Lee Carsley wants the England players at his disposal to "make the most of the situation" after nine others dropped out through injury.
Everton defender Jarrad Branthwaite on Wednesday became latest player to withdraw from the Nations League games with Greece and Republic of Ireland.
Trent Alexander-Arnold, Cole Palmer, Phil Foden, Jack Grealish, Bukayo Saka, Declan Rice, Aaron Ramsdale and Levi Colwill have also dropped out.
England captain Harry Kane has admitted to being unhappy with the large number of withdrawals for interim boss Carsley's final two games in charge.
However, Carsley attempted to put a positive spin on the situation when speaking at his pre-match press conference on Wednesday ahead of facing Greece.
"The focus all camp has been on the players that are here and it's important that we make the most of the situation," he told reporters.
"With the amount of players that have pulled out, it gives other players an opportunity to be here.
"We're really looking forward to the game and it's going to be a tough test for us and the focus has been purely on the players that are here.
"With the amount of pull-outs we've had in the window, historically it's been like that in the past - November has always been a challenging window.
"But the culture that Gareth [Southgate], Steve [Holland] and the rest of the lads created has made it a really positive environment and the players that are here thoroughly deserve to be here."
Grealish was one of the first players to withdraw from the squad, having been called up despite not playing for club side Manchester City since 20 October.
City boss Pep Guardiola questioned England's decision to include Grealish in their squad as he recovers from injury, but Carsley insisted he was justified in doing so.
"The medical teams are constantly talking throughout squad selection, regardless of whether there are games or not," Carsley said.
"We are constantly getting updates. The medical departments have brilliant communication between club and country.
"It was always the case we were going to get the players who were potentially going to miss out in to the assessed. Jack was one of them. He was assessed and sent back and it was as clear as that."
England trail Group B2 leaders Greece by three points with two rounds of fixtures to play, having lost the reverse fixture 2-1 at Wembley last month.
The Three Lions have won on all four of their previous trips to face Greece, doing so by an aggregate score of 9-1 - only against Luxembourg (5/5) do they hold a better 100% win rate away from home.
However, Greece are on the longest active winning run of any European nation in all competitions (five games) and could win six consecutive matches for the first time November 2013.
Carsley, who will step aside for Thomas Tuchel after next week's home match with Republic of Ireland, said: "We're expecting a tough game against Greece and it’s one we have to win.
"But we're really looking forward to it, we've had a good week's training, the players are in good spirits and it's going to be a sell out with a great atmosphere.
"We've had to wait four or five weeks for this, but this next window is so important to us, not just tomorrow but Republic of Ireland as well, so it's a great challenge for us."
Manchester United 2-3 Nottingham Forest: Wood hits winner as Amorim's side lose again
Manchester United suffered back-to-back defeats in the Premier League following a 3-2 defeat to Nottingham Forest at Old Trafford.
Chris Wood's 10th league goal of the season in the 54th minute proved to be the winner as Forest climbed to fifth place – only two points behind fourth-placed Manchester City.
Nikola Milenkovic put the visitors ahead with only 91 seconds on the clock as he headed in a corner from Elliot Anderson, but Rasmus Hojlund levelled the score for United 16 minutes later, following up after Alejandro Garnacho's initial effort was saved by Matz Sels.
Jota Silva and Bruno Fernandes were denied by the woodwork during the first half before Morgan Gibbs-White made it 2-1 to Forest just two minutes after the restart.
Wood then planted a looping header past Andre Onana to double Forest's lead before United captain Fernandes then pulled one back just past the hour mark.
Ruben Amorim's side pushed for an equaliser, but Forest kept them at bay to collect the full points.
Forest now have 25 points from 15 matches, while United are in 13th place with 19 points.
Data Debrief: Wood makes Forest history
Wood's winner was his 25th Premier League goal for Forest and helped him overtake Bryan Roy (24) to become their all-time leading scorer in the competition.
