Real Madrid cruised into the Champions League quarter-finals as Liverpool never threatened the three-goal fightback they required in a 1-0 defeat at the Santiago Bernabeu.
European champions Madrid had claimed a brilliant 5-2 win in England in the first leg of their last-16 tie, leaving Liverpool a mighty uphill battle in Wednesday's return match.
The Reds defence – and Alisson in particular – at least gave their team-mates a platform from which to build this time, but the goal threat that had briefly concerned Madrid on Merseyside was less evident.
Eventually, Karim Benzema, that familiar foe, put Jurgen Klopp's side out of their misery as Madrid continued their bid for yet another crown in their favourite competition of all.
The goalkeepers were the undoubted stars of a goalless first half, with Alisson brilliantly blocking from Vinicius Junior at close quarters and soon touching Eduardo Camavinga's deflected shot onto the crossbar. A VAR review might have overturned the offside given against Vinicius when he was denied again by Alisson.
Those stops just about kept Liverpool in the tie, but Thibaut Courtois – the hero of last season's final between the sides – was not to be outdone. His fingertip stop from Darwin Nunez was as impressive as any of Alisson's saves, and he then beat away a thunderous Cody Gakpo drive.
Federico Valverde ran through early in the second half but scuffed straight at Alisson, with the same man heading over following excellent work on the left from Luka Modric. Benzema also missed the target when well placed on his right foot.
The chances continued to fall Madrid's way, however, and Benzema made no mistake when Vinicius miscued his finish and instead prodded to his team-mate for an open goal in the 78th minute.
Benzema took a kick in the process, but that was about the extent of Madrid's concern in a dominant 6-2 aggregate triumph.
What does it mean? Madrid never under threat
Klopp had acknowledged Liverpool would have to be "extremely good" to stand any chance, and they were not that in an attacking sense – particularly in the second half.
Still three goals behind in the tie with 45 minutes to play, the visitors needed to let the handbrake off but instead struggled to pose any sort of threat.
After a James Milner shot in the 37th minute – their eighth of the match – Liverpool went until Harvey Elliott's tame effort in the 83rd minute before mustering another attempt.
Courtois king again
This was more like the Courtois who made a match-winning nine saves in the Paris final than the man whose early mishap had Liverpool in control of this tie for a time at Anfield.
It may have been comfortable in the end, but Courtois made four crucial saves in the first half when a goal might have invited tension.
Salah so disappointing
Mohamed Salah's woeful penalty at Bournemouth on Saturday consigned Liverpool to a Premier League defeat, yet at least that registered as an attempt. He did not have a single shot here.
Although Salah created a pair of chances for team-mates, he was also painfully wasteful in the final third, where he misplaced only four passes but seemed to kill momentum each time.
What's next?
It will be Madrid's turn to chase a result on Sunday when they go to Barcelona for the Clasico. Liverpool do not play again before the international break, which is followed by a daunting trip to Manchester City.
Coventry City 2-3 Hull City: Tigers win five-goal thriller to keep play-off hopes alive
Hull City kept their hopes of gatecrashing the Championship play-offs alive with a thrilling 3-2 win over beaten FA Cup semi-finalists Coventry City on Wednesday.
Noah Ohio scored the winner with his first touch after coming on as a second-half substitute as Hull moved within three points of sixth-placed Norwich City with two games to play.
Coventry, meanwhile, saw their own hopes of returning to Wembley Stadium for a second successive play-off final all but ended, as they sit six points further back with three matches remaining.
Three days on from their remarkable comeback against Manchester United, the Sky Blues twice fought back to level things at Coventry Building Society Arena. Jaden Philogene's shot squirmed under goalkeeper Bradley Collins to put Hull ahead 31 minutes in, but Kasey Palmer levelled within five minutes with a stunning free-kick.
Hull went back ahead in controversial circumstances on the stroke of half-time, Liverpool loanee Fabio Carvalho converting from the penalty spot despite replays showing Joel Latibeaudiere's foul on Liam Delap took place outside the area.
Mark Robins' men again dragged themselves back into the game as Bobby Thomas headed Jay Dasilva's cross in just before the hour mark, but it was Liam Rosenior's visitors who found a winner.
Thomas went from hero to villain as his poor back pass sold Collins short, and Ohio got a toe to the ball to score the winner, keeping Hull's hopes of Premier League football intact.
Van Dijk: Liverpool have 'no chance' in title race after derby defeat
Virgil van Dijk conceded Liverpool might be out of the Premier League title race after they suffered a surprise 2-0 defeat to Everton in Wednesday's Merseyside derby.
Jarrad Branthwaite and Dominic Calvert-Lewin scored in either half to give the Toffees their first win over Liverpool at Goodison Park since 2010.
Liverpool struggled to find a way through the Toffees' defence despite dominating for long periods, and the Reds' captain says they will not outlast Arsenal and Manchester City without major improvements.
Speaking to Sky Sports, Van Dijk said: "If we play like today, then we have no chance to consider ourselves in the title race.
"We have to just focus on the next game and that will be a tough one anyway, so we will see.
"We're very disappointed, in so many ways. I think everyone has to look at their own performances. Did they really give everything, and do they really want to win the league?
"We're still fighting and there are still games after tonight, but if we play like we did overall in the game today – not winning challenges and giving the referee a chance to give free-kicks like he did many times, then you have no chance to win the title."
Howe: Newcastle performance in Palace defeat 'way off' Spurs win
Eddie Howe admitted Newcastle United's performance in the 2-0 loss at Crystal Palace on Wednesday was "way off" the one that saw them thump Tottenham in their previous game.
Howe's men hammered Spurs 4-0 in their last match, but they never got close to matching the attacking verve from that outing and a Jean-Philippe Mateta double condemned the Magpies to defeat at Selhurst Park.
Newcastle didn't even manage a shot on target until the 87th minute, accumulating just 0.42 xG (expected goals) as the likes of Alexander Isak and Anthony Gordon struggled to make an impact.
Only against Manchester City in August (one) have Newcastle recorded fewer shots on target in a Premier League game this season than their two against Palace, and Howe was critical of his team's display in the loss, one that all but ends their hopes of finishing in the top four.
"[It is a] bad day for us," Howe told Newcastle's club media.
"I thought we were disappointing today, especially in the first 60 minutes. We were way off our levels against Tottenham and our best levels.
"I thought technically we didn't deliver a good performance, and out of possession I don't think it was a particularly good performance either."
Newcastle were unlocked twice for Mateta to score by a Palace side who themselves only generated 0.88 xG.
Howe was left frustrated by the manner in which his side conceded, adding: "I think we'll be disappointed with our performance technically today, and that's probably epitomised by the two goals where we're disappointed with how we've given them the ball in those situations and then how we defended.
"I think the goals sum up aspects of our performance where there was some good, lots of moments that could have led to opportunities, but we were slow to shoot around the box," he said.
The defeat, combined with Manchester United's 4-2 win over Sheffield United, means Newcastle drop to seventh, while eighth-placed West Ham are two points behind with a game in hand.
Newcastle have now lost eight of their last 11 Premier League away games, while they have lost on four occasions in London in the league this term, only doing so more times in a Premier League season in 2000-01 and 2005-06 (both five).
It's been a disappointing season for Howe and his side, especially compared to the heroics of last term when Newcastle finished in the top four, and the Magpies boss knows there's work to be done to get back to those levels.
"It's a day that we have to take our punishment, deal with it, and then try and improve," Howe continued. "It's frustrating because we know we're capable of much better."
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