jaden Philogene's shot squirmed under goalkeeper Bradley Collins to put Hull ahead 31 minutes in, but Kasey Palmer levelled within five minutes with a stunning free-kick.
Hull went back ahead in controversial circumstances on the stroke of half-time, Liverpool loanee Fabio Carvalho converting from the penalty spot despite replays showing Joel Latibeaudiere's foul on Liam Delap took place outside the area.
Mark Robins' men again dragged themselves back into the game as Bobby Thomas headed Jay Dasilva's cross in just before the hour mark, but it was Liam Rosenior's visitors who found a winner.
Thomas went from hero to villain as his poor back pass sold Collins short, and Ohio got a toe to the ball to score the winner, keeping Hull's hopes of Premier League football intact.
Van Dijk: Liverpool have 'no chance' in title race after derby defeat
Virgil van Dijk conceded Liverpool might be out of the Premier League title race after they suffered a surprise 2-0 defeat to Everton in Wednesday's Merseyside derby.
Jarrad Branthwaite and Dominic Calvert-Lewin scored in either half to give the Toffees their first win over Liverpool at Goodison Park since 2010.
Liverpool struggled to find a way through the Toffees' defence despite dominating for long periods, and the Reds' captain says they will not outlast Arsenal and Manchester City without major improvements.
Speaking to Sky Sports, Van Dijk said: "If we play like today, then we have no chance to consider ourselves in the title race.
"We have to just focus on the next game and that will be a tough one anyway, so we will see.
"We're very disappointed, in so many ways. I think everyone has to look at their own performances. Did they really give everything, and do they really want to win the league?
"We're still fighting and there are still games after tonight, but if we play like we did overall in the game today – not winning challenges and giving the referee a chance to give free-kicks like he did many times, then you have no chance to win the title."
Howe: Newcastle performance in Palace defeat 'way off' Spurs win
Eddie Howe admitted Newcastle United's performance in the 2-0 loss at Crystal Palace on Wednesday was "way off" the one that saw them thump Tottenham in their previous game.
Howe's men hammered Spurs 4-0 in their last match, but they never got close to matching the attacking verve from that outing and a Jean-Philippe Mateta double condemned the Magpies to defeat at Selhurst Park.
Newcastle didn't even manage a shot on target until the 87th minute, accumulating just 0.42 xG (expected goals) as the likes of Alexander Isak and Anthony Gordon struggled to make an impact.
Only against Manchester City in August (one) have Newcastle recorded fewer shots on target in a Premier League game this season than their two against Palace, and Howe was critical of his team's display in the loss, one that all but ends their hopes of finishing in the top four.
"[It is a] bad day for us," Howe told Newcastle's club media.
"I thought we were disappointing today, especially in the first 60 minutes. We were way off our levels against Tottenham and our best levels.
"I thought technically we didn't deliver a good performance, and out of possession I don't think it was a particularly good performance either."
Newcastle were unlocked twice for Mateta to score by a Palace side who themselves only generated 0.88 xG.
Howe was left frustrated by the manner in which his side conceded, adding: "I think we'll be disappointed with our performance technically today, and that's probably epitomised by the two goals where we're disappointed with how we've given them the ball in those situations and then how we defended.
"I think the goals sum up aspects of our performance where there was some good, lots of moments that could have led to opportunities, but we were slow to shoot around the box," he said.
The defeat, combined with Manchester United's 4-2 win over Sheffield United, means Newcastle drop to seventh, while eighth-placed West Ham are two points behind with a game in hand.
Newcastle have now lost eight of their last 11 Premier League away games, while they have lost on four occasions in London in the league this term, only doing so more times in a Premier League season in 2000-01 and 2005-06 (both five).
It's been a disappointing season for Howe and his side, especially compared to the heroics of last term when Newcastle finished in the top four, and the Magpies boss knows there's work to be done to get back to those levels.
"It's a day that we have to take our punishment, deal with it, and then try and improve," Howe continued. "It's frustrating because we know we're capable of much better."
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