Since Nuno Espírito Santo's appointment in December 2023, only Erling Haaland (21) has scored more non-penalty goals in the competition than Wood (19 – level with Cole Palmer).
Nuno became just the second Forest manager to win both of his first two league games against United, after Fred Earp in the 1909-10 campaign.
Meanwhile, his counterpart Amorim suffered two straight defeats for only the second time, with the first coming during his stint with former club Sporting in August 2022.
Unai Emery sets Champions League mission as Aston Villa edge Southampton win
Aston Villa boss Unai Emery is quickly turning his attention to the UEFA Champions League following their 1-0 Premier League win over Southampton.
Jhon Duran's first-half goal sealed successive league victories for Emery on the back of three straight top-flight losses against rivals Chelsea, Liverpool and Tottenham.
Victory against the Saints is a vital boost for Emery ahead of a crucial few weeks of action before the end of 2024.
Villa head to RB Leipzig on 10 December, looking to push their case for a spot in the Round of 16, followed by four more league clashes this month.
The immediate focus for Emery is on Leipzig, with Villa's contrasting European form a cause for concern, despite a brilliant start on their Champions League debut.
Three straight wins in their first appearance in the competition since it was renamed – including an historic 1-0 home victory over Bayern Munich – put Villa in a strong position, but defeat to Club Brugge and a 0-0 tie with Juventus has stalled their momentum.
The former Arsenal chief wants this result to act as a platform for his team ahead of their tricky trip to Germany in midweek.
"Over the 90 minutes we had chances to score more, but sometimes they dominated possession. We managed the game plan to try and find a way to win," as per quotes from BBC Sport.
"The most important thing is how we're progressively getting more comfortable on the field. We had to use substitutions because we have the Champions League on Tuesday. Three matches in nine days. We have to be ready with the players we have available to try and enjoy the competition.
"The Champions League is something we have to enjoy, but we also focus on the difficulties in the Premier League, and the challenge against Nottingham Forest is something else. But, we have to try and get to the next round of the Champions League."
Up next for Villa is that Midlands derby with Forest, followed by a crunch clash at home to Manchester City on 21 December.
A win for Villa puts them up to fifth in the table, but defeat for Southampton registers as their 12th league loss of the campaign so far, with Russell Martin's team still rooted to the foot of the table.
Individual mistakes are becoming a theme, and centre-back Taylor Harwood-Bellis was robbed by Duran for Villa's winner, with Martin left to rue a familiar frustrating story for his team.
"We gave away a poor goal when it was a good, tight game. We changed shape and then the game became transitional. They were trying to find another goal, so it became very open," he said.
"We're two v one, and we had a chance to clear the ball, and we don't. It's another mistake. We forced them long, and then we had another two v one, and he [Duran] somehow comes out with the ball and scores."
Up next for Southampton is a home tie with Tottenham next weekend, followed by an EFL Cup quarter-final at home to Liverpool on December 18.
JFF, Reggae Boyz Head Coach wish Antonio speedy recovery after car crash
The Jamaica Football Federation (JFF) has issued a statement wishing for the speedy recovery of Reggae Boyz and West Ham United striker Michail Antonio following a motor vehicle accident in Essex on Saturday.
Since news of the accident, West Ham have confirmed that Antonio is in stable condition at a London Hospital, conscious and communicating under careful supervision.
JFF President Michael Ricketts and Reggae Boyz Head Coach Steve McClaren have both offered world of encouragement to Antonio in the statement sent out by the federation this afternoon.
"On behalf of the entire group of players, support staff and technical staff, I would like to wish Michail a speedy recovery. Our thoughts and prayers are with him at this time,” McClaren said.
“On behalf of the entire Jamaica Football Federation family, I would like to wish Michail a safe and speedy recovery. At this point let us keep him in our prayers as he recovers,” Ricketts added.
Further updates will be issued in due course between West Ham United in collaboration with the Jamaica Football Federation.
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