Real Madrid centre-back Eder Militao has left Brazil's training camp ahead of World Cup qualifiers versus Ecuador and Paraguay due to a leg injury.
Brazil have made a dismal start to their 2026 World Cup qualification campaign and sit sixth in the 10-team CONMEBOL group after six games, with two wins, one draw and three defeats.
Dorival Junior's side will have to cope without key defender Militao for the first international break of the season, after the Brazilian FA (CBF) confirmed he had suffered an injury.
"Defender Eder Militao complained of muscle pain in his right thigh after training on Wednesday and after medical exams carried out on Thursday, it was identified a small muscle injury in his right thigh," the CBF said in a statement.
"The player has been ruled out of Brazil's next two qualifying matches and the CBF expresses its solidarity with the player at this time and wishes him a speedy recovery."
Militao, who missed most of last season after tearing his anterior cruciate ligament, is the latest Madrid player to suffer injury problems at the start of this season.
Midfielder Aurelien Tchouameni and left-back Ferland Mendy both left France's camp ahead of their Nations League clashes against Italy and Belgium due to injuries sustained in Los Blancos' 2-0 win over Real Betis on Sunday.
Eduardo Camavinga, Dani Ceballos and Jude Bellingham have also suffered from injuries in the last few weeks, while David Alaba is still recovering from an ACL tear suffered last term.